DK379985A - Fremgangsmaade til fremstilling af 6-chlor-n-methyl-2,3,4,5-tetrahydro-lh-benzazepin - Google Patents

Fremgangsmaade til fremstilling af 6-chlor-n-methyl-2,3,4,5-tetrahydro-lh-benzazepin Download PDF

Info

Publication number: DK379985A
Authority: DK; Denmark
Prior art keywords: benzazepine; chlor; tetrahydro; methyl; preparing
Prior art date: 1984-09-05

Application number

DK379985A

Other languages

Danish (da)

English (en)

Other versions

DK379985D0 (da

Inventor

Stanley John Borowski

Thomas Anthony Post

Original Assignee

Smithkline Beckman Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-09-05

Filing date

1985-08-21

Publication date

1986-03-06

1985-08-21 Application filed by Smithkline Beckman Corp filed Critical Smithkline Beckman Corp

1985-08-21 Publication of DK379985D0 publication Critical patent/DK379985D0/da

1986-03-06 Publication of DK379985A publication Critical patent/DK379985A/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)

DK379985A 1984-09-05 1985-08-21 Fremgangsmaade til fremstilling af 6-chlor-n-methyl-2,3,4,5-tetrahydro-lh-benzazepin DK379985A (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/647,552 US4541954A (en)	1984-09-05	1984-09-05	Method for preparing 6-chloro-N-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Publications (2)

Publication Number	Publication Date
DK379985D0 DK379985D0 (da)	1985-08-21
DK379985A true DK379985A (da)	1986-03-06

Family

ID=24597406

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK379985A DK379985A (da)	1984-09-05	1985-08-21	Fremgangsmaade til fremstilling af 6-chlor-n-methyl-2,3,4,5-tetrahydro-lh-benzazepin

Country Status (19)

Country	Link
US (1)	US4541954A (cs)
EP (1)	EP0174118A3 (cs)
JP (1)	JPS6168469A (cs)
KR (1)	KR860002470A (cs)
AU (1)	AU581918B2 (cs)
CA (1)	CA1244017A (cs)
DK (1)	DK379985A (cs)
EG (1)	EG17149A (cs)
ES (1)	ES8609266A1 (cs)
FI (1)	FI853255L (cs)
GR (1)	GR852041B (cs)
HU (1)	HU194181B (cs)
IL (1)	IL76100A0 (cs)
NO (1)	NO853255L (cs)
NZ (1)	NZ213141A (cs)
PH (1)	PH20796A (cs)
PT (1)	PT81018B (cs)
ZA (1)	ZA856268B (cs)
ZW (1)	ZW13385A1 (cs)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1993000811A1 (en) *	1991-07-01	1993-01-21	The General Hospital Corporation	Invertebrate phenylethanolamine transporter and the use thereof
EP0570590B1 (en) *	1991-12-06	1997-03-26	Yuasa Corporation	Thin battery and monolithic thin battery
US6953787B2 (en)	2002-04-12	2005-10-11	Arena Pharmaceuticals, Inc.	5HT2C receptor modulators
US8367657B2 (en) *	2003-06-17	2013-02-05	Arena Pharmaceuticals, Inc.	Processes for preparing 3-benzazepines
CN1805938B (zh)	2003-06-17	2010-06-16	艾尼纳制药公司	用于治疗5ht2c受体相关疾病的苯并氮杂卓衍生物
EP2149562A1 (en)	2004-12-21	2010-02-03	Arena Pharmaceuticals, Inc.	method of preparing (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride hemihydrate
NZ589951A (en) *	2004-12-23	2012-11-30	Arena Pharm Inc	5HT2C receptor modulator compositions and methods of use
CA2646044A1 (en)	2006-04-03	2007-10-25	Arena Pharmaceuticals, Inc.	Processes for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates related thereto
EP2099743B1 (en) *	2006-12-05	2014-08-27	Arena Pharmaceuticals, Inc.	Processes for preparing (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates thereof
US8822727B2 (en) *	2008-03-04	2014-09-02	Arena Pharmaceuticals, Inc.	Processes for the preparation of intermediates related to the 5-HT2C agonist (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
WO2010148207A2 (en)	2009-06-18	2010-12-23	Arena Pharmaceuticals, Inc.	Processes for the preparation of 5-ht2c receptor agonists
WO2011153206A1 (en)	2010-06-02	2011-12-08	Arena Pharmaceuticals, Inc.	Processes for the preparation of 5-ht2c receptor agonists
KR20180118801A (ko)	2010-09-01	2018-10-31	에자이 알앤드디 매니지먼트 가부시키가이샤	체중 관리에 유용한 5-ｈｔ2ｃ 작동제의 변형-방출 투여 형태
JP2013539470A (ja)	2010-09-01	2013-10-24	アリーナファーマシューティカルズ，インコーポレイテッド	ロルカセリンと光学活性な酸との塩
EA201390335A1 (ru)	2010-09-01	2013-09-30	Арена Фармасьютикалз, Инк.	Введение лоркасерина индивидуумам с почечной недостаточностью
KR20130101524A (ko)	2010-09-01	2013-09-13	아레나 파마슈티칼스, 인크.	5-ｈｔ2ｃ 아고니스트의 비-흡습성 염
RU2674670C1 (ru)	2012-10-09	2018-12-12	Арена Фармасьютикалз, Инк.	Способ коррекции массы тела

