DK407577A - Azabicycloforbindelser samt deres fremstilling og anvendelse - Google Patents

Azabicycloforbindelser samt deres fremstilling og anvendelse

Info

Publication number: DK407577A
Authority: DK; Denmark
Prior art keywords: manufacture; azabicyclo compounds; azabicyclo; compounds
Prior art date: 1976-09-15

Application number

DK407577A

Other languages

English (en)

Other versions

DK146245C (da

DK146245B (da

Inventor

W J Fanshawe

J W Epstein

L S Crawley

C M Hofmann

S R Safir

Original Assignee

American Cyanamid Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1976-09-15

Filing date

1977-09-14

Publication date

1978-03-16

1977-06-23 Priority claimed from US05/809,340 external-priority patent/US4118417A/en

1977-06-23 Priority claimed from US05/809,339 external-priority patent/US4131611A/en

1977-06-23 Priority claimed from US05/809,341 external-priority patent/US4118393A/en

1977-09-14 Application filed by American Cyanamid Co filed Critical American Cyanamid Co

1978-03-16 Publication of DK407577A publication Critical patent/DK407577A/da

1980-10-16 Priority to DK438480A priority Critical patent/DK438480A/da

1980-10-16 Priority to DK438580A priority patent/DK438580A/da

1983-08-08 Publication of DK146245B publication Critical patent/DK146245B/da

1984-01-16 Application granted granted Critical

1984-01-16 Publication of DK146245C publication Critical patent/DK146245C/da

Links

150000001875 compounds Chemical class 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C61/16—Unsaturated compounds
- C07C61/40—Unsaturated compounds containing halogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
- C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
- C07C29/147—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C33/36—Polyhydroxylic alcohols containing six-membered aromatic rings and other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C61/16—Unsaturated compounds
- C07C61/28—Unsaturated compounds polycyclic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C62/30—Unsaturated compounds
- C07C62/34—Unsaturated compounds containing ether groups, groups, groups, or groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
Pain & Pain Management (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK407577A 1976-09-15 1977-09-14 Analogifremgangsmaade til fremstilling af racemiske eller optisk aktive azabicycloforbindelser eller syreadditionssalte deraf DK146245C (da)

Priority Applications (2)

Application Number	Priority Date	Filing Date	Title
DK438480A DK438480A (da)	1976-09-15	1980-10-16	Fremgangsmaade til fremstilling af en optisk aktiv azabicycloforbindelse
DK438580A DK438580A (da)	1976-09-15	1980-10-16	Mellemprodukt til fremstilling af azabicycloforbindelser

Applications Claiming Priority (8)

Application Number	Priority Date	Filing Date	Title
US72340276A	1976-09-15	1976-09-15
US72340276		1976-09-15
US05/809,340 US4118417A (en)	1977-06-23	1977-06-23	Process for resolving cis-1-substituted phenyl-1,2-cyclopropanedicarboxylic acids
US80933977		1977-06-23
US80934177		1977-06-23
US05/809,339 US4131611A (en)	1975-07-31	1977-06-23	Azabicyclohexanes
US80934077		1977-06-23
US05/809,341 US4118393A (en)	1977-06-23	1977-06-23	Phenyl azabicyclohexanones

Publications (3)

Publication Number	Publication Date
DK407577A true DK407577A (da)	1978-03-16
DK146245B DK146245B (da)	1983-08-08
DK146245C DK146245C (da)	1984-01-16

Family

ID=27505564

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
DK407577A DK146245C (da)	1976-09-15	1977-09-14	Analogifremgangsmaade til fremstilling af racemiske eller optisk aktive azabicycloforbindelser eller syreadditionssalte deraf
DK438480A DK438480A (da)	1976-09-15	1980-10-16	Fremgangsmaade til fremstilling af en optisk aktiv azabicycloforbindelse
DK438580A DK438580A (da)	1976-09-15	1980-10-16	Mellemprodukt til fremstilling af azabicycloforbindelser

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
DK438480A DK438480A (da)	1976-09-15	1980-10-16	Fremgangsmaade til fremstilling af en optisk aktiv azabicycloforbindelse
DK438580A DK438580A (da)	1976-09-15	1980-10-16	Mellemprodukt til fremstilling af azabicycloforbindelser

Country Status (16)

