ES2040720T3 - Nuevos derivados de imidazolilguanidina, procedimiento para su fabricacion y medicamentos conteniendo estos compuestos. - Google Patents

Nuevos derivados de imidazolilguanidina, procedimiento para su fabricacion y medicamentos conteniendo estos compuestos.

Info

Publication number
ES2040720T3
ES2040720T3 ES198787112906T ES87112906T ES2040720T3 ES 2040720 T3 ES2040720 T3 ES 2040720T3 ES 198787112906 T ES198787112906 T ES 198787112906T ES 87112906 T ES87112906 T ES 87112906T ES 2040720 T3 ES2040720 T3 ES 2040720T3
Authority
ES
Spain
Prior art keywords
compounds
procedure
manufacture
new
medicines containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198787112906T
Other languages
English (en)
Inventor
Armin Dr. Buschauer
Helmut Dr.Dipl.-Chem. Schickaneder
Peter Dr.Dipl.-Chem. Morsdorf
Walter Prof.Dr.Dr. Schunack
Gert Dr. Baumann
Kurt Dr. Henning Ahrens
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Heumann Pharma GmbH and Co
Original Assignee
Heumann Pharma GmbH and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Heumann Pharma GmbH and Co filed Critical Heumann Pharma GmbH and Co
Application granted granted Critical
Publication of ES2040720T3 publication Critical patent/ES2040720T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE DESCRIBEN NUEVOS DERIVADOS DE IMIDAZOLIL GUANIDINA DE FORMULA GENERAL (I), QUE COMO CONSECUENCIA DE LA ACTIVIDAD AGONISTA SOBRE LOS RECEPTORES H2 DE HISTAMINA, ASI COMO TAMBIEN PARCIALMENTE COMO CONSECUENCIA DE SU ACTIVIDAD RECEPTORA ADICIONAL AGONISTA DE H1, PUEDEN APLICARSE EN ENFERMEDADES DEL CORAZON, EN DETERMINADAS FORMAS DE HIPERTONIA, ASI COMO EN ENFERMEDADES OBTURANTES DE LAS ARTERIAS.
ES198787112906T 1986-09-15 1987-09-03 Nuevos derivados de imidazolilguanidina, procedimiento para su fabricacion y medicamentos conteniendo estos compuestos. Expired - Lifetime ES2040720T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19863631334 DE3631334A1 (de) 1986-09-15 1986-09-15 Neue imidazolylguanidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Publications (1)

Publication Number Publication Date
ES2040720T3 true ES2040720T3 (es) 1993-11-01

Family

ID=6309606

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198787112906T Expired - Lifetime ES2040720T3 (es) 1986-09-15 1987-09-03 Nuevos derivados de imidazolilguanidina, procedimiento para su fabricacion y medicamentos conteniendo estos compuestos.

Country Status (17)

