DK3848038T3 - 11-Hydroxyl-6substituerede-derivater af galdesyrer og aminosyrerkonjugater heraf som farnesoid X receptor modulerer. - Google Patents

11-Hydroxyl-6substituerede-derivater af galdesyrer og aminosyrerkonjugater heraf som farnesoid X receptor modulerer. Download PDF

Info

Publication number: DK3848038T3
Authority: DK; Denmark
Prior art keywords: farnesoid; hydroxyl; amino acid; bile acids; substituted derivatives
Prior art date: 2013-05-14

Application number

DK20211780.0T

Other languages

English (en)

Inventor

Roberto Pellicciari

Original Assignee

Intercept Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2013-05-14

Filing date

2014-05-14

Publication date

2023-02-06

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50721801&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK3848038(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2014-05-14 Application filed by Intercept Pharmaceuticals Inc filed Critical Intercept Pharmaceuticals Inc

2023-02-06 Application granted granted Critical

2023-02-06 Publication of DK3848038T3 publication Critical patent/DK3848038T3/da

Links

102100038495 Bile acid receptor Human genes 0.000 title 1
101000603876 Homo sapiens Bile acid receptor Proteins 0.000 title 1
150000001413 amino acids Chemical class 0.000 title 1
239000003613 bile acid Substances 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
- C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Gastroenterology & Hepatology (AREA)
Pulmonology (AREA)
Urology & Nephrology (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK20211780.0T 2013-05-14 2014-05-14 11-Hydroxyl-6substituerede-derivater af galdesyrer og aminosyrerkonjugater heraf som farnesoid X receptor modulerer. DK3848038T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201361823169P	2013-05-14	2013-05-14
EP18163622.6A EP3360881B1 (en)	2013-05-14	2014-05-14	11-hydroxyl-6-substituted-derivatives of bile acids and amino acid conjugates thereof as farnesoid x receptor modulators

Publications (1)

Publication Number	Publication Date
DK3848038T3 true DK3848038T3 (da)	2023-02-06

Family

ID=50721801

Family Applications (4)

Application Number	Title	Priority Date	Filing Date
DK18163622.6T DK3360881T3 (da)	2013-05-14	2014-05-14	11-hydroxy-6-substituerede derivater af galdesyrer og aminosyrekonjagater deraf som farnesoid X receptormodulatorer
DK14723820.8T DK2997035T3 (da)	2013-05-14	2014-05-14	11-hydroxy-6-substituerede derivater af galdesyrer og aminosyrekonjugater deraf som farnesoid x-receptormodulatorer
DK20211780.0T DK3848038T3 (da)	2013-05-14	2014-05-14	11-Hydroxyl-6substituerede-derivater af galdesyrer og aminosyrerkonjugater heraf som farnesoid X receptor modulerer.
DK18163623.4T DK3360882T3 (da)	2013-05-14	2014-05-14	11-hydroxyl-6-substituterede derivater af galsyre og aminosyrekonjugater deraf som farnesoid x receptormodulatorer

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
DK18163622.6T DK3360881T3 (da)	2013-05-14	2014-05-14	11-hydroxy-6-substituerede derivater af galdesyrer og aminosyrekonjagater deraf som farnesoid X receptormodulatorer
DK14723820.8T DK2997035T3 (da)	2013-05-14	2014-05-14	11-hydroxy-6-substituerede derivater af galdesyrer og aminosyrekonjugater deraf som farnesoid x-receptormodulatorer

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK18163623.4T DK3360882T3 (da)	2013-05-14	2014-05-14	11-hydroxyl-6-substituterede derivater af galsyre og aminosyrekonjugater deraf som farnesoid x receptormodulatorer

Country Status (37)

Country	Link
US (7)	US9611289B2 (da)
EP (4)	EP3360882B1 (da)
JP (2)	JP6326131B2 (da)
KR (1)	KR102229952B1 (da)
CN (2)	CN105377870B (da)
AU (1)	AU2014267324B2 (da)
BR (1)	BR112015028399B1 (da)
CA (1)	CA2912139C (da)
CL (2)	CL2015003344A1 (da)
CR (1)	CR20150643A (da)
CY (1)	CY1122614T1 (da)
DK (4)	DK3360881T3 (da)
EA (1)	EA030152B1 (da)
ES (4)	ES2847002T3 (da)
GT (1)	GT201500324A (da)
HR (1)	HRP20180931T1 (da)
HU (1)	HUE037996T2 (da)
IL (2)	IL242555B (da)
LT (1)	LT2997035T (da)
MA (1)	MA38647B1 (da)
ME (1)	ME03082B (da)
MX (1)	MX352065B (da)
MY (1)	MY187886A (da)
NI (1)	NI201500160A (da)
PE (2)	PE20160665A1 (da)
PH (1)	PH12015502576B1 (da)
PL (3)	PL3360881T3 (da)
PT (3)	PT2997035T (da)
RS (1)	RS57372B1 (da)
SA (1)	SA515370140B1 (da)
SG (1)	SG11201509352XA (da)
SI (3)	SI2997035T1 (da)
SM (1)	SMT201800326T1 (da)
TN (1)	TN2015000497A1 (da)
TR (1)	TR201809041T4 (da)
UA (1)	UA118673C2 (da)
WO (1)	WO2014184271A1 (da)

