ME03082B - 11-hidroksil-6-supsтituisani-derivati žučnih kiselina i njihovi aminoкiselinski konjugati као modulatori receptora za farnezoid х - Google Patents

11-hidroksil-6-supsтituisani-derivati žučnih kiselina i njihovi aminoкiselinski konjugati као modulatori receptora za farnezoid х

Info

Publication number: ME03082B
Authority: ME; Montenegro
Prior art keywords: farnezoid; hydroxyl; substituted; receptor modulators; amino acid
Prior art date: 2013-05-14

Application number

MEP-2018-159A

Other languages

German (de)

English (en)

French (fr)

Inventor

Roberto Pellicciari

Original Assignee

Intercept Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2013-05-14

Filing date

2014-05-14

Publication date

2019-01-20

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50721801&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ME03082(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2014-05-14 Application filed by Intercept Pharmaceuticals Inc filed Critical Intercept Pharmaceuticals Inc

2019-01-20 Publication of ME03082B publication Critical patent/ME03082B/me

Links

150000001413 amino acids Chemical class 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
- C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Gastroenterology & Hepatology (AREA)
Urology & Nephrology (AREA)
Pulmonology (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

MEP-2018-159A 2013-05-14 2014-05-14 11-hidroksil-6-supsтituisani-derivati žučnih kiselina i njihovi aminoкiselinski konjugati као modulatori receptora za farnezoid х ME03082B (me)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US201361823169P	2013-05-14	2013-05-14
PCT/EP2014/059896 WO2014184271A1 (en)	2013-05-14	2014-05-14	11-hydroxyl-derivatives of bile acids and amino acid conjugates thereof as farnesoid x receptor modulators
EP14723820.8A EP2997035B8 (en)	2013-05-14	2014-05-14	11-hydroxyl-6-substituted-derivatives of bile acids and amino acid conjugates thereof as farnesoid x receptor modulators

Publications (1)

Publication Number	Publication Date
ME03082B true ME03082B (me)	2019-01-20

Family

ID=50721801

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MEP-2018-159A ME03082B (me)	2013-05-14	2014-05-14	11-hidroksil-6-supsтituisani-derivati žučnih kiselina i njihovi aminoкiselinski konjugati као modulatori receptora za farnezoid х

Country Status (37)

