DK484787A - Bis-dioxopiperazin-derivater - Google Patents

Bis-dioxopiperazin-derivater

Info

Publication number: DK484787A
Authority: DK; Denmark
Prior art keywords: group; substituted; denotes; unsubstituted; lower alkyl
Prior art date: 1986-02-07

Application number

DK484787A

Other languages

English (en)

Other versions

DK156831C (da

DK156831B (da

DK484787D0 (da

Inventor

Muneaki Takase

Jun-Chao Cai

Original Assignee

Zenyaku Kogyo Kk

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-02-07

Filing date

1987-09-15

Publication date

1987-09-15

1987-09-15 Application filed by Zenyaku Kogyo Kk filed Critical Zenyaku Kogyo Kk

1987-09-15 Publication of DK484787A publication Critical patent/DK484787A/da

1987-09-15 Publication of DK484787D0 publication Critical patent/DK484787D0/da

1989-10-09 Publication of DK156831B publication Critical patent/DK156831B/da

1990-03-19 Application granted granted Critical

1990-03-19 Publication of DK156831C publication Critical patent/DK156831C/da

Links

JTHRRMFZHSDGNJ-UHFFFAOYSA-N piperazine-2,3-dione Chemical class O=C1NCCNC1=O JTHRRMFZHSDGNJ-UHFFFAOYSA-N 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 3
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
241001484259 Lacuna Species 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
230000000118 anti-neoplastic effect Effects 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
125000002541 furyl group Chemical group 0.000 abstract 1
125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
125000006239 protecting group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
238000001228 spectrum Methods 0.000 abstract 1
125000005504 styryl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

DK484787A 1986-02-07 1987-09-15 Bis-dioxopiperazin-derivater med antitumor-aktivitet og farmaceutisk acceptable salte deraf DK156831C (da)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
JP2519186		1986-02-07
JP2519186		1986-02-07
JP8700074		1987-02-05
PCT/JP1987/000074 WO1987004707A1 (fr)	1986-02-07	1987-02-05	Derives de bis-dioxopiperazine
CA000536472A CA1305484C (en)	1986-02-07	1987-05-06	Bis-dioxopiperazine derivatives and process for preparation thereof
CA536472		1987-05-06

Publications (4)

Publication Number	Publication Date
DK484787A true DK484787A (da)	1987-09-15
DK484787D0 DK484787D0 (da)	1987-09-15
DK156831B DK156831B (da)	1989-10-09
DK156831C DK156831C (da)	1990-03-19

Family

ID=25671332

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK484787A DK156831C (da)	1986-02-07	1987-09-15	Bis-dioxopiperazin-derivater med antitumor-aktivitet og farmaceutisk acceptable salte deraf

Country Status (8)

Country	Link
US (1)	US4868303A (da)
EP (1)	EP0256137B1 (da)
JP (1)	JPH0674251B2 (da)
CA (1)	CA1305484C (da)
DE (1)	DE3783176T2 (da)
DK (1)	DK156831C (da)
NO (1)	NO173604C (da)
WO (1)	WO1987004707A1 (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE69117025T2 (de) *	1990-07-04	1996-06-20	Zenyaku Kogyo Kk	Wasserlösliche bis-dioxopiperazinderivate mit antitumor wirkung
US5633158A (en) *	1991-10-23	1997-05-27	Cancer Research Campaign Technology Limited	Bacterial nitroreductase for the reduction of CB 1954 and analogues thereof to a cytotoxic form
JP6450323B2 (ja)	2013-01-07	2019-01-09	ユニバーシティオブサザンカリフォルニア	デオキシウリジントリホスファターゼ阻害剤
CA2935717C (en)	2014-01-03	2022-06-21	University Of Southern California	Uracil isostere and pharmaceutical compositions thereof useful as deoxyuridine triphosphatase inhibitors
WO2017006270A1 (en)	2015-07-08	2017-01-12	University Of Southern California	Deoxyuridine triphosphatase inhibitors
SI3319939T1 (sl)	2015-07-08	2025-04-30	Cv6 Therapeutics (Ni) Limited	Zaviralci deoksiuridin trifosfataze, ki vsebujejo hidantoin
WO2017006283A1 (en)	2015-07-08	2017-01-12	Cv6 Therapeutics (Ni) Limited	Deoxyuridine triphosphatase inhibitors containing cyclopropano linkage
WO2017006271A1 (en)	2015-07-08	2017-01-12	University Of Southern California	Deoxyuridine triphosphatase inhibitors containing amino sulfonyl linkage
WO2018098208A1 (en)	2016-11-23	2018-05-31	Cv6 Therapeutics (Ni) Limited	Nitrogen ring linked deoxyuridine triphosphatase inhibitors
US10858344B2 (en)	2016-11-23	2020-12-08	Cv6 Therapeutics (Ni) Limited	Hydantoin containing deoxyuridine triphosphatase inhibitors
US11014924B2 (en)	2016-11-23	2021-05-25	Cv6 Therapeutics (Ni) Limited	Hydantoin containing deoxyuridine triphosphatase inhibitors
US11168059B2 (en)	2016-11-23	2021-11-09	Cv6 Therapeutics (Ni) Limited	Amino sulfonyl compounds
US11174271B2 (en)	2016-11-23	2021-11-16	Cv6 Therapeutics (Ni) Limited	6-membered uracil isosteres
US11247984B2 (en)	2017-01-05	2022-02-15	Cv6 Therapeutics (Ni) Limited	Uracil containing compounds

