ECSP21033637A - Methods and Compositions for Editing RNAs - Google Patents
Methods and Compositions for Editing RNAsInfo
- Publication number
- ECSP21033637A ECSP21033637A ECSENADI202133637A ECDI202133637A ECSP21033637A EC SP21033637 A ECSP21033637 A EC SP21033637A EC SENADI202133637 A ECSENADI202133637 A EC SENADI202133637A EC DI202133637 A ECDI202133637 A EC DI202133637A EC SP21033637 A ECSP21033637 A EC SP21033637A
- Authority
- EC
- Ecuador
- Prior art keywords
- rna
- methods
- compositions
- editing
- present application
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 2
- 102000040650 (ribonucleotides)n+m Human genes 0.000 title 1
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 abstract 2
- 230000007115 recruitment Effects 0.000 abstract 2
- 239000002126 C01EB10 - Adenosine Substances 0.000 abstract 1
- 238000010357 RNA editing Methods 0.000 abstract 1
- 230000026279 RNA modification Effects 0.000 abstract 1
- 229960005305 adenosine Drugs 0.000 abstract 1
- 230000009615 deamination Effects 0.000 abstract 1
- 238000006481 deamination reaction Methods 0.000 abstract 1
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
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- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- Health & Medical Sciences (AREA)
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Abstract
La presente solicitud proporciona métodos para editar ARN mediante la introducción de un ARN de reclutamiento de desaminasas en una célula hospedera para la desaminación de una adenosina en un ARN objetivo; la presente solicitud proporciona además ARN de reclutamiento de desaminasas usados en los métodos de edición de ARN y composiciones que los comprenden.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2018110105 | 2018-10-12 | ||
| CN2019082713 | 2019-04-15 | ||
| PCT/CN2019/110782 WO2020074001A1 (en) | 2018-10-12 | 2019-10-12 | Methods and Compositions for Editing RNAs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP21033637A true ECSP21033637A (es) | 2021-08-31 |
Family
ID=70163607
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSENADI202133637A ECSP21033637A (es) | 2018-10-12 | 2021-05-12 | Methods and Compositions for Editing RNAs |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US20210355494A1 (es) |
| EP (3) | EP4306116A3 (es) |
| JP (2) | JP7252328B2 (es) |
| KR (1) | KR102666695B1 (es) |
| CN (4) | CN115651927B (es) |
| AU (2) | AU2019357450B2 (es) |
| BR (1) | BR112021006844A8 (es) |
| CA (1) | CA3115864A1 (es) |
| CL (1) | CL2021000880A1 (es) |
| CO (1) | CO2021005956A2 (es) |
| CR (1) | CR20210243A (es) |
| DK (1) | DK3864152T5 (es) |
| EC (1) | ECSP21033637A (es) |
| ES (1) | ES2962434T3 (es) |
| IL (1) | IL282191A (es) |
| MX (1) | MX2021004187A (es) |
| PE (1) | PE20211402A1 (es) |
| PH (1) | PH12021550805A1 (es) |
| SG (1) | SG11202103666PA (es) |
| TW (1) | TW202028466A (es) |
| WO (1) | WO2020074001A1 (es) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3589751A4 (en) | 2017-03-03 | 2021-11-17 | The Regents of The University of California | RNA TARGETING OF MUTATIONS VIA SUPPRESSOR RNA AND DEAMINASES |