Country	Link
US (7)	US9611289B2 (me)
EP (4)	EP3848038B1 (me)
JP (2)	JP6326131B2 (me)
KR (1)	KR102229952B1 (me)
CN (2)	CN108245523B (me)
AU (1)	AU2014267324B2 (me)
BR (1)	BR112015028399B1 (me)
CA (1)	CA2912139C (me)
CL (2)	CL2015003344A1 (me)
CR (1)	CR20150643A (me)
CY (1)	CY1122614T1 (me)
DK (4)	DK2997035T3 (me)
EA (1)	EA030152B1 (me)
ES (4)	ES2671427T3 (me)
GT (1)	GT201500324A (me)
HR (1)	HRP20180931T1 (me)
HU (1)	HUE037996T2 (me)
IL (2)	IL242555B (me)
LT (1)	LT2997035T (me)
MA (1)	MA38647B1 (me)
ME (1)	ME03082B (me)
MX (1)	MX352065B (me)
MY (1)	MY187886A (me)
NI (1)	NI201500160A (me)
PE (2)	PE20160665A1 (me)
PH (1)	PH12015502576B1 (me)
PL (3)	PL3360881T3 (me)
PT (3)	PT3360882T (me)
RS (1)	RS57372B1 (me)
SA (1)	SA515370140B1 (me)
SG (1)	SG11201509352XA (me)
SI (3)	SI2997035T1 (me)
SM (1)	SMT201800326T1 (me)
TN (1)	TN2015000497A1 (me)
TR (1)	TR201809041T4 (me)
UA (1)	UA118673C2 (me)
WO (1)	WO2014184271A1 (me)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE303399T1 (de)	2001-03-12	2005-09-15	Intercept Pharmaceuticals Inc	Steroide als agonisten für fxr
EP2545964A1 (en)	2011-07-13	2013-01-16	Phenex Pharmaceuticals AG	Novel FXR (NR1H4) binding and activity modulating compounds
CA2912139C (en)	2013-05-14	2021-04-20	Roberto Pellicciari	11-hydroxyl-derivatives of bile acids and amino acid conjugates thereof as farnesoid x receptor modulators
US10077268B2 (en)	2014-03-13	2018-09-18	Salk Institute For Biological Studies	FXR agonists and methods for making and using
US10301268B2 (en)	2014-03-13	2019-05-28	The Salk Institute For Biological Studies	Analogs of fexaramine and methods of making and using
EP3626725B1 (en) *	2014-05-29	2022-11-30	Bar Pharmaceuticals S.r.l.	Cholane derivatives for use in the treatment and/or prevention of fxr and tgr5/gpbar1 mediated diseases
HK1243930A1 (zh)	2014-11-06	2018-07-27	英安塔制药有限公司	作爲fxr/tgr5激动剂的胆汁酸类似物和其使用方法
EP3221333B1 (en)	2014-11-19	2019-07-24	NZP UK Limited	6.alpha.-alkyl-3,7-dione steroids as intermediates for the production of steroidal fxr modulators
EA033445B1 (ru)	2014-11-19	2019-10-31	Nzp Uk Ltd	5-бета-6-алкил-7-гидрокси-3-оновые стероиды в качестве промежуточных соединений для получения стероидных модуляторов fxr
JP6698085B2 (ja)	2014-11-19	2020-05-27	エヌゼットピーユーケーリミテッド	ステロイドＦＸＲモジュレーター製造のための中間体としての６α−アルキル−６，７−ジオン−ステロイド
EP3221331B1 (en)	2014-11-19	2019-09-18	Nzp Uk Limited	6-alkyl-7-hydroxy-4-en-3-one steroids as intermediates for the production of steroidal fxr modulators
HK1244708A1 (zh)	2014-11-26	2018-08-17	英安塔制药有限公司	作爲fxr/tgr5激动剂的胆汁酸类似物及其使用方法
WO2016086115A1 (en)	2014-11-26	2016-06-02	Enanta Pharmaceuticals, Inc.	Tetrazole derivatives of bile acids as fxr/tgr5 agonists and methods of use thereof
US10208081B2 (en) *	2014-11-26	2019-02-19	Enanta Pharmaceuticals, Inc.	Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof
MA41094A (fr) *	2014-12-02	2017-10-10	Lilly Co Eli	Procédés de traitement de troubles rénaux
CN105348365A (zh) *	2014-12-03	2016-02-24	四川百利药业有限责任公司	一种胆酸衍生物及其制备方法、药物组合物和用途
CN104523703A (zh) *	2014-12-24	2015-04-22	聂飚	一种游离脂肪酸转运蛋白小分子抑制物的应用
TN2017000344A1 (en) *	2015-02-06	2019-01-16	Intercept Pharmaceuticals Inc	Pharmaceutical compositions for combination therapy
MX2017010376A (es)	2015-02-11	2017-12-20	Enanta Pharm Inc	Análogos de ácido biliar como agonistas de fxr/tgr5 y métodos para el uso de los mismos.
KR20170125927A (ko) *	2015-03-09	2017-11-15	인터셉트 파마슈티컬즈, 인크.	골밀도의 조절 방법
CN107531741A (zh)	2015-03-10	2018-01-02	美莱斯股份有限公司	氟化和烷基化胆酸
WO2016149111A1 (en) *	2015-03-13	2016-09-22	Salk Institute For Biological Studies	Treating latent autoimmune diabetes of adults with farnesoid x receptor agonists to activate intestinal receptors
WO2016161003A1 (en) *	2015-03-31	2016-10-06	Enanta Phamraceuticals, Inc.	Bile acid derivatives as fxr/tgr5 agonists and methods of use thereof
US10894054B2 (en) *	2015-04-07	2021-01-19	Intercept Pharmaceuticals, Inc.	FXR agonist compositions for combination therapy
WO2016168553A1 (en) *	2015-04-17	2016-10-20	Concert Pharmaceuticals, Inc.	Deuterated obeticholic acid
PE20180690A1 (es)	2015-04-27	2018-04-23	Intercept Pharmaceuticals Inc	Composiciones de acido obeticolico y metodos de uso
CN106478759A (zh) *	2015-08-31	2017-03-08	陕西合成药业股份有限公司	奥贝胆酸衍生物及其制备方法和用途
