DK472887A - Imidazolylguanidinderivater, fremgangsmaade til fremstilling deraf og laegemidler, der indeholder disse forbindelser - Google Patents

Imidazolylguanidinderivater, fremgangsmaade til fremstilling deraf og laegemidler, der indeholder disse forbindelser

Info

Publication number: DK472887A
Authority: DK; Denmark
Prior art keywords: ingrediates; imidazolylguanide; procedures; preparing; compounds
Prior art date: 1986-09-15

Application number

DK472887A

Other languages

English (en)

Other versions

DK472887D0 (da

DK165982B (da

DK165982C (da

Inventor

Armin Buschauer

Helmut Schickaneder

Peter Moersdorf

Walter Schunack

Gert Baumann

Kurt-Henning Ahrens

Original Assignee

Heumann Pharma Gmbh & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-09-15

Filing date

1987-09-10

Publication date

1988-03-16

1987-09-10 Application filed by Heumann Pharma Gmbh & Co filed Critical Heumann Pharma Gmbh & Co

1987-09-10 Publication of DK472887D0 publication Critical patent/DK472887D0/da

1988-03-16 Publication of DK472887A publication Critical patent/DK472887A/da

1993-02-22 Publication of DK165982B publication Critical patent/DK165982B/da

1993-07-26 Application granted granted Critical

1993-07-26 Publication of DK165982C publication Critical patent/DK165982C/da

Links

150000001875 compounds Chemical class 0.000 title 1
239000003814 drug Substances 0.000 title 1
238000000034 method Methods 0.000 title 1
JBARCTHFPUHCED-UHFFFAOYSA-N 2-(1h-imidazol-2-yl)guanidine Chemical class NC(=N)NC1=NC=CN1 JBARCTHFPUHCED-UHFFFAOYSA-N 0.000 abstract 1
208000031104 Arterial Occlusive disease Diseases 0.000 abstract 1
102000003710 Histamine H2 Receptors Human genes 0.000 abstract 1
108090000050 Histamine H2 Receptors Proteins 0.000 abstract 1
206010020772 Hypertension Diseases 0.000 abstract 1
230000001270 agonistic effect Effects 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
208000019622 heart disease Diseases 0.000 abstract 1
102000005962 receptors Human genes 0.000 abstract 1
108020003175 receptors Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Diabetes (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK472887A 1986-09-15 1987-09-10 Imidazolylguanidinderivater og laegemidler, der indeholder disse forbindelser DK165982C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19863631334 DE3631334A1 (de)	1986-09-15	1986-09-15	Neue imidazolylguanidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3631334		1986-09-15

Publications (4)

Publication Number	Publication Date
DK472887D0 DK472887D0 (da)	1987-09-10
DK472887A true DK472887A (da)	1988-03-16
DK165982B DK165982B (da)	1993-02-22
DK165982C DK165982C (da)	1993-07-26

Family

ID=6309606

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK472887A DK165982C (da)	1986-09-15	1987-09-10	Imidazolylguanidinderivater og laegemidler, der indeholder disse forbindelser

Country Status (17)

Country	Link
US (1)	US4912119A (da)
EP (1)	EP0262448B1 (da)
JP (1)	JPS6383072A (da)
KR (1)	KR950010326B1 (da)
AT (1)	ATE70533T1 (da)
AU (1)	AU606882B2 (da)
CA (1)	CA1249829A (da)
DE (2)	DE3631334A1 (da)
DK (1)	DK165982C (da)
ES (1)	ES2040720T3 (da)
GR (1)	GR3003388T3 (da)
HU (1)	HU212302B (da)
IE (1)	IE59278B1 (da)
IL (1)	IL83804A (da)
NZ (1)	NZ221611A (da)
PT (1)	PT85697B (da)
ZA (1)	ZA876163B (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0199845B1 (de) *	1985-04-02	1990-08-01	HEUMANN PHARMA GMBH & CO	Imidazolylalkylguanidinderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE3726381A1 (de) *	1987-08-07	1989-02-16	Heumann Pharma Gmbh & Co	Guanidincarbonsaeureester, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3814057A1 (de) *	1988-04-26	1989-11-09	Heumann Pharma Gmbh & Co	6-oxo-pyridazinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
ES2058651T3 (es) *	1990-03-30	1994-11-01	Heumann Pharma Gmbh & Co	Uso derivados de guanidina para la fabricacion de un medicamento con actividad antagonista de npy.
JPH06505265A (ja) *	1991-02-27	1994-06-16	シード・キャピタル・インベストメント・（エス・シー・アイ）・ベスローテン・フェンノートシャップ	ヒスタミンｈ↓３受容体に対する作動的または拮抗的活性を有するイミダゾール誘導体
NL9100365A (nl) *	1991-02-27	1992-09-16	Seed Capital Investments	Imidazoolderivaten met agonistische of antagonistische activiteit op de histamine h3-receptor.
EP0526395A1 (de) *	1991-07-22	1993-02-03	Zyma SA	Arylalkylaminderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
FR2686084B1 (fr) *	1992-01-10	1995-12-22	Bioprojet Soc Civ	Nouveaux derives de l'imidazole, leur preparation et leurs applications therapeutiques.
USRE37303E1 (en) *	1992-01-10	2001-07-31	Institut National Del La Sante Et De La Recherche Medicale	Imidazole compounds and their therapeutic applications
AU2764797A (en) *	1996-05-14	1997-12-05	Novo Nordisk A/S	Somatostatin agonists and antagonists
US6127343A (en) *	1996-05-14	2000-10-03	Novo Nordisk A/S	Somatostatin agonists and antagonists
JP2001502712A (ja) *	1996-10-31	2001-02-27	ノボノルディスクアクティーゼルスカブ	束縛されたソマトスタチン・アゴニスト及びアンタゴニスト
US5889016A (en) *	1997-06-26	1999-03-30	Bristol-Myers Squibb Company	Dihydropyrimidone derivatives as NPY antagonists
US6177429B1 (en)	1999-06-21	2001-01-23	Bristol-Myers Squibb Company	Dihydropyrazine derivatives as NPY antagonists
AU2001292723A1 (en) *	2000-09-20	2002-04-02	Schering Corporation	Substituted imidazoles as dual histamine h1 and h3 agonists or antagonists
KR101892241B1 (ko) *	2015-11-06	2018-08-27	송재근	유분 분리 장치

