DK3820874T3 - Selektive estrogenreceptornedbrydere - Google Patents

Selektive estrogenreceptornedbrydere Download PDF

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Publication number
DK3820874T3
DK3820874T3 DK19746252.6T DK19746252T DK3820874T3 DK 3820874 T3 DK3820874 T3 DK 3820874T3 DK 19746252 T DK19746252 T DK 19746252T DK 3820874 T3 DK3820874 T3 DK 3820874T3
Authority
DK
Denmark
Prior art keywords
receptor antagonists
estrogen receptor
selective estrogen
selective
antagonists
Prior art date
Application number
DK19746252.6T
Other languages
English (en)
Inventor
Jeffrey Daniel Cohen
Daniel Jon Sall
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=67480324&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK3820874(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of DK3820874T3 publication Critical patent/DK3820874T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Professional, Industrial, Or Sporting Protective Garments (AREA)
  • Finger-Pressure Massage (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
DK19746252.6T 2018-07-12 2019-07-11 Selektive estrogenreceptornedbrydere DK3820874T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862697100P 2018-07-12 2018-07-12
US201962825172P 2019-03-28 2019-03-28
PCT/US2019/041342 WO2020014440A1 (en) 2018-07-12 2019-07-11 Selective estrogen receptor degraders

Publications (1)

Publication Number Publication Date
DK3820874T3 true DK3820874T3 (da) 2022-12-12

Family

ID=67480324

Family Applications (1)

Application Number Title Priority Date Filing Date
DK19746252.6T DK3820874T3 (da) 2018-07-12 2019-07-11 Selektive estrogenreceptornedbrydere

Country Status (33)

Country Link
US (1) US12128040B2 (da)
EP (1) EP3820874B1 (da)
JP (1) JP7085056B2 (da)
KR (1) KR102577142B1 (da)
CN (1) CN112424205B (da)
AU (1) AU2019299952B2 (da)
BR (1) BR112020025381A2 (da)
CA (1) CA3105491C (da)
CL (1) CL2021000046A1 (da)
CO (1) CO2021000041A2 (da)
CR (1) CR20210006A (da)
DK (1) DK3820874T3 (da)
EC (1) ECSP21001786A (da)
ES (1) ES2932867T3 (da)
FI (1) FI3820874T3 (da)
HR (1) HRP20230080T1 (da)
HU (1) HUE061032T2 (da)
IL (1) IL279990B2 (da)
JO (1) JOP20210004B1 (da)
LT (1) LT3820874T (da)
MD (1) MD3820874T2 (da)
MX (1) MX2021000377A (da)
MY (1) MY210254A (da)
PE (1) PE20211245A1 (da)
PH (1) PH12021550048A1 (da)
PL (1) PL3820874T3 (da)
PT (1) PT3820874T (da)
RS (1) RS63876B1 (da)
SA (1) SA521421006B1 (da)
SG (1) SG11202100145YA (da)
SI (1) SI3820874T1 (da)
UA (1) UA125890C2 (da)
WO (1) WO2020014440A1 (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3355884T3 (da) 2015-10-01 2021-08-02 Olema Pharmaceuticals Inc Tetrahydro-1h-pyrido[3,4-b]indol-antiøstrogenlægemidler
CA3001969C (en) 2015-12-17 2023-10-03 Eisai R&D Management Co., Ltd. Therapeutic agent for breast cancer
CA3017740A1 (en) 2016-03-16 2017-09-21 Pearlie BURNETTE Small molecules against cereblon to enhance effector t cell function
EA202190248A1 (ru) 2018-07-11 2021-06-16 Х. Ли Моффитт Кэнсер Сентер Энд Рисерч Инститьют, Инк. Димерные иммуномодулирующие соединения против механизмов на основе цереблона
TWI702219B (zh) * 2018-07-12 2020-08-21 美商美國禮來大藥廠 選擇性雌激素受體降解劑
CA3144791A1 (en) 2019-07-07 2021-01-14 Olema Pharmaceuticals, Inc. Regimens of estrogen receptor antagonists
TWI894443B (zh) * 2021-03-16 2025-08-21 美商美國禮來大藥廠 選擇性雌激素受體降解劑
CN117715902A (zh) * 2021-08-31 2024-03-15 卫材R&D管理有限公司 单环吡啶衍生物的制造方法
KR102743629B1 (ko) * 2022-02-01 2024-12-17 일라이 릴리 앤드 캄파니 선택적 에스트로겐 수용체 분해제의 제조 방법
JP2025528249A (ja) 2022-08-25 2025-08-26 サノフイ 新規な置換キノリン及びテトラヒドロナフタレンカルボン酸誘導体並びにその治療的使用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6756388B1 (en) * 1993-10-12 2004-06-29 Pfizer Inc. Benzothiophenes and related compounds as estrogen agonists
US5521214A (en) * 1995-01-25 1996-05-28 Eli Lilly And Company Methods of inhibiting environmental estrogens
JPH10204082A (ja) * 1996-10-25 1998-08-04 Eli Lilly & Co 選択的エストロゲンレセプターモジュレーターとしての活性を有する置換されたベンゾ［ｂ］チオフェン化合物
WO2002094788A1 (en) 2001-05-22 2002-11-28 Eli Lilly And Company 2-substituted 1,2,3,4-tetrahydroquinolines and derivatives thereof, compositions and methods
US7329654B2 (en) 2001-12-19 2008-02-12 Janssen Pharmaceutica N.V. Heteroatom containing tetracyclic derivatives as selective estrogen receptor modulators
EP1497277A1 (en) * 2002-04-19 2005-01-19 Signal Pharmaceuticals, Inc. Benzopyranone compounds, compositions thereof, and methods of treatment therewith
DE20301728U1 (de) * 2002-10-11 2004-03-11 Ligand Pharmaceuticals, Inc., San Diego 5-substituierte 7,9-Difluor-5H-Chromeno(3,4-f) -Chinolin-Verbindungen als selektive Progesteronrezeptormodulator-Verbindungen
CL2004000985A1 (es) * 2003-05-16 2005-01-14 Wyeth Corp Compuestos derivados de fenilquinolinas; composicion farmaceutica, proceso de preparacion; y uso para tratar osteoporosis, enfermedad de paget, dano vascular, osteoartritis, cancer oseo, cancer ovarico, cancer prostatico, hipercolesterolemia, aterosc
AU2005207821B2 (en) 2004-01-22 2011-02-10 Eli Lilly And Company Selective estrogen receptor modulators for the treatment of vasomotor symptoms
BRPI0514974A (pt) * 2004-09-07 2008-07-01 Wyeth Corp composto, composição, métodos de tratar ou inibir uma doença ou condição, estados de doença induzidos por radical livre em um mamìfero, dano à junta secundário aos procedimentos artroscópicos ou cirúrgicos em um mamìfero, infertilidade em um mamìfero, de diminuir os nìveis de colesterol, triglicerìdeos, lp(a), ou ldl, de fornecer realce na cognição ou neuroproteção, de contracepção em um mamìfero, e para preparar um composto, e, produto
US20080221163A1 (en) 2005-01-18 2008-09-11 Jeffrey Alan Dodge Selective Estrogen Receptor Modulators
MX2015016171A (es) 2013-06-19 2016-08-08 Seragon Pharmaceuticals Inc Moduladores del receptor de estrogeno de azetidina y usos de los mismos.
CN107406424B (zh) * 2014-12-18 2020-08-25 豪夫迈·罗氏有限公司 雌激素受体调节剂及其用途
EP3303326B1 (en) * 2015-05-26 2020-12-16 H. Hoffnabb-La Roche Ag Heterocyclic estrogen receptor modulators and uses thereof
US9969732B2 (en) * 2016-04-08 2018-05-15 Genentech, Inc. Tetrahydroisoquinoline estrogen receptor modulators and uses thereof
AR110728A1 (es) * 2017-01-06 2019-04-24 G1 Therapeutics Inc Terapia combinada para el tratamiento del cáncer
TWI702219B (zh) * 2018-07-12 2020-08-21 美商美國禮來大藥廠 選擇性雌激素受體降解劑

