ES2167571T3 - Terapia de combinacion de antagonista de aldosterona epoxi-esteroideo y antagonista de angiotensina ii para el tratamiento del fallo cardiaco congestivo. - Google Patents

Terapia de combinacion de antagonista de aldosterona epoxi-esteroideo y antagonista de angiotensina ii para el tratamiento del fallo cardiaco congestivo.

Info

Publication number
ES2167571T3
ES2167571T3 ES96919170T ES96919170T ES2167571T3 ES 2167571 T3 ES2167571 T3 ES 2167571T3 ES 96919170 T ES96919170 T ES 96919170T ES 96919170 T ES96919170 T ES 96919170T ES 2167571 T3 ES2167571 T3 ES 2167571T3
Authority
ES
Spain
Prior art keywords
angiotensin
epoxy
treatment
antagonist
antigonist
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96919170T
Other languages
English (en)
Inventor
John C Alexander
Joseph R Schuh
Richard J Gorczynski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Application granted granted Critical
Publication of ES2167571T3 publication Critical patent/ES2167571T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

SE DESCRIBE UNA TERAPIA DE COMBINACION QUE COMPRENDE UNA CANTIDAD TERAPEUTICAMENTE EFICAZ DE UN ANTAGONISTA DE RECEPTOR DE ALDOSTERONA EPOXI NTE EFICAZ DE UN ANTAGONISTA DEL RECEPTOR DE ANGIOTENSINA II PARA EL TRATAMIENTO DE TRASTORNOS CIRCULATORIOS, INCLUYENDO TRASTORNOS CARDIOVASCULARES TALES COMO HIPERTENSION, INSUFICIENCIA CARDIACA CONGESTIVA, CIRROSIS Y ASCITES. LOS ANTAGONISTAS PREFERIDOS DEL RECEPTOR DE ANGIOTENSINA II SON AQUELLOS COMPUESTOS QUE POSEEN UNA ELEVADA POTENCIA Y BIODISPONIBILIDAD Y QUE SE CARACTERIZAN POR POSEER UN GRUPO IMIDAZOL O TRIAZOL UNIDO A UNA PORCION DE BIFENILMETILO O PIRIDINIL/FENILMETILO. LOS ANTAGONISTAS DEL RECEPTOR DE ALDOSTERONA EPOXI SON COMPUESTOS ESTEROIDEOS DE SPIROXANO OR LA PRESENCIA DE UNA PORCION EPOXI SUSTITUIDA EN 9 AL}, 11 AL}. UNA TERAPIA DE COMBINACION PREFERIDA INCLUYE EL ANTAGONISTA DE RECEPTOR DE ANGIOTENSINA II 5 TETRAZOL Y EL ANTAGONISTA DEL RECEPTOR DE ALDOSTERONA EPOXIMEXRENONA.
ES96919170T 1995-06-07 1996-06-05 Terapia de combinacion de antagonista de aldosterona epoxi-esteroideo y antagonista de angiotensina ii para el tratamiento del fallo cardiaco congestivo. Expired - Lifetime ES2167571T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US48645695A 1995-06-07 1995-06-07

Publications (1)

Publication Number Publication Date
ES2167571T3 true ES2167571T3 (es) 2002-05-16

Family

ID=23931955

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96919170T Expired - Lifetime ES2167571T3 (es) 1995-06-07 1996-06-05 Terapia de combinacion de antagonista de aldosterona epoxi-esteroideo y antagonista de angiotensina ii para el tratamiento del fallo cardiaco congestivo.

Country Status (21)

Country Link
US (1) US6653306B1 (es)
EP (1) EP0831910B1 (es)
JP (1) JPH11507627A (es)
KR (1) KR100618466B1 (es)
CN (2) CN1522701A (es)
AT (1) ATE209047T1 (es)
AU (1) AU725689B2 (es)
BR (1) BR9609066A (es)
CA (1) CA2224079A1 (es)
CZ (1) CZ297975B6 (es)
DE (1) DE69617235T2 (es)
DK (1) DK0831910T3 (es)
ES (1) ES2167571T3 (es)
IL (1) IL122242A (es)
NO (1) NO318184B1 (es)
NZ (1) NZ310730A (es)
PL (1) PL185150B1 (es)
PT (1) PT831910E (es)
RO (1) RO118046B1 (es)
RU (1) RU2166330C2 (es)
WO (1) WO1996040257A1 (es)

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Also Published As

Publication number Publication date
AU6157796A (en) 1996-12-30
JPH11507627A (ja) 1999-07-06
CZ297975B6 (cs) 2007-05-09
ATE209047T1 (de) 2001-12-15
CN1142793C (zh) 2004-03-24
DK0831910T3 (da) 2002-05-21
IL122242A (en) 2001-07-24
EP0831910B1 (en) 2001-11-21
KR100618466B1 (ko) 2006-12-13
NO975741D0 (no) 1997-12-05
NO318184B1 (no) 2005-02-14
PL185150B1 (pl) 2003-03-31
WO1996040257A1 (en) 1996-12-19
EP0831910A1 (en) 1998-04-01
NO975741L (no) 1998-01-29
US6653306B1 (en) 2003-11-25
DE69617235T2 (de) 2002-07-25
AU725689B2 (en) 2000-10-19
BR9609066A (pt) 1999-01-26
CZ385097A3 (cs) 1998-06-17
NZ310730A (en) 2001-01-26
IL122242A0 (en) 1998-04-05
CA2224079A1 (en) 1996-12-19
RU2166330C2 (ru) 2001-05-10
RO118046B1 (ro) 2003-01-30
PL324001A1 (en) 1998-04-27
KR19990022548A (ko) 1999-03-25
DE69617235D1 (de) 2002-01-03
CN1192697A (zh) 1998-09-09
CN1522701A (zh) 2004-08-25
PT831910E (pt) 2002-05-31

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