DK3873904T3 - Tetrahydropyran (THP)-substitueret bicycklisk pyrimidindionforbindelser - Google Patents

Tetrahydropyran (THP)-substitueret bicycklisk pyrimidindionforbindelser Download PDF

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Publication number
DK3873904T3
DK3873904T3 DK19817827.9T DK19817827T DK3873904T3 DK 3873904 T3 DK3873904 T3 DK 3873904T3 DK 19817827 T DK19817827 T DK 19817827T DK 3873904 T3 DK3873904 T3 DK 3873904T3
Authority
DK
Denmark
Prior art keywords
thp
tetrahydropyran
substituted bicyclic
dione compounds
pyrimidine dione
Prior art date
Application number
DK19817827.9T
Other languages
English (en)
Inventor
Mark Grillo
Brian Kane
Johan Oslob
Min Zhong
Fabienne Thompson
Original Assignee
Myokardia Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Myokardia Inc filed Critical Myokardia Inc
Application granted granted Critical
Publication of DK3873904T3 publication Critical patent/DK3873904T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hospice & Palliative Care (AREA)
DK19817827.9T 2018-10-29 2019-10-28 Tetrahydropyran (THP)-substitueret bicycklisk pyrimidindionforbindelser DK3873904T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862752278P 2018-10-29 2018-10-29
PCT/US2019/058297 WO2020092208A1 (en) 2018-10-29 2019-10-28 Tetrahydropyran (thp)-substituted bicyclic-pyrimidinedione compounds

Publications (1)

Publication Number Publication Date
DK3873904T3 true DK3873904T3 (da) 2024-08-05

Family

ID=68841171

Family Applications (2)

Application Number Title Priority Date Filing Date
DK19817827.9T DK3873904T3 (da) 2018-10-29 2019-10-28 Tetrahydropyran (THP)-substitueret bicycklisk pyrimidindionforbindelser
DK24186221.8T DK4464321T3 (da) 2018-10-29 2019-10-28 Tetrahydropyran (thp)-substituerede bicykliske pyrimidindionforbindelser

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK24186221.8T DK4464321T3 (da) 2018-10-29 2019-10-28 Tetrahydropyran (thp)-substituerede bicykliske pyrimidindionforbindelser

Country Status (29)

Country Link
US (5) US11034693B2 (da)
EP (3) EP4736855A2 (da)
JP (3) JP7447110B2 (da)
KR (2) KR20250053228A (da)
CN (3) CN113056465B (da)
AR (1) AR116880A1 (da)
AU (2) AU2019373206B2 (da)
BR (1) BR112021008077A2 (da)
CA (1) CA3118293A1 (da)
CL (1) CL2021001083A1 (da)
CO (1) CO2021005540A2 (da)
DK (2) DK3873904T3 (da)
EA (1) EA202191152A1 (da)
ES (1) ES2986923T3 (da)
FI (2) FI3873904T3 (da)
HR (2) HRP20241065T1 (da)
HU (1) HUE068265T2 (da)
IL (2) IL325304A (da)
LT (2) LT3873904T (da)
MX (2) MX2021004955A (da)
PE (1) PE20211780A1 (da)
PL (1) PL3873904T3 (da)
PT (2) PT4464321T (da)
RS (1) RS65963B1 (da)
SG (1) SG11202104218SA (da)
SI (2) SI3873904T1 (da)
SM (2) SMT202400358T1 (da)
TW (3) TWI837202B (da)
WO (1) WO2020092208A1 (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL276013B2 (en) 2018-01-17 2024-03-01 Glaxosmithkline Ip Dev Ltd Pi4kiiibeta inhibitors
DK3873904T3 (da) * 2018-10-29 2024-08-05 Myokardia Inc Tetrahydropyran (THP)-substitueret bicycklisk pyrimidindionforbindelser
IL300775A (en) 2020-08-28 2023-04-01 Myokardia Inc Treatment methods with myosin modulator
CN114149423B (zh) * 2020-09-08 2023-12-12 江苏恒瑞医药股份有限公司 四氢吡啶并嘧啶二酮类衍生物、其制备方法及其在医药上的应用
CN114456163B (zh) * 2020-11-09 2023-08-11 江苏恒瑞医药股份有限公司 四氢吡啶并嘧啶二酮类衍生物、其制备方法及其在医药上的应用
CN116323598B (zh) 2020-11-20 2024-11-15 江苏恒瑞医药股份有限公司 三嗪二酮类衍生物、其制备方法及其在医药上的应用
TW202302594A (zh) 2021-03-04 2023-01-16 美商胞質動力學公司 心臟肌節抑制劑
CA3254710A1 (en) 2022-05-20 2025-07-03 Jiangsu Hengrui Pharmaceuticals Co., Ltd. CRYSTALLINE FORMS OF A TRIAZINE-DIONE DERIVATIVE AND THEIR PREPARATION PROCESS
IL318417A (en) 2022-07-29 2025-03-01 Myokardia Inc Crystalline forms of (6s,7s)-6-fluoro-7-(2-fluoro-5-methylphenyl)-3-(tetrahydro-2h-pyran-4-yl)-5,6,7,8-tetrahydropyrido[2 ,3-d]pyrimidine-2,4(lh,3h)-dione

