DK0784974T3 - Fremstilling af xanthinderivater i fast dispersion - Google Patents
Fremstilling af xanthinderivater i fast dispersionInfo
- Publication number
- DK0784974T3 DK0784974T3 DK96916342T DK96916342T DK0784974T3 DK 0784974 T3 DK0784974 T3 DK 0784974T3 DK 96916342 T DK96916342 T DK 96916342T DK 96916342 T DK96916342 T DK 96916342T DK 0784974 T3 DK0784974 T3 DK 0784974T3
- Authority
- DK
- Denmark
- Prior art keywords
- solid dispersion
- preparation
- xanthine derivatives
- hxdrogen
- hxdroxy
- Prior art date
Links
- 239000007962 solid dispersion Substances 0.000 title abstract 3
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical class O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 title abstract 2
- 229940083747 low-ceiling diuretics xanthine derivative Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000002605 large molecules Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP19005895 | 1995-07-26 | ||
| PCT/JP1996/001555 WO1997004782A1 (en) | 1995-07-26 | 1996-06-07 | Solid dispersion or solid dispersion preparation of xanthine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0784974T3 true DK0784974T3 (da) | 2003-09-01 |
Family
ID=16251650
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK96916342T DK0784974T3 (da) | 1995-07-26 | 1996-06-07 | Fremstilling af xanthinderivater i fast dispersion |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6254889B1 (da) |
| EP (1) | EP0784974B1 (da) |
| JP (1) | JP3938938B2 (da) |
| AT (1) | ATE240734T1 (da) |
| DE (1) | DE69628276T2 (da) |
| DK (1) | DK0784974T3 (da) |
| ES (1) | ES2199289T3 (da) |
| PT (1) | PT784974E (da) |
| WO (1) | WO1997004782A1 (da) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0901786T3 (da) | 1997-08-11 | 2007-10-08 | Pfizer Prod Inc | Faste farmaceutiske dispersioner med foröget biotilgængelighed |
| US6350786B1 (en) * | 1998-09-22 | 2002-02-26 | Hoffmann-La Roche Inc. | Stable complexes of poorly soluble compounds in ionic polymers |
| US6706283B1 (en) * | 1999-02-10 | 2004-03-16 | Pfizer Inc | Controlled release by extrusion of solid amorphous dispersions of drugs |
| EP1027886B1 (en) * | 1999-02-10 | 2008-07-09 | Pfizer Products Inc. | Pharmaceutical solid dispersions |
| EP1239831B1 (en) | 1999-12-23 | 2012-10-31 | Mayne Pharma International Pty Ltd. | Improved pharmaceutical compositions for poorly soluble drugs |
| DZ3227A1 (fr) | 1999-12-23 | 2001-07-05 | Pfizer Prod Inc | Compositions pharmaceutiques fournissant des concentrations de medicaments ameliorees |
| UY26615A1 (es) * | 2000-03-16 | 2001-10-25 | Pfizer Prod Inc | Inhibidor de la glucogeno fosforilasa. |
| CA2430288C (en) * | 2000-12-01 | 2009-03-10 | Kyowa Hakko Kogyo Co., Ltd. | A composition improved in the solubility or oral absorbability |
| WO2002062393A2 (en) * | 2001-02-02 | 2002-08-15 | Metagenics, Inc. | Coating for orally administered compositions |
| JP4310605B2 (ja) * | 2001-05-25 | 2009-08-12 | 大塚製薬株式会社 | 医薬用組成物 |
| MXPA03011784A (es) * | 2001-06-22 | 2004-04-02 | Pfizer Prod Inc | Composiciones farmaceuticas de dispersiones de farmacos y polimeros neutros. |
| WO2003063833A1 (en) | 2002-02-01 | 2003-08-07 | Pfizer Products Inc. | Pharmaceutical compositions of amorphous dispersions of drugs and lipophilic microphase-forming materials |
| DE60329744D1 (de) * | 2002-02-22 | 2009-12-03 | Ajinomoto Kk | Aminosäurepulver und verfahren zu seiner herstellung |
