DK461377A - R fremgangsmaade til fremstilling af spirohydantoin-forbindelse - Google Patents

R fremgangsmaade til fremstilling af spirohydantoin-forbindelse

Info

Publication number: DK461377A
Authority: DK; Denmark
Prior art keywords: procedure; making; spirohydantoin; compound; spirohydantoin compound
Prior art date: 1976-10-18

Application number

DK461377A

Other languages

English (en)

Other versions

DK150302B (da

DK150302C (da

Inventor

R Sarges

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1976-10-18

Filing date

1977-10-17

Publication date

1978-04-19

1977-02-11 Priority claimed from US05/767,803 external-priority patent/US4117230A/en

1977-10-17 Application filed by Pfizer filed Critical Pfizer

1978-04-19 Publication of DK461377A publication Critical patent/DK461377A/da

1987-02-02 Publication of DK150302B publication Critical patent/DK150302B/da

1987-09-28 Application granted granted Critical

1987-09-28 Publication of DK150302C publication Critical patent/DK150302C/da

Links

-1 SPIROHYDANTOIN COMPOUND Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Diabetes (AREA)
Ophthalmology & Optometry (AREA)
Emergency Medicine (AREA)
Hematology (AREA)
Obesity (AREA)
Endocrinology (AREA)
Psychiatry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

DK461377A 1976-10-18 1977-10-17 Analogifremgangsmaade til fremstilling af spiro-hydantoin-forbindelser eller farmakologisk acceptable basesalte deraf DK150302C (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US73306276A	1976-10-18	1976-10-18
US73306276		1976-10-18
US05/767,803 US4117230A (en)	1976-10-18	1977-02-11	Hydantoin derivatives as therapeutic agents
US76780377		1977-02-11

Publications (3)

Publication Number	Publication Date
DK461377A true DK461377A (da)	1978-04-19
DK150302B DK150302B (da)	1987-02-02
DK150302C DK150302C (da)	1987-09-28

Family

ID=27112515

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK461377A DK150302C (da)	1976-10-18	1977-10-17	Analogifremgangsmaade til fremstilling af spiro-hydantoin-forbindelser eller farmakologisk acceptable basesalte deraf

Country Status (29)