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1118688A (en) *	1967-02-17	1968-07-03	Scherico Ltd	Novel benzazepines and process for making same
CH481110A (de) *	1967-02-17	1969-11-15	Geigy Ag J R	Verfahren zur Herstellung von 1,2,4,5-Tetrahydro-3-azepinen
US4251660A (en) *	1978-08-10	1981-02-17	Smithkline Corporation	Method for preparing tetrahydroisoquinolines
US4200754A (en) *	1979-02-02	1980-04-29	Smithkline Corporation	Method for preparing 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline
EP0080779B1 (en) *	1981-11-27	1986-07-16	Smithkline Beckman Corporation	3-benzazepines as alpha-2 antagonists
ZA827887B (en) *	1981-11-27	1983-11-30	Smithkline Beckman Corp	Pharmaceutical compositions and method of producing alpha2 antagonism
IE53962B1 (en) *	1981-11-27	1989-04-26	Smithkline Beckman Corp	3-benzazepines as alpha-2 antagonists

1984
- 1984-09-05 US US06/647,552 patent/US4541954A/en not_active Expired - Fee Related
1985
- 1985-08-14 EP EP85305780A patent/EP0174118A3/en not_active Ceased
- 1985-08-15 IL IL76100A patent/IL76100A0/xx unknown
- 1985-08-19 CA CA000488976A patent/CA1244017A/en not_active Expired
- 1985-08-19 PH PH32660A patent/PH20796A/en unknown
- 1985-08-19 NO NO853255A patent/NO853255L/no unknown
- 1985-08-19 ZA ZA856268A patent/ZA856268B/xx unknown
- 1985-08-19 NZ NZ213141A patent/NZ213141A/xx unknown
- 1985-08-20 ES ES546285A patent/ES8609266A1/es not_active Expired
- 1985-08-20 JP JP60183788A patent/JPS6168469A/ja active Pending
- 1985-08-20 ZW ZW133/85A patent/ZW13385A1/xx unknown
- 1985-08-21 DK DK379985A patent/DK379985A/da not_active Application Discontinuation
- 1985-08-21 AU AU46481/85A patent/AU581918B2/en not_active Ceased
- 1985-08-21 HU HU853190A patent/HU194181B/hu unknown
- 1985-08-22 KR KR1019850006061A patent/KR860002470A/ko not_active Withdrawn
- 1985-08-22 GR GR852041A patent/GR852041B/el unknown
- 1985-08-23 PT PT81018A patent/PT81018B/pt unknown
- 1985-08-23 FI FI853255A patent/FI853255L/fi not_active Application Discontinuation
- 1985-09-04 EG EG545/85A patent/EG17149A/xx active

Also Published As

Publication number	Publication date
US4541954A (en)	1985-09-17
CA1244017A (en)	1988-11-01
EP0174118A2 (en)	1986-03-12
EP0174118A3 (en)	1986-12-30
FI853255A0 (fi)	1985-08-23
FI853255A7 (fi)	1986-03-06
ZA856268B (en)	1986-07-30
DK379985D0 (da)	1985-08-21
ES8609266A1 (es)	1986-09-01
KR860002470A (ko)	1986-04-26
ZW13385A1 (en)	1985-11-20
PT81018B (en)	1987-06-24
PH20796A (en)	1987-04-14
HUT38617A (en)	1986-06-30
JPS6168469A (ja)	1986-04-08
ES546285A0 (es)	1986-09-01
FI853255L (fi)	1986-03-06
NZ213141A (en)	1988-07-28
GR852041B (cs)	1985-12-19
EG17149A (en)	1989-06-30
AU581918B2 (en)	1989-03-09
IL76100A0 (en)	1985-12-31
HU194181B (en)	1988-01-28
PT81018A (en)	1985-09-01
NO853255L (no)	1986-03-06
AU4648185A (en)	1986-03-13

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Legal Events

Date	Code	Title	Description
1990-04-09	AHB	Application shelved due to non-payment