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1431589A (en) *	1973-07-13	1976-04-07	Smith Kline French Lab	Ureas, thioureas and guanidines n,n-disubstituted by heterocyclo- alkylene and/or heterocycloalkylenethioalkylene groups
IL49528A (en) *	1975-05-21	1980-11-30	Smith Kline French Lab	Imidazolyl(or thiazolyl)methylthio(or butyl)guanidine or thiourea derivatives,their preparation and pharmaceutical compositions comprising them
DE2835695A1 (de) *	1977-08-29	1979-03-15	Yamanouchi Pharma Co Ltd	Neue heterocyclische verbindungen, verfahren zu ihrer herstellung und arzneimittel, die diese enthalten
DK221081A (da) *	1980-05-31	1981-12-01	Smith Kline French Lab	Fremgangsmaade til fremstilling af heterocyklylalkylanidiner mellemprodukter til anvendelse ved denne fremgangsmaade og en fremgangsmaade til fremstilling af disse mellemprodukter
JPH0660096B2 (ja) *	1983-11-04	1994-08-10	富山化学工業株式会社	アミン誘導体またはその塩を含有する抗潰瘍剤
EP0199845B1 (de) *	1985-04-02	1990-08-01	HEUMANN PHARMA GMBH & CO	Imidazolylalkylguanidinderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE3528214A1 (de) *	1985-08-06	1987-02-12	Heumann Ludwig & Co Gmbh	Arylalkylguanidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3726381A1 (de) *	1987-08-07	1989-02-16	Heumann Pharma Gmbh & Co	Guanidincarbonsaeureester, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

1986
- 1986-09-15 DE DE19863631334 patent/DE3631334A1/de not_active Withdrawn
1987
- 1987-08-20 ZA ZA876163A patent/ZA876163B/xx unknown
- 1987-08-21 CA CA000545051A patent/CA1249829A/en not_active Expired
- 1987-08-28 AU AU77672/87A patent/AU606882B2/en not_active Ceased
- 1987-08-28 NZ NZ221611A patent/NZ221611A/xx unknown
- 1987-09-03 EP EP87112906A patent/EP0262448B1/de not_active Expired - Lifetime
- 1987-09-03 DE DE8787112906T patent/DE3775319D1/de not_active Expired - Fee Related
- 1987-09-03 AT AT87112906T patent/ATE70533T1/de not_active IP Right Cessation
- 1987-09-03 ES ES198787112906T patent/ES2040720T3/es not_active Expired - Lifetime
- 1987-09-06 IL IL83804A patent/IL83804A/xx not_active IP Right Cessation
- 1987-09-10 DK DK472887A patent/DK165982C/da active
- 1987-09-11 KR KR1019870010072A patent/KR950010326B1/ko not_active Expired - Lifetime
- 1987-09-14 HU HU874069A patent/HU212302B/hu not_active IP Right Cessation
- 1987-09-14 JP JP62230875A patent/JPS6383072A/ja active Pending
- 1987-09-14 IE IE246387A patent/IE59278B1/en not_active IP Right Cessation
- 1987-09-14 US US07/095,892 patent/US4912119A/en not_active Expired - Fee Related
- 1987-09-14 PT PT85697A patent/PT85697B/pt not_active IP Right Cessation
1991
- 1991-12-19 GR GR91400990T patent/GR3003388T3/el unknown