WO2017053428A1 (en)	2015-09-21	2017-03-30	Intercept Pharmaceuticals, Inc.	Methods of promoting hepatic regeneration
KR20180061351A (ko) *	2015-10-07	2018-06-07	인터셉트 파마슈티컬즈, 인크.	파네소이드 x 수용체 조절제
EP3409684B1 (en) *	2016-01-28	2024-01-03	Chia Tai Tianqing Pharmaceutical Group Co., Ltd.	Steroid derivative fxr agonist
WO2017147137A1 (en) *	2016-02-23	2017-08-31	Enanta Pharmaceuticals, Inc.	Benzoic acid derivatives of bile acid as fxr/tgr5 agonists and methods of use thereof
US10323061B2 (en)	2016-02-23	2019-06-18	Enanta Pharmaceuticals, Inc.	Heteroaryl containing bile acid analogs as FXR/TGR5 agonists and methods of use thereof
WO2017147159A1 (en)	2016-02-23	2017-08-31	Enanta Pharmaceuticals, Inc.	Deuterated bile acid derivatives as fxr/tgr5 agonists and methods of use thereof
EA038632B1 (ru) *	2016-03-11	2021-09-27	Интерсепт Фармасьютикалз, Инк.	7,11-дигидрокси-6-этил-5-холан-24-овая кислота и фармацевтические композиции на ее основе для лечения или предупреждения заболевания или состояния, опосредованных фарнезоидным х-рецептором (fxr)
WO2017180577A1 (en) *	2016-04-13	2017-10-19	Intercept Pharmaceuticals, Inc.	Methods of treating cancer
GB201608777D0 (en)	2016-05-18	2016-06-29	Dextra Lab Ltd	Compounds
CA3252823A1 (en)	2016-06-13	2025-02-25	Gilead Sciences, Inc.	Substituted tert-butyl-3-(2-chloro-phenyl)-3-hydroxyazetidine-1-carboxylate compounds
BR112018075734A2 (pt)	2016-06-13	2019-04-02	Gilead Sciences, Inc.	composto, composição farmacêutica, método para tratar um paciente com uma doença ou condição mediada pelo menos em parte por fxr, e, uso de um composto.
CN110121347A (zh)	2016-11-29	2019-08-13	英安塔制药有限公司	制备磺酰脲胆汁酸衍生物的方法
US10472386B2 (en)	2017-02-14	2019-11-12	Enanta Pharmaceuticals, Inc.	Bile acid derivatives as FXR agonists and methods of use thereof
AU2018223146B2 (en)	2017-02-21	2023-12-21	Genfit	Combination of a PPAR agonist with a FXR agonist
CA3053935A1 (en) *	2017-02-23	2018-08-30	Intercept Pharmaceuticals, Inc.	Pharmaceutical compositions of a bile acid derivative and microbiome and uses thereof
CN110461328A (zh)	2017-03-28	2019-11-15	吉利德科学公司	治疗肝疾病的治疗组合
BR112019020780A2 (pt)	2017-04-07	2020-04-28	Enanta Pharm Inc	processo para preparação de derivados de ácido biliar de carbamato de sulfonila
WO2018226724A1 (en) *	2017-06-05	2018-12-13	Intercept Pharmaceuticals, Inc.	Treatment and prevention of diabetic eye diseases with a bile acid derivatives
KR20250109791A (ko) *	2017-06-23	2025-07-17	인터셉트 파마슈티컬즈, 인크.	담즙산 유도체 제조를 위한 방법 및 중간체
MX2020000873A (es)	2017-07-24	2020-07-22	Intercept Pharmaceuticals Inc	Derivados de ácidos biliares marcados isotópicamente.
GB201812382D0 (en)	2018-07-30	2018-09-12	Nzp Uk Ltd	Compounds
CN109182451B (zh) *	2018-08-21	2021-06-11	四川大学	细胞色素cyp3a7酶的新型特异性探针反应及其应用
EP4360632B1 (en)	2019-01-15	2025-10-29	Gilead Sciences, Inc.	Fxr (nr1h4) modulating compounds
US11524005B2 (en)	2019-02-19	2022-12-13	Gilead Sciences, Inc.	Solid forms of FXR agonists
EA202193334A1 (ru)	2019-05-30	2022-03-14	Интерсепт Фармасьютикалз, Инк.	Фармацевтические композиции, содержащие агонист fxr и фибрат, для применения при лечении холестатического заболевания печени
AU2020312735A1 (en)	2019-07-18	2021-12-16	Enyo Pharma	Method for decreasing adverse-effects of interferon
CN110540955B (zh) *	2019-08-28	2021-09-17	北京协同创新研究院	一种提高分化细胞中nrob2基因表达量的方法
US20230060715A1 (en)	2020-01-15	2023-03-02	INSERM (Institut National de la Santé et de la Recherche Médicale)	Use of fxr agonists for treating an infection by hepatitis d virus
US20240100125A1 (en)	2021-01-14	2024-03-28	Enyo Pharma	Synergistic effect of a fxr agonist and ifn for the treatment of hbv infection
CN117320722A (zh)	2021-04-28	2023-12-29	埃尼奥制药公司	使用fxr激动剂作为联合治疗强烈增强tlr3激动剂的作用
WO2022233398A1 (en) *	2021-05-04	2022-11-10	Kostner Pharma Gmbh	COMPOUNDS FOR REDUCING LIPOPROTEIN(a)
WO2023288123A1 (en)	2021-07-16	2023-01-19	Interecept Pharmaceuticals, Inc.	Methods and intermediates for the preparation of 3.alpha.,7.alpha.,11.beta.-trihydroxy-6.alpha.-ethyl-5.beta.-cholan-24-oic acid
WO2025059651A1 (en) *	2023-09-14	2025-03-20	The Regents Of The University Of California	Bile salt modification to prevent and treat enteric disease
WO2025240669A1 (en) *	2024-05-15	2025-11-20	Intercept Pharmaceuticals, Inc.	Crystalline forms of a farnesoid x receptor agonist