| KR102666695B1 (ko) * | 2018-10-12 | 2024-05-23 | 페킹 유니버시티 | Rna를 편집하기 위한 방법 및 조성물 |
| WO2020154343A1 (en) | 2019-01-22 | 2020-07-30 | Korro Bio, Inc. | Rna-editing oligonucleotides and uses thereof |
| WO2020154344A1 (en) | 2019-01-22 | 2020-07-30 | Korro Bio, Inc. | Rna-editing oligonucleotides and uses thereof |
| WO2020154342A1 (en) | 2019-01-22 | 2020-07-30 | Korro Bio, Inc. | Rna-editing oligonucleotides and uses thereof |
| TW202043249A (zh) | 2019-04-15 | 2020-12-01 | 大陸商博雅輯因(北京)生物科技有限公司 | 編輯rna的方法和組合物 |
| PH12022550059A1 (en) | 2019-07-12 | 2022-11-21 | Univ Beijing | Targeted rna editing by leveraging endogenous adar using engineered rnas |
| CN115038789A (zh) | 2019-12-02 | 2022-09-09 | 塑造治疗公司 | 治疗性编辑 |
| TW202138561A (zh) | 2019-12-30 | 2021-10-16 | 大陸商博雅輯因(北京)生物科技有限公司 | 治療Usher綜合症的方法和其組合物 |
| WO2021136408A1 (zh) | 2019-12-30 | 2021-07-08 | 博雅辑因(北京)生物科技有限公司 | 一种基于leaper技术治疗mps ih的方法和组合物 |
| PH12022552687A1 (en) * | 2020-04-15 | 2024-03-25 | Edigene Therapeutics Beijing Inc | Method and drug for treating hurler syndrome |
| WO2021216853A1 (en) * | 2020-04-22 | 2021-10-28 | Shape Therapeutics Inc. | Compositions and methods using snrna components |
| US20210380980A1 (en) * | 2020-05-28 | 2021-12-09 | Korro Bio, Inc. | Methods and Compositions for the ADAR-Mediated Editing of SERPINA1 |
| CN113897359A (zh) * | 2020-07-06 | 2022-01-07 | 博雅辑因(北京)生物科技有限公司 | 一种改善的rna编辑方法 |
| US20230272379A1 (en) * | 2020-07-06 | 2023-08-31 | Edigene Therapeutics (Beijing ) Inc. | Improved rna editing method |
| IL278401A (en) | 2020-10-29 | 2022-05-01 | Yeda Res & Dev | Polynucleotides for editing RNA and a method for using them |
| WO2022147573A1 (en) * | 2021-01-04 | 2022-07-07 | The Regents Of The University Of California | Programmable rna editing in vivo via recruitment of endogenous adars |
| WO2022150974A1 (en) * | 2021-01-12 | 2022-07-21 | Peking University | Targeted rna editing by leveraging endogenous adar using engineered rnas |
| CA3222560A1 (en) * | 2021-06-15 | 2022-12-22 | Massachusetts Institute Of Technology | Deaminase-based rna sensors |
| EP4363576A1 (en) * | 2021-06-29 | 2024-05-08 | Shape Therapeutics Inc. | Engineered guide rnas and polynucleotides |
| EP4388089A4 (en) * | 2021-08-18 | 2025-01-15 | Peking University | Engineered adar-recruiting rnas and methods of use thereof |
| WO2023060186A1 (en) | 2021-10-07 | 2023-04-13 | Hepatx Corporation | Methods of tracking donor cells in a recipient |
| WO2023077138A1 (en) * | 2021-10-29 | 2023-05-04 | Duke Univeristy | Compositions and systems for rna-programable cell editing and methods of making and using same |
| WO2023143539A1 (en) * | 2022-01-28 | 2023-08-03 | Edigene Therapeutics (Beijing) Inc. | Engineered adar-recruiting rnas and methods of use thereof |
| WO2023185231A1 (en) * | 2022-04-02 | 2023-10-05 | Edigene Therapeutics (Beijing) Inc. | Engineered adar-recruiting rnas and methods of use for usher syndrome |
| WO2024228735A2 (en) * | 2022-07-15 | 2024-11-07 | Georgia Tech Research Corporation | Anti-sars-cov-1 and anti-sars-cov-2 activatable rnase guide sequences |