Also Published As

Publication number Publication date
ES2932867T3 (es) 2023-01-27
JOP20210004A1 (ar) 2021-01-10
IL279990B1 (en) 2023-03-01
KR20210018460A (ko) 2021-02-17
SG11202100145YA (en) 2021-02-25
PT3820874T (pt) 2023-01-06
JP7085056B2 (ja) 2022-06-15
IL279990B2 (en) 2023-07-01
MX2021000377A (es) 2021-03-25
CL2021000046A1 (es) 2021-06-25
AU2019299952A1 (en) 2021-01-21
UA125890C2 (uk) 2022-06-29
MD3820874T2 (ro) 2023-05-31
CA3105491C (en) 2023-09-05
EP3820874B1 (en) 2022-11-30
US20210260052A1 (en) 2021-08-26
CR20210006A (es) 2021-02-05
AU2019299952B2 (en) 2022-06-16
WO2020014440A1 (en) 2020-01-16
IL279990A (en) 2021-03-01
SA521421006B1 (ar) 2023-02-08
JP2021530486A (ja) 2021-11-11
CO2021000041A2 (es) 2021-01-18
LT3820874T (lt) 2023-02-10
US12128040B2 (en) 2024-10-29
PL3820874T3 (pl) 2023-02-06
BR112020025381A2 (pt) 2021-03-09
FI3820874T3 (fi) 2023-03-06
CA3105491A1 (en) 2020-01-16
CN112424205B (zh) 2023-10-31
EP3820874A1 (en) 2021-05-19
KR102577142B1 (ko) 2023-09-12
JOP20210004B1 (ar) 2024-04-18
HRP20230080T1 (hr) 2023-03-17
CN112424205A (zh) 2021-02-26
MY210254A (en) 2025-09-04
PH12021550048A1 (en) 2021-09-20
NZ771719A (en) 2024-02-23
RS63876B1 (sr) 2023-02-28
HUE061032T2 (hu) 2023-05-28
PE20211245A1 (es) 2021-07-13
ECSP21001786A (es) 2021-02-26
SI3820874T1 (sl) 2023-02-28

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