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2080775A (en) *	1934-08-22	1937-05-18	Celanese Corp	Shedding mechanism for circular looms
US2802775A (en) *	1953-05-29	1957-08-13	Merck & Co Inc	11 alpha-hydroxylation of steroids by aspergillus ochraceus
JPS59205396A (ja) *	1983-05-09	1984-11-20	Kuraray Co Ltd	１１β−ヒドロキシプレグナ−４−エン−３−オン−２０−カルブアルデヒド及びその製造法
ES2326850T3 (es)	1998-12-23	2009-10-20	Glaxo Group Limited	Ensayos para ligandos de receptores nucleares.
ITMI20021532A1 (it) *	2002-07-12	2004-01-12	Roberto Pellicciari	Composti chimici
EP1568706A1 (en) *	2004-02-26	2005-08-31	Intercept Pharmaceuticals, Inc.	Novel steroid agonist for FXR
PL1734970T3 (pl) *	2004-03-12	2015-05-29	Intercept Pharmaceuticals Inc	Leczenie zwłóknienia z zastosowaniem ligandów FXR
CN101522703B (zh) *	2006-06-27	2013-04-17	英特塞普特医药品公司	胆酸派生物及其在制备预防或治疗fxr介导的疾病或状况的药物中的应用
CA2912139C (en)	2013-05-14	2021-04-20	Roberto Pellicciari	11-hydroxyl-derivatives of bile acids and amino acid conjugates thereof as farnesoid x receptor modulators

