DK531089A - Bicycliske imidazolforbindelser til anvendelse ved behandling af hyperaldosteronisme - Google Patents

Bicycliske imidazolforbindelser til anvendelse ved behandling af hyperaldosteronisme

Info

Publication number: DK531089A
Authority: DK; Denmark
Prior art keywords: hyperaldosteronism; treatment; imidazole compounds; compounds; bicyclic imidazole
Prior art date: 1988-10-26

Application number

DK531089A

Other languages

Danish (da)

English (en)

Other versions

DK531089D0 (da

Inventor

Albert Haeusler

Ajay Bhatnagar

Original Assignee

Ciba Geigy Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-10-26

Filing date

1989-10-25

Publication date

1990-04-27

1989-10-25 Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag

1989-10-25 Publication of DK531089D0 publication Critical patent/DK531089D0/da

1990-04-27 Publication of DK531089A publication Critical patent/DK531089A/da

Links

206010020571 Hyperaldosteronism Diseases 0.000 title abstract 4
201000009395 primary hyperaldosteronism Diseases 0.000 title abstract 4
RAXXELZNTBOGNW-UHFFFAOYSA-N 1H-imidazole Chemical class C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
CLPFFLWZZBQMAO-UHFFFAOYSA-N 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile Chemical compound C1=CC(C#N)=CC=C1C1N2C=NC=C2CCC1 CLPFFLWZZBQMAO-UHFFFAOYSA-N 0.000 abstract 1
-1 bicyclic imidazole compounds Chemical class 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
231100000252 nontoxic Toxicity 0.000 abstract 1
230000003000 nontoxic effect Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones

Landscapes

Health & Medical Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Endocrinology (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK531089A 1988-10-26 1989-10-25 Bicycliske imidazolforbindelser til anvendelse ved behandling af hyperaldosteronisme DK531089A (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CH399488		1988-10-26

Publications (2)

Publication Number	Publication Date
DK531089D0 DK531089D0 (da)	1989-10-25
DK531089A true DK531089A (da)	1990-04-27

Family

ID=4267831

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK531089A DK531089A (da)	1988-10-26	1989-10-25	Bicycliske imidazolforbindelser til anvendelse ved behandling af hyperaldosteronisme

Country Status (12)

Country	Link
US (1)	US5057521A (fr)
EP (1)	EP0366609B1 (fr)
JP (1)	JPH02169518A (fr)
KR (1)	KR900005976A (fr)
AT (1)	ATE104852T1 (fr)
AU (1)	AU631814B2 (fr)
CA (1)	CA2001301A1 (fr)
DE (1)	DE58907570D1 (fr)
DK (1)	DK531089A (fr)
IE (1)	IE63481B1 (fr)
IL (1)	IL92078A (fr)
ZA (1)	ZA898074B (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH683151A5 (de) *	1991-04-24	1994-01-31	Ciba Geigy Ag	Antikonzeption bei weiblichen Primaten ohne Beeinflussung des menstruellen Zyklus.
US6333335B1 (en)	1999-07-23	2001-12-25	Merck & Co., Inc.	Phenyl-protein transferase inhibitors
US20030083342A1 (en) *	2002-08-27	2003-05-01	Steele Ronald Edward	Combination of organic compounds
CA2429133C (fr) *	2000-11-17	2009-08-18	Takeda Chemical Industries, Ltd.	Nouveaux derives imidazole, procede de production correspondant et utilisation de ces derives
AR049126A1 (es) *	2004-05-28	2006-06-28	Speedel Experimenta Ag	Derivados de 5, 6, 7, 8 - tetrahidroimidazo[1,5a]piridina con actividad inhibitoria de la aldosterona sintasa, composiciones farmaceuticas que los contienen y su uso en la preparacion de medicamentos para el tratamiento del hiperaldosterismo y del sindrome de cushing.
US7612088B2 (en) *	2004-05-28	2009-11-03	Speedel Experimenta Ag	Heterocyclic compounds and their use as aldosterone synthase inhibitors
US20080076794A1 (en) *	2004-05-28	2008-03-27	Peter Herold	Heterocyclic Compounds And Their Use As Aldosterone Synthase Inhibitors
TW200716105A (en) *	2005-05-31	2007-05-01	Speedel Experimenta Ag	Imidazole compounds
GT200600381A (es)	2005-08-25	2007-03-28		Compuestos organicos
TW200804378A (en) *	2005-12-09	2008-01-16	Speedel Experimenta Ag	Organic compounds
EP1842543A1 (fr)	2006-04-05	2007-10-10	Speedel Pharma AG	Composition pharmaceutique comprennant un inhibiteur de l'aldosteron synthase et un antagoniste de recepteur mineralcorticoide
DE102008022221A1 (de) *	2008-05-06	2009-11-12	Universität des Saarlandes	Inhibitoren der humanen Aldosteronsynthase CYP11B2
US8541404B2 (en) *	2009-11-09	2013-09-24	Elexopharm Gmbh	Inhibitors of the human aldosterone synthase CYP11B2
AR086665A1 (es)	2011-06-14	2014-01-15	Lilly Co Eli	Inhibidor de aldosterona sintasa y composiciones farmaceuticas
WO2018078049A1 (fr)	2016-10-27	2018-05-03	Damian Pharma Ag	Inhibiteur de l'aldostérone synthase
SG11201903803UA (en)	2016-10-27	2019-05-30	Damian Pharma Ag	Aldosterone synthase inhibitor
WO2019211394A1 (fr)	2018-05-03	2019-11-07	Damian Pharma Ag	R-fadrozole destiné à être utilisé dans le traitement de l'aldostéronisme
CN110507630A (zh) *	2019-09-29	2019-11-29	陈汝霖	一种便携式腔道杀菌软胶囊

