DK3759113T3 - 10-(di(phenyl)methyl)-4-hydroxy-8,9,9A,10-tetrahydro- 7H-pyrrolo[1',2':4,5]pyrazino[1,2-b]pyridazin-3,5-dionderivat og lignende forbindelser som inhibitorer af orthomyxovirus-replikation til behandling af influenza - Google Patents
10-(di(phenyl)methyl)-4-hydroxy-8,9,9A,10-tetrahydro- 7H-pyrrolo[1',2':4,5]pyrazino[1,2-b]pyridazin-3,5-dionderivat og lignende forbindelser som inhibitorer af orthomyxovirus-replikation til behandling af influenza Download PDFInfo
- Publication number
- DK3759113T3 DK3759113T3 DK19713572.6T DK19713572T DK3759113T3 DK 3759113 T3 DK3759113 T3 DK 3759113T3 DK 19713572 T DK19713572 T DK 19713572T DK 3759113 T3 DK3759113 T3 DK 3759113T3
- Authority
- DK
- Denmark
- Prior art keywords
- pyrazino
- pyrrolo
- pyridazine
- influenza
- tetrahydro
- Prior art date
Links
- VRXNLNSKYRSTFJ-UHFFFAOYSA-N 2-benzhydryl-10-hydroxy-1,7,13-triazatricyclo[7.4.0.03,7]trideca-9,12-diene-8,11-dione Chemical class Oc1c2C(=O)N3CCCC3C(C(c3ccccc3)c3ccccc3)n2ncc1=O VRXNLNSKYRSTFJ-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 206010022000 influenza Diseases 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 230000010076 replication Effects 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862636378P | 2018-02-28 | 2018-02-28 | |
| PCT/IB2019/051549 WO2019166950A1 (en) | 2018-02-28 | 2019-02-26 | 10-(di(phenyl)methyl)-4-hydroxy-8,9,9a,10-tetrahydro-7h-pyrrolo[1 ',2':4,5]pyrazino[1,2-b]pyridazine-3,5-dione derivatives and related compounds as inhibitors of the orthomyxovirus replication for treating influenza |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3759113T3 true DK3759113T3 (da) | 2024-10-28 |
Family
ID=65911219
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK19713572.6T DK3759113T3 (da) | 2018-02-28 | 2019-02-26 | 10-(di(phenyl)methyl)-4-hydroxy-8,9,9A,10-tetrahydro- 7H-pyrrolo[1',2':4,5]pyrazino[1,2-b]pyridazin-3,5-dionderivat og lignende forbindelser som inhibitorer af orthomyxovirus-replikation til behandling af influenza |
Country Status (31)
| Country | Link |
|---|---|
| US (3) | US11629149B2 (da) |
| EP (2) | EP3759113B1 (da) |
| JP (4) | JP7065989B2 (da) |
| KR (3) | KR20230031990A (da) |
| CN (2) | CN118878544A (da) |
| AU (1) | AU2019227250B2 (da) |
| BR (1) | BR112020017121A2 (da) |
| CA (1) | CA3092544A1 (da) |
| CL (1) | CL2020002202A1 (da) |
| CR (2) | CR20240350A (da) |
| DK (1) | DK3759113T3 (da) |
| EA (1) | EA202091696A1 (da) |
| ES (1) | ES2993277T3 (da) |
| FI (1) | FI3759113T3 (da) |
| HR (1) | HRP20241522T1 (da) |
| HU (1) | HUE069183T2 (da) |
| IL (3) | IL276901B2 (da) |
| LT (1) | LT3759113T (da) |
| MX (2) | MX2020008959A (da) |
| MY (1) | MY203207A (da) |
| NZ (1) | NZ767072A (da) |
| PE (1) | PE20210403A1 (da) |
| PH (1) | PH12020500660A1 (da) |
| PL (1) | PL3759113T3 (da) |
| PT (1) | PT3759113T (da) |
| SA (1) | SA520420046B1 (da) |
| SG (1) | SG11202007718SA (da) |
| SI (1) | SI3759113T1 (da) |
| UA (1) | UA126253C2 (da) |
| WO (1) | WO2019166950A1 (da) |
| ZA (1) | ZA202005507B (da) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2881776T3 (es) | 2016-03-08 | 2021-11-30 | Novartis Ag | Compuestos tricíclicos útiles para tratar las infecciones por ortomixovirus |
| JOP20170169A1 (ar) * | 2016-08-29 | 2019-01-30 | Novartis Ag | مركبات بيريدازين ثلاثية الحلقة مندمجة تفيد في علاج العدوى بفيروس أورثوميكسو |
