DK373479A - Fremgangsmaade til fremstilling af et enzymderivat - Google Patents
Fremgangsmaade til fremstilling af et enzymderivatInfo
- Publication number
- DK373479A DK373479A DK373479A DK373479A DK373479A DK 373479 A DK373479 A DK 373479A DK 373479 A DK373479 A DK 373479A DK 373479 A DK373479 A DK 373479A DK 373479 A DK373479 A DK 373479A
- Authority
- DK
- Denmark
- Prior art keywords
- procedure
- preparation
- enzyme derivative
- enzyme
- derivative
- Prior art date
Links
- 102000004190 Enzymes Human genes 0.000 title 1
- 108090000790 Enzymes Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
- C07K14/3153—Streptokinase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7835960 | 1978-09-07 | ||
| GB7835960 | 1978-09-07 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK373479A true DK373479A (da) | 1980-04-11 |
| DK160996B DK160996B (da) | 1991-05-13 |
| DK160996C DK160996C (da) | 1991-10-28 |
Family
ID=10499512
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK373479A DK160996C (da) | 1978-09-07 | 1979-09-06 | Analogifremgangsmaade til fremstilling af et derivat af et in-vivo-fibrinolytisk enzym |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US4285932A (da) |
| EP (1) | EP0009879B1 (da) |
| JP (3) | JPS5537198A (da) |
| AR (1) | AR220575A1 (da) |
| AU (1) | AU524295B2 (da) |
| CA (1) | CA1134295A (da) |
| DE (1) | DE2966301D1 (da) |
| DK (1) | DK160996C (da) |
| ES (1) | ES483888A0 (da) |
| HK (1) | HK65986A (da) |
| HU (1) | HU182458B (da) |
| IE (1) | IE48478B1 (da) |
| IL (1) | IL58079A0 (da) |
| LU (1) | LU88326I2 (da) |
| MY (1) | MY8500995A (da) |
| NZ (1) | NZ191320A (da) |
| ZA (1) | ZA794294B (da) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ191320A (en) * | 1978-09-07 | 1982-09-14 | Beecham Group Ltd | In vivo fibrinolytic enzyme having active site blocked by hydrolytically removable group pharmaceutical compositions |
| JPS55167275A (en) * | 1979-06-15 | 1980-12-26 | Kowa Co | Preparation of amidinophenyl ester derivative |
| EP0028489B1 (en) * | 1979-11-05 | 1983-10-05 | Beecham Group Plc | Enzyme derivatives, and their preparation |
| DE3207033C2 (de) * | 1981-02-27 | 1984-09-13 | Torii & Co., Ltd., Tokyo | Amidinverbindungen, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Mittel |
| IT1170913B (it) * | 1981-04-23 | 1987-06-03 | Manetti & Roberts Italo Brit | Procedimento per la produzione di un principio attivo fibrinolitico vasale prodotto enzimatico specifico angiochinasi cosi' ottenuto e sue applicazioni farmaceutiche |
| DE3361610D1 (en) * | 1982-04-07 | 1986-02-06 | Beecham Group Plc | Enzyme derivatives, process for preparing them and pharmaceutical compositions containing them |
| WO1984001960A1 (en) * | 1982-11-11 | 1984-05-24 | Beecham Group Plc | Pharmaceutically active compounds |
| US4536391A (en) * | 1982-11-17 | 1985-08-20 | Otsuka Pharmaceutical Co. | Process for preparing urokinase complex |
| GB8319538D0 (en) * | 1983-07-20 | 1983-08-24 | Beecham Group Plc | Compounds |
