DK42887A - Fremgangsmaade til fremstilling af et proteinkompleks med human faktor viii:c aktivitet ved rekombinant-teknik - Google Patents

Fremgangsmaade til fremstilling af et proteinkompleks med human faktor viii:c aktivitet ved rekombinant-teknik

Info

Publication number: DK42887A
Authority: DK; Denmark
Prior art keywords: factor viii; protein complex; preparing; procedure; activity
Prior art date: 1986-01-27

Application number

DK042887A

Other languages

English (en)

Other versions

DK42887D0 (da

DK175407B1 (da

Inventor

Rae Lyn Burke

Mirella Ezban Rasmussen

Original Assignee

Chiron Corp

Nordisk Gentofte

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-01-27

Filing date

1987-01-27

Publication date

1987-07-28

1987-01-27 Application filed by Chiron Corp, Nordisk Gentofte filed Critical Chiron Corp

1987-01-27 Publication of DK42887D0 publication Critical patent/DK42887D0/da

1987-07-28 Publication of DK42887A publication Critical patent/DK42887A/da

2004-09-27 Application granted granted Critical

2004-09-27 Publication of DK175407B1 publication Critical patent/DK175407B1/da

Links

108090000623 proteins and genes Proteins 0.000 title abstract 4
230000000694 effects Effects 0.000 title abstract 3
102000004169 proteins and genes Human genes 0.000 title abstract 2
101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 title 1
102000057593 human F8 Human genes 0.000 title 1
229960000900 human factor viii Drugs 0.000 title 1
102000001690 Factor VIII Human genes 0.000 abstract 4
108010054218 Factor VIII Proteins 0.000 abstract 4
229960000301 factor viii Drugs 0.000 abstract 4
101150111062 C gene Proteins 0.000 abstract 1
108010076504 Protein Sorting Signals Proteins 0.000 abstract 1
210000004962 mammalian cell Anatomy 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
230000001105 regulatory effect Effects 0.000 abstract 1
230000002103 transcriptional effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/108—Plasmid DNA episomal vectors

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Biochemistry (AREA)
Wood Science & Technology (AREA)
General Health & Medical Sciences (AREA)
Biophysics (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
Microbiology (AREA)
Physics & Mathematics (AREA)
Toxicology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Plant Pathology (AREA)
Medicinal Chemistry (AREA)
Hematology (AREA)
Gastroenterology & Hepatology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)

DK198700428A 1986-01-27 1987-01-27 Fremgangsmåde til fremstilling af et proteinkompleks med human faktor VIII:C aktivitet ved rekombinant-teknik DK175407B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US82298986A	1986-01-27	1986-01-27
US82298986		1986-01-27

Publications (3)

Publication Number	Publication Date
DK42887D0 DK42887D0 (da)	1987-01-27
DK42887A true DK42887A (da)	1987-07-28
DK175407B1 DK175407B1 (da)	2004-09-27

Family

ID=25237495

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK198700428A DK175407B1 (da)	1986-01-27	1987-01-27	Fremgangsmåde til fremstilling af et proteinkompleks med human faktor VIII:C aktivitet ved rekombinant-teknik

Country Status (9)

