DK509884A - Haemoglobinholdige forbindelser og fremgangsmaade til deres fremstilling - Google Patents

Haemoglobinholdige forbindelser og fremgangsmaade til deres fremstilling Download PDF

Info

Publication number: DK509884A
Authority: DK; Denmark
Prior art keywords: haemoglobin; molecular weight; linked; procedures; preparation
Prior art date: 1983-10-28

Application number

DK509884A

Other languages

English (en)

Other versions

DK162395C (da

DK509884D0 (da

DK162395B (da

Inventor

Jeffrey Tze-Fei Wong

Original Assignee

Fisons Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-10-28

Filing date

1984-10-25

Publication date

1985-04-29

1984-10-25 Application filed by Fisons Plc filed Critical Fisons Plc

1984-10-25 Publication of DK509884D0 publication Critical patent/DK509884D0/da

1985-04-29 Publication of DK509884A publication Critical patent/DK509884A/da

1991-10-21 Publication of DK162395B publication Critical patent/DK162395B/da

1992-03-09 Application granted granted Critical

1992-03-09 Publication of DK162395C publication Critical patent/DK162395C/da

Links

238000000034 method Methods 0.000 title abstract 2
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 3
229910052760 oxygen Inorganic materials 0.000 abstract 3
239000001301 oxygen Substances 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 2
239000003446 ligand Substances 0.000 abstract 2
INAPMGSXUVUWAF-GCVPSNMTSA-N [(2r,3s,5r,6r)-2,3,4,5,6-pentahydroxycyclohexyl] dihydrogen phosphate Chemical compound OC1[C@H](O)[C@@H](O)C(OP(O)(O)=O)[C@H](O)[C@@H]1O INAPMGSXUVUWAF-GCVPSNMTSA-N 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
238000009472 formulation Methods 0.000 abstract 1
150000004676 glycans Chemical class 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 abstract 1
229920000642 polymer Polymers 0.000 abstract 1
229920001282 polysaccharide Polymers 0.000 abstract 1
239000005017 polysaccharide Substances 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08H—DERIVATIVES OF NATURAL MACROMOLECULAR COMPOUNDS
- C08H1/00—Macromolecular products derived from proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0021—Dextran, i.e. (alpha-1,4)-D-glucan; Derivatives thereof, e.g. Sephadex, i.e. crosslinked dextran

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Polymers & Plastics (AREA)
Materials Engineering (AREA)
General Chemical & Material Sciences (AREA)
Diabetes (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Hematology (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Dental Preparations (AREA)
Medicinal Preparation (AREA)

DK509884A 1983-10-28 1984-10-25 Vandoploeselige haemoglobinholdige forbindelser,fremgangsmaade til deres fremstilling samt farmaceutiske praeparater indeholdende forbindelserne DK162395C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB838328917A GB8328917D0 (en)	1983-10-28	1983-10-28	Blood substitute
GB8328917		1983-10-28

Publications (4)

Publication Number	Publication Date
DK509884D0 DK509884D0 (da)	1984-10-25
DK509884A true DK509884A (da)	1985-04-29
DK162395B DK162395B (da)	1991-10-21
DK162395C DK162395C (da)	1992-03-09

Family

ID=10550912

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK509884A DK162395C (da)	1983-10-28	1984-10-25	Vandoploeselige haemoglobinholdige forbindelser,fremgangsmaade til deres fremstilling samt farmaceutiske praeparater indeholdende forbindelserne

Country Status (12)

Country	Link
US (2)	US4650786A (da)
EP (1)	EP0140640B1 (da)
JP (2)	JPH0643444B2 (da)
AT (1)	ATE51629T1 (da)
AU (1)	AU567593B2 (da)
CA (1)	CA1236014A (da)
DE (1)	DE3481844D1 (da)
DK (1)	DK162395C (da)
FI (1)	FI74979C (da)
GB (1)	GB8328917D0 (da)
IL (1)	IL73334A (da)
NO (1)	NO165709C (da)

Families Citing this family (45)

