DK421787A - Dna-konstruktion, der er i stand til at dirigere ekispression og sekretion af biologisk aktive pdgf-analoger i eukaryotiske celler, samt saadanne celler transformeret hermed og fremgangsmaade til fremstilling af pdgf-analogerne under anvendelse af disse - Google Patents

Dna-konstruktion, der er i stand til at dirigere ekispression og sekretion af biologisk aktive pdgf-analoger i eukaryotiske celler, samt saadanne celler transformeret hermed og fremgangsmaade til fremstilling af pdgf-analogerne under anvendelse af disse

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Publication number
DK421787A
DK421787A DK421787A DK421787A DK421787A DK 421787 A DK421787 A DK 421787A DK 421787 A DK421787 A DK 421787A DK 421787 A DK421787 A DK 421787A DK 421787 A DK421787 A DK 421787A
Authority
DK
Denmark
Prior art keywords
pdgf
chain
chains
disclosed
cells
Prior art date
Application number
DK421787A
Other languages
English (en)
Other versions
DK176036B1 (da
DK421787D0 (da
Inventor
Mark J Murray
James D Kelly
Original Assignee
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/896,485 external-priority patent/US4766073A/en
Priority claimed from US06/941,970 external-priority patent/US4849407A/en
Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc
Publication of DK421787D0 publication Critical patent/DK421787D0/da
Publication of DK421787A publication Critical patent/DK421787A/da
Application granted granted Critical
Publication of DK176036B1 publication Critical patent/DK176036B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/49—Platelet-derived growth factor [PDGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/11011—Alpharetrovirus, e.g. avian leucosis virus
    • C12N2740/11022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plant Pathology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK198704217A 1986-08-13 1987-08-12 Ekspression af biologisk aktive PDGF analoger i eukaroyte celler DK176036B1 (da)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US06/896,485 US4766073A (en) 1985-02-25 1986-08-13 Expression of biologically active PDGF analogs in eucaryotic cells
US89648586 1986-08-13
US94216186 1986-12-15
US06/941,970 US4849407A (en) 1986-08-13 1986-12-15 Biologically active mosaic proteins
US06/942,484 US4889919A (en) 1986-08-13 1986-12-15 Biologically active PDGF derived A-chain homodimers
US94248486 1986-12-15
US94197086 1986-12-15
US06/942,161 US4845075A (en) 1985-02-25 1986-12-15 Biologically active B-chain homodimers

Publications (3)

Publication Number Publication Date
DK421787D0 DK421787D0 (da) 1987-08-12
DK421787A true DK421787A (da) 1988-02-14
DK176036B1 DK176036B1 (da) 2006-01-09

Family

ID=27505982

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198704217A DK176036B1 (da) 1986-08-13 1987-08-12 Ekspression af biologisk aktive PDGF analoger i eukaroyte celler

Country Status (7)

Country Link
EP (1) EP0259632B1 (da)
JP (1) JPH085797B2 (da)
AT (1) ATE131532T1 (da)
AU (1) AU7681687A (da)
CA (1) CA1341398C (da)
DE (1) DE3751632T2 (da)
DK (1) DK176036B1 (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988007057A1 (en) * 1987-03-13 1988-09-22 Amgen Inc. Purified platelet-derived growth factor and methods for purification thereof
JPH0198489A (ja) * 1987-04-22 1989-04-17 Chiron Corp 血小板由来成長因子ａ鎖ポリペプチドの組換え生産
US6939849B1 (en) 1987-04-22 2005-09-06 Chiron Corporation Recombinant PDGF A-chain homodimers and methods of use
EP0422125B1 (en) * 1988-06-30 1996-10-23 Cor Therapeutics, Inc. Platelet blocking peptides
EP0366816A1 (en) * 1988-10-31 1990-05-09 Rorer Biotechnology Inc. Recombinant platelet-derived growth factor A-chain derived from endothelial cells
DE3900770A1 (de) * 1989-01-12 1990-07-26 Juergen Prof Dr Hoppe Verfahren zur herstellung von pdgf-a und pdgf-aa
US5968778A (en) * 1989-01-12 1999-10-19 Jurgen Hoppe PDGF-AB, preparation process and pharmaceuticals containing them
IL96682A0 (en) * 1989-12-15 1991-09-16 Amgen Inc Production of biologically active platelet-derived growth factor from high expression host cell systems
US5272064A (en) * 1989-12-19 1993-12-21 Amgen Inc. DNA molecules encoding platelet-derived growth factor B chain analogs and method for expression thereof
WO1992001716A1 (en) * 1990-07-23 1992-02-06 Zymogenetics, Inc. Protease resistant pdgf and methods of use
JPH06503966A (ja) * 1990-12-21 1994-05-12 クリエイティブ　バイオモレキュルズ　インコーポレイテッド 生合成したｐｄｇｆアンタゴニスト
GB9101645D0 (en) * 1991-01-25 1991-03-06 British Bio Technology Compounds
ZA932179B (en) * 1992-03-30 1994-09-26 Schering Corp Monomeric platelet-derived growth factor and prevention of stenosis or restenosis
CA2137367A1 (en) * 1992-06-05 1993-12-23 Amrit K. Judd Peptides having platelet-derived growth factor (pdgf) activity
DE4228457A1 (de) * 1992-08-27 1994-04-28 Beiersdorf Ag Herstellung von heterodimerem PDGF-AB mit Hilfe eines bicistronischen Vektorsystems in Säugerzellen
DE4228458A1 (de) * 1992-08-27 1994-06-01 Beiersdorf Ag Multicistronische Expressionseinheiten und deren Verwendung
ZA942206B (en) * 1993-04-01 1994-10-31 Amgen Inc Biologically active polypeptide fusion dimers
AU7248896A (en) * 1995-10-11 1997-04-30 Chiron Corporation Combination pdgf, kgf, igf and igfbp for wound healing
PT948538E (pt) 1996-12-13 2008-08-05 Novartis Vaccines & Diagnostic Análise e separação de proteínas do factor de crescimento derivado de plaquetas
CA2962954A1 (en) 2014-10-14 2016-04-21 Samuel Lynch Compositions for treating wounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH064673B2 (ja) * 1980-11-10 1994-01-19 ゲネンテツク・インコ−ポレ−テツド ハイブリド型ヒト白血球インタフエロン
US4840896A (en) * 1983-11-02 1989-06-20 Integrated Genetics, Inc. Heteropolymeric protein
AU600885B2 (en) * 1984-05-25 1990-08-30 Zymogenetics Inc. Stable DNA constructs
US4801542A (en) * 1984-10-12 1989-01-31 Zymogenetics, Inc. Expression of biologically active PDGF analogs in eucaryotic cells

Also Published As

Publication number Publication date
EP0259632B1 (en) 1995-12-13
DE3751632D1 (de) 1996-01-25
JPS63119682A (ja) 1988-05-24
DK176036B1 (da) 2006-01-09
DK421787D0 (da) 1987-08-12
AU7681687A (en) 1988-02-18
CA1341398C (en) 2002-11-19
JPH085797B2 (ja) 1996-01-24
DE3751632T2 (de) 1996-06-13
ATE131532T1 (de) 1995-12-15
EP0259632A1 (en) 1988-03-16

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