Country	Link
EP (1)	EP0232112B1 (da)
JP (3)	JPH0797996B2 (da)
AT (1)	ATE97956T1 (da)
AU (1)	AU610059B2 (da)
DE (1)	DE3788289T2 (da)
DK (1)	DK175407B1 (da)
ES (1)	ES2059361T3 (da)
FI (1)	FI98829C (da)
NO (1)	NO179106C (da)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7138505B1 (en)	1984-01-12	2006-11-21	Novartis Vaccines And Diagnostics, Inc.	Factor VIII:C nucleic acid molecules
KR910006424B1 (ko) *	1985-08-21	1991-08-24	인코텍스 비.브이	편성브리프(brief) 제조방법
US5198349A (en) *	1986-01-03	1993-03-30	Genetics Institute, Inc.	Method for producing factor VIII:C and analogs
US5595886A (en)	1986-01-27	1997-01-21	Chiron Corporation	Protein complexes having Factor VIII:C activity and production thereof
US5422260A (en) *	1986-05-29	1995-06-06	Genetics Institute, Inc. -Legal Affairs	Human factor VIII:c muteins
EP0251843A1 (fr) *	1986-06-06	1988-01-07	Transgene S.A.	Procédé de préparation de facteur VIII à partir de cellules de mammifères
FR2613379B2 (fr) *	1987-04-03	1990-04-06	Transgene Sa	Procede de preparation de fragments du facteur viii a partir de cellules de mammiferes
NO872932L (no) *	1986-07-18	1988-01-19	Gist Brocades Nv	Fremgangsmaate for fremstilling av proteiner med faktorviiiaktivitet ved hjelp av mikrobielle vertsceller, eksprimeringsvektorer, vertsceller, antibiotika.
US6060447A (en) *	1987-05-19	2000-05-09	Chiron Corporation	Protein complexes having Factor VIII:C activity and production thereof
AU627150B2 (en) *	1987-06-12	1992-08-20	Immuno Ag	Novel proteins with factor viii activity: process for their preparation using genetically-engineered cells and pharmaceutical compositions containing them
IL86693A (en) *	1987-06-12	1994-06-24	Stichting Centraal Lab	Proteins with factor VIII activity, process for their preparation using genetically engineered cells and pharmaceutical compositions containing them
US6346513B1 (en)	1987-06-12	2002-02-12	Baxter Trading Gmbh	Proteins with factor VIII activity: process for their preparation using genetically-engineered cells and pharmaceutical compositions containing them
EP0690126B1 (en) *	1987-06-12	2001-11-28	Baxter Aktiengesellschaft	Novel proteins with factor VIII activitiy: process for their preparation using genetically-engineered cells and pharmaceutical compositions containing them
JPH0387173A (ja) *	1987-09-10	1991-04-11	Teijin Ltd	ヒト活性化天然型ファクター８ｃの製造方法及びそれに用いる形質転換体
ZA909167B (en) *	1989-11-17	1993-10-15	Chiron Corp	Protein complexes having Factor VIII:C activity and production thereof
FR2657884B1 (fr)	1990-02-05	1994-09-02	Tm Innovation	Procede pour la preparation du facteur viii humain et d'analogues du facteur viii.
US5610033A (en) *	1990-04-25	1997-03-11	Novo Nordisk A/S	Method of producing proteins with FVIII activity and/or FVIII derivatives
CA2078721A1 (en) *	1991-09-24	1993-03-25	Hiroshi Yonemura	Process for preparing human coagulation factor viii protein complex
DK53792D0 (da) *	1992-04-24	1992-04-24	Novo Nordisk As	Fremgangsmaade til fremstilling af proteiner
US6200560B1 (en)	1998-10-20	2001-03-13	Avigen, Inc.	Adeno-associated virus vectors for expression of factor VIII by target cells
US6221349B1 (en)	1998-10-20	2001-04-24	Avigen, Inc.	Adeno-associated vectors for expression of factor VIII by target cells
CN1856576B (zh)	2003-09-30	2011-05-04	宾夕法尼亚州立大学托管会	腺伴随病毒(aav)进化支、序列、含有这些序列的载体及它们的应用
EP1707634A1 (en)	2005-03-29	2006-10-04	Octapharma AG	Method for isolation of recombinantly produced proteins
WO2006110689A2 (en)	2005-04-07	2006-10-19	The Trustees Of The University Of Pennsylvania	Method of increasing the function of an aav vector
EP1739179A1 (en)	2005-06-30	2007-01-03	Octapharma AG	Serum-free stable transfection and production of recombinant human proteins in human cell lines
WO2011095604A1 (en)	2010-02-04	2011-08-11	Octapharma Biopharmaceuticals Gmbh	Half-life prolongation of proteins
US9315825B2 (en)	2010-03-29	2016-04-19	The Trustees Of The University Of Pennsylvania	Pharmacologically induced transgene ablation system
US20130023033A1 (en)	2010-03-29	2013-01-24	The Trustees Of The University Of Pennsylvania	Pharmacologically induced transgene ablation system
DK2675902T3 (da)	2011-02-17	2019-06-03	Univ Pennsylvania	Sammensætninger og fremgangsmåder til at ændre vævsspecificitet og forbedre aav9-medieret genoverførsel
US9719106B2 (en)	2013-04-29	2017-08-01	The Trustees Of The University Of Pennsylvania	Tissue preferential codon modified expression cassettes, vectors containing same, and uses thereof
CN115074366A (zh)	2015-04-16	2022-09-20	埃默里大学	用于肝脏中蛋白质表达的重组启动子和载体及其用途
JP6577401B2 (ja)	2016-03-31	2019-09-18	本田技研工業株式会社	ダクトへのレゾネータの取付け構造
JP2023537070A (ja)	2020-08-07	2023-08-30	アミカスセラピューティックスインコーポレイテッド	小胞を標的とするタンパク質及びその使用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2534273B1 (fr) *	1982-10-07	1985-09-13	Pasteur Institut	Lignees cellulaires originaires de mammiferes superieurs, productrices d'hormone de croissance, de preference humaine, et vecteurs pour leur obtention
GB8308235D0 (en) *	1983-03-25	1983-05-05	Celltech Ltd	Polypeptides
US4657894A (en) *	1983-03-31	1987-04-14	Scripps Clinic & Research Foundation	New factor VIII coagulant polypeptides
US4840896A (en) *	1983-11-02	1989-06-20	Integrated Genetics, Inc.	Heteropolymeric protein
DE10399011I1 (de) *	1984-01-12	2003-10-23	Chiron Corp	F}r Fakton-VIIIc kodierende DNA-Sequenzen und ver wandte DNA-Konstruktionen
SE8501050D0 (sv) *	1985-03-05	1985-03-05	Kabivitrum Ab	Biologically active fragments of human antihemophilic factor and method for preparation thereof
ATE72838T1 (de) *	1985-04-12	1992-03-15	Genetics Inst	Neue prokoagulierungsproteine.
NO872932L (no) *	1986-07-18	1988-01-19	Gist Brocades Nv	Fremgangsmaate for fremstilling av proteiner med faktorviiiaktivitet ved hjelp av mikrobielle vertsceller, eksprimeringsvektorer, vertsceller, antibiotika.