| KR20230031990A (ko) | 2018-02-28 | 2023-03-07 | 노파르티스 아게 | 인플루엔자의 치료를 위한 오르토믹소바이러스 복제의 억제제로서의 10-(디(페닐)메틸)-4-히드록시-8,9,9a,10-테트라히드로-7h-피롤로[1',2':4,5]피라지노[1,2-b]피리다진-3,5-디온 유도체 및 관련 화합물 |
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| GB8501542D0 (en) | 1985-01-22 | 1985-02-20 | Erba Farmitalia | 4 5 6 7-tetrahydro-imidazo(4 5-clpyridine derivatives |
| AUPM354694A0 (en) | 1994-01-27 | 1994-02-17 | Biota Scientific Management Pty Ltd | Chemical compounds |
| BR0211750A (pt) | 2001-08-10 | 2004-10-13 | Shionogi & Co | Agente antiviral |
| WO2004078163A2 (en) | 2003-02-28 | 2004-09-16 | Transform Pharmaceuticals, Inc. | Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen |
| TW200510425A (en) | 2003-08-13 | 2005-03-16 | Japan Tobacco Inc | Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor |
| TW200526635A (en) | 2003-12-22 | 2005-08-16 | Shionogi & Co | Hydroxypyrimidinone derivative having HIV integrase inhibitory activity |
| WO2005087766A1 (en) | 2004-03-09 | 2005-09-22 | Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa | Hiv integrase inhibitors |
| FR2901795A1 (fr) | 2006-05-30 | 2007-12-07 | Fourtillan Snc | Derives de pyrimidino[1',6'-1,2]pyrido[3,4-b]indoles et leur utilisation en therapeutique |
| US9238657B2 (en) | 2008-10-31 | 2016-01-19 | Shionogi & Co., Ltd. | Cephalosporin having catechol group |
| US8835461B2 (en) | 2009-03-26 | 2014-09-16 | Shionogi & Co., Ltd. | Substituted 3-hydroxy-4-pyridone derivative |
| TWI518084B (zh) | 2009-03-26 | 2016-01-21 | 鹽野義製藥股份有限公司 | 哌喃酮與吡啶酮衍生物之製造方法 |
| LT2444400T (lt) | 2009-06-15 | 2018-06-11 | Shionogi & Co., Ltd. | Pakeistasis policiklinis karbamoilpiridono darinys |
| US8541418B2 (en) | 2009-12-23 | 2013-09-24 | Elan Pharmaceutical, Inc. | Inhibitors of polo-like kinase |
| TW201201813A (en) | 2010-03-31 | 2012-01-16 | Arqule Inc | Substituted benzo-pyrido-triazolo-diazepine compounds |
| US20120195857A1 (en) | 2010-08-12 | 2012-08-02 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| MX2013003139A (es) | 2010-09-24 | 2013-06-18 | Shionogi & Co | Profarmaco de derivado de carbamoilpiridona policiclica substituida. |
| WO2012151567A1 (en) | 2011-05-05 | 2012-11-08 | St. Jude Children's Research Hospital | Pyrimidinone compounds and methods for preventing and treating influenza |
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| CN105530946A (zh) | 2013-09-11 | 2016-04-27 | 南加利福尼亚大学 | 具有高度表达的fas配体的干细胞组合物 |
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| WO2016005330A1 (en) | 2014-07-07 | 2016-01-14 | F. Hoffmann-La Roche Ag | Dihydropyridopyrazine-1,8-diones and their use in the treatment, amelioration or prevention of viral diseases |
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| ES2881776T3 (es) | 2016-03-08 | 2021-11-30 | Novartis Ag | Compuestos tricíclicos útiles para tratar las infecciones por ortomixovirus |
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| KR20200127177A (ko) | 2018-02-28 | 2020-11-10 | 니뽄 다바코 산교 가부시키가이샤 | 포화 환 축합 디히드로피리미디논 또는 디히드로트리아지논 화합물 및 그의 의약 용도 |
| RU2020131012A (ru) | 2018-02-28 | 2022-03-28 | Ф. Хоффманн-Ля Рош Аг | 7-замещенные соединения сульфонимидоилпуринонов и их производные для лечения и профилактики рака печени |
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| KR20230031990A (ko) * | 2018-02-28 | 2023-03-07 | 노파르티스 아게 | 인플루엔자의 치료를 위한 오르토믹소바이러스 복제의 억제제로서의 10-(디(페닐)메틸)-4-히드록시-8,9,9a,10-테트라히드로-7h-피롤로[1',2':4,5]피라지노[1,2-b]피리다진-3,5-디온 유도체 및 관련 화합물 |
