DK3864152T5 - Fremgangsmåder og sammensætninger til editering af rna'er - Google Patents

Fremgangsmåder og sammensætninger til editering af rna'er Download PDF

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Publication number
DK3864152T5
DK3864152T5 DK19870299.5T DK19870299T DK3864152T5 DK 3864152 T5 DK3864152 T5 DK 3864152T5 DK 19870299 T DK19870299 T DK 19870299T DK 3864152 T5 DK3864152 T5 DK 3864152T5
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compositions
methods
rnas
editing
editing rnas
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DK19870299.5T
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DK3864152T3 (da
Inventor
Wensheng Wei
Liang Qu
Zongyi Yi
Shiyou Zhu
Chunhui Wang
Zhongzheng Cao
Zhuo Zhou
Pengfei Yuan
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Univ Beijing
Edigene Therapeutics Beijing Inc
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Application filed by Univ Beijing, Edigene Therapeutics Beijing Inc filed Critical Univ Beijing
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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    • A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
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DK19870299.5T 2018-10-12 2019-10-12 Fremgangsmåder og sammensætninger til editering af rna'er DK3864152T5 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2018110105 2018-10-12
CN2019082713 2019-04-15
PCT/CN2019/110782 WO2020074001A1 (en) 2018-10-12 2019-10-12 Methods and Compositions for Editing RNAs

Publications (2)

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DK3864152T3 DK3864152T3 (da) 2023-10-09
DK3864152T5 true DK3864152T5 (da) 2024-08-12