1987
- 1987-01-21 FI FI870261A patent/FI98829C/fi not_active IP Right Cessation
- 1987-01-27 DE DE3788289T patent/DE3788289T2/de not_active Expired - Lifetime
- 1987-01-27 ES ES87300695T patent/ES2059361T3/es not_active Expired - Lifetime
- 1987-01-27 NO NO870323A patent/NO179106C/no unknown
- 1987-01-27 AU AU68014/87A patent/AU610059B2/en not_active Expired
- 1987-01-27 DK DK198700428A patent/DK175407B1/da not_active IP Right Cessation
- 1987-01-27 EP EP87300695A patent/EP0232112B1/en not_active Expired - Lifetime
- 1987-01-27 JP JP62018141A patent/JPH0797996B2/ja not_active Expired - Fee Related
- 1987-01-27 AT AT87300695T patent/ATE97956T1/de not_active IP Right Cessation
1993
- 1993-04-20 JP JP5093391A patent/JPH0771496B2/ja not_active Expired - Lifetime
1995
- 1995-03-06 JP JP7045906A patent/JP2513993B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
AU610059B2 (en)	1991-05-16
JPH07278197A (ja)	1995-10-24
FI870261L (fi)	1987-07-28
JPS62282594A (ja)	1987-12-08
JPH06205678A (ja)	1994-07-26
FI98829B (fi)	1997-05-15
EP0232112A3 (en)	1987-12-23
AU6801487A (en)	1987-07-30
NO179106B (no)	1996-04-29
EP0232112A2 (en)	1987-08-12
JPH0771496B2 (ja)	1995-08-02
NO870323D0 (no)	1987-01-27
DK42887D0 (da)	1987-01-27
JP2513993B2 (ja)	1996-07-10
EP0232112B1 (en)	1993-12-01
DE3788289D1 (de)	1994-01-13
FI870261A0 (fi)	1987-01-21
FI98829C (fi)	1997-08-25
NO179106C (no)	1996-08-07
JPH0797996B2 (ja)	1995-10-25
DK175407B1 (da)	2004-09-27
NO870323L (no)	1987-07-28
ES2059361T3 (es)	1994-11-16
ATE97956T1 (de)	1993-12-15
DE3788289T2 (de)	1994-06-23

