LT4387730T - Uolienų inhibitoriaus kietosios formos - Google Patents

Uolienų inhibitoriaus kietosios formos

Info

Publication number
LT4387730T
LT4387730T LTEPPCT/GB2023/052341T LTGB2023052341T LT4387730T LT 4387730 T LT4387730 T LT 4387730T LT GB2023052341 T LTGB2023052341 T LT GB2023052341T LT 4387730 T LT4387730 T LT 4387730T
Authority
LT
Lithuania
Prior art keywords
solid forms
rock inhibitor
rock
inhibitor
solid
Prior art date
Application number
LTEPPCT/GB2023/052341T
Other languages
English (en)
Inventor
Andrew BELFIELD
Clifford D Jones
Richard Armer
Original Assignee
Redx Pharma Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB2213103.1A external-priority patent/GB202213103D0/en
Priority claimed from GBGB2214708.6A external-priority patent/GB202214708D0/en
Application filed by Redx Pharma Limited filed Critical Redx Pharma Limited
Publication of LT4387730T publication Critical patent/LT4387730T/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/02—Dicarboxylic acids
    • C07C55/10—Succinic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
LTEPPCT/GB2023/052341T 2022-09-08 2023-09-08 Uolienų inhibitoriaus kietosios formos LT4387730T (lt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB2213103.1A GB202213103D0 (en) 2022-09-08 2022-09-08 Crystalline form of a rock inhibitor
GBGB2214708.6A GB202214708D0 (en) 2022-10-06 2022-10-06 Crystalline form of a rock inhibitor
PCT/GB2023/052341 WO2024052704A1 (en) 2022-09-08 2023-09-08 Solid forms of a rock inhibitor

Publications (1)

Publication Number Publication Date
LT4387730T true LT4387730T (lt) 2025-09-10

Family

ID=88188945

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEPPCT/GB2023/052341T LT4387730T (lt) 2022-09-08 2023-09-08 Uolienų inhibitoriaus kietosios formos

Country Status (20)

Country Link
US (1) US20260078108A1 (lt)
EP (2) EP4387730B1 (lt)
JP (2) JP2024534810A (lt)
KR (1) KR20250057882A (lt)
CN (1) CN119894884A (lt)
AU (1) AU2023336823A1 (lt)
CA (1) CA3262882A1 (lt)
DK (1) DK4387730T3 (lt)
ES (1) ES3040251T3 (lt)
FI (1) FI4387730T3 (lt)
HR (1) HRP20251018T1 (lt)
HU (1) HUE073310T2 (lt)
IL (1) IL319110A (lt)
LT (1) LT4387730T (lt)
MX (1) MX2025002776A (lt)
PL (1) PL4387730T3 (lt)
PT (1) PT4387730T (lt)
SI (1) SI4387730T1 (lt)
SM (1) SMT202500313T1 (lt)
WO (1) WO2024052704A1 (lt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB202403179D0 (en) 2024-03-05 2024-04-17 Redx Pharma Plc Method of making kinase inhibitors

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60115077T2 (de) * 2000-09-29 2006-06-29 Bristol-Myers Squibb Co. Dynamische trennung von isomeren und getrennte isomere
PE20081889A1 (es) * 2007-03-23 2009-03-05 Smithkline Beecham Corp Indol carboxamidas como inhibidores de ikk2
JP2014525425A (ja) * 2011-08-31 2014-09-29 アマケン エンヴェー 新規のｒｏｃｋキナーゼ阻害剤
SMT201700317T1 (it) * 2013-01-29 2017-09-07 Redx Pharma Plc Derivati piridinici in qualità di inibitori rock teneri
US9562121B2 (en) * 2013-02-12 2017-02-07 National University Corporation Kanazawa University Optically active poly(diphenylacetylene) compound, preparation method therefor, and use thereof as optical isomer separating agent
KR102720461B1 (ko) * 2016-01-22 2024-10-21 잔센파마슈티카엔.브이. Nik 억제제로서의 신규 6원 헤테로방향족 치환된 시아노인돌린 유도체
AU2018241940B2 (en) * 2017-04-01 2023-09-28 Adeptio Pharmaceuticals Limited Dihydrotetrabenazine for use in the treatment a movement disorder
JP7576581B2 (ja) * 2019-06-27 2024-10-31 バイオジェン・エムエイ・インコーポレイテッド イミダゾ［１，２－ａ］ピリジニル誘導体及び疾患の処置におけるそれらの使用

Also Published As

Publication number Publication date
IL319110A (en) 2025-04-01
US20260078108A1 (en) 2026-03-19
PL4387730T3 (pl) 2025-09-22
DK4387730T3 (da) 2025-09-01
JP2025090729A (ja) 2025-06-17
PT4387730T (pt) 2025-08-27
KR20250057882A (ko) 2025-04-29
CA3262882A1 (en) 2024-03-14
JP2024534810A (ja) 2024-09-26
ES3040251T3 (en) 2025-10-29
WO2024052704A1 (en) 2024-03-14
CN119894884A (zh) 2025-04-25
EP4520746A3 (en) 2025-06-04
EP4387730A1 (en) 2024-06-26
MX2025002776A (es) 2025-04-02
EP4387730B1 (en) 2025-05-28
HUE073310T2 (hu) 2026-01-28
HRP20251018T1 (hr) 2025-10-24
SMT202500313T1 (it) 2025-09-12
EP4520746A2 (en) 2025-03-12
AU2023336823A1 (en) 2025-02-20
FI4387730T3 (fi) 2025-08-25
SI4387730T1 (sl) 2025-10-30

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