Country	Link
JP (3)	JPS5353653A (da)
AR (1)	AR220901A1 (da)
AT (1)	AT356136B (da)
AU (1)	AU504978B2 (da)
BG (1)	BG28847A3 (da)
CA (1)	CA1088945A (da)
CH (1)	CH625511A5 (da)
DD (1)	DD131931A5 (da)
DE (4)	DE2759542C2 (da)
DK (1)	DK150302C (da)
ES (1)	ES463267A1 (da)
FI (1)	FI62307C (da)
FR (1)	FR2367754A1 (da)
GB (1)	GB1566171A (da)
GR (1)	GR70201B (da)
HK (1)	HK53881A (da)
IE (1)	IE45805B1 (da)
IL (1)	IL53094A0 (da)
KE (1)	KE3167A (da)
LU (1)	LU78330A1 (da)
MX (1)	MX4899E (da)
MY (1)	MY8200157A (da)
NL (1)	NL167434C (da)
NO (1)	NO148453C (da)
NZ (1)	NZ185358A (da)
PH (1)	PH15639A (da)
PT (1)	PT67164B (da)
SE (1)	SE437024B (da)
YU (1)	YU40821B (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4130714A (en) *	1977-05-23	1978-12-19	Pfizer Inc.	Hydantoin therapeutic agents
US4127665A (en) *	1978-01-18	1978-11-28	Pfizer Inc.	Thienohydantoin derivatives
US4147797A (en) *	1978-08-11	1979-04-03	Pfizer Inc.	Spiro-furanohydantoin derivatives
US4200642A (en) *	1978-08-21	1980-04-29	Pfizer Inc.	Spiro-oxazolidindiones
US4181728A (en) *	1978-11-16	1980-01-01	Pfizer Inc.	Spiro-polycyclicimidazolidinedione derivatives
US4181729A (en) *	1979-03-21	1980-01-01	Pfizer Inc.	Phenyl or phenoxy substituted spiro-imidazolidinedione derivatives
US4235911A (en) *	1979-06-13	1980-11-25	Pfizer Inc.	Hydantoin derivatives
US4283409A (en) *	1979-10-29	1981-08-11	Pfizer Inc.	Imidazolone derivatives
US4286098A (en) *	1980-03-28	1981-08-25	Pfizer Inc.	Process for the preparation of chiral hydantoins
JPS5745185A (en) *	1980-07-21	1982-03-13	Eisai Co Ltd	Hydantoin derivative and its preparation
DE3262294D1 (en) *	1981-05-13	1985-03-28	Ici Plc	Pharmaceutical compositions containing spiro succinimide derivatives
JPS58213717A (ja) *	1982-01-20	1983-12-12	Eisai Co Ltd	ヒダントイン誘導体を含有する治療用薬剤
JPS59500617A (ja) *	1982-04-15	1984-04-12	アルコン・ラボラトリ−ズ・インコ−ポレ−テッド	ヒダントイン治療剤
SU1380610A3 (ru) *	1982-12-06	1988-03-07	Пфайзер Инк. (Фирма)	Способ получени спирогетероазолидиндионов или их фармацевтически приемлемых солей
US4474967A (en) *	1983-04-27	1984-10-02	Pfizer Inc.	8-Deutero and 8-tritio-substituted derivatives of D-4S-6-fluoro-spiro-[chroman-4,4'-imidazolidine]-2',5'-dione
WO1986002647A1 (en) *	1984-10-30	1986-05-09	Pfizer Inc.	Spiro-heteroazolones for treatment of diabetes complications
JPS61200991A (ja) *	1985-03-04	1986-09-05	Sanwa Kagaku Kenkyusho:Kk	スピロ―３―ヘテロアゾリジン化合物、その製法及びそれを有効成分とする糖尿病合併症の予防及び治療剤
US4575507A (en) *	1985-05-29	1986-03-11	Pfizer Inc.	Spiro-imidazolidines as aldose reductase inhibitors and their pharmaceutical use
JPS6357588A (ja) *	1986-08-28	1988-03-12	Sanwa Kagaku Kenkyusho Co Ltd	ヒダントイン誘導体、その塩並びに該化合物を有効成分とする糖尿病合併症の予防及び治療剤
WO1989001775A1 (en) *	1987-09-04	1989-03-09	Pfizer Inc.	Azolidinedione derivatives
GB2355264A (en)	1999-09-30	2001-04-18	Merck & Co Inc	Spirohydantoin derivatives useful as alpha 1a adrenoceptor antagonists
WO2003088915A2 (en)	2002-04-18	2003-10-30	University Of Virginia Patent Foundation	Novel sodium channel blockers
FR2955107B1 (fr)	2010-01-08	2012-03-02	Servier Lab	Nouveaux derives thiochromanes, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB818724A (en) *	1956-10-18	1959-08-19	Ici Ltd	Hydantoin derivatives
DE1135915B (de) *	1961-06-29	1962-09-06	Asta Werke Ag Chem Fab	Verfahren zur Herstellung neuer, antikonvulsiv wirksamer Spirohydantoine
US3532744A (en) *	1967-07-28	1970-10-06	American Home Prod	1- and 2-amino substituted indane and tetralene carboxylic acids
US3821383A (en) *	1972-07-10	1974-06-28	Ayerst Mckenna & Harrison	Compositions for and a method of treating diabetic complications
DE2449030A1 (de) *	1974-10-11	1976-05-20	Schering Ag	Neue pyridin-derivate
US4130714A (en) *	1977-05-23	1978-12-19	Pfizer Inc.	Hydantoin therapeutic agents