Also Published As

Publication number	Publication date
ES2040720T3 (es)	1993-11-01
ATE70533T1 (de)	1992-01-15
DK472887D0 (da)	1987-09-10
NZ221611A (en)	1989-09-27
DK165982B (da)	1993-02-22
EP0262448B1 (de)	1991-12-18
US4912119A (en)	1990-03-27
DE3775319D1 (de)	1992-01-30
IE59278B1 (en)	1994-02-09
EP0262448A1 (de)	1988-04-06
IL83804A0 (en)	1988-02-29
PT85697B (pt)	1990-08-31
AU7767287A (en)	1988-03-17
DE3631334A1 (de)	1988-03-17
HU212302B (en)	1996-05-28
ZA876163B (en)	1988-02-23
KR950010326B1 (ko)	1995-09-14
JPS6383072A (ja)	1988-04-13
GR3003388T3 (en)	1993-02-17
IE872463L (en)	1988-03-15
IL83804A (en)	1993-02-21
PT85697A (de)	1987-10-01
AU606882B2 (en)	1991-02-21
CA1249829A (en)	1989-02-07
KR880003937A (ko)	1988-06-01
HUT56352A (en)	1991-08-28
DK165982C (da)	1993-07-26

Publication	Publication Date	Title
DK472887A (da)	1988-03-16	Imidazolylguanidinderivater, fremgangsmaade til fremstilling deraf og laegemidler, der indeholder disse forbindelser
FI872756A0 (fi)	1987-06-22	Med laserstraolning fungerande terapeutisk anordning.
DK233586D0 (da)	1986-05-20	5-substituerede 1,3-thiazolidon-2,4-dion-forbindelser og farmaceutiske praeparater indeholdende disse
DK122291A (da)	1991-06-24	Benzimidazolderivat og fysiologisk acceptable salte heraf samt fremgangsmaade til fremstilling af samme
FI874702A7 (fi)	1988-04-28	Menetelmä uusien bentsimidatsolijohdannaisten valmistamiseksi.
NO166639C (no)	1991-08-21	Analogifremgangsmaate for fremstilling av terapeutisk aktive substituerte, basiske 2-aminotetraliner.
MX162676A (es)	1991-06-17	Procedimiento para la preparacion de derivados de 2-(piridilalquensulfinii.)benzimidazoles n-substituidos
DK0639275T3 (da)	1998-04-14	Hidtil ukendte GABAa-receptorundertyper og fremgangsmåder til screening af lægemiddelforbindelser under anvendelse af imidazoquinoxaliner og pyrrolopyimidiner til binding til GABAa-receptorundertyper
IT1207589B (it)	1989-05-25	Composizione di anticorpi monoclonali umani cross-protettivi.
DK0521768T3 (da)	1994-08-15	Nye triazolopyrimidin-derivater som er angiotensin II-receptor-antagonister, fremgangsmåder til deres fremstilling og farmaceutiske præparater med indhold deraf
DK204686D0 (da)	1986-05-02	Quinolylglycinamidderivater og fremgangsmaade til fremstilling deraf
ES549776A0 (es)	1987-01-16	Procedimiento para la preparacion de pirrolo-bencimidazoles
AR228011A1 (es)	1983-01-14	Procedimiento para la preparacion de derivados sustituidos de 2,5,5,8a-tetrametil-1,2,3,4,4a,5,6,7,8,8a-decahidronaftaleno-1-spiro-2'-(4',6',7'-sustituido-2',3'-dihidrobenzofurano)
ES2171663T3 (es)	2002-09-16	Nuevo procedimiento para la preparacion de nucleosidos.
AR216558A1 (es)	1979-12-28	Procedimiento de preparacion de 1,3-dihidro-3-(3',4',5'-trimetoxi-estiril)-6-metil-7-hidroxi-furo-(3,4,c)-piridina
IT1158450B (it)	1987-02-18	Procedimento per la preparazione dell'eritro-alfa-2-piperidil-2,8-bis-(trifluorometil)-4-chinolinmetanolo
NO167807C (no)	1991-12-11	Analogifremgangsmaate til fremstilling av 3',4'-dinitrogensubstituerte epipodofyllotoksinglukosidderivater.
IT8622467A0 (it)	1986-11-27	Procedimento per la sintesi di perfluoroalcadieni.
DK413188D0 (da)	1988-07-22	Benzimidazol-derivater til terapeutisk anvendelse og fremgangsmaade til fremstilling deraf
FI873606A7 (fi)	1988-02-23	Ihmisen glykoalbumiinin määrittämiseen käyttökelpoisia vasta-aineita.
IT7820912A0 (it)	1978-03-06	Procedimento per la preparazione di derivati di cefalosporina, e composti cosi' preparati.
ES8303412A1 (es)	1983-02-01	Procedimiento de obtencion de nuevas xantinas con actividad farmacologica
IT1225483B (it)	1990-11-14	Protesi ortopedica, particolarmente per la testa del femore.
DK688087A (da)	1988-06-30	Imidazolderivater, fremgangsmaade til fremstilling deraf og anvendelse deraf som antimycotiske midler
ES515068A0 (es)	1983-06-01	"procedimiento para la preparacion de n-(2-(((5-dimetilamino)-metil-2-furanil)-metil)-tio)-etil)-n'-(3,4-metilendioxibencil)-2-nitro-1,1-etendiamina".