DK3720840T3 - Cathepsinhæmmere - Google Patents

Cathepsinhæmmere Download PDF

Info

Publication number
DK3720840T3
DK3720840T3 DK18839759.0T DK18839759T DK3720840T3 DK 3720840 T3 DK3720840 T3 DK 3720840T3 DK 18839759 T DK18839759 T DK 18839759T DK 3720840 T3 DK3720840 T3 DK 3720840T3
Authority
DK
Denmark
Prior art keywords
catheps
inhibitors
catheps inhibitors
Prior art date
Application number
DK18839759.0T
Other languages
English (en)
Inventor
Huib Ovaa
Maria Wilhelmina Elisabeth Mons
Boeckel Stan Van
Original Assignee
Academisch Ziekenhuis Leiden
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from NL2020021A external-priority patent/NL2020021B1/en
Application filed by Academisch Ziekenhuis Leiden filed Critical Academisch Ziekenhuis Leiden
Application granted granted Critical
Publication of DK3720840T3 publication Critical patent/DK3720840T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/14—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/40—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK18839759.0T 2017-12-05 2018-12-05 Cathepsinhæmmere DK3720840T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NL2020021A NL2020021B1 (en) 2017-12-05 2017-12-05 Cathepsin inhibitors
NL2021544 2018-09-03
PCT/NL2018/050810 WO2019112426A1 (en) 2017-12-05 2018-12-05 Cathepsin inhibitors

Publications (1)

Publication Number Publication Date
DK3720840T3 true DK3720840T3 (da) 2022-03-21

Family

ID=65228614

Family Applications (2)

Application Number Title Priority Date Filing Date
DK22150956.5T DK4046987T3 (da) 2017-12-05 2018-12-05 Cathepsin-hæmmere
DK18839759.0T DK3720840T3 (da) 2017-12-05 2018-12-05 Cathepsinhæmmere

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK22150956.5T DK4046987T3 (da) 2017-12-05 2018-12-05 Cathepsin-hæmmere

Country Status (6)

Country Link
US (3) US11174224B2 (da)
EP (2) EP3720840B1 (da)
DK (2) DK4046987T3 (da)
ES (2) ES2908999T3 (da)
FI (1) FI4046987T3 (da)
WO (1) WO2019112426A1 (da)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2908999T3 (es) 2017-12-05 2022-05-04 Academisch Ziekenhuis Leiden Inhibidores de catepsina

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002145849A (ja) * 2000-11-10 2002-05-22 Kyorin Pharmaceut Co Ltd アルキニルアミノ酸誘導体及びその製造法
RU2312861C2 (ru) * 2002-03-05 2007-12-20 Мерк Фросст Кэнада Лтд. Ингибиторы катепсин-цистеинпротеазы
ES2908999T3 (es) * 2017-12-05 2022-05-04 Academisch Ziekenhuis Leiden Inhibidores de catepsina

Also Published As

Publication number Publication date
US20240182409A1 (en) 2024-06-06
ES2908999T3 (es) 2022-05-04
ES3045582T3 (en) 2025-11-28
US20200385341A1 (en) 2020-12-10
US20220227705A1 (en) 2022-07-21
US11820734B2 (en) 2023-11-21
FI4046987T3 (fi) 2025-10-03
EP4046987B1 (en) 2025-08-27
WO2019112426A1 (en) 2019-06-13
US11174224B2 (en) 2021-11-16
EP4046987A1 (en) 2022-08-24
DK4046987T3 (da) 2025-10-06
EP3720840A1 (en) 2020-10-14
EP3720840B1 (en) 2022-01-19
US12371400B2 (en) 2025-07-29

Similar Documents

Publication Publication Date Title
IL283639A (en) Kif18a inhibitors
IL269196A (en) Novel inhibitors
MA54550A (fr) Inhibiteurs de kif18a
IL263586A (en) Inhibitors of the menin-mll interaction
EP3541932A4 (en) INHIBITORS OF CRISPR-CAS9
DK3612525T3 (da) Pd-1-/pd-l1-inhibitorer
DK3571192T3 (da) Jak1-selektive inhibitorer
MA52812A (fr) Inhibiteurs de sarm1
DK3497103T3 (da) Pyridopyrimdinon-cdk2/4/6-inhibitorer
DK3442972T3 (da) Bromdomænehæmmere
LT3303334T (lt) Tirozinkinazės inhibitoriai
CL2018000524S1 (es) Golilla
MA52813A (fr) Inhibiteurs de sarm1
HUE042335T2 (hu) ROR-gamma dihidropirrolopiridin inhibitorai
DK3672976T3 (da) Bcl-2-hæmmere
DE202018003363U8 (de) Handgelenkssphygmomanometer
EP3801499A4 (en) INHIBITORS OF SARM1
EP3313828A4 (en) METALLO-BETA-Lactamase INHIBITORS
DK3681884T3 (da) Rad51-inhibitorer
DK3351526T3 (da) Diisopentylterephthalat
EP3817736A4 (en) PIKFYVE INHIBITORS
DK3630744T3 (da) Pyrazol-magl-inhibitorer
DK3186242T3 (da) Alfa-amino-beta-carboxymuconsyre-semialdehyd-decarboxylasehæmmere
EP3720436A4 (en) TUBULIN INHIBITORS
DK3568655T3 (da) Rekuperator