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4889861A (en) *	1982-12-21	1989-12-26	Ciba-Geigy Corp.	Substituted imidazo[1,5-a]pyridine derivatives and other substituted bicyclic derivatives and their use as aromatase inhibitors
US4588732A (en) *	1982-12-21	1986-05-13	Ciba-Geigy Corporation	Certain imidazo(1,5-a)pyridine derivatives and their use as thromboxane synthetase inhibitors
US4617307A (en) *	1984-06-20	1986-10-14	Ciba-Geigy Corporation	Substituted imidazo[1,5-A]pyridine derivatives as aromatase inhibitors
US4728645A (en) *	1982-12-21	1988-03-01	Ciba-Geigy Corporation	Substituted imidazo[1,5-A]pyridine derivatives and other substituted bicyclic derivatives, useful as aromatase inhibitors

1989
- 1989-09-26 US US07/412,369 patent/US5057521A/en not_active Expired - Fee Related
- 1989-10-17 DE DE58907570T patent/DE58907570D1/de not_active Expired - Fee Related
- 1989-10-17 EP EP89810787A patent/EP0366609B1/fr not_active Expired - Lifetime
- 1989-10-17 AT AT8989810787T patent/ATE104852T1/de not_active IP Right Cessation
- 1989-10-22 IL IL9207889A patent/IL92078A/en not_active IP Right Cessation
- 1989-10-24 AU AU43722/89A patent/AU631814B2/en not_active Ceased
- 1989-10-24 CA CA002001301A patent/CA2001301A1/fr not_active Abandoned
- 1989-10-25 IE IE344189A patent/IE63481B1/en not_active IP Right Cessation
- 1989-10-25 KR KR1019890015327A patent/KR900005976A/ko not_active Ceased
- 1989-10-25 DK DK531089A patent/DK531089A/da not_active Application Discontinuation
- 1989-10-25 ZA ZA898074A patent/ZA898074B/xx unknown
- 1989-10-26 JP JP1277326A patent/JPH02169518A/ja active Pending