1977
- 1977-09-30 CA CA287,868A patent/CA1088945A/en not_active Expired
- 1977-10-03 SE SE7711053A patent/SE437024B/sv not_active IP Right Cessation
- 1977-10-04 GR GR54503A patent/GR70201B/el unknown
- 1977-10-05 NZ NZ185358A patent/NZ185358A/xx unknown
- 1977-10-06 AU AU29431/77A patent/AU504978B2/en not_active Expired
- 1977-10-10 YU YU2442/77A patent/YU40821B/xx unknown
- 1977-10-10 IL IL53094A patent/IL53094A0/xx not_active IP Right Cessation
- 1977-10-14 DE DE2759542A patent/DE2759542C2/de not_active Expired
- 1977-10-14 DE DE2759927A patent/DE2759927C2/de not_active Expired
- 1977-10-14 PH PH20335A patent/PH15639A/en unknown
- 1977-10-14 DE DE2746244A patent/DE2746244C2/de not_active Expired
- 1977-10-14 FI FI773060A patent/FI62307C/fi not_active IP Right Cessation
- 1977-10-14 DE DE2759543A patent/DE2759543C2/de not_active Expired
- 1977-10-15 ES ES463267A patent/ES463267A1/es not_active Expired
- 1977-10-17 LU LU78330A patent/LU78330A1/xx unknown
- 1977-10-17 GB GB43122/77A patent/GB1566171A/en not_active Expired
- 1977-10-17 IE IE2114/77A patent/IE45805B1/en not_active IP Right Cessation
- 1977-10-17 PT PT67164A patent/PT67164B/pt unknown
- 1977-10-17 MX MX776490U patent/MX4899E/es unknown
- 1977-10-17 DK DK461377A patent/DK150302C/da not_active IP Right Cessation
- 1977-10-17 NO NO773548A patent/NO148453C/no unknown
- 1977-10-17 FR FR7731216A patent/FR2367754A1/fr active Granted
- 1977-10-17 JP JP12437177A patent/JPS5353653A/ja active Granted
- 1977-10-17 NL NL7711358.A patent/NL167434C/xx not_active IP Right Cessation
- 1977-10-17 CH CH1262677A patent/CH625511A5/fr not_active IP Right Cessation
- 1977-10-18 AT AT745977A patent/AT356136B/de not_active IP Right Cessation
- 1977-10-18 DD DD7700201582A patent/DD131931A5/xx unknown
- 1977-10-18 BG BG037604A patent/BG28847A3/xx unknown
- 1977-10-18 AR AR269623A patent/AR220901A1/es active
1978
- 1978-11-25 JP JP53145925A patent/JPS5940388B2/ja not_active Expired
- 1978-11-25 JP JP53145926A patent/JPS607997B2/ja not_active Expired
1981
- 1981-10-09 KE KE3167A patent/KE3167A/xx unknown
- 1981-11-05 HK HK538/81A patent/HK53881A/xx unknown
1982
- 1982-12-30 MY MY157/82A patent/MY8200157A/xx unknown

Also Published As

Publication number	Publication date
JPS607997B2 (ja)	1985-02-28
AU504978B2 (en)	1979-11-01
MY8200157A (en)	1982-12-31
CH625511A5 (en)	1981-09-30
SE7711053L (sv)	1978-04-19
DD131931A5 (de)	1978-08-09
IE45805L (en)	1978-04-18
FI62307C (fi)	1982-12-10
IL53094A0 (en)	1977-12-30
YU244277A (en)	1982-08-31
DE2759543C2 (de)	1987-04-09
JPS5940388B2 (ja)	1984-09-29
BG28847A3 (bg)	1980-07-15
DK150302B (da)	1987-02-02
LU78330A1 (fr)	1979-06-01
FI62307B (fi)	1982-08-31
PT67164A (en)	1977-11-01
YU40821B (en)	1986-06-30
NO773548L (no)	1978-04-19
JPS5353653A (en)	1978-05-16
NL7711358A (nl)	1978-04-20
FR2367754A1 (fr)	1978-05-12
AT356136B (de)	1980-04-10
ES463267A1 (es)	1978-07-16
AR220901A1 (es)	1980-12-15
SE437024B (sv)	1985-02-04
DE2746244C2 (de)	1983-05-19
FI773060A7 (fi)	1978-04-19
JPS5495575A (en)	1979-07-28
JPS5534132B2 (da)	1980-09-04
DK150302C (da)	1987-09-28
PT67164B (en)	1979-03-20
CA1088945A (en)	1980-11-04
NL167434C (nl)	1981-12-16
DE2759542C2 (da)	1988-07-07
JPS5495570A (en)	1979-07-28
NO148453B (no)	1983-07-04
PH15639A (en)	1983-03-11
NZ185358A (en)	1979-06-08
HK53881A (en)	1981-11-13
DE2746244A1 (de)	1978-04-20
DE2759927C2 (de)	1986-12-04
KE3167A (en)	1981-11-06
GR70201B (da)	1982-08-31
NL167434B (nl)	1981-07-16
IE45805B1 (en)	1982-12-01
MX4899E (es)	1982-12-14
AU2943177A (en)	1979-04-12
GB1566171A (en)	1980-04-30
FR2367754B1 (da)	1982-07-09
NO148453C (no)	1983-10-12
ATA745977A (de)	1979-09-15