| US20040229901A1 (en) * | 2003-02-24 | 2004-11-18 | Lauren Otsuki | Method of treatment of disease using an adenosine A1 receptor antagonist |
| EP1932529A1 (en) | 2003-04-25 | 2008-06-18 | Novacardia, Inc. | Method of improved diuresis in individuals with impaired renal function |
| AU2004233852A1 (en) * | 2003-04-25 | 2004-11-11 | Novacardia, Inc. | Method of improved diuresis in individuals with impaired renal function |
| US20060293312A1 (en) * | 2003-04-25 | 2006-12-28 | Howard Dittrich | Method of improved diuresis in individuals with impaired renal function |
| EP1626049B1 (en) * | 2003-05-09 | 2012-02-22 | Kyowa Hakko Kirin Co., Ltd. | Microcrystal of (E)-8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione |
| MXPA06001417A (es) | 2003-08-04 | 2006-05-15 | Pfizer Prod Inc | Composiciones farmaceuticas de adsorbatos de farmacos amorfos y materiales que forman microfases lipofilas. |
| JP2007532671A (ja) * | 2004-04-16 | 2007-11-15 | ノヴァカーディア，インク． | アデノシンａ１受容体アンタゴニストおよびアルドステロン阻害剤を含む併用療法 |
| US20080312587A1 (en) * | 2005-06-10 | 2008-12-18 | Gruenethal Gmbh | System for the Oral Administration of Solids to Persons Suffering from Dementia |
| JPWO2007069675A1 (ja) * | 2005-12-14 | 2009-05-28 | 協和発酵キリン株式会社 | キサンチン誘導体の易吸収性経口製剤 |
| JP2007308480A (ja) * | 2006-04-20 | 2007-11-29 | Shin Etsu Chem Co Ltd | 腸溶性固体分散体を含んでなる固形製剤 |
| EP2035009A1 (en) * | 2006-06-16 | 2009-03-18 | Novacardia, Inc. | Prolonged improvement of renal function comprising infrequent administration of an aa1ra |
| WO2008121893A1 (en) * | 2007-03-29 | 2008-10-09 | Novacardia, Inc. | Methods of treating heart failure and renal dysfunction in individuals with an adenosine a1 receptor antagonist |
| WO2008121882A1 (en) * | 2007-03-29 | 2008-10-09 | Novacardia, Inc. | Improved methods of administration of adenosine a1 receptor antagonists |
| GB0708258D0 (en) * | 2007-04-27 | 2007-06-06 | Katholleke Universiteit Leuven | New anti-viral nulceoside analogs |
| US8309129B2 (en) | 2007-05-03 | 2012-11-13 | Bend Research, Inc. | Nanoparticles comprising a drug, ethylcellulose, and a bile salt |
| US8703204B2 (en) | 2007-05-03 | 2014-04-22 | Bend Research, Inc. | Nanoparticles comprising a cholesteryl ester transfer protein inhibitor and anon-ionizable polymer |
| EP2162120B1 (en) | 2007-06-04 | 2016-05-04 | Bend Research, Inc | Nanoparticles comprising a non-ionizable cellulosic polymer and an amphiphilic non-ionizable block copolymer |
| WO2008149230A2 (en) | 2007-06-04 | 2008-12-11 | Pfizer Products Inc. | Nanoparticles comprising drug, a non-ionizable cellulosic polymer and tocopheryl polyethylene glycol succinate |
| SI2200588T1 (sl) * | 2007-09-25 | 2019-08-30 | Solubest Ltd. | Sestavki, ki obsegajo lipofilne aktivne spojine, in postopek za njihovo pripravo |
| EP2231169B1 (en) | 2007-12-06 | 2016-05-04 | Bend Research, Inc. | Pharmaceutical compositions comprising nanoparticles and a resuspending material |
| EP2240162A4 (en) | 2007-12-06 | 2013-10-09 | Bend Res Inc | NANOTE PARTICLES WITH A NON-IONIZABLE POLYMER AND AN AMIN-FUNCTIONALIZED METHACRYLATE COPOLYMER |
| AU2009223014A1 (en) * | 2008-03-11 | 2009-09-17 | Dr. Reddy's Laboratories Ltd. | Preparation of lenalidomide |
| WO2013192566A1 (en) | 2012-06-21 | 2013-12-27 | Mayne Pharma International Pty. Ltd. | Itraconazole compositions and dosage forms, and methods of using the same |
| TWI615157B (zh) * | 2013-02-06 | 2018-02-21 | 大塚製藥股份有限公司 | 包括不定形西洛他唑的固體分散劑 |