Country	Link
JP (1)	JPS5337656A (da)
AR (2)	AR220684A1 (da)
AT (2)	AT367036B (da)
AU (1)	AU519620B2 (da)
BE (1)	BE858683A (da)
CH (2)	CH637929A5 (da)
DD (1)	DD133943A5 (da)
DE (1)	DE2740562A1 (da)
DK (3)	DK146245C (da)
FR (1)	FR2375212A1 (da)
GR (1)	GR72713B (da)
HU (1)	HU177531B (da)
NL (1)	NL189041C (da)
PL (1)	PL115869B1 (da)
SE (2)	SE435384B (da)
YU (2)	YU39499B (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4183857A (en) *	1978-07-06	1980-01-15	Shell Oil Company	3-Benzyl-3-azabicyclo(3.1.0)hexane-2,4-dione
IL65843A (en) *	1977-08-11	1986-12-31	American Cyanamid Co	Pharmaceutical compositions for the treatment of depression containing 3-aza-bicyclo(3.1.0)hexane derivatives and certain novel compounds of this type
CA1117127A (en) *	1978-06-27	1982-01-26	Janet A. Day	Derivatives of 3-azabicyclo(3.1.0)hexane and a process for their preparation
US4225499A (en) *	1978-07-06	1980-09-30	Shell Oil Company	Process for preparing 3-azabicyclo(3.1.0)hexane-2-carbonitrile
JPS6332100A (ja) *	1986-07-25	1988-02-10	東京電力株式会社	シ−ルド掘進機
JPH0658037B2 (ja) *	1989-09-01	1994-08-03	日本鋼管株式会社	シールド掘進装置
US6372919B1 (en)	2001-01-11	2002-04-16	Dov Pharmaceutical, Inc.	(+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as an anti-depressant agent
US6569887B2 (en)	2001-08-24	2003-05-27	Dov Pharmaceuticals Inc.	(−)-1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as a dopamine-reuptake
US20080081834A1 (en)	2002-07-31	2008-04-03	Lippa Arnold S	Methods and compositions employing bicifadine for treating disability or functional impairment associated with acute pain, chronic pain, or neuropathic disorders
KR20070034129A (ko) *	2004-07-22	2007-03-27	와이어쓰	신경계 질환 및 장애의 치료 방법
RU2007102292A (ru) *	2004-07-22	2008-08-27	Вайет (Us)	Способ лечения расстройств и заболеваний нервной системы
US20070043100A1 (en)	2005-08-16	2007-02-22	Hagen Eric J	Novel polymorphs of azabicyclohexane
ZA200801825B (en)	2005-07-27	2009-12-30	Dov Pharmaceutical Inc	Novel 1-aryl-3-azabicyclo[3.1.0]hexanes: Preparation and use to treat neuropsychiatric disorders
US20080045725A1 (en)	2006-04-28	2008-02-21	Murry Jerry A	Process For The Synthesis of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane
US8138377B2 (en)	2006-11-07	2012-03-20	Dov Pharmaceutical, Inc.	Arylbicyclo[3.1.0]hexylamines and methods and compositions for their preparation and use
US9133159B2 (en)	2007-06-06	2015-09-15	Neurovance, Inc.	1-heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments
US20140206740A1 (en)	2011-07-30	2014-07-24	Neurovance, Inc.	Use Of (1R,5S)-(+)-(Napthalen-2-yl)-3-Azabicyclo[3.1.0]Hexane In The Treatment Of Conditions Affected By Monoamine Neurotransmitters

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1351754A (en) *	1970-07-02	1974-05-01	Allen & Hanburys Ltd	Indenopyrrole derivatives

1977
- 1977-08-16 GR GR54169A patent/GR72713B/el unknown
- 1977-08-26 AR AR268968A patent/AR220684A1/es active
- 1977-09-01 AU AU28441/77A patent/AU519620B2/en not_active Ceased
- 1977-09-02 NL NLAANVRAGE7709691,A patent/NL189041C/xx not_active IP Right Cessation
- 1977-09-08 DE DE19772740562 patent/DE2740562A1/de active Granted
- 1977-09-13 YU YU2174/77A patent/YU39499B/xx unknown
- 1977-09-13 CH CH1118977A patent/CH637929A5/de not_active IP Right Cessation
- 1977-09-14 DK DK407577A patent/DK146245C/da not_active IP Right Cessation
- 1977-09-14 BE BE180894A patent/BE858683A/xx not_active IP Right Cessation
- 1977-09-14 HU HU77AE508A patent/HU177531B/hu unknown
- 1977-09-14 FR FR7727755A patent/FR2375212A1/fr active Granted
- 1977-09-14 PL PL1977200831A patent/PL115869B1/pl unknown
- 1977-09-14 AT AT0661577A patent/AT367036B/de not_active IP Right Cessation
- 1977-09-15 SE SE7710367A patent/SE435384B/xx not_active IP Right Cessation
- 1977-09-15 DD DD77201039A patent/DD133943A5/xx unknown
- 1977-09-16 JP JP11064777A patent/JPS5337656A/ja active Granted
1978
- 1978-09-19 AR AR273764A patent/AR227507A1/es active
1980
- 1980-05-30 AT AT0288280A patent/AT367037B/de not_active IP Right Cessation
- 1980-10-16 DK DK438480A patent/DK438480A/da not_active Application Discontinuation
- 1980-10-16 DK DK438580A patent/DK438580A/da not_active Application Discontinuation
1982
- 1982-04-05 CH CH209382A patent/CH637931A5/de not_active IP Right Cessation
- 1982-06-03 SE SE8203437A patent/SE452610B/sv not_active IP Right Cessation
- 1982-08-23 YU YU1885/82A patent/YU43523B/xx unknown