Legal Events

Date	Code	Title	Description
1994-06-20	PBP	Patent lapsed

Publication	Publication Date	Title
DK81277A (da)	1977-08-26	Fremgangsmade til fremstilling af bis-pyridinium-forbindelser
DK461377A (da)	1978-04-19	R fremgangsmaade til fremstilling af spirohydantoin-forbindelse
DK143706C (da)	1982-03-15	Fremgangsmaade til fremstilling af svovlholdige organosiliciumforbindelser
DK13177A (da)	1977-07-15	Fremgangsmade til fremstilling af phthalaner
DK116177A (da)	1977-09-18	Fremgangsmade til fremstilling af hentriakontapeptider
DK145644C (da)	1983-07-04	Analogifremgangsmaade til fremstilling af imidazolforbindelser
DK147777A (da)	1977-10-03	Fremgangsmade til fremstilling af acylchromaner
DK484576A (da)	1977-04-29	Fremgangsmade til fremstilling af 2-aroyl-3-phenyl-benzothiophenforbindelser
DK57977A (da)	1977-08-12	Fremgangsmade til fremstilling af anilinforbindelser
DK148059C (da)	1985-07-29	Analogifremgangsmaade til fremstilling af anthracyclinglycosidforbindelser
DK144177A (da)	1977-10-03	Fremgangsmade til fremstilling af acylayanider
DK153484C (da)	1988-11-28	Fremgangsmaade til fremstilling af gamma-pyroner
DK271780A (da)	1980-12-27	Fremgangsmaade til fremstilling af cephalosporinforbindelser
DK145877A (da)	1977-10-03	Fremgangsmade til immoblisering af glucoseisomerase
DK377577A (da)	1978-02-26	Fremgangsmaade til fremstilling af antiserum
DK123277A (da)	1977-09-23	Fremgangsmade til fremstilling af 3-halogenmethyl-3-cephem-forbindelser
DK566977A (da)	1978-06-21	Fremgangsmaade til fremstilling af polyenforbindelser
DK20777A (da)	1977-07-29	Fremgangsmade til fremstilling af pyrrolidinforbindelser
DK38577A (da)	1977-08-01	Fremgangsmade til fremstilling af betalactamholdige forbindelser
DK52777A (da)	1977-08-18	Fremgangsmade til fremstilling af organiske forbindelser
DK247877A (da)	1977-12-05	Fremgangsmade til fremstilling af klavamforbindelser
DK65877A (da)	1978-02-18	Fremgangsmaade til fremstilling af mikrokapsler
DK428377A (da)	1978-03-31	Fremgangsmaade til fremstilling af pyridobenzodiazepinoner
DK310777A (da)	1978-01-10	Fremgangsmade til fremstilling af guaiacol-p-isobutyl-hydratropat
DK88677A (da)	1977-09-02	Fremgangsmade til fremstilling af substituerede puriner