Country Link
US (1) US4912119A (es)
EP (1) EP0262448B1 (es)
JP (1) JPS6383072A (es)
KR (1) KR950010326B1 (es)
AT (1) ATE70533T1 (es)
AU (1) AU606882B2 (es)
CA (1) CA1249829A (es)
DE (2) DE3631334A1 (es)
DK (1) DK165982C (es)
ES (1) ES2040720T3 (es)
GR (1) GR3003388T3 (es)
HU (1) HU212302B (es)
IE (1) IE59278B1 (es)
IL (1) IL83804A (es)
NZ (1) NZ221611A (es)
PT (1) PT85697B (es)
ZA (1) ZA876163B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0199845B1 (de) * 1985-04-02 1990-08-01 HEUMANN PHARMA GMBH & CO Imidazolylalkylguanidinderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE3726381A1 (de) * 1987-08-07 1989-02-16 Heumann Pharma Gmbh & Co Guanidincarbonsaeureester, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3814057A1 (de) * 1988-04-26 1989-11-09 Heumann Pharma Gmbh & Co 6-oxo-pyridazinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
EP0448765B1 (de) * 1990-03-30 1994-08-17 HEUMANN PHARMA GMBH & CO Verwendung von Guanidinderivaten zur Herstellung eines Arzneimittels mit NPY-antagonistischer Wirkung
NL9100365A (nl) * 1991-02-27 1992-09-16 Seed Capital Investments Imidazoolderivaten met agonistische of antagonistische activiteit op de histamine h3-receptor.
EP0573542B1 (en) * 1991-02-27 1997-10-15 Seed Capital Investments( Sci) B.V. Imidazole-derivatives having antagonistic activity on the histamine h3-receptor
EP0526395A1 (de) * 1991-07-22 1993-02-03 Zyma SA Arylalkylaminderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
FR2686084B1 (fr) * 1992-01-10 1995-12-22 Bioprojet Soc Civ Nouveaux derives de l'imidazole, leur preparation et leurs applications therapeutiques.
USRE37303E1 (en) * 1992-01-10 2001-07-31 Institut National Del La Sante Et De La Recherche Medicale Imidazole compounds and their therapeutic applications
AU2764797A (en) * 1996-05-14 1997-12-05 Novo Nordisk A/S Somatostatin agonists and antagonists
US6127343A (en) * 1996-05-14 2000-10-03 Novo Nordisk A/S Somatostatin agonists and antagonists
JP2001502712A (ja) * 1996-10-31 2001-02-27 ノボ ノルディスク アクティーゼルスカブ 束縛されたソマトスタチン・アゴニスト及びアンタゴニスト
US5889016A (en) * 1997-06-26 1999-03-30 Bristol-Myers Squibb Company Dihydropyrimidone derivatives as NPY antagonists
JP2003502374A (ja) 1999-06-21 2003-01-21 ブリストルーマイヤーズ スクイブ カンパニー Ｎｐｙ拮抗薬としてのジヒドロピラジン誘導体
MY129677A (en) * 2000-09-20 2007-04-30 Schering Corp Substituted imidazoles as dual histamine h1 and h3 agonists or antagonists
KR101892241B1 (ko) * 2015-11-06 2018-08-27 송재근 유분 분리 장치

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1431589A (en) * 1973-07-13 1976-04-07 Smith Kline French Lab Ureas, thioureas and guanidines n,n-disubstituted by heterocyclo- alkylene and/or heterocycloalkylenethioalkylene groups
IL49528A (en) * 1975-05-21 1980-11-30 Smith Kline French Lab Imidazolyl(or thiazolyl)methylthio(or butyl)guanidine or thiourea derivatives,their preparation and pharmaceutical compositions comprising them
DE2835695A1 (de) * 1977-08-29 1979-03-15 Yamanouchi Pharma Co Ltd Neue heterocyclische verbindungen, verfahren zu ihrer herstellung und arzneimittel, die diese enthalten
DK221081A (da) * 1980-05-31 1981-12-01 Smith Kline French Lab Fremgangsmaade til fremstilling af heterocyklylalkylanidiner mellemprodukter til anvendelse ved denne fremgangsmaade og en fremgangsmaade til fremstilling af disse mellemprodukter
JPH0660096B2 (ja) * 1983-11-04 1994-08-10 富山化学工業株式会社 アミン誘導体またはその塩を含有する抗潰瘍剤
EP0199845B1 (de) * 1985-04-02 1990-08-01 HEUMANN PHARMA GMBH & CO Imidazolylalkylguanidinderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE3528214A1 (de) * 1985-08-06 1987-02-12 Heumann Ludwig & Co Gmbh Arylalkylguanidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3726381A1 (de) * 1987-08-07 1989-02-16 Heumann Pharma Gmbh & Co Guanidincarbonsaeureester, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Also Published As

Publication number Publication date
DK472887D0 (da) 1987-09-10
DK472887A (da) 1988-03-16
GR3003388T3 (en) 1993-02-17
HU212302B (en) 1996-05-28
DE3631334A1 (de) 1988-03-17
KR880003937A (ko) 1988-06-01
CA1249829A (en) 1989-02-07
EP0262448A1 (de) 1988-04-06
KR950010326B1 (ko) 1995-09-14
IL83804A0 (en) 1988-02-29
DK165982B (da) 1993-02-22
PT85697A (de) 1987-10-01
DE3775319D1 (de) 1992-01-30
ZA876163B (en) 1988-02-23
AU606882B2 (en) 1991-02-21
JPS6383072A (ja) 1988-04-13
DK165982C (da) 1993-07-26
IL83804A (en) 1993-02-21
US4912119A (en) 1990-03-27
NZ221611A (en) 1989-09-27
PT85697B (pt) 1990-08-31
ATE70533T1 (de) 1992-01-15
HUT56352A (en) 1991-08-28
EP0262448B1 (de) 1991-12-18
IE872463L (en) 1988-03-15
AU7767287A (en) 1988-03-17
IE59278B1 (en) 1994-02-09

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