DK4387730T3 - Faste former af en rock-hæmmer - Google Patents

Faste former af en rock-hæmmer

Info

Publication number
DK4387730T3
DK4387730T3 DK23776436.0T DK23776436T DK4387730T3 DK 4387730 T3 DK4387730 T3 DK 4387730T3 DK 23776436 T DK23776436 T DK 23776436T DK 4387730 T3 DK4387730 T3 DK 4387730T3
Authority
DK
Denmark
Prior art keywords
solid forms
rock inhibitor
rock
inhibitor
solid
Prior art date
Application number
DK23776436.0T
Other languages
English (en)
Inventor
Andrew Belfield
Clifford D Jones
Richard Armer
Original Assignee
Redx Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB2213103.1A external-priority patent/GB202213103D0/en
Priority claimed from GBGB2214708.6A external-priority patent/GB202214708D0/en
Application filed by Redx Pharma Ltd filed Critical Redx Pharma Ltd
Application granted granted Critical
Publication of DK4387730T3 publication Critical patent/DK4387730T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/02—Dicarboxylic acids
    • C07C55/10—Succinic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK23776436.0T 2022-09-08 2023-09-08 Faste former af en rock-hæmmer DK4387730T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB2213103.1A GB202213103D0 (en) 2022-09-08 2022-09-08 Crystalline form of a rock inhibitor
GBGB2214708.6A GB202214708D0 (en) 2022-10-06 2022-10-06 Crystalline form of a rock inhibitor
PCT/GB2023/052341 WO2024052704A1 (en) 2022-09-08 2023-09-08 Solid forms of a rock inhibitor

Publications (1)

Publication Number Publication Date
DK4387730T3 true DK4387730T3 (da) 2025-09-01

Family

ID=88188945

Family Applications (1)

Application Number Title Priority Date Filing Date
DK23776436.0T DK4387730T3 (da) 2022-09-08 2023-09-08 Faste former af en rock-hæmmer

Country Status (20)

Country Link
US (1) US20260078108A1 (da)
EP (2) EP4387730B1 (da)
JP (2) JP2024534810A (da)
KR (1) KR20250057882A (da)
CN (1) CN119894884A (da)
AU (1) AU2023336823A1 (da)
CA (1) CA3262882A1 (da)
DK (1) DK4387730T3 (da)
ES (1) ES3040251T3 (da)
FI (1) FI4387730T3 (da)
HR (1) HRP20251018T1 (da)
HU (1) HUE073310T2 (da)
IL (1) IL319110A (da)
LT (1) LT4387730T (da)
MX (1) MX2025002776A (da)
PL (1) PL4387730T3 (da)
PT (1) PT4387730T (da)
SI (1) SI4387730T1 (da)
SM (1) SMT202500313T1 (da)
WO (1) WO2024052704A1 (da)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB202403179D0 (en) 2024-03-05 2024-04-17 Redx Pharma Plc Method of making kinase inhibitors

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004521865A (ja) * 2000-09-29 2004-07-22 ブリストル−マイヤーズ　スクイブ　カンパニー 異性体の動的分割および分割された異性体
AR065804A1 (es) * 2007-03-23 2009-07-01 Smithkline Beecham Corp Compuesto de indol carboxamida, composicion farmaceutica que lo comprende y uso de dicho compuesto para preparar un medicamento
EP2751079A1 (en) * 2011-08-31 2014-07-09 Amakem NV Biphenylcarboxamides as rock kinase inhibitors
HUE033962T2 (en) 2013-01-29 2018-01-29 Redx Pharma Plc Pyridine derivatives as soft rock (RHO kinase) inhibitors
JP6083832B2 (ja) * 2013-02-12 2017-02-22 国立大学法人金沢大学 光学活性ポリ（ジフェニルアセチレン）化合物及びその製造方法、並びにその光学異性体分離剤としての用途
EP3405464B1 (en) * 2016-01-22 2019-12-04 Janssen Pharmaceutica NV New 6-membered heteroaromatic substituted cyanoindoline derivatives as nik inhibitors
CN110691596A (zh) * 2017-04-01 2020-01-14 阿德普蒂奥制药有限公司 药物组合物
KR20220027196A (ko) * 2019-06-27 2022-03-07 바이오젠 엠에이 인코포레이티드 이미다조[1,2-a]피리디닐 유도체 및 질병의 치료에서 이것들의 용도

Also Published As

Publication number Publication date
PL4387730T3 (pl) 2025-09-22
EP4387730A1 (en) 2024-06-26
ES3040251T3 (en) 2025-10-29
PT4387730T (pt) 2025-08-27
JP2024534810A (ja) 2024-09-26
EP4520746A2 (en) 2025-03-12
US20260078108A1 (en) 2026-03-19
HRP20251018T1 (hr) 2025-10-24
WO2024052704A1 (en) 2024-03-14
MX2025002776A (es) 2025-04-02
HUE073310T2 (hu) 2026-01-28
EP4520746A3 (en) 2025-06-04
CA3262882A1 (en) 2024-03-14
LT4387730T (lt) 2025-09-10
KR20250057882A (ko) 2025-04-29
AU2023336823A1 (en) 2025-02-20
IL319110A (en) 2025-04-01
CN119894884A (zh) 2025-04-25
SMT202500313T1 (it) 2025-09-12
JP2025090729A (ja) 2025-06-17
FI4387730T3 (fi) 2025-08-25
EP4387730B1 (en) 2025-05-28
SI4387730T1 (sl) 2025-10-30

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