Legal Events

Date	Code	Title	Description
2007-02-12	PUP	Patent expired

Publication	Publication Date	Title
DK42887D0 (da)	1987-01-27	Fremgangsmaade til fremstilling af et proteinkompleks med human faktor viii:c aktivitet ved rekombinant-teknik
DK374087A (da)	1988-01-19	Fremgangsmaade til fremstilling af proteiner med faktor viii-aktivitet ved hjaelp af mikrobielle voertsceller og ekspressionsvektorer, vaertsceller og antistoffer til anvendelse ved denne
NO963358D0 (no)	1996-08-13	Vertsvektor-system til anvendelse i genterapi
NO874495D0 (no)	1987-10-28	Ekspresjon av protein c.
DE68929043D1 (de)	1999-09-09	Für androgen-rezeptor-protein kodierende dna
ATE87655T1 (de)	1993-04-15	Markierer der t-zelle aktivierung.
ATE212672T1 (de)	2002-02-15	System zur freisetzung von infektiösen proteinen
FI101720B1 (fi)	1998-08-14	Synteettisen DNA:n konstruointi ja sen käyttö suurten polypeptidien synteesissä
NO2003008I1 (no)	2004-01-05	Fremgangsmaate for fremstilling av et polypeptid med én eller flere av de hematopoietiske biologiskeegenskaper til grnulocyttkolonistimulerende faktor(hpg-csf)
DK0550665T3 (da)	1996-12-02	Ny neurotrofisk faktor
AU5222498A (en)	1998-06-10	Type i recombinant clostridium histolyticum collagenase and its use for isolating cells and cell aggregates
HUT46061A (en)	1988-09-28	Dna sequences encoding hirudin-like protein and process for producing such proteins
ATE93272T1 (de)	1993-09-15	Expression von protein c.
DK175843B1 (da)	2005-03-29	Polypeptider af overfladeaktive alvelolarproteiner (ASP), farmaceutisk sammensætning indeholdende polypeptidet, DNA-ekspressionssystem der koder for polypeptidet, samt fremgangsmåde til fremstilling af polypeptider med ASP-aktivitet
ATE79403T1 (de)	1992-08-15	Herstellung von thrombin-inhibitoren.
FI103987B1 (fi)	1999-10-29	Interleukiini-7
DK491487A (da)	1988-03-20	Dna-sekvens til ekspressionering af biologisk aktivt faktor xiii og anvendelse af samme
ES8706208A1 (es)	1987-06-01	Un metodo para preparar proteinas que son inmunologicamente reactivas con anticuerpos para virus asociados con linfadenopatia
DE69837475D1 (de)	2007-05-16	Polypeptide mit aminopeptidaseaktivität und dafür kodierende nukleinsäuren
DE3881023D1 (de)	1993-06-17	Proteine, expressionsvektoren, die fuer solche proteine kodierende dna enthalten und zellen, die solche expressionsvektoren enthalten.
JPS6420095A (en)	1989-01-24	Polypeptide having anti-blood coagulating action
JPS642572A (en)	1989-01-06	Polypeptide, dna and use thereof
IL130164A0 (en)	2000-06-01	Mammalian chemokines
ATE196165T1 (de)	2000-09-15	Methoden zur herstellung von protein c
DK285986D0 (da)	1986-06-18	Proteiner af typen human che samt fremgangsmaade til fremstilling heraf