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2019
- 2019-02-26 KR KR1020237006152A patent/KR20230031990A/ko not_active Ceased
- 2019-02-26 US US16/975,784 patent/US11629149B2/en active Active
- 2019-02-26 HU HUE19713572A patent/HUE069183T2/hu unknown
- 2019-02-26 PT PT197135726T patent/PT3759113T/pt unknown
- 2019-02-26 CR CR20240350A patent/CR20240350A/es unknown
- 2019-02-26 DK DK19713572.6T patent/DK3759113T3/da active
- 2019-02-26 AU AU2019227250A patent/AU2019227250B2/en active Active
- 2019-02-26 PE PE2020001286A patent/PE20210403A1/es unknown
- 2019-02-26 CN CN202410938055.0A patent/CN118878544A/zh active Pending
- 2019-02-26 WO PCT/IB2019/051549 patent/WO2019166950A1/en not_active Ceased
- 2019-02-26 IL IL276901A patent/IL276901B2/en unknown
- 2019-02-26 KR KR1020207027420A patent/KR102521320B1/ko active Active
- 2019-02-26 EP EP19713572.6A patent/EP3759113B1/en active Active
- 2019-02-26 MX MX2020008959A patent/MX2020008959A/es unknown
- 2019-02-26 CN CN201980015931.XA patent/CN111801333B/zh active Active
- 2019-02-26 SG SG11202007718SA patent/SG11202007718SA/en unknown
- 2019-02-26 PL PL19713572.6T patent/PL3759113T3/pl unknown
- 2019-02-26 ES ES19713572T patent/ES2993277T3/es active Active
- 2019-02-26 NZ NZ767072A patent/NZ767072A/en unknown
- 2019-02-26 KR KR1020247015694A patent/KR20240073143A/ko active Pending
- 2019-02-26 IL IL326515A patent/IL326515A/en unknown
- 2019-02-26 UA UAA202005624A patent/UA126253C2/uk unknown
- 2019-02-26 JP JP2020544932A patent/JP7065989B2/ja active Active
- 2019-02-26 BR BR112020017121-2A patent/BR112020017121A2/pt unknown
- 2019-02-26 CR CR20200372A patent/CR20200372A/es unknown
- 2019-02-26 EP EP24195375.1A patent/EP4467198A3/en active Pending
- 2019-02-26 LT LTEPPCT/IB2019/051549T patent/LT3759113T/lt unknown
- 2019-02-26 FI FIEP19713572.6T patent/FI3759113T3/fi active
- 2019-02-26 EA EA202091696A patent/EA202091696A1/ru unknown
- 2019-02-26 CA CA3092544A patent/CA3092544A1/en active Pending
- 2019-02-26 HR HRP20241522TT patent/HRP20241522T1/hr unknown
- 2019-02-26 SI SI201930859T patent/SI3759113T1/sl unknown
- 2019-02-26 MY MYPI2020004423A patent/MY203207A/en unknown
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2020
- 2020-08-26 CL CL2020002202A patent/CL2020002202A1/es unknown
- 2020-08-26 SA SA520420046A patent/SA520420046B1/ar unknown
- 2020-08-27 MX MX2023000084A patent/MX2023000084A/es unknown
- 2020-08-27 PH PH12020500660A patent/PH12020500660A1/en unknown
- 2020-09-03 ZA ZA2020/05507A patent/ZA202005507B/en unknown
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2022
- 2022-02-04 JP JP2022016352A patent/JP2022048391A/ja not_active Withdrawn
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2023
- 2023-02-27 US US18/114,336 patent/US12071441B2/en active Active
- 2023-09-14 IL IL305957A patent/IL305957B1/en unknown
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2024
- 2024-02-05 JP JP2024016007A patent/JP2024033009A/ja not_active Withdrawn
- 2024-07-03 US US18/764,058 patent/US20250034156A1/en active Pending
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2025
- 2025-12-11 JP JP2025245272A patent/JP2026034569A/ja active Pending
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