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US4831012A (en) *	1984-03-23	1989-05-16	Baxter International Inc.	Purified hemoglobin solutions and method for making same
US5464814A (en) *	1986-06-20	1995-11-07	Northfield Laboratories, Inc.	Acellular red blood cell substitute
FR2600894B1 (fr) *	1986-07-02	1989-01-13	Centre Nat Rech Scient	Conjugues macromoleculaires d'hemoglobine, leur procede de preparation et leurs applications
DE3636590A1 (de) *	1986-10-28	1988-05-26	Braun Melsungen Ag	Blutersatzmittel
US5449759A (en) *	1987-05-16	1995-09-12	Somatogen, Inc.	Hemoglobins with intersubunit desulfide bonds
GB8712240D0 (en) *	1987-05-23	1987-07-01	Fisons Plc	Pharmaceutical formulation
DK110188D0 (da) *	1988-03-02	1988-03-02	Claus Selch Larsen	High molecular weight prodrug derivatives of antiinflammatory drugs
FR2630329B1 (fr) *	1988-04-20	1991-07-05	Merieux Inst	Conjugues macromoleculaires d'hemoglobine, leur procede de preparation et leurs applications
US4900780A (en) *	1988-05-25	1990-02-13	Masonic Medical Research Laboratory	Acellular resuscitative fluid
DE69117054T2 (de) *	1990-03-14	1996-06-27	Univ Toronto	Acylphosphatester und modifikation von proteinen damit
US6172039B1 (en)	1990-04-16	2001-01-09	Apex Bioscience, Inc.	Expression of recombinant hemoglobin and hemoglobin variants in yeast
US5334705A (en) *	1991-08-15	1994-08-02	Duke University	Benzenetricarboxylate derivative-crosslinked low oxygen affinity hemoglobin
EP0611306B1 (en) *	1991-11-08	1998-07-08	Somatogen, Inc.	Hemoglobins as drug delivery agents
US5900477A (en) *	1992-01-30	1999-05-04	Baxter International, Inc.	Use of hemoglobin in the treatment of hemorrhagic shock
US5334706A (en) *	1992-01-30	1994-08-02	Baxter International	Administration of low dose hemoglobin to increase perfusion
US5554638A (en) *	1993-05-24	1996-09-10	Duke University	Methods for improving therapeutic effectiveness of agents for the treatment of solid tumors and other disorders
US5612310A (en) *	1993-05-24	1997-03-18	Duke University	Methods for improving therapeutic effectiveness of agents for the treatment of solid tumors and other disorders
US5840851A (en) *	1993-07-23	1998-11-24	Plomer; J. Jeffrey	Purification of hemoglobin
US5578564A (en) *	1993-07-23	1996-11-26	Somatogen, Inc.	Nickel-free hemoglobin and methods for producing such hemoglobin
US5631219A (en) *	1994-03-08	1997-05-20	Somatogen, Inc.	Method of stimulating hematopoiesis with hemoglobin
US6242417B1 (en)	1994-03-08	2001-06-05	Somatogen, Inc.	Stabilized compositions containing hemoglobin
US6458762B1 (en)	1994-03-28	2002-10-01	Baxter International, Inc.	Therapeutic use of hemoglobin for preserving tissue viability and reducing restenosis
EP0767675A4 (en) *	1995-04-10	1998-08-05	Baxter Int	USE OF CROSS-LINKED HEMOGLOBIN IN THE TREATMENT OF SUBARACHNOIDAL BLEEDING
US5733869A (en) *	1995-10-06	1998-03-31	Baxter International, Inc.	Therapeutic administration of hemoglobin in cardiac arrest
WO1998017289A1 (en) *	1996-10-21	1998-04-30	Baxter International Inc.	Therapeutic use of hemoglobin to treat head injury
ATE302019T1 (de)	1997-02-28	2005-09-15	Univ California	Verfahren und zusammensetzungen zur optimierung des sauerstofftransportes in zellfreien systemen
US5814601A (en) *	1997-02-28	1998-09-29	The Regents Of The University Of California	Methods and compositions for optimization of oxygen transport by cell-free systems
US6894150B1 (en)	1999-10-01	2005-05-17	Ross Walden Tye	Non-pyrogenic, endotoxin-free, stroma-free tetrameric hemoglobin
CA2319966A1 (en) *	2000-09-19	2002-03-19	Dextro-Sang Corporation	Improved dextran-hemoglobin conjugate as potential blood substitute
FR2828206B1 (fr) *	2001-08-03	2004-09-24	Centre Nat Rech Scient	Utilisation d'inhibiteurs des lysyl oxydases pour la culture cellulaire et le genie tissulaire
US20030153491A1 (en) *	2002-01-11	2003-08-14	Winslow Robert M.	Methods and compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
US20050164915A1 (en) *	2002-04-01	2005-07-28	Sangart, Inc.	Compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
US7084115B2 (en) *	2002-04-29	2006-08-01	Oxyplus, Inc.	Inositol pyrophosphates, and methods of use thereof
JP3912206B2 (ja) *	2002-07-05	2007-05-09	株式会社日立製作所	筒内直接燃料噴射装置用燃料ポンプ
US7135553B2 (en) *	2003-01-29	2006-11-14	Northfield Laboratories, Inc.	Polymerized hemoglobin solutions having reduced amounts of tetramer and method for preparing
US7745423B2 (en) *	2004-07-06	2010-06-29	NormOxys, Inc	Calcium/sodium salt of inositol tripyrophosphate as an allosteric effector of hemoglobin
US20060258626A1 (en) *	2004-07-06	2006-11-16	Claude Nicolau	Use of inositol-tripyrophosphate in treating tumors and diseases
US20060106000A1 (en) *	2004-07-06	2006-05-18	Claude Nicolau	Use of inositol-tripyrophosphate in treating tumors and diseases
US20070135389A1 (en) *	2004-07-06	2007-06-14	Claude Nicolau	Tumor eradication by inositol-tripyrophosphate
US20070196810A1 (en) *	2006-01-24	2007-08-23	Northfield Laboratories Inc.	Polymerized Hemoglobin Media and its Use in Isolation and Transplantation of Islet Cells
US20090004159A1 (en) *	2006-01-24	2009-01-01	The Board Of Trustees Of The University Of Illinoi	Polymerized Hemoglobin Media and Its Use in Isolation and Transplantation of Islet Cells
US7494974B2 (en) *	2006-10-24	2009-02-24	Ikor, Inc.	Carboxymethylated cross-linked tetrameric hemoglobin
US7504377B2 (en) *	2006-10-23	2009-03-17	Ikor, Inc.	Nitric oxide-blocked cross-linked tetrameric hemoglobin
CN101784193A (zh) *	2007-05-01	2010-07-21	诺尔姆奥克西斯公司	促红细胞生成素互补或替代
US20140227677A1 (en) *	2013-02-07	2014-08-14	OPK Biotech, LLC	Perfusion of prospective donor hearts with polymerized hemoglobin

