DK502389A - Pyridazinonderivater og fremgangsmaade til fremstilling deraf - Google Patents
Pyridazinonderivater og fremgangsmaade til fremstilling derafInfo
- Publication number
- DK502389A DK502389A DK502389A DK502389A DK502389A DK 502389 A DK502389 A DK 502389A DK 502389 A DK502389 A DK 502389A DK 502389 A DK502389 A DK 502389A DK 502389 A DK502389 A DK 502389A
- Authority
- DK
- Denmark
- Prior art keywords
- alkyl
- alkoxy
- denotes
- hydrogen
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/14—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/36—Benzo-cinnolines
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3161888 | 1988-02-13 | ||
| JP3161888 | 1988-02-13 | ||
| JP7591088 | 1988-03-31 | ||
| JP7591088 | 1988-03-31 | ||
| PCT/JP1989/000127 WO1989007594A1 (en) | 1988-02-13 | 1989-02-09 | Pyridazinone derivatives |
| JP8900127 | 1989-02-09 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK502389D0 DK502389D0 (da) | 1989-10-10 |
| DK502389A true DK502389A (da) | 1989-11-20 |
| DK170096B1 DK170096B1 (da) | 1995-05-22 |
Family
ID=26370117
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK502389A DK170096B1 (da) | 1988-02-13 | 1989-10-10 | 4,5-dihydro-6-cykloalkenylaminophenyl-3(24)-pyridazinoner og fremgangsmåder til fremstilling deraf |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5110925A (da) |
| EP (1) | EP0357788B1 (da) |
| JP (1) | JP2717687B2 (da) |
| KR (1) | KR910005233B1 (da) |
| CA (1) | CA1320957C (da) |
| DE (1) | DE68910447T2 (da) |
| DK (1) | DK170096B1 (da) |
| ES (1) | ES2012646A6 (da) |
| FI (1) | FI95570C (da) |
| NO (1) | NO176275C (da) |
| WO (1) | WO1989007594A1 (da) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8903130D0 (en) * | 1989-02-11 | 1989-03-30 | Orion Yhtymae Oy | Substituted pyridazinones |
| JP2806192B2 (ja) * | 1992-11-02 | 1998-09-30 | 日本曹達株式会社 | 血小板凝集抑制剤 |
| US5678114A (en) * | 1994-06-14 | 1997-10-14 | Noritsu Koki Co., Ltd. | Automatic photographic developing apparatus for photosensitive materials |
| CA2204915A1 (en) * | 1994-11-11 | 1996-05-23 | Seiichi Uchida | Optically active compound |
| US6110471A (en) * | 1996-09-13 | 2000-08-29 | The Board Of Trustees Of The Leland Stanford Junior University | Non-hormonal method of contraception |
| AU6005999A (en) * | 1998-10-09 | 2000-05-01 | Nihon Nohyaku Co., Ltd. | Pyridazinone derivatives |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| US8067433B2 (en) | 2005-11-09 | 2011-11-29 | Zalicus Inc. | Methods, compositions, and kits for the treatment of ophthalmic disorders |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| WO2008151257A2 (en) | 2007-06-04 | 2008-12-11 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| ES2627848T3 (es) | 2008-06-04 | 2017-07-31 | Synergy Pharmaceuticals Inc. | Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos |
| ES2624828T3 (es) | 2008-07-16 | 2017-07-17 | Synergy Pharmaceuticals Inc. | Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| MX357121B (es) | 2011-03-01 | 2018-06-27 | Synergy Pharmaceuticals Inc Star | Proceso de preparacion de agonistas c de guanilato ciclasa. |
| WO2013106547A1 (en) | 2012-01-10 | 2013-07-18 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
| EP2958577A2 (en) | 2013-02-25 | 2015-12-30 | Synergy Pharmaceuticals Inc. | Guanylate cyclase receptor agonists for use in colonic cleansing |
| EP2968439A2 (en) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
| US9708367B2 (en) | 2013-03-15 | 2017-07-18 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase and their uses |
| PL3004138T3 (pl) | 2013-06-05 | 2024-07-29 | Bausch Health Ireland Limited | Ultra-oczyszczeni agoniści peptydowi cyklazy guanylanowej C, sposób ich uzyskiwania i ich zastosowanie |
| CA2920856C (en) | 2013-08-09 | 2026-03-03 | Ardelyx, Inc. | Ph modulating compounds for inhibiting gastrointestinal phosphate uptake |
| US9884806B2 (en) | 2013-08-30 | 2018-02-06 | Icahn School Of Medicine At Mount Sinai | Cyclic vinylogous amides as bromodomain inhibitors |