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1240700B (de) *	1960-10-31	1967-05-18	Eastman Kodak Co	Duesentreibstoffe
NL273692A (da) *	1961-01-19	1900-01-01
GB1234935A (en) *	1967-07-03	1971-06-09	Nat Res Dev	Piperazine derivatives
NL163957C (nl) *	1968-07-02	1980-11-17	Nat Res Dev	Werkwijze voor het bereiden van een geneesmiddel tegen kanker, alsmede werkwijze voor het bereiden van een 1,2-di(3,5-dioxopiperazinoalkaanverbinding.
DE2511891A1 (de) *	1975-03-19	1976-10-07	Gruenenthal Chemie	Neue derivate des 2,6-dioxopiperazins, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel sowie verfahren zu deren herstellung
US4404381A (en) *	1981-06-19	1983-09-13	The Dow Chemical Company	Novel 3,5-diketo-piperazinyl compounds containing epoxide substituted imides
US4737497A (en) *	1983-04-12	1988-04-12	Zenyaki Kogyo Kabushiki Kaisha	Bis-dioxopiperazine derivatives, antitumor agents comprising them and compositions containing them
JPS6097963A (ja) *	1983-10-31	1985-05-31	Zenyaku Kogyo Kk	ビス−ジオキソピペラジン誘導体，その製造方法及びそれからなる抗腫瘍剤
US4536564A (en) *	1983-12-09	1985-08-20	The Dow Chemical Company	Polyamide from bis-carboxy containing 3,5,3',5'-tetraoxo-1,2-dipiperazine compound and diamine
JPS60152660A (ja) *	1984-01-23	1985-08-10	Nisshin Steel Co Ltd	高硬度マルテンサイト系析出硬化型ステンレス鋼材の製造方法
JPS61152660A (ja) *	1984-12-26	1986-07-11	Zenyaku Kogyo Kk	ビス−ジオキソピペラジン誘導体
JPH0676392B2 (ja) *	1985-06-26	1994-09-28	全薬工業株式会社	ビス−ジオキソピペラジン誘導体及びそれからなる抗腫瘍剤
US4764614A (en) *	1987-03-23	1988-08-16	Monsanto Company	Process for preparing (S)(+)-4,4'(methyl-1,2-ethanediyl)-bis(2,6-piperazinedione)
JPH0697963A (ja) *	1992-07-02	1994-04-08	Oki Electric Ind Co Ltd	パケット交換システム