| JPS60136520A (ja) * | 1983-12-23 | 1985-07-20 | Otsuka Pharmaceut Co Ltd | フイブリン吸着性ウロキナ−ゼ複合体 |
| GB8609948D0 (en) * | 1986-04-23 | 1986-05-29 | Beecham Group Plc | Compounds |
| GB8334498D0 (en) * | 1983-12-24 | 1984-02-01 | Beecham Group Plc | Compounds |
| GB8334499D0 (en) * | 1983-12-24 | 1984-02-01 | Beecham Group Plc | Derivatives |
| US4880776A (en) * | 1983-12-24 | 1989-11-14 | Beecham Group P.L.C. | Plasmin A-chain urokinase B-chain hybrid protein |
| GB8400653D0 (en) * | 1984-01-11 | 1984-02-15 | Beecham Group Plc | Conjugates |
| US5174994A (en) * | 1985-11-11 | 1992-12-29 | Leuven Research & Development Vzw | Pharmaceutical composition having thrombolytic activity |
| EP0266032A1 (en) * | 1986-08-29 | 1988-05-04 | Beecham Group Plc | Modified fibrinolytic enzyme |
| GB8707369D0 (en) * | 1987-03-27 | 1987-04-29 | Beecham Group Plc | Enzyme derivatives |
| US5009888A (en) * | 1987-04-13 | 1991-04-23 | Genzyme Corporation | Therapeutic enzyme-antibody complexes |
| GB8715302D0 (en) * | 1987-06-30 | 1987-08-05 | Ordidge R J | Nmr spectroscopy |
| US5302390A (en) * | 1987-07-01 | 1994-04-12 | Beecham Group Plc | Hybrid proteins of human plasminogen and human t-PA, pharmaceutical compositions and methods of treatment |
| EP0297882B1 (en) * | 1987-07-01 | 1993-08-25 | Beecham Group Plc | Hybrid plasminogen activators |
| US5256642A (en) * | 1988-04-01 | 1993-10-26 | The Johns Hopkins University | Compositions of soluble complement receptor 1 (CR1) and a thrombolytic agent, and the methods of use thereof |
| US6458360B1 (en) | 1990-04-25 | 2002-10-01 | The Johns Hopkins University | Soluble complement regulatory molecules |
| GB9011861D0 (en) * | 1990-05-26 | 1990-07-18 | Beecham Group Plc | Novel compounds |
| GB9013345D0 (en) * | 1990-06-14 | 1990-08-08 | Beecham Group Plc | Novel compounds |
| US5583107A (en) * | 1990-09-04 | 1996-12-10 | Cor Therapeutics, Inc. | Agents affecting thrombosis and hemostasis |
| US20040072757A1 (en) * | 1990-09-04 | 2004-04-15 | Cor Therapeutics, Inc. | Agents affecting thrombosis and hemostasis |
| US5597799A (en) * | 1990-09-04 | 1997-01-28 | Cor Therapeutics, Inc. | Recombinant agents affecting thrombosis |
| WO1992018139A1 (en) * | 1991-04-09 | 1992-10-29 | Brigham And Women's Hospital | Chimeric molecule with plasminogen activator activity and affinity for atherosclerotic plaques |
| GB9301289D0 (en) * | 1993-01-22 | 1993-03-17 | Smithkline Beecham Plc | Novel composition |
| US5589571A (en) * | 1994-10-28 | 1996-12-31 | Cor Therapeutics, Inc. | Process for production of inhibited forms of activated blood factors |
| US7544500B2 (en) | 1999-11-13 | 2009-06-09 | Talecris Biotherapeutics, Inc. | Process for the production of a reversibly inactive acidified plasmin composition |
| NZ589557A (en) | 2008-06-04 | 2012-08-31 | Talecris Biotherapeutics Inc | Immobilised streptokinase, method and kit for preparing plasmin |
| HUE025670T2 (en) | 2009-03-03 | 2016-04-28 | Grifols Therapeutics Inc | A method for producing plasminogen |