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2014
- 2014-05-14 TN TN2015000497A patent/TN2015000497A1/en unknown
- 2014-05-14 UA UAA201511098A patent/UA118673C2/uk unknown
- 2014-05-14 SM SM20180326T patent/SMT201800326T1/it unknown
- 2014-05-14 MX MX2015015730A patent/MX352065B/es active IP Right Grant
- 2014-05-14 DK DK18163622.6T patent/DK3360881T3/da active
- 2014-05-14 DK DK14723820.8T patent/DK2997035T3/da active
- 2014-05-14 BR BR112015028399-3A patent/BR112015028399B1/pt active IP Right Grant
- 2014-05-14 US US14/120,366 patent/US9611289B2/en active Active
- 2014-05-14 EP EP18163623.4A patent/EP3360882B1/en active Active
- 2014-05-14 PT PT147238208T patent/PT2997035T/pt unknown
- 2014-05-14 PT PT181636226T patent/PT3360881T/pt unknown
- 2014-05-14 PL PL18163622T patent/PL3360881T3/pl unknown
- 2014-05-14 WO PCT/EP2014/059896 patent/WO2014184271A1/en not_active Ceased
- 2014-05-14 ES ES18163622T patent/ES2847002T3/es active Active
- 2014-05-14 SG SG11201509352XA patent/SG11201509352XA/en unknown
- 2014-05-14 CN CN201480036949.5A patent/CN105377870B/zh active Active
- 2014-05-14 PL PL14723820T patent/PL2997035T3/pl unknown
- 2014-05-14 CA CA2912139A patent/CA2912139C/en active Active
- 2014-05-14 DK DK20211780.0T patent/DK3848038T3/da active
- 2014-05-14 SI SI201430701T patent/SI2997035T1/sl unknown
- 2014-05-14 MA MA38647A patent/MA38647B1/fr unknown
- 2014-05-14 HU HUE14723820A patent/HUE037996T2/hu unknown
- 2014-05-14 RS RS20180690A patent/RS57372B1/sr unknown
- 2014-05-14 HR HRP20180931TT patent/HRP20180931T1/hr unknown
- 2014-05-14 MY MYPI2015002734A patent/MY187886A/en unknown
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Also Published As

Publication number	Publication date
HUE037996T2 (hu)	2018-09-28
PH12015502576A1 (en)	2016-02-29
MY187886A (en)	2021-10-26
RS57372B1 (sr)	2018-08-31
EP3360881B1 (en)	2020-12-09
ES2843737T3 (es)	2021-07-20
JP2016518429A (ja)	2016-06-23
EA201592055A1 (ru)	2016-11-30
ES2671427T3 (es)	2018-06-06
EP2997035B1 (en)	2018-03-28
PL2997035T3 (pl)	2018-10-31
JP6326131B2 (ja)	2018-05-16
IL242555B (en)	2020-04-30
US20230233581A1 (en)	2023-07-27
HK1253326A1 (zh)	2019-06-14
EA030152B1 (ru)	2018-06-29
SA515370140B1 (ar)	2017-04-11
EP3360882B1 (en)	2020-12-09
EP3360881A1 (en)	2018-08-15
CY1122614T1 (el)	2020-07-31
PE20200844A1 (es)	2020-08-18
HK1221471A1 (zh)	2017-06-02
US10532061B2 (en)	2020-01-14
US20240398834A1 (en)	2024-12-05
PL3360881T3 (pl)	2021-11-15
HRP20180931T1 (hr)	2018-10-05
TN2015000497A1 (en)	2017-04-06
EP2997035A1 (en)	2016-03-23
MA38647B1 (fr)	2019-05-31
PE20160665A1 (es)	2016-08-07
US9611289B2 (en)	2017-04-04
LT2997035T (lt)	2018-08-10
EP3848038A1 (en)	2021-07-14
ES2936638T3 (es)	2023-03-21
CN108245523B (zh)	2021-03-26
PT3360882T (pt)	2021-02-12
CL2016001809A1 (es)	2017-01-27
US20210228599A1 (en)	2021-07-29
DK3360882T3 (da)	2021-03-08
JP2018127481A (ja)	2018-08-16
KR20160007586A (ko)	2016-01-20
GT201500324A (es)	2017-09-28
TR201809041T4 (tr)	2018-07-23
SI3360881T1 (sl)	2021-06-30
NI201500160A (es)	2016-01-04
SMT201800326T1 (it)	2018-07-17
AU2014267324B2 (en)	2017-11-02
SG11201509352XA (en)	2015-12-30
WO2014184271A1 (en)	2014-11-20
EP3360882A1 (en)	2018-08-15
US20170216316A1 (en)	2017-08-03
EP2997035B8 (en)	2018-05-23
IL272718A (en)	2020-04-30
US20200297739A1 (en)	2020-09-24
PL3360882T3 (pl)	2021-10-25
KR102229952B1 (ko)	2021-03-22
DK3360881T3 (da)	2021-03-15
SI3360882T1 (sl)	2021-06-30
US11000532B2 (en)	2021-05-11
CN105377870A (zh)	2016-03-02
EP3848038B1 (en)	2022-11-09
US20190209586A1 (en)	2019-07-11
US20140371190A1 (en)	2014-12-18
IL272718B (en)	2020-11-30
SI2997035T1 (sl)	2018-10-30
BR112015028399B1 (pt)	2021-11-16
ES2847002T3 (es)	2021-07-30
CR20150643A (es)	2016-06-01
ME03082B (me)	2019-01-20
PT3360881T (pt)	2021-02-19
PT2997035T (pt)	2018-07-18
CN105377870B (zh)	2018-04-03
IL242555A0 (en)	2016-02-01
CA2912139C (en)	2021-04-20
BR112015028399A2 (pt)	2017-07-25
CA2912139A1 (en)	2014-11-20
CL2015003344A1 (es)	2016-07-15
AU2014267324A1 (en)	2015-11-26
CN108245523A (zh)	2018-07-06
DK2997035T3 (da)	2018-07-02
MX352065B (es)	2017-11-08
PH12015502576B1 (en)	2018-09-12
NZ714082A (en)	2021-02-26
UA118673C2 (uk)	2019-02-25

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