DK415181A - Fremgangsmaade til fremtilling af en alfa-l-aspartyl-l-phenylalaninalkylester - Google Patents

Fremgangsmaade til fremtilling af en alfa-l-aspartyl-l-phenylalaninalkylester

Info

Publication number: DK415181A
Authority: DK; Denmark
Prior art keywords: alpha; aspartyl; phenylalanine; preparing; alkyl ester
Prior art date: 1980-09-19

Application number

DK415181A

Other languages

English (en)

Inventor

P S Sampathkumar

B K Dwivedi

Original Assignee

Chimicasa Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-09-19

Filing date

1981-09-18

Publication date

1982-03-20

1981-09-18 Application filed by Chimicasa Gmbh filed Critical Chimicasa Gmbh

1982-03-20 Publication of DK415181A publication Critical patent/DK415181A/da

Links

238000000034 method Methods 0.000 title abstract 2
-1 halo ester compound Chemical class 0.000 abstract 4
COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract 2
150000001447 alkali salts Chemical class 0.000 abstract 2
125000005907 alkyl ester group Chemical group 0.000 abstract 2
229940009098 aspartate Drugs 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
YZQCXOFQZKCETR-UWVGGRQHSA-N Asp-Phe Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(O)=O)CC1=CC=CC=C1 YZQCXOFQZKCETR-UWVGGRQHSA-N 0.000 abstract 1
CKLJMWTZIZZHCS-UHFFFAOYSA-N D-OH-Asp Natural products OC(=O)C(N)CC(O)=O CKLJMWTZIZZHCS-UHFFFAOYSA-N 0.000 abstract 1
CKLJMWTZIZZHCS-UWTATZPHSA-N L-Aspartic acid Natural products OC(=O)[C@H](N)CC(O)=O CKLJMWTZIZZHCS-UWTATZPHSA-N 0.000 abstract 1
CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 abstract 1
230000002378 acidificating effect Effects 0.000 abstract 1
150000008064 anhydrides Chemical class 0.000 abstract 1
229960005261 aspartic acid Drugs 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
230000005494 condensation Effects 0.000 abstract 1
238000009833 condensation Methods 0.000 abstract 1
229960005190 phenylalanine Drugs 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
- C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
- C07K5/0613—Aspartame
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/801—Peptide sweetners

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Life Sciences & Earth Sciences (AREA)
Peptides Or Proteins (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK415181A 1980-09-19 1981-09-18 Fremgangsmaade til fremtilling af en alfa-l-aspartyl-l-phenylalaninalkylester DK415181A (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/185,721 US4333872A (en)	1980-05-27	1980-09-19	Method of producing α-L-aspartyl-L-phenylalanine methylester

Publications (1)

Publication Number	Publication Date
DK415181A true DK415181A (da)	1982-03-20

Family

ID=22682204

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK415181A DK415181A (da)	1980-09-19	1981-09-18	Fremgangsmaade til fremtilling af en alfa-l-aspartyl-l-phenylalaninalkylester

Country Status (8)

Country	Link
US (1)	US4333872A (da)
EP (1)	EP0048345B1 (da)
JP (1)	JPS5782356A (da)
AT (1)	ATE4703T1 (da)
DE (1)	DE3160965D1 (da)
DK (1)	DK415181A (da)
ES (1)	ES8302628A1 (da)
PT (1)	PT73695B (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE12632T1 (de) *	1982-07-20	1985-04-15	Eprova Ag	Verfahren zur herstellung von niederalkylestern von n-l-alpha-aspartyl-l-phenylalanin und neue zwischenprodukte zu deren herstellung.
JPS5921656A (ja) *	1982-07-28	1984-02-03	Takeda Chem Ind Ltd	ポリペプチド誘導体
EP0143881A3 (de) *	1983-09-07	1986-10-29	Gema S.A.	Verfahren zur Herstellung eines alpha-L-Aspartyl-L-Phenylalanin-alkylesters
FR2558471B1 (fr) *	1984-01-19	1987-11-20	Isochem Sa	Procede de preparation d'aspartyl peptides, et nouveaux intermediaires de synthese
ES8607216A1 (es) *	1984-01-19	1986-05-16	Isochem Sa	Procedimiento de preparacion de &-aspartil peptidos
IT8419324A0 (it) *	1984-01-26	1984-01-26	Pierrel Spa	Procedimento per la sintesi di derivati n-acilici dell'aspartame.
JPH0680074B2 (ja) *	1985-07-01	1994-10-12	味の素株式会社	Ｎ―ホルミル―Ｌ―α―アスパルチル―Ｌ―フェニルアラニンの製法
ES2042583T3 (es) *	1986-12-05	1993-12-16	Mitsui Toatsu Chemicals	Preparacion de metil ester de alpha-l-aspartil-l-fenil-alanina o uno de sus hidrohaluros.
ES2042417B1 (es) *	1992-05-18	1994-06-01	Genesis Para La Investigacion	Procedimiento de obtencion de alfa-aspartame.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3475403A (en) *	1967-01-20	1969-10-28	Searle & Co	Aspartic acid containing dipeptide lower alkyl esters
US3786039A (en) *	1969-04-30	1974-01-15	Ajinomoto Kk	Method of producing alpha-l-aspartyl-l-phenylalanine lower alkyl esters
US3830792A (en) *	1969-05-05	1974-08-20	Lilly Co Eli	Method for synthesizing peptides using an excess of an unsymmetrical acid anhydride
BE791544A (fr) *	1971-11-19	1973-05-17	Stamicarbon	Preparation d'esters alkyliques de dipeptide
US3901871A (en) *	1973-09-21	1975-08-26	American Cyanamid Co	Process of preparing ' -l-aspartyl-l-phenylalanine methyl ester
US3933781A (en) *	1973-11-05	1976-01-20	Monsanto Company	Process for the preparation of α-L-aspartyl-L-phenylalanine alkyl esters

1980
- 1980-09-19 US US06/185,721 patent/US4333872A/en not_active Expired - Lifetime
1981
- 1981-08-22 AT AT81106544T patent/ATE4703T1/de not_active IP Right Cessation
- 1981-08-22 EP EP81106544A patent/EP0048345B1/de not_active Expired
- 1981-08-22 DE DE8181106544T patent/DE3160965D1/de not_active Expired
- 1981-09-18 DK DK415181A patent/DK415181A/da not_active Application Discontinuation
- 1981-09-18 JP JP56146470A patent/JPS5782356A/ja active Pending
- 1981-09-18 ES ES505613A patent/ES8302628A1/es not_active Expired
- 1981-09-18 PT PT73695A patent/PT73695B/pt unknown

Also Published As

Publication number	Publication date
EP0048345B1 (de)	1983-09-21
DE3160965D1 (en)	1983-10-27
ES505613A0 (es)	1982-12-01
ES8302628A1 (es)	1982-12-01
ATE4703T1 (de)	1983-10-15
EP0048345A1 (de)	1982-03-31
JPS5782356A (en)	1982-05-22
US4333872A (en)	1982-06-08
PT73695A (en)	1981-10-01
PT73695B (en)	1982-12-10

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Legal Events

Date	Code	Title	Description
1986-06-09	AHB	Application shelved due to non-payment