DK4011898T3 - 3-hydroxy-5-pregnan-20-one derivat og anvendelse deraf - Google Patents
3-hydroxy-5-pregnan-20-one derivat og anvendelse derafInfo
- Publication number
- DK4011898T3 DK4011898T3 DK20852240.9T DK20852240T DK4011898T3 DK 4011898 T3 DK4011898 T3 DK 4011898T3 DK 20852240 T DK20852240 T DK 20852240T DK 4011898 T3 DK4011898 T3 DK 4011898T3
- Authority
- DK
- Denmark
- Prior art keywords
- pregnan
- hydroxy
- derivative
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
- C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
- C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Addiction (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910736020.8A CN112341511A (zh) | 2019-08-09 | 2019-08-09 | 3-羟基-5-孕烷-20-酮衍生物及其用途 |
| PCT/CN2020/107965 WO2021027744A1 (zh) | 2019-08-09 | 2020-08-07 | 3-羟基-5-孕烷-20-酮衍生物及其用途 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK4011898T3 true DK4011898T3 (da) | 2026-03-09 |
Family
ID=74366997
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK20852240.9T DK4011898T3 (da) | 2019-08-09 | 2020-08-07 | 3-hydroxy-5-pregnan-20-one derivat og anvendelse deraf |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20220289788A1 (da) |
| EP (1) | EP4011898B8 (da) |
| JP (1) | JP7785674B2 (da) |
| CN (2) | CN112341511A (da) |
| DK (1) | DK4011898T3 (da) |
| ES (1) | ES3060711T3 (da) |
| FI (1) | FI4011898T3 (da) |
| PL (1) | PL4011898T3 (da) |
| PT (1) | PT4011898T (da) |
| RS (1) | RS67876B1 (da) |
| WO (1) | WO2021027744A1 (da) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114907436B (zh) * | 2021-02-08 | 2026-08-11 | 安成生物科技股份有限公司 | 3-羟基-5-孕烷-20-酮衍生物的晶型及其制备方法和用途 |
| US20240383942A1 (en) * | 2021-09-14 | 2024-11-21 | Nanjing Minova Pharmaceutical Co., Ltd. | Water-soluble allopregnanolone derivative, and preparation method therefor and use thereof |
| IT202100030671A1 (it) * | 2021-12-03 | 2023-06-03 | Ind Chimica Srl | PROCESSO PER LA PREPARAZIONE DI (3a,5a)-20-OSSOPREGNAN-3-IL GLICIL-L-VALINATO CLORIDRATO |
| CN117801047B (zh) * | 2023-01-19 | 2024-12-20 | 北京华睿鼎信科技有限公司 | 神经甾体衍生物及其用途 |
| CN118620015A (zh) * | 2023-03-10 | 2024-09-10 | 南京迈诺威医药科技有限公司 | 别孕烷醇酮衍生物的盐型、多晶型及其制备方法和用途 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5232917A (en) * | 1987-08-25 | 1993-08-03 | University Of Southern California | Methods, compositions, and compounds for allosteric modulation of the GABA receptor by members of the androstane and pregnane series |
| DK1038880T3 (da) * | 1994-02-14 | 2008-03-03 | Euro Celtique Sa | Androstaner og pregnaner til allosterisk modulering af GABA-receptor |
| AU2005330504B2 (en) * | 2004-09-29 | 2010-10-28 | Harbor Biosciences, Inc. | Steroid analogs and characterization and treatment methods |
| CA2955684A1 (en) * | 2008-02-26 | 2009-09-03 | Emory University | Steroid analogues for neuroprotection |
| WO2009120565A2 (en) * | 2008-03-25 | 2009-10-01 | University Of Maryland, Baltimore | Novel prodrugs of c-17-heteroaryl steroidal cyp17 inhibitors/antiandrogens: synthesis, in vitro biological activities, pharmacokinetics and antitumor activity |
