ES553651A0 - Un procedimiento para preparar un activante de plasminogeno. - Google Patents

Un procedimiento para preparar un activante de plasminogeno.

Info

Publication number
ES553651A0
ES553651A0 ES553651A ES553651A ES553651A0 ES 553651 A0 ES553651 A0 ES 553651A0 ES 553651 A ES553651 A ES 553651A ES 553651 A ES553651 A ES 553651A ES 553651 A0 ES553651 A0 ES 553651A0
Authority
ES
Spain
Prior art keywords
plasminogen
activator
preparing
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES553651A
Other languages
English (en)
Other versions
ES8801374A1 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB858508972A external-priority patent/GB8508972D0/en
Priority claimed from GB868604852A external-priority patent/GB8604852D0/en
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES553651A0 publication Critical patent/ES553651A0/es
Publication of ES8801374A1 publication Critical patent/ES8801374A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
ES553651A 1985-04-04 1986-04-02 Un procedimiento para preparar un activante de plasminogeno. Expired ES8801374A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB858508972A GB8508972D0 (en) 1985-04-04 1985-04-04 Compounds
GB868604852A GB8604852D0 (en) 1986-02-27 1986-02-27 Compounds

Publications (2)

Publication Number Publication Date
ES553651A0 true ES553651A0 (es) 1988-01-01
ES8801374A1 ES8801374A1 (es) 1988-01-01

Family

ID=26289098

Family Applications (5)

Application Number Title Priority Date Filing Date
ES553651A Expired ES8801374A1 (es) 1985-04-04 1986-04-02 Un procedimiento para preparar un activante de plasminogeno.
ES557675A Expired ES8801551A1 (es) 1985-04-04 1987-08-17 Un procedimiento para preparar un vector de expresion replicable.
ES557676A Expired ES8802537A1 (es) 1985-04-04 1987-08-17 Un procedimiento para preparar una celula huesped con un vector de expresion correspondiente a un activante de plasminogenos de tipo tejido modificado.
ES557677A Expired ES8801552A1 (es) 1985-04-04 1987-08-17 Un procedimiento para preparar una proteina hibrida fibrinoliticamente activa.
ES557674A Expired ES8802442A1 (es) 1985-04-04 1987-08-17 Un procedimiento para preparar un polimero de adn.

Family Applications After (4)

Application Number Title Priority Date Filing Date
ES557675A Expired ES8801551A1 (es) 1985-04-04 1987-08-17 Un procedimiento para preparar un vector de expresion replicable.
ES557676A Expired ES8802537A1 (es) 1985-04-04 1987-08-17 Un procedimiento para preparar una celula huesped con un vector de expresion correspondiente a un activante de plasminogenos de tipo tejido modificado.
ES557677A Expired ES8801552A1 (es) 1985-04-04 1987-08-17 Un procedimiento para preparar una proteina hibrida fibrinoliticamente activa.
ES557674A Expired ES8802442A1 (es) 1985-04-04 1987-08-17 Un procedimiento para preparar un polimero de adn.

Country Status (6)