| JP2022533251A (ja) | 2019-05-21 | 2022-07-21 | アルデリックス， インコーポレイテッド | 患者において血清リン酸塩を低下させるための組み合わせ |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4019575A (en) * | 1975-12-22 | 1977-04-26 | Chevron Research Company | System for recovering viscous petroleum from thick tar sand |
| JPS5746966A (en) * | 1980-09-03 | 1982-03-17 | Mitsui Toatsu Chem Inc | Pyridazinone derivative and its production |
| US4665174A (en) * | 1981-05-12 | 1987-05-12 | Sumitomo Chemical Company, Limited | Production of cyclopentenone derivatives |
| JPS58113180A (ja) * | 1981-12-28 | 1983-07-05 | Mitsui Toatsu Chem Inc | ピリダジノン誘導体 |
| DE3302442A1 (de) * | 1983-01-26 | 1984-07-26 | Basf Ag, 6700 Ludwigshafen | Neue pyridazinone, verfahren zu ihrer herstellung, diese verbindungen enthaltende therapeutische mittel und deren verwendung |
| US4602019A (en) * | 1983-04-22 | 1986-07-22 | Warner-Lambert Company | Indeno[1,2-c]pyridazin-3-one derivatives useful as cardiotonic and antihypertensive agents |
| US4666902A (en) * | 1983-06-20 | 1987-05-19 | Cassella Aktiengesellschaft | Tetrahydropyridazinone derivatives, processes for their preparation and their use |
| GB2164643B (en) * | 1984-07-27 | 1988-11-02 | Boehringer Biochemia Srl | Tricyclic dihydropyridazinones and pharmaceutical compositions containing them |
| JPH06763B2 (ja) * | 1984-08-28 | 1994-01-05 | 吉富製薬株式会社 | ベンゾ〔ｈ〕シンノリン誘導体 |
| US4816454A (en) * | 1984-09-21 | 1989-03-28 | Cassella Aktiengesellschaft | 4,5-dihydro-3(2H)-pyridazinones and their pharmacological use |
| US4681621A (en) * | 1984-12-20 | 1987-07-21 | Stauffer Chemical Company | Herbicidal 2-(2-substituted benzoyl)-1,3-cyclopentanediones |
| DE3505609A1 (de) * | 1985-02-19 | 1986-08-21 | Merck Patent Gmbh, 6100 Darmstadt | Benzimidazolyl-pyridazinone |
| GB2177689B (en) * | 1985-07-09 | 1989-07-19 | Boehringer Biochemia Srl | Tricyclic dihydropyridazinones and pharmaceutical compositions containing them |
| JPH0633277B2 (ja) * | 1986-01-10 | 1994-05-02 | 吉富製薬株式会社 | ベンゾチオピラノ〔４，３−ｃ〕ピリダジン化合物 |
| US4775411A (en) * | 1986-06-09 | 1988-10-04 | Stauffer Chemica Company | Certain substituted 3-amino-2-benzoylcyclohex-2-enones |
| EP0281045B1 (en) * | 1987-03-02 | 1991-12-27 | Yoshitomi Pharmaceutical Industries, Ltd. | Benzothiepino (5,4-c) pyridazine compounds and their pharmaceutical uses |
| DE3804490A1 (de) * | 1988-02-12 | 1989-08-24 | Heumann Pharma Gmbh & Co | Substituierte 6-phenyldihydro-3(2h)-pyridazinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| JPH0216991A (ja) * | 1988-07-04 | 1990-01-19 | Mitsui Toatsu Chem Inc | Ｌ−トリプトファンの製法 |
-
1989
- 1989-01-31 JP JP1019514A patent/JP2717687B2/ja not_active Expired - Lifetime
- 1989-02-09 EP EP89902288A patent/EP0357788B1/en not_active Expired - Lifetime
- 1989-02-09 KR KR1019890701882A patent/KR910005233B1/ko not_active Expired
- 1989-02-09 WO PCT/JP1989/000127 patent/WO1989007594A1/en not_active Ceased
- 1989-02-09 US US07/427,123 patent/US5110925A/en not_active Expired - Fee Related
- 1989-02-09 DE DE89902288T patent/DE68910447T2/de not_active Expired - Fee Related
- 1989-02-09 CA CA000590590A patent/CA1320957C/en not_active Expired - Fee Related
- 1989-02-10 ES ES8900493A patent/ES2012646A6/es not_active Expired - Fee Related
- 1989-10-10 DK DK502389A patent/DK170096B1/da not_active IP Right Cessation
- 1989-10-12 NO NO894088A patent/NO176275C/no unknown
- 1989-10-12 FI FI894844A patent/FI95570C/fi not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NO176275B (no) | 1994-11-28 |
| DE68910447T2 (de) | 1994-03-17 |
| DK170096B1 (da) | 1995-05-22 |
| FI95570C (fi) | 1996-02-26 |
| DK502389D0 (da) | 1989-10-10 |
| KR900700462A (ko) | 1990-08-13 |
| NO894088L (no) | 1989-10-12 |
| EP0357788B1 (en) | 1993-11-03 |
| WO1989007594A1 (en) | 1989-08-24 |
| US5110925A (en) | 1992-05-05 |
| NO894088D0 (no) | 1989-10-12 |
| KR910005233B1 (ko) | 1991-07-24 |
| CA1320957C (en) | 1993-08-03 |
| ES2012646A6 (es) | 1990-04-01 |
| EP0357788A1 (en) | 1990-03-14 |
| NO176275C (no) | 1995-03-08 |
| JP2717687B2 (ja) | 1998-02-18 |
| FI95570B (fi) | 1995-11-15 |
| DE68910447D1 (de) | 1993-12-09 |
| FI894844A0 (fi) | 1989-10-12 |
| JPH0256468A (ja) | 1990-02-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B1 | Patent granted (law 1993) | ||
| PBP | Patent lapsed |