| EP3340982B1 (en) | 2015-08-26 | 2021-12-15 | Achillion Pharmaceuticals, Inc. | Compounds for treatment of immune and inflammatory disorders |
| AR106018A1 (es) | 2015-08-26 | 2017-12-06 | Achillion Pharmaceuticals Inc | Compuestos de arilo, heteroarilo y heterocíclicos para el tratamiento de trastornos médicos |
| CN109414441A (zh) | 2016-06-27 | 2019-03-01 | 艾其林医药公司 | 治疗医学障碍的喹唑啉和吲哚化合物 |
| KR102632860B1 (ko) | 2017-03-01 | 2024-02-02 | 아칠리온 파르마세우티칼스 인코포레이티드 | 의학적 장애의 치료를 위한 아릴, 헤테로아릴, 및 헤테로사이클릭 약학적 화합물 |
| TWI780270B (zh) | 2017-11-28 | 2022-10-11 | 靜岡縣公立大學法人 | 固體分散體 |
| US20230022157A1 (en) | 2018-08-20 | 2023-01-26 | Achillion Pharmaceuticals, Inc. | Pharmaceutical compounds for the treatment of complement factor d medical disorders |
| EP3846803A4 (en) | 2018-09-06 | 2022-08-10 | Achillion Pharmaceuticals, Inc. | Macrocyclic compounds for the treatment of medical disorders |
| WO2020081723A1 (en) | 2018-10-16 | 2020-04-23 | Georgia State University Research Foundation, Inc. | Carbon monoxide prodrugs for the treatment of medical disorders |
| CN119837855A (zh) | 2019-12-19 | 2025-04-18 | 乔治亚州大学研究基金会 | 用于治疗细菌感染和增强抗生素的化合物 |
| CN115362162A (zh) | 2020-02-20 | 2022-11-18 | 艾其林医药公司 | 用于治疗补体因子d介导的障碍的杂芳基化合物 |
| CA3193488A1 (en) | 2020-09-23 | 2022-03-31 | Jason Allan Wiles | Pharmaceutical compounds for the treatment of complement mediated disorders |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3976071A (en) * | 1974-01-07 | 1976-08-24 | Dynatech Corporation | Methods of improving control of release rates and products useful in same |
| US5286489A (en) * | 1985-08-26 | 1994-02-15 | The Procter & Gamble Company | Taste masking compositions |
| CH674148A5 (da) * | 1986-06-24 | 1990-05-15 | Racz Istvan | |
| JP2521461B2 (ja) | 1987-03-10 | 1996-08-07 | エスエス製薬株式会社 | 持続性錠剤 |
| EP0386967B1 (en) * | 1989-03-10 | 1995-07-12 | Yamanouchi Pharmaceutical Co. Ltd. | A drug-release controlling coating material for long acting formulations |
| US5290782A (en) | 1989-09-01 | 1994-03-01 | Kyowa Hakko Kogyo Co., Ltd. | Xanthine derivatives |
| JPH06102662B2 (ja) * | 1989-09-01 | 1994-12-14 | 協和醗酵工業株式会社 | キサンチン誘導体 |
| AU1537292A (en) * | 1991-04-16 | 1992-11-17 | Nippon Shinyaku Co. Ltd. | Method of manufacturing solid dispersion |
-
1996
- 1996-06-07 WO PCT/JP1996/001555 patent/WO1997004782A1/ja not_active Ceased
- 1996-06-07 DK DK96916342T patent/DK0784974T3/da active
- 1996-06-07 US US08/809,651 patent/US6254889B1/en not_active Expired - Fee Related
- 1996-06-07 JP JP50744297A patent/JP3938938B2/ja not_active Expired - Fee Related
- 1996-06-07 AT AT96916342T patent/ATE240734T1/de not_active IP Right Cessation
- 1996-06-07 EP EP96916342A patent/EP0784974B1/en not_active Expired - Lifetime
- 1996-06-07 PT PT96916342T patent/PT784974E/pt unknown
- 1996-06-07 DE DE69628276T patent/DE69628276T2/de not_active Expired - Fee Related
- 1996-06-07 ES ES96916342T patent/ES2199289T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US6254889B1 (en) | 2001-07-03 |
| PT784974E (pt) | 2003-09-30 |
| JP3938938B2 (ja) | 2007-06-27 |
| DE69628276T2 (de) | 2004-04-08 |
| DE69628276D1 (de) | 2003-06-26 |
| WO1997004782A1 (en) | 1997-02-13 |
| ATE240734T1 (de) | 2003-06-15 |
| EP0784974B1 (en) | 2003-05-21 |
| EP0784974A1 (en) | 1997-07-23 |
| EP0784974A4 (en) | 2000-09-27 |
| ES2199289T3 (es) | 2004-02-16 |
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