DK441585A - Humant livmodervaevsplasminogen-aktivator - Google Patents

Humant livmodervaevsplasminogen-aktivator Download PDF

Info

Publication number: DK441585A
Authority: DK; Denmark
Prior art keywords: motor; plasminogen activator; human liver; sequence encoding; cdna sequence
Prior art date: 1984-10-01

Application number

DK441585A

Other languages

English (en)

Other versions

DK175327B1 (da

DK441585D0 (da

Inventor

Cha-Mer Wei

Nancy Hsiung

Vermuri B Reddy

Jeffreyf Lemontt

William Dackowski

Richard Douglas

Edward S Cole

Jr Richard D Purcell

David Tai-Yui Lau

Original Assignee

Integrated Genetics Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-10-01

Filing date

1985-09-30

Publication date

1986-04-02

1985-09-30 Application filed by Integrated Genetics Inc filed Critical Integrated Genetics Inc

1985-09-30 Publication of DK441585D0 publication Critical patent/DK441585D0/da

1986-04-02 Publication of DK441585A publication Critical patent/DK441585A/da

2004-08-23 Application granted granted Critical

2004-08-23 Publication of DK175327B1 publication Critical patent/DK175327B1/da

Links

102000001938 Plasminogen Activators Human genes 0.000 title 1
108010001014 Plasminogen Activators Proteins 0.000 title 1
210000004185 liver Anatomy 0.000 title 1
229940127126 plasminogen activator Drugs 0.000 title 1
239000002299 complementary DNA Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/14011—Details ssDNA Bacteriophages
- C12N2795/14111—Inoviridae
- C12N2795/14141—Use of virus, viral particle or viral elements as a vector
- C12N2795/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/70—Vector systems having a special element relevant for transcription from fungi
- C12N2830/702—Vector systems having a special element relevant for transcription from fungi yeast
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
- C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Biomedical Technology (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Microbiology (AREA)
Physics & Mathematics (AREA)
Mycology (AREA)
Biophysics (AREA)
Plant Pathology (AREA)
Medicinal Chemistry (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Enzymes And Modification Thereof (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Saccharide Compounds (AREA)
Control Of Ac Motors In General (AREA)

DK198504415A 1984-10-01 1985-09-30 Replicerbar ekspressionsvektor og rekombinant DNA-molekyle, som indkoder aktiv human livmodervævsplasminogen-aktivator, pattedyrscelle transformeret med vektoren og fremgangsmåde til fremstilling af aktiv human vævsplasminogen-aktivator (TPA) DK175327B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US65677084A	1984-10-01	1984-10-01
US65677084		1984-10-01

Publications (3)

Publication Number	Publication Date
DK441585D0 DK441585D0 (da)	1985-09-30
DK441585A true DK441585A (da)	1986-04-02
DK175327B1 DK175327B1 (da)	2004-08-23

Family

ID=24634490

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK198504415A DK175327B1 (da)	1984-10-01	1985-09-30	Replicerbar ekspressionsvektor og rekombinant DNA-molekyle, som indkoder aktiv human livmodervævsplasminogen-aktivator, pattedyrscelle transformeret med vektoren og fremgangsmåde til fremstilling af aktiv human vævsplasminogen-aktivator (TPA)

Country Status (14)