1987
- 1987-02-04 JP JP62024348A patent/JPH0674251B2/ja not_active Expired - Lifetime
- 1987-02-05 DE DE8787901122T patent/DE3783176T2/de not_active Expired - Fee Related
- 1987-02-05 WO PCT/JP1987/000074 patent/WO1987004707A1/ja not_active Ceased
- 1987-02-05 US US07/124,932 patent/US4868303A/en not_active Expired - Fee Related
- 1987-02-05 EP EP87901122A patent/EP0256137B1/en not_active Expired - Lifetime
- 1987-05-06 CA CA000536472A patent/CA1305484C/en not_active Expired - Fee Related
- 1987-09-15 DK DK484787A patent/DK156831C/da not_active IP Right Cessation
- 1987-10-07 NO NO874197A patent/NO173604C/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
JPH0674251B2 (ja)	1994-09-21
EP0256137A4 (en)	1989-01-19
AU602332B2 (en)	1990-10-11
EP0256137A1 (en)	1988-02-24
AU7025587A (en)	1987-08-25
EP0256137B1 (en)	1992-12-23
DK156831C (da)	1990-03-19
NO173604C (no)	1994-01-05
WO1987004707A1 (fr)	1987-08-13
US4868303A (en)	1989-09-19
DK156831B (da)	1989-10-09
NO874197D0 (no)	1987-10-07
JPS62281870A (ja)	1987-12-07
DE3783176D1 (de)	1993-02-04
DK484787D0 (da)	1987-09-15
NO173604B (no)	1993-09-27
DE3783176T2 (de)	1993-04-22
NO874197L (no)	1987-12-07
CA1305484C (en)	1992-07-21

Legal Events

Date	Code	Title	Description
2002-09-30	PBP	Patent lapsed

Publication	Publication Date	Title
DK0784974T3 (da)	2003-09-01	Fremstilling af xanthinderivater i fast dispersion
SE8804586D0 (sv)	1988-12-20	1,4-dihydro-4-oxonaftyridinderivat och salter daerav foerfarande foer framstaellning av dessa jaemte antibakteriella medel innefattande dessa
ATE138921T1 (de)	1996-06-15	Xanthinderivate
MX9306831A (es)	1995-01-31	Nuevos compuestos heterociclicos.
SE8503922L (sv)	1986-02-24	Analgetiska 1,2-bensisotiazol-3-ylpiperazin-derivat
ES2036145A1 (es)	1993-05-01	Procedimiento de preparacion de derivados de aril (o heteroaril)-pipe-razinil-butil-azoles.
KR950010888A (ko)	1995-05-15	평활근세포 증식 및 재발협착증을 억제하는 방법
MX9201556A (es)	1992-10-01	Nuevos antihistaminicos no sedativos, derivados de benc imidazoles.
KR900006296A (ko)	1990-05-07	이미다졸린 유도체 및 그의 제조방법
KR910009672A (ko)	1991-06-28	피리다진 유도체, 이의 제조방법 및 이것을 함유하는 약학 조성물
KR920016448A (ko)	1992-09-24	피페리딘 유도체
EP0256137A4 (en)	1989-01-19	BIS-DIOXOPIPERAZINE COMBINATIONS.
NO890440L (no)	1990-01-15	Fremgangsmaate for fremstilling av terapeutisk aktive isokinolinderivater.
DK322588D0 (da)	1988-06-14	Cycloalkylamider af 6-substituerede (8beta)-1-alkylergoliner og fremgangsmaade til fremstilling af saadanne forbindelser
ATE204278T1 (de)	2001-09-15	Serotoninergische ergolin derivate
NO911004L (no)	1992-02-10	(benzhydryloksyetylpiperidyl)alifatiske syrederivater og anvendelse derav.
KR860000286A (ko)	1986-01-27	디히드로피리딘 유도체의 제조방법
DE69221634D1 (de)	1997-09-18	5-Piperazinylalkyl)-1,5-Benzothiazepinone verwendbar als Calciumantagonisten
GR871066B (en)	1987-11-03	Preparation method of piperazine dione -2,6 derivatives
FI870067A0 (fi)	1987-01-08	Metionin-substituerade 1,4-dihydropyridiner, foerfarande foer deras framstaellning och deras anvaendning.
ZA892312B (en)	1989-12-27	7-(imidazol-1-yl)-1,4-dihydro-4-oxo-6,8-difluoro-1-cyclo-propylquinoline-3-carboxylic acid derivatives their preparation and their application as drugs
ATE194621T1 (de)	2000-07-15	Pyrazolothiazolopyrimidin-derivate
DK168284D0 (da)	1984-03-26	Troponderivater
RU93052381A (ru)	1996-04-27	Производные бензамида, способ получения, фармацевтический препарат
SE8900256L (sv)	1989-07-27	Ergolinderivat, deras framstaellning och deras anvaendning