2014
- 2014-05-14 CA CA2912139A patent/CA2912139C/en active Active
- 2014-05-14 CN CN201810162562.4A patent/CN108245523B/zh not_active Expired - Fee Related
- 2014-05-14 ES ES14723820.8T patent/ES2671427T3/es active Active
- 2014-05-14 MX MX2015015730A patent/MX352065B/es active IP Right Grant
- 2014-05-14 PL PL18163622T patent/PL3360881T3/pl unknown
- 2014-05-14 PE PE2015002397A patent/PE20160665A1/es unknown
- 2014-05-14 EP EP20211780.0A patent/EP3848038B1/en active Active
- 2014-05-14 DK DK14723820.8T patent/DK2997035T3/en active
- 2014-05-14 MA MA38647A patent/MA38647B1/fr unknown
- 2014-05-14 UA UAA201511098A patent/UA118673C2/uk unknown
- 2014-05-14 SI SI201430701T patent/SI2997035T1/sl unknown
- 2014-05-14 AU AU2014267324A patent/AU2014267324B2/en active Active
- 2014-05-14 PL PL14723820T patent/PL2997035T3/pl unknown
- 2014-05-14 LT LTEP14723820.8T patent/LT2997035T/lt unknown
- 2014-05-14 ES ES18163623T patent/ES2843737T3/es active Active
- 2014-05-14 DK DK18163623.4T patent/DK3360882T3/da active
- 2014-05-14 TR TR2018/09041T patent/TR201809041T4/tr unknown
- 2014-05-14 ES ES18163622T patent/ES2847002T3/es active Active
- 2014-05-14 US US14/120,366 patent/US9611289B2/en active Active
- 2014-05-14 SM SM20180326T patent/SMT201800326T1/it unknown
- 2014-05-14 WO PCT/EP2014/059896 patent/WO2014184271A1/en not_active Ceased
- 2014-05-14 MY MYPI2015002734A patent/MY187886A/en unknown
- 2014-05-14 BR BR112015028399-3A patent/BR112015028399B1/pt active IP Right Grant
- 2014-05-14 SI SI201431742T patent/SI3360881T1/sl unknown
- 2014-05-14 EP EP18163622.6A patent/EP3360881B1/en active Active
- 2014-05-14 PT PT181636234T patent/PT3360882T/pt unknown
- 2014-05-14 ES ES20211780T patent/ES2936638T3/es active Active
- 2014-05-14 KR KR1020157034951A patent/KR102229952B1/ko active Active
- 2014-05-14 DK DK20211780.0T patent/DK3848038T3/da active
- 2014-05-14 CN CN201480036949.5A patent/CN105377870B/zh active Active
- 2014-05-14 DK DK18163622.6T patent/DK3360881T3/da active
- 2014-05-14 SI SI201431741T patent/SI3360882T1/sl unknown
- 2014-05-14 PL PL18163623T patent/PL3360882T3/pl unknown
- 2014-05-14 SG SG11201509352XA patent/SG11201509352XA/en unknown
- 2014-05-14 PE PE2020000355A patent/PE20200844A1/es unknown
- 2014-05-14 HU HUE14723820A patent/HUE037996T2/hu unknown
- 2014-05-14 TN TN2015000497A patent/TN2015000497A1/en unknown
- 2014-05-14 EP EP14723820.8A patent/EP2997035B8/en active Active
- 2014-05-14 HR HRP20180931TT patent/HRP20180931T1/hr unknown
- 2014-05-14 PT PT181636226T patent/PT3360881T/pt unknown
- 2014-05-14 ME MEP-2018-159A patent/ME03082B/me unknown
- 2014-05-14 RS RS20180690A patent/RS57372B1/sr unknown
- 2014-05-14 EA EA201592055A patent/EA030152B1/ru unknown
- 2014-05-14 EP EP18163623.4A patent/EP3360882B1/en active Active
- 2014-05-14 JP JP2016513357A patent/JP6326131B2/ja active Active
- 2014-05-14 PT PT147238208T patent/PT2997035T/pt unknown
2015
- 2015-11-12 IL IL242555A patent/IL242555B/en active IP Right Grant
- 2015-11-12 SA SA515370140A patent/SA515370140B1/ar unknown
- 2015-11-13 NI NI201500160A patent/NI201500160A/es unknown
- 2015-11-13 GT GT201500324A patent/GT201500324A/es unknown
- 2015-11-13 PH PH12015502576A patent/PH12015502576B1/en unknown
- 2015-11-13 CL CL2015003344A patent/CL2015003344A1/es unknown
- 2015-12-07 CR CR20150643A patent/CR20150643A/es unknown
2016
- 2016-07-15 CL CL2016001809A patent/CL2016001809A1/es unknown
2017
- 2017-02-16 US US15/434,685 patent/US20170216316A1/en not_active Abandoned
2018
- 2018-04-13 JP JP2018077654A patent/JP2018127481A/ja not_active Withdrawn
- 2018-06-01 CY CY20181100583T patent/CY1122614T1/el unknown
- 2018-09-06 US US16/124,139 patent/US10532061B2/en active Active
2019
- 2019-11-26 US US16/695,528 patent/US11000532B2/en active Active
2020
- 2020-02-17 IL IL272718A patent/IL272718B/en active IP Right Grant
2021
- 2021-04-13 US US17/228,819 patent/US20210228599A1/en not_active Abandoned
2023
- 2023-04-03 US US18/295,091 patent/US20230233581A1/en not_active Abandoned
2024
- 2024-08-12 US US18/800,808 patent/US20240398834A1/en active Pending