| EP2451835A1 (en) | 2009-07-10 | 2012-05-16 | ThromboGenics N.V. | Variants of plasminogen and plasmin |
| ES2534911T3 (es) | 2009-08-28 | 2015-04-30 | Thrombogenics N.V. | Uso de plasmina para el tratamiento de fallo de filtración después de trabeculectomía |
| RU2604807C2 (ru) | 2011-01-05 | 2016-12-10 | ТромбоДженикс НВ | Варианты плазминогена и плазмина |
| JP6000353B2 (ja) | 2011-08-12 | 2016-09-28 | スロンボジェニックス・ナムローゼ・フェンノートシャップＴｈｒｏｍｂｏＧｅｎｉｃｓ ＮＶ | プラスミノーゲンおよびプラスミンの変異体 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ191320A (en) * | 1978-09-07 | 1982-09-14 | Beecham Group Ltd | In vivo fibrinolytic enzyme having active site blocked by hydrolytically removable group pharmaceutical compositions |
-
1979
- 1979-08-15 NZ NZ191320A patent/NZ191320A/xx unknown
- 1979-08-16 ZA ZA00794294A patent/ZA794294B/xx unknown
- 1979-08-16 CA CA333,909A patent/CA1134295A/en not_active Expired
- 1979-08-17 AU AU50046/79A patent/AU524295B2/en not_active Expired
- 1979-08-20 US US06/068,205 patent/US4285932A/en not_active Expired - Lifetime
- 1979-08-20 IL IL58079A patent/IL58079A0/xx unknown
- 1979-08-22 AR AR277800A patent/AR220575A1/es active
- 1979-08-30 EP EP79301773A patent/EP0009879B1/en not_active Expired
- 1979-08-30 DE DE7979301773T patent/DE2966301D1/de not_active Expired
- 1979-09-04 ES ES483888A patent/ES483888A0/es active Granted
- 1979-09-06 IE IE1696/79A patent/IE48478B1/en not_active IP Right Cessation
- 1979-09-06 DK DK373479A patent/DK160996C/da not_active IP Right Cessation
- 1979-09-06 HU HU79BE1364A patent/HU182458B/hu not_active IP Right Cessation
- 1979-09-07 JP JP11430579A patent/JPS5537198A/ja active Granted
-
1980
- 1980-12-16 US US06/216,799 patent/US4337244A/en not_active Expired - Lifetime
-
1985
- 1985-12-30 MY MY995/85A patent/MY8500995A/xx unknown
-
1986
- 1986-09-04 HK HK659/86A patent/HK65986A/en not_active IP Right Cessation
-
1989
- 1989-11-24 JP JP1306342A patent/JPH02154687A/ja active Pending
-
1992
- 1992-07-13 JP JP4207007A patent/JPH05304957A/ja active Pending
-
1993
- 1993-06-24 LU LU88326C patent/LU88326I2/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0009879B1 (en) | 1983-10-12 |
| AU5004679A (en) | 1980-03-13 |
| JPH0231952B2 (da) | 1990-07-17 |
| HK65986A (en) | 1986-09-12 |
| ES8101385A1 (es) | 1980-12-16 |
| ZA794294B (en) | 1980-08-27 |
| MY8500995A (en) | 1985-12-31 |
| CA1134295A (en) | 1982-10-26 |
| JPS5537198A (en) | 1980-03-15 |
| IE791696L (en) | 1980-03-07 |
| ES483888A0 (es) | 1980-12-16 |
| HU182458B (en) | 1984-01-30 |
| DE2966301D1 (en) | 1983-11-17 |
| EP0009879A1 (en) | 1980-04-16 |
| AR220575A1 (es) | 1980-11-14 |
| LU88326I2 (fr) | 1994-05-04 |
| IE48478B1 (en) | 1985-02-06 |
| JPH05304957A (ja) | 1993-11-19 |
| US4285932A (en) | 1981-08-25 |
| JPH02154687A (ja) | 1990-06-14 |
| DK160996B (da) | 1991-05-13 |
| US4337244A (en) | 1982-06-29 |
| DK160996C (da) | 1991-10-28 |
| IL58079A0 (en) | 1979-12-30 |
| NZ191320A (en) | 1982-09-14 |
| AU524295B2 (en) | 1982-09-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUP | Patent expired |