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2449885C3 (de) *	1974-10-21	1980-04-30	Biotest-Serum-Institut Gmbh, 6000 Frankfurt	Verfahren zur Herstellung von chemisch modifizierten haltbaren Hämoglobinpräparaten sowie das nach diesem Verfahren hergestellte modifizierte Hämoglobinpräparat
US4053590A (en) *	1975-02-27	1977-10-11	Alza Corporation	Compositions of matter comprising macromolecular hemoglobin
CA1055932A (en) *	1975-10-22	1979-06-05	Hematech Inc.	Blood substitute based on hemoglobin
DE2616086C2 (de) *	1976-04-13	1986-04-03	Dr. Eduard Fresenius, Chemisch-pharmazeutische Industrie KG, 6380 Bad Homburg	Substanz zur Verwendung in einem kolloidalen Blutvolumenersatzmittel aus Hydroxyethylstärke und Hämoglobin
US4136093A (en) *	1976-04-23	1979-01-23	Biotest-Serum-Institut Gmbh	Hemoglobin preparation with increased oxygen release
DE2740053A1 (de) *	1977-09-06	1979-05-03	Klaus Prof Dr Med Gersonde	Verwendung von allosterischen effektoren mit hilfe von lipidvesikeln ueber eine irreversible inkorporierung zwecks verbesserter o tief 2 -entladung des haemoglobins in erythrozyten
JPS5716815A (en) *	1980-07-02	1982-01-28	Ajinomoto Co Inc	Oxygen transporting agent for artificial blood
US4343715A (en) *	1980-10-10	1982-08-10	Duke University	Immobilized hemoglobin, and processes for extracting oxygen from fluids using the same
US4401652A (en) *	1980-12-31	1983-08-30	Allied Corporation	Process for the preparation of stroma-free hemoglobin solutions
JPS57206622A (en) *	1981-06-10	1982-12-18	Ajinomoto Co Inc	Blood substitute
IN158551B (da) *	1981-08-12	1986-12-06	Gen Electric Co Plc
US4473496A (en) *	1981-09-14	1984-09-25	The United States Of America As Represented By The Secretary Of The Army	Intramolecularly crosslinked hemoglobin
DE3144705C2 (de) *	1981-11-11	1983-12-08	Biotest-Serum-Institut Gmbh, 6000 Frankfurt	Verfahren zur Herstellung eines lagerstabilen, vernetzten Hämoglobinpräparates mit hoher Sauerstoff-Transportkapazität, sowie das nach diesem Verfahren hergestellte Hämoglobinpräparat
US4529719A (en) *	1983-05-04	1985-07-16	Tye Ross W	Modified crosslinked stroma-free tetrameric hemoglobin
FR2551660B1 (fr) *	1983-09-13	1986-11-14	Centre Nat Rech Scient	Hemoglobine modifiee chimiquement, sa preparation, solutions aqueuses en contenant et leur utilisation
US4600531A (en) *	1984-06-27	1986-07-15	University Of Iowa Research Foundation	Production of alpha-alpha cross-linked hemoglobins in high yield