Also Published As

Publication number	Publication date
PH12015502576A1 (en)	2016-02-29
CA2912139A1 (en)	2014-11-20
EP3360881A1 (en)	2018-08-15
PL3360882T3 (pl)	2021-10-25
US11000532B2 (en)	2021-05-11
MY187886A (en)	2021-10-26
RS57372B1 (sr)	2018-08-31
ES2847002T3 (es)	2021-07-30
EP3848038A1 (en)	2021-07-14
BR112015028399B1 (pt)	2021-11-16
HUE037996T2 (hu)	2018-09-28
EA201592055A1 (ru)	2016-11-30
SMT201800326T1 (it)	2018-07-17
PE20200844A1 (es)	2020-08-18
US20140371190A1 (en)	2014-12-18
KR20160007586A (ko)	2016-01-20
CN105377870A (zh)	2016-03-02
SI3360882T1 (sl)	2021-06-30
HK1253326A1 (zh)	2019-06-14
KR102229952B1 (ko)	2021-03-22
PL2997035T3 (pl)	2018-10-31
DK3360882T3 (da)	2021-03-08
US9611289B2 (en)	2017-04-04
US20210228599A1 (en)	2021-07-29
CL2015003344A1 (es)	2016-07-15
TR201809041T4 (tr)	2018-07-23
PT3360882T (pt)	2021-02-12
JP2018127481A (ja)	2018-08-16
CN108245523B (zh)	2021-03-26
MA38647B1 (fr)	2019-05-31
DK3848038T3 (da)	2023-02-06
CY1122614T1 (el)	2020-07-31
TN2015000497A1 (en)	2017-04-06
UA118673C2 (uk)	2019-02-25
SA515370140B1 (ar)	2017-04-11
JP6326131B2 (ja)	2018-05-16
BR112015028399A2 (pt)	2017-07-25
MX352065B (es)	2017-11-08
PH12015502576B1 (en)	2018-09-12
EP2997035B8 (en)	2018-05-23
CR20150643A (es)	2016-06-01
CN105377870B (zh)	2018-04-03
US20200297739A1 (en)	2020-09-24
EP2997035A1 (en)	2016-03-23
NI201500160A (es)	2016-01-04
SI2997035T1 (sl)	2018-10-30
IL272718B (en)	2020-11-30
CA2912139C (en)	2021-04-20
WO2014184271A1 (en)	2014-11-20
DK3360881T3 (da)	2021-03-15
EP3360882B1 (en)	2020-12-09
IL242555B (en)	2020-04-30
NZ714082A (en)	2021-02-26
EP3360881B1 (en)	2020-12-09
IL272718A (en)	2020-04-30
HRP20180931T1 (hr)	2018-10-05
US20230233581A1 (en)	2023-07-27
EP3848038B1 (en)	2022-11-09
JP2016518429A (ja)	2016-06-23
HK1221471A1 (zh)	2017-06-02
US20190209586A1 (en)	2019-07-11
US20170216316A1 (en)	2017-08-03
DK2997035T3 (en)	2018-07-02
PT2997035T (pt)	2018-07-18
AU2014267324A1 (en)	2015-11-26
AU2014267324B2 (en)	2017-11-02
SI3360881T1 (sl)	2021-06-30
PE20160665A1 (es)	2016-08-07
LT2997035T (lt)	2018-08-10
ES2936638T3 (es)	2023-03-21
CN108245523A (zh)	2018-07-06
PL3360881T3 (pl)	2021-11-15
PT3360881T (pt)	2021-02-19
US20240398834A1 (en)	2024-12-05
EA030152B1 (ru)	2018-06-29
SG11201509352XA (en)	2015-12-30
EP2997035B1 (en)	2018-03-28
IL242555A0 (en)	2016-02-01
ES2671427T3 (es)	2018-06-06
CL2016001809A1 (es)	2017-01-27
GT201500324A (es)	2017-09-28
US10532061B2 (en)	2020-01-14
EP3360882A1 (en)	2018-08-15
ES2843737T3 (es)	2021-07-20