| CN101585862B (zh) * | 2008-05-20 | 2014-12-17 | 梅克芳股份公司 | 甾族化合物 |
| WO2010088409A2 (en) * | 2009-01-30 | 2010-08-05 | Emory University | Methods of neuroprotection using neuroprotective steroids and a vitamin d |
| JP5687287B2 (ja) * | 2010-01-14 | 2015-03-18 | ウメクライン ムード エービー | 改善された保存性及び溶解特性を有する３−ベータ−ヒドロキシ−５−アルファ−プレグナン−２０−オンを含有する薬学的組成物 |
| WO2011120044A1 (en) * | 2010-03-26 | 2011-09-29 | Duke University | Conjugated neuroactive steroid compositions and methods of use |
| US9670247B2 (en) * | 2012-07-02 | 2017-06-06 | The University Of Kansas | Contraceptive agents |
| US20170022245A1 (en) * | 2013-11-26 | 2017-01-26 | Biopharma Works | Ganaxolone derivatives for treatment of central nervous systems disorders |
| CN103772469A (zh) * | 2014-02-21 | 2014-05-07 | 中国科学院上海有机化学研究所 | 一种含有动物固醇和天然精氨酸结构片段的合成阳离子脂质、合成方法及其应用 |
| JOP20200195A1 (ar) * | 2014-09-08 | 2017-06-16 | Sage Therapeutics Inc | سترويدات وتركيبات نشطة عصبياً، واستخداماتها |
| CN108148106A (zh) * | 2016-12-05 | 2018-06-12 | 江苏恩华络康药物研发有限公司 | 一类水溶性别孕烯醇酮衍生物及其用途 |
| US20200276211A1 (en) * | 2017-11-28 | 2020-09-03 | Viewpoint Therapeutics, Inc. | Compounds for treating near vision disorders |
| CN108517001A (zh) * | 2018-05-17 | 2018-09-11 | 江苏恩华络康药物研发有限公司 | 水溶性别孕烯醇酮衍生物及其用途 |
| CN109776647B (zh) * | 2019-02-14 | 2021-09-17 | 烟台大学 | 具有抗炎活性的Pyxinol酯化衍生物及其制备方法和应用 |
| CZ309617B6 (cs) * | 2019-04-05 | 2023-05-24 | Ústav organické chemie a biochemie AV ČR, v. v. i | 3α5ß-Neuroaktivní steroidy pro léčbu epilepsie a záchvatových onemocnění |
-
2019
- 2019-08-09 CN CN201910736020.8A patent/CN112341511A/zh active Pending
-
2020
- 2020-08-07 PL PL20852240.9T patent/PL4011898T3/pl unknown
- 2020-08-07 EP EP20852240.9A patent/EP4011898B8/en active Active
- 2020-08-07 RS RS20260316A patent/RS67876B1/sr unknown
- 2020-08-07 ES ES20852240T patent/ES3060711T3/es active Active
- 2020-08-07 JP JP2022534483A patent/JP7785674B2/ja active Active
- 2020-08-07 WO PCT/CN2020/107965 patent/WO2021027744A1/zh not_active Ceased
- 2020-08-07 PT PT208522409T patent/PT4011898T/pt unknown
- 2020-08-07 CN CN202080054158.0A patent/CN114206899B/zh active Active
- 2020-08-07 US US17/632,770 patent/US20220289788A1/en active Pending
- 2020-08-07 DK DK20852240.9T patent/DK4011898T3/da active
- 2020-08-07 FI FIEP20852240.9T patent/FI4011898T3/fi active
Also Published As
| Publication number | Publication date |
|---|---|
| CN112341511A (zh) | 2021-02-09 |
| US20220289788A1 (en) | 2022-09-15 |
| RS67876B1 (sr) | 2026-04-30 |
| EP4011898B1 (en) | 2026-01-07 |
| EP4011898A4 (en) | 2023-09-20 |
| PT4011898T (pt) | 2026-03-25 |
| PL4011898T3 (pl) | 2026-05-11 |
| EP4011898B8 (en) | 2026-02-18 |
| CN114206899B (zh) | 2025-09-05 |
| ES3060711T3 (en) | 2026-03-27 |
| EP4011898A1 (en) | 2022-06-15 |
| FI4011898T3 (fi) | 2026-02-24 |
| JP2022545047A (ja) | 2022-10-24 |
| JP7785674B2 (ja) | 2025-12-15 |
| CN114206899A (zh) | 2022-03-18 |
| WO2021027744A1 (zh) | 2021-02-18 |
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