1983
- 1983-10-28 GB GB838328917A patent/GB8328917D0/en active Pending
1984
- 1984-10-16 DE DE8484307070T patent/DE3481844D1/de not_active Expired - Fee Related
- 1984-10-16 EP EP84307070A patent/EP0140640B1/en not_active Expired - Lifetime
- 1984-10-16 AT AT84307070T patent/ATE51629T1/de not_active IP Right Cessation
- 1984-10-19 US US06/662,588 patent/US4650786A/en not_active Expired - Lifetime
- 1984-10-25 DK DK509884A patent/DK162395C/da not_active IP Right Cessation
- 1984-10-26 NO NO844282A patent/NO165709C/no not_active IP Right Cessation
- 1984-10-26 IL IL73334A patent/IL73334A/xx not_active IP Right Cessation
- 1984-10-26 CA CA000466410A patent/CA1236014A/en not_active Expired
- 1984-10-26 AU AU34753/84A patent/AU567593B2/en not_active Ceased
- 1984-10-26 JP JP59224269A patent/JPH0643444B2/ja not_active Expired - Lifetime
- 1984-10-26 FI FI844204A patent/FI74979C/fi not_active IP Right Cessation
1986
- 1986-09-12 US US06/906,371 patent/US4710488A/en not_active Expired - Lifetime
1993
- 1993-10-13 JP JP5254619A patent/JPH0714961B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
NO844282L (no)	1985-04-29
FI74979C (fi)	1988-04-11
EP0140640A3 (en)	1986-05-28
DK162395C (da)	1992-03-09
US4650786A (en)	1987-03-17
DE3481844D1 (de)	1990-05-10
DK509884D0 (da)	1984-10-25
EP0140640A2 (en)	1985-05-08
JPS60123503A (ja)	1985-07-02
ATE51629T1 (de)	1990-04-15
GB8328917D0 (en)	1983-11-30
AU3475384A (en)	1985-05-09
NO165709C (no)	1991-04-03
US4710488A (en)	1987-12-01
IL73334A0 (en)	1985-01-31
JPH0643444B2 (ja)	1994-06-08
JPH06298802A (ja)	1994-10-25
FI844204L (fi)	1985-04-29
IL73334A (en)	1989-03-31
CA1236014A (en)	1988-05-03
FI74979B (fi)	1987-12-31
EP0140640B1 (en)	1990-04-04
JPH0714961B2 (ja)	1995-02-22
NO165709B (no)	1990-12-17
AU567593B2 (en)	1987-11-26
FI844204A0 (fi)	1984-10-26
DK162395B (da)	1991-10-21

Legal Events

Date	Code	Title	Description
1996-06-17	PBP	Patent lapsed
1996-10-14	PGE	Re-establishment of rights: approved
2004-06-07	PBP	Patent lapsed	Country of ref document: DK

Publication	Publication Date	Title
DK509884D0 (da)	1984-10-25	Haemoglobinholdige forbindelser og fremgangsmaade til deres fremstilling
EP0310321A3 (en)	1991-02-06	Immunomodulatory azaspiranes
IL77396A (en)	1990-02-09	Pharmaceutical compositions containing bicyclic heteroarylpiperazine derivatives,certain such novel compounds and their preparation
ES8307806A1 (es)	1983-08-01	"procedimiento para la preparacion de 1,2-a piridinas y pirazinas".
AU3085184A (en)	1985-01-24	Silicon hydride compounds and polymers modified therewith
LU88306I2 (fr)	1994-05-04	Felodipine (Plendil)
ES8703472A1 (es)	1987-02-16	Procedimiento para preparar nuevos derivados imidazo
ES8700942A1 (es)	1986-12-01	Procedimiento para la fabricacion de un agente para dialisisperitoneal
ES8604258A1 (es)	1986-01-16	Un procedimiento para preparar una adenosina sustituida en n6
MY105538A (en)	1994-10-31	Derivatives of thieno-triazolo-diazepine, a preparation process of the same and therapeutic compositions containing them.
ATE52075T1 (de)	1990-05-15	Insektizide alkene.
ES8607313A1 (es)	1986-05-16	Un metodo de preparar espiro-(benzofuran-azalcanos)
EA199900897A2 (ru)	2000-06-26	Катализаторы на основе ванадия, их получение и применение при (со)полимеризации альфа-олефинов
ES8600768A1 (es)	1985-10-16	Imidazotiadiazolalquencarboxiamidas
ES2000614A6 (es)	1988-03-01	Procedimiento de obtencion de nuevos complejos de platino (ii) derivados del 2,3-dimercapto-2-butene-dinitrilato (2-)-s,s'"
ES511836A0 (es)	1983-07-01	"procedimiento para la preparacion de nuevos a1-pirrolin-tiolactimeteres".
IE820960L (en)	1982-10-24	Dioxaheterocyclic compounds