Publication	Publication Date	Title
HRP20180931T1 (hr)	2018-10-05	11-hidroksil-6-supstituirani-derivati žučnih kiselina i njihovi aminokiselinski konjugati kao modulatori receptora za farnezoid x
CY2022027I2 (el)	2023-01-05	Παραγωγα βενζιμιδαζολο-προλινης
IL269045A (en)	2019-10-31	Aptamers and uses thereof
ME03442B (me)	2020-01-20	Stabilizovani rastvorljivi pre-fuzioni rsv f polipeptidi
HUE042512T2 (hu)	2019-07-29	Anti-trop2 antitest-gyógyszer konjugátum
DK3030262T3 (da)	2019-12-02	Kombineret farmaceutisk sammensætning
DK3054991T3 (da)	2019-05-06	Protein-polymer-lægemiddelkonjugater
LT3363438T (lt)	2019-11-11	Pakeistieji 2-azabiciklai ir jų panaudojimas kaip oreksino receptorių moduliatorių
DK3054992T3 (da)	2019-10-28	Protein-polymer-lægemiddelkonjugater
DK3848027T3 (da)	2023-05-01	Octahydro-kondenserede azadecalinglucocorticoidreceptormodulatorer
DK3460054T3 (da)	2021-01-18	Histidyl-tRNA-syntetase-Fc-konjugater
HRP20180817T1 (hr)	2018-06-29	Sastavi i postupci za modulaciju farnesoid-x-receptora
EP2987125A4 (en)	2016-05-04	LINKED ADVERTISING CONTENT
DK2932980T3 (da)	2021-07-19	Multivalent pneumokok-polysaccharid-proteinkonjugatsammensætning
HRP20181882T1 (hr)	2019-01-11	Peptidi i konjugat peptid-aktivni sastojak za ciljanje bubrega lijekom
PT3003386T (pt)	2020-01-21	Conjugados anticorpo-fármaco
BR112016015105A8 (pt)	2018-04-24	conjugados var2csa-droga
EP2970569A4 (en)	2016-07-27	PERSISTENT CARBENE AND COMPOSITIONS WITH IT
IL243728B (en)	2018-10-31	Indole derivatives as rorc2 inhibitors and uses thereof
DK2745849T3 (da)	2022-10-31	Polydeoxyribonukleotidsammensætning og anvendelser deraf
SG11201600473UA (en)	2016-02-26	Amino acid derivatives
KR102714760B9 (ko)	2025-09-15	Xten을 지닌 트롬빈 절단가능한 링커 및 이의 용도
DK2917181T3 (da)	2020-01-13	Heteroarylderivater og anvendelser deraf
PT2931313T (pt)	2019-07-10	Formulações de solução de anticorpos anti-il-23p19 modificados
CO7020919A2 (es)	2014-08-11	Derivados de tetrahidro-quinazolinona