Also Published As

Publication number	Publication date
DK146245C (da)	1984-01-16
NL189041B (nl)	1992-07-16
YU43523B (en)	1989-08-31
PL200831A1 (da)	1980-02-11
AU519620B2 (en)	1981-12-17
ATA661577A (de)	1981-10-15
AR220684A1 (es)	1980-11-28
HU177531B (en)	1981-11-28
DE2740562A1 (de)	1978-03-23
DE2740562C2 (da)	1989-05-03
AU2844177A (en)	1979-03-08
AT367037B (de)	1982-05-25
DK438480A (da)	1980-10-16
BE858683A (fr)	1978-03-14
SE435384B (sv)	1984-09-24
YU39499B (en)	1984-12-31
SE7710367L (sv)	1978-03-16
PL115869B1 (en)	1981-05-30
NL7709691A (nl)	1978-03-17
CH637931A5 (en)	1983-08-31
FR2375212B1 (da)	1981-07-31
DK146245B (da)	1983-08-08
CH637929A5 (en)	1983-08-31
JPS5337656A (en)	1978-04-06
GR72713B (da)	1983-12-01
JPS6129341B2 (da)	1986-07-05
FR2375212A1 (fr)	1978-07-21
DD133943A5 (de)	1979-01-31
YU188582A (en)	1985-03-20
DK438580A (da)	1980-10-16
YU217477A (en)	1983-01-21
SE452610B (sv)	1987-12-07
ATA288280A (de)	1981-10-15
AT367036B (de)	1982-05-25
NL189041C (nl)	1992-12-16
SE8203437L (sv)	1982-06-03
AR227507A1 (es)	1982-11-15

Legal Events

Date	Code	Title	Description
1993-05-24	PBP	Patent lapsed

Publication	Publication Date	Title
DK120077A (da)	1977-09-20	Cycliske sulfonyloxiimider samt deres fremstilling og anvendelse
DK56876A (da)	1976-08-15	Prostaglandinanaloge samt deres fremstilling og anvendelse
DK194377A (da)	1977-11-05	Pyrrolidoner samt deres fremstilling og anvendelse
DK358678A (da)	1979-02-16	1,4-bis-amino-anthraquinonforbindelser samt deres anvendelse og fremstilling
DK154877A (da)	1977-10-09	Trans-hexahydro-pyrido-indoler samt deres fremstilling og anvendelse
DK287476A (da)	1976-12-28	Pyrrolidoner samt deres fremstilling og anvendelse
DK286676A (da)	1976-12-28	Bicycloheptenforbindelser samt deres fremstilling og anvendelse
DK97179A (da)	1979-09-10	Bicyclooctanderivater samt deres fremstilling og anvendelse
DK318278A (da)	1979-01-17	Beta-lactamforbindelser samt deres femstilling og anvendelse
DK388377A (da)	1978-03-02	Cephalosporiner samt fremgangsmaade til fremstilling deraf
DK83677A (da)	1977-08-27	Pyrrolbenzoxazalkaner samt deres fremstilling og anvendelse
DK214577A (da)	1977-11-19	Benzensulfonylurinstoffer deres fremstilling og anvendelse
DK227177A (da)	1977-11-26	1-aryloxy-2-hydroxy-3-aminopropaner samt deres fremstilling og anvendelse
DK581577A (da)	1978-06-29	Dehydrooligopeptider samt deres fremstilling og anvendelse
DK299578A (da)	1979-01-02	Bleomyciner samt deres fremstilling og anvendelse
DK279777A (da)	1977-12-25	Carbostyriler samt deres fremstilling og anvendelse
DK554776A (da)	1977-06-14	Prostaglandinanaloge pyrrolidoner samt deres fremstilling og anvendelse
DK281476A (da)	1976-12-25	Pyrrolidoner samt deres fremstilling og anvendelse
DK574976A (da)	1977-07-17	Substituerede cycloalkanpyrazoler samt deres fremstilling og anvendelse
DK426376A (da)	1977-03-24	4-hydroxymethyl-2-pyrrolidinoner samt deres fremstilling og anvendelse
DK464176A (da)	1977-04-16	Cycloalkanpyrazoler samt deres fremstilling og anvendelse
DK84377A (da)	1977-08-29	Substituerede phenylguanidiner samt deres fremstilling og anvendelse
DK582378A (da)	1979-06-29	Simipermeable membraner samt deres fremstilling og anvendelse
DK153777A (da)	1977-10-08	Sulfonamider samt deres fremstilling og anvendelse
DK446078A (da)	1979-04-08	Ureidonitriler samt deres fremstilling og anvendelse