| WO2024086650A1 (en) * | 2022-10-18 | 2024-04-25 | Locanabio, Inc. | Compositions and methods comprising programmable snrnas for rna editing |
| WO2024137990A2 (en) | 2022-12-21 | 2024-06-27 | Trustees Of Boston University | Compositions and methods for controlled mrna translation and stability |
| CN118620958A (zh) * | 2023-03-08 | 2024-09-10 | 广州医科大学 | 一种抗原表位的制备方法 |
| CN121152627A (zh) * | 2023-03-31 | 2025-12-16 | 时夕(广州)生物科技有限公司 | 一种与rna编辑靶位点形成编辑底物的序列 |
| CN118853661A (zh) * | 2023-04-28 | 2024-10-29 | 时夕(广州)生物科技有限公司 | 编辑rna的方法、组合物及其应用 |
| CN121311590A (zh) * | 2023-05-16 | 2026-01-09 | 北京大学 | 调控rna剪接的方法 |
| CN121059628A (zh) * | 2024-06-03 | 2025-12-05 | 时夕(广州)生物科技有限公司 | 调控RNA剪接的向导agRNA |
| CN119505015B (zh) * | 2024-11-15 | 2025-10-17 | 北京大学 | 一种融合蛋白及其应用方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| KR101297830B1 (ko) * | 2010-09-10 | 2013-08-19 | 한국생명공학연구원 | 신규한 rna 결합 단백질 및 이를 이용한 무표지 마이크로 rna 검출방법 |
| EP4372091A3 (en) | 2014-12-12 | 2024-07-31 | Tod M. Woolf | Compositions and methods for editing nucleic acids in cells utilizing oligonucleotides |
| CA2968336C (en) * | 2014-12-17 | 2021-11-23 | Proqr Therapeutics Ii B.V. | Construct for site directed editing of an adenosine nucleotide in target rna |
| JP6624743B2 (ja) * | 2015-07-14 | 2019-12-25 | 学校法人福岡大学 | 部位特異的rna変異導入方法およびそれに使用する標的編集ガイドrnaならびに標的rna−標的編集ガイドrna複合体 |
| US11396672B2 (en) * | 2015-08-31 | 2022-07-26 | The University Of Chicago | Composition and methods for detecting adenosine modifications |
| DE102015012522B3 (de) * | 2015-09-26 | 2016-06-02 | Eberhard Karls Universität Tübingen | Verfahren und Substanzen zur gerichteten RNA-Editierung |
| CN109477103A (zh) * | 2016-06-22 | 2019-03-15 | ProQR治疗上市公司Ⅱ | 单链rna-编辑寡核苷酸 |
| EP3507366B1 (en) * | 2016-09-01 | 2020-10-07 | ProQR Therapeutics II B.V. | Chemically modified single-stranded rna-editing oligonucleotides |
| EP3571300A1 (en) | 2017-01-19 | 2019-11-27 | ProQR Therapeutics II B.V. | Oligonucleotide complexes for use in rna editing |
| EP3589751A4 (en) * | 2017-03-03 | 2021-11-17 | The Regents of The University of California | RNA TARGETING OF MUTATIONS VIA SUPPRESSOR RNA AND DEAMINASES |
| CN120330163A (zh) | 2017-03-15 | 2025-07-18 | 博德研究所 | 新型cas13b直向同源物crispr酶和系统 |
| KR20200066616A (ko) * | 2017-09-21 | 2020-06-10 | 더 브로드 인스티튜트, 인코퍼레이티드 | 표적화된 핵산 편집을 위한 시스템, 방법 및 조성물 |
| KR102666695B1 (ko) * | 2018-10-12 | 2024-05-23 | 페킹 유니버시티 | Rna를 편집하기 위한 방법 및 조성물 |
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2019
- 2019-10-12 KR KR1020217014349A patent/KR102666695B1/ko active Active
- 2019-10-12 CN CN202210717093.4A patent/CN115651927B/zh active Active
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- 2019-10-12 CN CN201980067380.1A patent/CN113631708B/zh active Active
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2021
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- 2021-04-09 US US17/226,961 patent/US20210310026A1/en not_active Abandoned
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