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2167571T3 (es) 1995-06-07 2002-05-16 Searle & Co Terapia de combinacion de antagonista de aldosterona epoxi-esteroideo y antagonista de angiotensina ii para el tratamiento del fallo cardiaco congestivo.
GB9715892D0 (en) 1997-07-29 1997-10-01 Zeneca Ltd Heterocyclic compounds
SMT202000071T1 (it) * 2013-06-21 2020-03-13 Myokardia Inc Composti di pirimidinadione contro le condizioni cardiache
US9663516B2 (en) * 2014-12-18 2017-05-30 MyoKardia, Inc. Bicyclic-pyrimidinedione compounds
DK3873904T3 (da) 2018-10-29 2024-08-05 Myokardia Inc Tetrahydropyran (THP)-substitueret bicycklisk pyrimidindionforbindelser

Also Published As

Publication number Publication date
JP2022506524A (ja) 2022-01-17
US20240025894A1 (en) 2024-01-25
PL3873904T3 (pl) 2024-12-23
AU2019373206A1 (en) 2021-06-17
IL282740B1 (en) 2026-01-01
TW202030189A (zh) 2020-08-16
EP4464321B1 (en) 2026-01-21
FI4464321T3 (fi) 2026-03-11
US20220106314A1 (en) 2022-04-07
US20220340569A1 (en) 2022-10-27
EP4464321A2 (en) 2024-11-20
JP7447110B2 (ja) 2024-03-11
KR102797129B1 (ko) 2025-04-18
CN119977962A (zh) 2025-05-13
EP3873904A1 (en) 2021-09-08
US20200165247A1 (en) 2020-05-28
EA202191152A1 (ru) 2022-01-19
SMT202400358T1 (it) 2024-11-15
IL282740B2 (en) 2026-05-01
TW202521537A (zh) 2025-06-01
HUE068265T2 (hu) 2024-12-28
EP3873904B1 (en) 2024-07-10
EP4464321A3 (en) 2025-01-01
AU2025200975A1 (en) 2025-03-06
FI3873904T3 (fi) 2024-08-09
LT4464321T (lt) 2026-03-25
AR116880A1 (es) 2021-06-23
LT3873904T (lt) 2024-11-11
CN113056465B (zh) 2025-01-28
JP7703716B2 (ja) 2025-07-15
US12344607B2 (en) 2025-07-01
TW202426449A (zh) 2024-07-01
TWI837202B (zh) 2024-04-01
CN113056465A (zh) 2021-06-29
KR20210086673A (ko) 2021-07-08
US11034693B2 (en) 2021-06-15
MX2024004892A (es) 2024-05-07
RS65963B1 (sr) 2024-10-31
JP2024063091A (ja) 2024-05-10
JP2025138748A (ja) 2025-09-25
WO2020092208A1 (en) 2020-05-07
KR20250053228A (ko) 2025-04-21
ES2986923T3 (es) 2024-11-13
CA3118293A1 (en) 2020-05-07
DK4464321T3 (da) 2026-02-09
IL282740A (en) 2021-06-30
PT3873904T (pt) 2024-10-08
SMT202600122T1 (it) 2026-05-12
IL325304A (en) 2026-02-01
US20250282779A1 (en) 2025-09-11
SI3873904T1 (sl) 2024-10-30
PE20211780A1 (es) 2021-09-08
CO2021005540A2 (es) 2021-07-30
CN119977963A (zh) 2025-05-13
PT4464321T (pt) 2026-04-02
SG11202104218SA (en) 2021-05-28
TWI876902B (zh) 2025-03-11
CL2021001083A1 (es) 2021-09-24
SI4464321T1 (sl) 2026-03-31
BR112021008077A2 (pt) 2021-08-03
HRP20241065T1 (hr) 2024-11-08
EP4736855A2 (en) 2026-05-06
MX2021004955A (es) 2021-07-21
HRP20260161T1 (hr) 2026-03-27
AU2019373206B2 (en) 2024-11-14

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