Country	Link
US (1)	US5344773A (da)
EP (1)	EP0178105B1 (da)
JP (1)	JPS61149094A (da)
AT (1)	ATE151111T1 (da)
AU (1)	AU599576B2 (da)
DE (1)	DE3588149T2 (da)
DK (1)	DK175327B1 (da)
ES (3)	ES8702945A1 (da)
FI (1)	FI89723C (da)
IE (1)	IE81135B1 (da)
NO (1)	NO175158C (da)
NZ (1)	NZ213647A (da)
PT (1)	PT81231B (da)
ZA (1)	ZA857574B (da)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3479520D1 (en) *	1983-11-21	1989-09-28	Ciba Geigy Ag	Synthesis of tissue plasminogen activator(tpa) by yeast
US5073494A (en) *	1985-04-22	1991-12-17	Genentech, Inc.	Human tissue plasminogen activator substituted at position 275 or at positions 275 and 277
GB8528321D0 (en) *	1985-11-18	1985-12-24	Ciba Geigy Ag	Modified fibrinolytic agents
JP2581668B2 (ja) *	1985-11-27	1997-02-12	三井東圧化学株式会社	ヒト正常細胞由来のヒト組織プラスミノ−ゲン活性化因子をコ−ドする新しいｄｎａ配列とそれを含むベクタ−及び細胞
ES2031826T3 (es) *	1985-12-23	1993-01-01	Chiron Corporation	Procedimiento para producir nuevos peptidos activadores del plasminogeno.
US5837518A (en) *	1986-01-31	1998-11-17	Genetics Institute, Inc.	Thrombolytic proteins
WO1987004722A1 (en) *	1986-01-31	1987-08-13	Genetics Institute, Inc.	Novel thrombolytic proteins
US5258298A (en) *	1986-01-31	1993-11-02	Genetics Institute, Inc.	Deletion and glycosylation mutant of human tissue plasminogen activator
US5589361A (en) *	1986-03-18	1996-12-31	Genentech, Inc.	Human tissue-type plasminogen activator variant
IE81073B1 (en) *	1986-03-18	2000-01-12	Genentech Inc	Modified human tissue-type plasminogen activator and its preparation
DE122007000007I2 (de)	1986-04-09	2010-12-30	Genzyme Corp	Genetisch transformierte Tiere, die ein gewünschtes Protein in Milch absondern
US5047241A (en) *	1986-07-11	1991-09-10	American Home Products Corporation	Tris-Kringle plasminogen activator with novel K2 insert
WO1988000615A1 (en) *	1986-07-16	1988-01-28	Celltech Limited	Process for purifying a plasminogen activator
US5242819A (en) *	1986-12-05	1993-09-07	Ciba-Geigy Corporation	DNA molecules encoding hybrid proteins of tissue plasminogen activator and urokinase
US5580559A (en) *	1986-12-05	1996-12-03	Ciba-Geigy Corporation	Hybrid plasminogen activator
EP0276846A3 (en) *	1987-01-29	1989-07-26	Zymogenetics, Inc.	Colony-stimulating factor derivatives
EP0299053A1 (en) *	1987-01-30	1989-01-18	American Home Products Corporation	Des-epidermal growth factor plasminogen activators
JPH084501B2 (ja) *	1987-03-20	1996-01-24	エーザイ株式会社	糖鎖に関する変異ｔＰＡ
NO882226L (no) *	1987-05-22	1988-11-23	Zymogenetics Inc	Fibrinolytiske proteiner.
AU1668988A (en) *	1987-06-03	1988-12-08	Smithkline Beckman Corporation	Purification of tpa
US6682733B1 (en) *	1987-06-18	2004-01-27	Roche Diagnostics, Gmbh	Fibrinolytic enzymes
DE3726019A1 (de) *	1987-08-05	1989-02-16	Boehringer Mannheim Gmbh	Verfahren zur abtrennung und reinigung von t-pa
US5100666A (en) *	1987-10-09	1992-03-31	Monsanto Company	Modified tissue plasminogen activator K2K2SP
US4963357A (en) *	1987-10-09	1990-10-16	Monsanto Company	Tissue plasminogen activator modified by the substitution of Arg for Cys at position 73, methods and pharmaceutical compositions therefor
US5244676A (en) *	1987-10-09	1993-09-14	Monsanto Company	Modified tissue plasminogen activator with modified glycosylation site
US5037752A (en) *	1987-10-09	1991-08-06	Monsanto Company	Modified tissue plasminogen activator substituted at cysteine-73 and lysine-277
US5270198A (en) *	1988-05-20	1993-12-14	Genentech, Inc.	DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells
US5665583A (en)	1988-08-12	1997-09-09	Arch Dev Corp	Methods and materials relating to IMPDH and GMP production
US5714145A (en) *	1988-09-02	1998-02-03	Genentech, Inc.	Tissue plasminogen activator having zymogenic or fibrin specific properties
US5262170A (en) *	1988-09-02	1993-11-16	Genentech, Inc.	Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells
US5070021A (en) *	1989-01-10	1991-12-03	Monsanto Company	Method of modifying oligosaccharide structure of tissue plasminogen activator
US5268273A (en) *	1990-12-14	1993-12-07	Phillips Petroleum Company	Pichia pastoris acid phosphatase gene, gene regions, signal sequence and expression vectors comprising same
ATE155816T1 (de) *	1992-06-03	1997-08-15	Genentech Inc	Varianten des gewebeplasminogenaktivators mit verbesserter therapeutischer wirkung
US7299805B2 (en)	2002-06-07	2007-11-27	Marctec, Llc	Scaffold and method for implanting cells
US10160813B2 (en)	2013-01-22	2018-12-25	University Of Tennessee Research Foundation	Tissue plasminogen activator antibodies and methods of use