Also Published As

Publication number	Publication date
ZA898074B (en)	1990-08-29
JPH02169518A (ja)	1990-06-29
DK531089D0 (da)	1989-10-25
AU631814B2 (en)	1992-12-10
IE893441L (en)	1990-04-26
AU4372289A (en)	1990-05-31
IE63481B1 (en)	1995-05-03
ATE104852T1 (de)	1994-05-15
EP0366609A2 (fr)	1990-05-02
IL92078A0 (en)	1990-07-12
DE58907570D1 (de)	1994-06-01
US5057521A (en)	1991-10-15
KR900005976A (ko)	1990-05-07
IL92078A (en)	1995-08-31
CA2001301A1 (fr)	1990-04-26
EP0366609A3 (fr)	1992-01-02
EP0366609B1 (fr)	1994-04-27

Legal Events

Date	Code	Title	Description
1992-07-27	AHB	Application shelved due to non-payment
1999-07-19	AHB	Application shelved due to non-payment

Publication	Publication Date	Title
AU631814B2 (en)	1992-12-10	Use of bicyclic imidazole compounds for the treatment of hyperaldosteronism
AU544345B2 (en)	1985-05-23	Imidazo(1,2-a)pyridine derivatives
CA2272705A1 (fr)	1998-06-04	Derives de pyrimidines bicycliques fusionnes
DK0802913T3 (da)	2000-09-25	Imidazo[4,5-c]quinolinaminer
BG101934A (en)	1999-04-30	Imidazo(1,2-a)pyridine derivatives
ES8308327A1 (es)	1983-08-16	Un procedimiento para la preparacion de nuevos derivados biciclicos de piridin-5-ona.
DE3478810D1 (en)	1989-08-03	Benzazocinone and benzazoninone derivatives, process for their preparation, pharmaceutical preparations containing these compounds, and their therapeutical use
NO954878L (no)	1996-06-03	Pyrrolderivater
PT83080A (en)	1986-08-01	Process for the preparation of biciclic naphthyridine compounds or analogs and their salts soluates hydrates and esters
FI981709L (fi)	1998-08-06	Menetelmä 5-substituoitujen 2-amino-4-okso-pyrrolo/2,3-d/-pyrimidiinien valmistamiseksi
AU549240B2 (en)	1986-01-23	Imidazo(pyrimido)(1,2-c)quinazoles and imidazol(1,2-c( pyrido)2,3-e)pyrimidines
FI955906A7 (fi)	1996-02-02	O6-substituoituja guaniinijohdannaisia, menetelmä niiden valmistamiseksi ja niiden käyttö kasvainsolujen hoidossa
ID29790A (id)	2001-10-11	PENGGUNAAN IMIDAZO(1,5-a)-PIRIDO(3,2-e)-PIRAZINON SEBAGAI OBAT
DK1109814T3 (da)	2004-08-02	5-Heterocyclylpyrazolo[4,3-d]pyrimidin-7-oner til behandling af mandlig erektil dysfunktion
DE69908608D1 (de)	2003-07-10	Derivate von Imidazo[1,2-a]pyridin zur Behandlung von gastrointestinalen Krankheiten
DE69320668D1 (de)	1998-10-08	Verfahren zur Herstellung von Imidazo(4,5-b)Pyridinderivaten
FI911533A7 (fi)	1991-10-01	Bentsoksatsiini-johdannaisia, menetelmä niiden valmistamiseksi ja niiden käyttö sairauksien hoitamiseen tai ennalta ehkäisemiseksi
PT1025101E (pt)	2003-04-30	Derivados de nafto-imidazo¬1,2-a\|piridina sua preparacao e uso no tratamento de perturbacoes do sistema nervoso central
NO984196D0 (no)	1998-09-11	Fremgangsmåte for behandling av stoffmisbruk
GB8812620D0 (en)	1988-06-29	Pharmaceutical composition for treatment of migraine &c
HK1004889A1 (en)	1998-12-11	Pharmaceutical formulations containing vincamine for treatment of peripheral vascular diseases
PH24031A (en)	1990-02-09	Pharmaceutical formulation for the treatment of androgenetic alopecia
SE8604669D0 (sv)	1986-10-31	Medel for behandling av svampinfektioner i naglar
HRP930588B1 (en)	1997-10-31	Process for the preparation of therapeutic transdermal system having physostigmine as an active ingredient