Country Link
EP (1) EP0207589A1 (es)
DK (1) DK149786A (es)
ES (5) ES8801374A1 (es)
GR (1) GR860875B (es)
NZ (1) NZ215660A (es)
PT (1) PT82326B (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5106741A (en) * 1985-12-20 1992-04-21 The Upjohn Company Tissue plasminogen activator (TPA) analogs
EP0231624B1 (en) * 1985-12-20 1993-01-27 The Upjohn Company Tissue plasminogen activator (tpa) analogs
US5002887A (en) * 1986-01-31 1991-03-26 Genetics Institute, Inc. Truncated thrombolytic proteins
US5258298A (en) * 1986-01-31 1993-11-02 Genetics Institute, Inc. Deletion and glycosylation mutant of human tissue plasminogen activator
US5837518A (en) * 1986-01-31 1998-11-17 Genetics Institute, Inc. Thrombolytic proteins
ATE70301T1 (de) * 1986-02-17 1991-12-15 Stichting Centraal Lab Gewebeplasminogen-aktivator-mutant, dafuer kodierende rekombinante genetische information und verfahren zur herstellung dieser mutanten, deren verwendung und pharmazeutische zusammensetzungen.
AU7090887A (en) * 1986-04-02 1987-10-08 Beecham Group Plc Plasminogen activators modified in first kringle domain
PT84587B (pt) * 1986-04-02 1989-11-30 Beecham Group Plc Processo para preparacao de uma enzima fibrinolitica
PT84589B (en) * 1986-04-02 1989-05-09 Beecham Group Plc Process for preparing a fibrinolytic enzyme
DE3643158A1 (de) * 1986-04-21 1987-11-19 Boehringer Mannheim Gmbh Gewebs-plasminogen-aktivator(tpa) - derivat und seine herstellung
EP0266032A1 (en) * 1986-08-29 1988-05-04 Beecham Group Plc Modified fibrinolytic enzyme
US5242819A (en) * 1986-12-05 1993-09-07 Ciba-Geigy Corporation DNA molecules encoding hybrid proteins of tissue plasminogen activator and urokinase
US5580559A (en) * 1986-12-05 1996-12-03 Ciba-Geigy Corporation Hybrid plasminogen activator
GB8701811D0 (en) * 1987-01-28 1987-03-04 Beecham Group Plc Compounds
EP0299053A1 (en) * 1987-01-30 1989-01-18 American Home Products Corporation Des-epidermal growth factor plasminogen activators
NL8701021A (nl) * 1987-04-29 1988-11-16 Stichting Centraal Lab Humane t-pa(u-pa) substitutie-mutant eiwitten, daarvoor coderend recombinant dna, getransfecteerde gastheercellen, bereiding van de mutant eiwitten, en farmaceutische preparaten.
ATE110772T1 (de) * 1987-06-04 1994-09-15 Zymogenetics Inc Mutierter t-pa mit kringle-ersatz.
ATE118815T1 (de) * 1987-06-04 1995-03-15 Zymogenetics Inc Gewebs-plasminogen-aktivator-analoge mit modifizierten wachstumsfaktordomänen.
SE8702562L (sv) * 1987-06-18 1988-12-19 Kabigen Ab Nya fibrinolytiska enzymer
US4935237A (en) * 1988-03-21 1990-06-19 Genentech, Inc. Processes for the preparation of t-PA mutants
AU613942B2 (en) * 1987-06-30 1991-08-15 Genentech Inc. Improved processes for the treatment of vascular disease
JPH02504102A (ja) * 1987-06-30 1990-11-29 ジェネンテク，インコーポレイテッド 血管障害治療のための改良法
EP0394261A4 (en) * 1987-07-06 1991-09-11 Genetics Institute, Inc. Novel thrombolytic proteins
GB8721023D0 (en) * 1987-09-07 1987-10-14 Lepetit Spa Modified plasminogen activators
US5100666A (en) * 1987-10-09 1992-03-31 Monsanto Company Modified tissue plasminogen activator K2K2SP
US5244676A (en) * 1987-10-09 1993-09-14 Monsanto Company Modified tissue plasminogen activator with modified glycosylation site
US5037646A (en) * 1988-04-29 1991-08-06 Genentech, Inc. Processes for the treatment of vascular disease
US5270198A (en) * 1988-05-20 1993-12-14 Genentech, Inc. DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells
US5346824A (en) * 1988-05-20 1994-09-13 Genentech, Inc. DNA encoding variants of tissue plasminogen activators and expression vectors and hosts thereof
US5714145A (en) * 1988-09-02 1998-02-03 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
US5262170A (en) * 1988-09-02 1993-11-16 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells
DE69333127T2 (de) * 1992-06-03 2004-05-06 Genentech, Inc., South San Francisco Varianten des Gewebeplasminogenaktivators mit verbesserter therapeutischer Wirkung
GB9614871D0 (en) 1996-07-15 1996-09-04 Smithkline Beecham Plc Compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR241654A1 (es) * 1982-05-05 1992-10-30 Genentech Inc Procedimiento para producir activador de plasminogeno de tejido humano.
AU572108B2 (en) * 1983-01-19 1988-05-05 Genentech Inc. Human tpa production using vectors coding for dhfr protein

Also Published As

Publication number Publication date
ES557676A0 (es) 1988-07-16
ES8802537A1 (es) 1988-07-16
ES8802442A1 (es) 1988-06-01
DK149786A (da) 1986-10-04
PT82326B (pt) 1988-10-14
ES8801551A1 (es) 1987-12-16
ES557677A0 (es) 1987-12-16
DK149786D0 (da) 1986-04-02
AU596093B2 (en) 1990-04-26
EP0207589A1 (en) 1987-01-07
ES557674A0 (es) 1988-06-01
AU5551486A (en) 1986-10-09
PT82326A (en) 1986-05-01
ES8801374A1 (es) 1988-01-01
NZ215660A (en) 1990-03-27
ES8801552A1 (es) 1987-12-16
GR860875B (en) 1986-07-29
ES557675A0 (es) 1987-12-16

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970303