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4370417A (en) *	1980-04-03	1983-01-25	Abbott Laboratories	Recombinant deoxyribonucleic acid which codes for plasminogen activator
US4419446A (en) *	1980-12-31	1983-12-06	The United States Of America As Represented By The Department Of Health And Human Services	Recombinant DNA process utilizing a papilloma virus DNA as a vector
HU200615B (en) *	1982-05-05	1990-07-28	Genentech Inc	Methods of preparing tissue plasiminogen activator derivative composition
GR79202B (da) *	1982-05-05	1984-10-22	Genentech Inc
EP0125254A1 (en) *	1982-10-28	1984-11-21	Beecham Group Plc	Enzyme derivatives and their use in the treatment of thrombosis
AU554862B2 (en) *	1982-12-14	1986-09-04	Implico B.V.	Plasminogen activator isolated by affinity chromatography
AU572108B2 (en) *	1983-01-19	1988-05-05	Genentech Inc.	Human tpa production using vectors coding for dhfr protein
DE3479520D1 (en) *	1983-11-21	1989-09-28	Ciba Geigy Ag	Synthesis of tissue plasminogen activator(tpa) by yeast
US4753879A (en) *	1984-08-27	1988-06-28	Biogen N.V.	Modified tissue plasminogen activators
GB8528321D0 (en) *	1985-11-18	1985-12-24	Ciba Geigy Ag	Modified fibrinolytic agents
ES2031826T3 (es) *	1985-12-23	1993-01-01	Chiron Corporation	Procedimiento para producir nuevos peptidos activadores del plasminogeno.
IE81073B1 (en) *	1986-03-18	2000-01-12	Genentech Inc	Modified human tissue-type plasminogen activator and its preparation

1985
- 1985-09-30 EP EP85306957A patent/EP0178105B1/en not_active Expired - Lifetime
- 1985-09-30 DK DK198504415A patent/DK175327B1/da not_active IP Right Cessation
- 1985-09-30 ES ES547416A patent/ES8702945A1/es not_active Expired
- 1985-09-30 IE IE239485A patent/IE81135B1/en not_active IP Right Cessation
- 1985-09-30 AT AT85306957T patent/ATE151111T1/de not_active IP Right Cessation
- 1985-09-30 NO NO853851A patent/NO175158C/no not_active IP Right Cessation
- 1985-09-30 FI FI853761A patent/FI89723C/fi not_active IP Right Cessation
- 1985-09-30 DE DE3588149T patent/DE3588149T2/de not_active Expired - Lifetime
- 1985-09-30 NZ NZ213647A patent/NZ213647A/xx unknown
- 1985-10-01 AU AU48148/85A patent/AU599576B2/en not_active Expired
- 1985-10-01 US US06/782,686 patent/US5344773A/en not_active Expired - Lifetime
- 1985-10-01 JP JP60216313A patent/JPS61149094A/ja active Pending
- 1985-10-01 ZA ZA857574A patent/ZA857574B/xx unknown
- 1985-10-01 PT PT81231A patent/PT81231B/pt unknown
1986
- 1986-04-28 ES ES554449A patent/ES8706726A1/es not_active Expired
- 1986-04-28 ES ES554450A patent/ES8801306A1/es not_active Expired