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US (2) US20210355494A1 (da)
EP (3) EP4527931A1 (da)
JP (2) JP7252328B2 (da)
KR (1) KR102666695B1 (da)
CN (4) CN116218836A (da)
AU (2) AU2019357450B2 (da)
BR (1) BR112021006844A8 (da)
CA (1) CA3115864A1 (da)
CL (1) CL2021000880A1 (da)
CO (1) CO2021005956A2 (da)
CR (1) CR20210243A (da)
DK (1) DK3864152T5 (da)
EC (1) ECSP21033637A (da)
ES (1) ES2962434T3 (da)
IL (1) IL282191A (da)
MX (1) MX2021004187A (da)
PE (1) PE20211402A1 (da)
PH (1) PH12021550805A1 (da)
SG (1) SG11202103666PA (da)
TW (1) TW202028466A (da)
WO (1) WO2020074001A1 (da)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110612353A (zh) 2017-03-03 2019-12-24 加利福尼亚大学董事会 经由抑制性tRNAs和脱氨酶对突变进行RNA靶向
PE20211402A1 (es) * 2018-10-12 2021-08-02 Univ Beijing Metodos y composiciones para editar acidos ribonucleicos
CN113573717A (zh) 2019-01-22 2021-10-29 科罗生物公司 Rna编辑的寡核苷酸及其用途
CA3127241A1 (en) 2019-01-22 2020-07-30 Korro Bio, Inc. Rna-editing oligonucleotides and uses thereof
AU2020210900B2 (en) 2019-01-22 2025-04-24 Korro Bio, Inc. RNA-editing oligonucleotides and uses thereof
CA3136735A1 (en) 2019-04-15 2020-10-22 Edigene Inc. Methods and compositions for editing rnas
AU2020313143B2 (en) 2019-07-12 2024-04-04 Peking University Targeted RNA editing by leveraging endogenous adar using engineered RNAs
US11827880B2 (en) 2019-12-02 2023-11-28 Shape Therapeutics Inc. Therapeutic editing
AU2020418228A1 (en) 2019-12-30 2022-08-18 Edigene Therapeutics (Beijing) Inc. Leaper technology based method for treating MPS IH and composition
AU2020418026A1 (en) 2019-12-30 2022-08-18 Edigene Therapeutics (Beijing) Inc. Method for treating usher syndrome and composition thereof
PE20230703A1 (es) * 2020-04-15 2023-04-24 Edigene Therapeutics Beijing Inc Metodo y farmaco para tratar el sindrome de hurler
CA3173012A1 (en) * 2020-04-22 2021-10-28 Susan BYRNE Compositions and methods using snrna components
WO2021243023A1 (en) * 2020-05-28 2021-12-02 Korro Bio, Inc. Methods and compositions for the adar-mediated editing of serpina1
CN113897359A (zh) * 2020-07-06 2022-01-07 博雅辑因（北京）生物科技有限公司 一种改善的rna编辑方法
KR20230035362A (ko) * 2020-07-06 2023-03-13 에디진 테라퓨틱스 (베이징) 인크. 개선된 rna 편집 방법
IL278401A (en) 2020-10-29 2022-05-01 Yeda Res & Dev Polynucleotides for editing RNA and a method for using them
EP4240338A4 (en) * 2021-01-04 2025-08-06 Univ California IN VIVO PROGRAMMABLE RNA EDITING BY RECRUITMENT OF ENDOGENOUS ADARS
JP2024504608A (ja) * 2021-01-12 2024-02-01 北京大学 遺伝子操作ｒｎａを使用した内因性ａｄａｒの活用による標的化ｒｎａの編集
KR20240021893A (ko) * 2021-06-15 2024-02-19 메사추세츠 인스티튜트 오브 테크놀로지 데아미나제 기반 rna 센서
US20240279656A1 (en) * 2021-06-29 2024-08-22 Shape Therapeutics Inc. Engineered Guide RNAs and Polynucleotides
TW202321451A (zh) * 2021-08-18 2023-06-01 北京大學 工程化的 adar 招募 rnas 及其使用方法
US20250102522A1 (en) 2021-10-07 2025-03-27 Hepatx Corporation Methods of tracking donor cells in a recipient
EP4423266A1 (en) * 2021-10-27 2024-09-04 Shape Therapeutics Inc. Engineered rnas
JP2024541983A (ja) * 2021-10-29 2024-11-13 デューク ユニバーシティ Ｒｎａプログラム可能な細胞編集のための組成物およびシステム、ならびにそれを作製および使用する方法
WO2023143539A1 (en) * 2022-01-28 2023-08-03 Edigene Therapeutics (Beijing) Inc. Engineered adar-recruiting rnas and methods of use thereof
WO2023185231A1 (en) * 2022-04-02 2023-10-05 Edigene Therapeutics (Beijing) Inc. Engineered adar-recruiting rnas and methods of use for usher syndrome
WO2024228735A2 (en) * 2022-07-15 2024-11-07 Georgia Tech Research Corporation Anti-sars-cov-1 and anti-sars-cov-2 activatable rnase guide sequences
EP4605529A1 (en) * 2022-10-18 2025-08-27 Regeneron Pharmaceuticals, Inc. Compositions and methods comprising programmable snrnas for rna editing
US12565665B2 (en) 2022-12-21 2026-03-03 Trustees Of Boston University Compositions and methods for controlled mRNA translation and stability
CN118620958A (zh) * 2023-03-08 2024-09-10 广州医科大学 一种抗原表位的制备方法
WO2024197951A1 (zh) * 2023-03-31 2024-10-03 时夕(广州)生物科技有限公司 一种与rna编辑靶位点形成编辑底物的序列
CN118853661A (zh) * 2023-04-28 2024-10-29 时夕(广州)生物科技有限公司 编辑rna的方法、组合物及其应用
WO2024235283A1 (en) * 2023-05-16 2024-11-21 Peking University Method of modulating rna splicing
EP4763979A1 (en) 2023-08-18 2026-06-24 EdiGene Biotechnology, Inc. Engineered t cell having prolonged in vivo half-life and preparation method therefor
WO2025206105A1 (ja) * 2024-03-29 2025-10-02 株式会社Frest 標的アデノシンに対する部位特異的編集を誘導するオリゴヌクレオチド
CN121059628A (zh) * 2024-06-03 2025-12-05 时夕(广州)生物科技有限公司 调控RNA剪接的向导agRNA
CN119505015B (zh) * 2024-11-15 2025-10-17 北京大学 一种融合蛋白及其应用方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101297830B1 (ko) * 2010-09-10 2013-08-19 한국생명공학연구원 신규한 ｒｎａ 결합 단백질 및 이를 이용한 무표지 마이크로 ｒｎａ 검출방법
CN107532162A (zh) 2014-12-12 2018-01-02 托德·M·伍尔夫 用于利用寡核苷酸编辑细胞中核酸的组合物和方法
AU2015367378A1 (en) * 2014-12-17 2017-06-15 Proqr Therapeutics Ii B.V. Targeted RNA editing
WO2017010556A1 (ja) 2015-07-14 2017-01-19 学校法人福岡大学 部位特異的ｒｎａ変異導入方法およびそれに使用する標的編集ガイドｒｎａならびに標的ｒｎａ－標的編集ガイドｒｎａ複合体
US11396672B2 (en) * 2015-08-31 2022-07-26 The University Of Chicago Composition and methods for detecting adenosine modifications
DE102015012522B3 (de) * 2015-09-26 2016-06-02 Eberhard Karls Universität Tübingen Verfahren und Substanzen zur gerichteten RNA-Editierung
EP3475424A1 (en) * 2016-06-22 2019-05-01 ProQR Therapeutics II B.V. Single-stranded rna-editing oligonucleotides
WO2018041973A1 (en) * 2016-09-01 2018-03-08 Proqr Therapeutics Ii B.V. Chemically modified single-stranded rna-editing oligonucleotides
US11274300B2 (en) 2017-01-19 2022-03-15 Proqr Therapeutics Ii B.V. Oligonucleotide complexes for use in RNA editing
CN110612353A (zh) * 2017-03-03 2019-12-24 加利福尼亚大学董事会 经由抑制性tRNAs和脱氨酶对突变进行RNA靶向
CN110959039B (zh) 2017-03-15 2025-03-14 博德研究所 新型cas13b直向同源物crispr酶和系统
KR102338449B1 (ko) * 2017-09-21 2021-12-10 더 브로드 인스티튜트, 인코퍼레이티드 표적화된 핵산 편집을 위한 시스템, 방법, 및 조성물
PE20211402A1 (es) * 2018-10-12 2021-08-02 Univ Beijing Metodos y composiciones para editar acidos ribonucleicos

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