Also Published As

Publication number	Publication date
FI853761L (fi)	1986-04-02
US5344773A (en)	1994-09-06
NO175158C (no)	1994-09-07
ES547416A0 (es)	1987-01-16
JPS61149094A (ja)	1986-07-07
DE3588149D1 (de)	1997-05-07
EP0178105B1 (en)	1997-04-02
AU4814885A (en)	1986-04-10
ES554449A0 (es)	1987-07-01
NO853851L (no)	1986-04-02
FI853761A0 (fi)	1985-09-30
EP0178105A2 (en)	1986-04-16
DK175327B1 (da)	2004-08-23
ATE151111T1 (de)	1997-04-15
PT81231A (en)	1985-11-01
EP0178105A3 (en)	1988-11-17
AU599576B2 (en)	1990-07-26
ES554450A0 (es)	1988-01-01
ES8702945A1 (es)	1987-01-16
FI89723C (fi)	1993-11-10
IE852394L (en)	1986-04-01
ES8706726A1 (es)	1987-07-01
DE3588149T2 (de)	1997-10-09
FI89723B (fi)	1993-07-30
ZA857574B (en)	1986-06-25
NZ213647A (en)	1989-05-29
PT81231B (pt)	1987-10-20
IE81135B1 (en)	2000-03-22
DK441585D0 (da)	1985-09-30
ES8801306A1 (es)	1988-01-01
NO175158B (no)	1994-05-30

Legal Events

Date	Code	Title	Description
2005-10-17	PUP	Patent expired

Publication	Publication Date	Title
DK441585D0 (da)	1985-09-30	Humant livmodervaevsplasminogen-aktivator
DE3676760D1 (de)	1991-02-14	Poly-kringle-plasminogenaktivator.
NO165708C (no)	1991-03-27	Vannfritt tannpleiemiddel.
DE3588108D1 (de)	1996-06-27	Stabilisierende Leistungsquellenvorrichtung
DE3579196D1 (de)	1990-09-20	Mikrobizide enthaltende filmbildende mischung.
DK173586D0 (da)	1986-04-16	Midler mod daarlig aande
DE69012888D1 (de)	1994-11-03	Plasminogenaktivator.
NO864569L (no)	1987-05-19	Modifiserte fibrinolyttiske midler.
ES553651A0 (es)	1988-01-01	Un procedimiento para preparar un activante de plasminogeno.
DE3382389D1 (de)	1991-10-02	Plasminogenaktivator.
DK96787D0 (da)	1987-02-25	Human vaevs-plasminogenaktivator
FI831484A7 (fi)	1983-11-06	Ihmiskudoksen plasminogeenien aktivaattori.
FI840891A7 (fi)	1984-09-10	Yhdistämisaineet.
FI883943A0 (fi)	1988-08-26	Modifierade plasminogen-aktivatorer.
FI873060L (fi)	1988-01-12	Modifierad vaevnads-plasmin-aktivator.
DK459088D0 (da)	1988-08-16	Plasminogenaktivatorer
DE3581399D1 (de)	1991-02-21	Fet-stromquelle.
DE3483585D1 (de)	1990-12-20	Stromtreiberschaltung.
ES279450Y (es)	1986-01-16	Mesa de operaciones
KR850004522U (ko)	1985-07-22	파워 트랜지스터의 구동회로
SE8304648D0 (sv)	1983-08-26	Blandare
ATE32741T1 (de)	1988-03-15	Kautschukgemisch.
FI844991A0 (fi)	1984-12-18	Tillsats foer en motordriven graesklippare.
SE8306022D0 (sv)	1983-11-02	Lasring
KR860000931U (ko)	1986-02-15	모우터 구동회로