DK537589A - Renininhiberende peptidasesubstratanaloge, hydrater, isostere eller farmaceutisk acceptable salte deraf - Google Patents
Renininhiberende peptidasesubstratanaloge, hydrater, isostere eller farmaceutisk acceptable salte derafInfo
- Publication number
- DK537589A DK537589A DK537589A DK537589A DK537589A DK 537589 A DK537589 A DK 537589A DK 537589 A DK537589 A DK 537589A DK 537589 A DK537589 A DK 537589A DK 537589 A DK537589 A DK 537589A
- Authority
- DK
- Denmark
- Prior art keywords
- isosters
- hydrates
- inhibited
- pure
- acceptable salts
- Prior art date
Links
- 108091005804 Peptidases Proteins 0.000 title abstract 2
- 102000035195 Peptidases Human genes 0.000 title abstract 2
- 235000019833 protease Nutrition 0.000 title abstract 2
- 239000000758 substrate Substances 0.000 title abstract 2
- 150000004677 hydrates Chemical class 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 108090000783 Renin Proteins 0.000 abstract 1
- 102100028255 Renin Human genes 0.000 abstract 1
- 150000001412 amines Chemical group 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- -1 difluoro-methylene moiety Chemical group 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/20—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/18—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by doubly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Crystallography & Structural Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Luminescent Compositions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compounds Of Unknown Constitution (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
- Radio Relay Systems (AREA)
- Pyridine Compounds (AREA)
- Pyrrole Compounds (AREA)
- Photoreceptors In Electrophotography (AREA)
- Inspection Of Paper Currency And Valuable Securities (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP88402735A EP0371179A1 (en) | 1988-10-28 | 1988-10-28 | Novel analogs of peptidase substrates |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK537589D0 DK537589D0 (da) | 1989-10-27 |
| DK537589A true DK537589A (da) | 1990-04-29 |
Family
ID=8200435
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK537589A DK537589A (da) | 1988-10-28 | 1989-10-27 | Renininhiberende peptidasesubstratanaloge, hydrater, isostere eller farmaceutisk acceptable salte deraf |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5114927A (da) |
| EP (2) | EP0371179A1 (da) |
| JP (1) | JP2899327B2 (da) |
| CN (1) | CN1031880C (da) |
| AT (1) | ATE147405T1 (da) |
| AU (1) | AU622723B2 (da) |
| CA (1) | CA2001265C (da) |
| DE (1) | DE68927630T2 (da) |
| DK (1) | DK537589A (da) |
| ES (1) | ES2099072T3 (da) |
| FI (1) | FI95272C (da) |
| GR (1) | GR3023027T3 (da) |
| HU (1) | HU209311B (da) |
| IL (1) | IL92102A (da) |
| NO (1) | NO301074B1 (da) |
| PH (1) | PH27239A (da) |
| PT (1) | PT92140B (da) |
| ZA (1) | ZA898026B (da) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0356595A1 (en) * | 1988-09-01 | 1990-03-07 | Merrell Dow Pharmaceuticals Inc. | Novel peptidase inhibitors |
| ZA905737B (en) * | 1989-07-26 | 1991-05-29 | Merrell Dow Pharma | Novel peptidase inhibitors |
| IL95380A0 (en) * | 1989-09-05 | 1991-06-30 | Abbott Lab | Peptidyl difluorodiol renin inhibitors |
| US5478811A (en) * | 1991-08-22 | 1995-12-26 | Merrell Dow Pharmaceuticals Inc. | Orally-active elastase inhibitors |
| US5714470A (en) | 1991-08-22 | 1998-02-03 | Merrell Pharmaceuticals, Inc. | Orally-active elastase inhibitors |
| DE69522940T2 (de) * | 1994-06-02 | 2002-04-04 | Merrell Pharmaceuticals Inc., Cincinnati | Acylierte enolderivate als vorläufdrogen von elastaseinhibitoren |
| NZ284766A (en) * | 1994-06-02 | 1998-06-26 | Merrell Pharma Inc | Perfluoro amino ketones; medicaments as elastase inhibitors |
| US6172044B1 (en) | 1995-12-01 | 2001-01-09 | Aventis Pharmaceuticals Inc. | Acylated enol derivative of α-ketoesters and α-ketoamides |
| US5948886A (en) * | 1996-11-20 | 1999-09-07 | Hoechst Marion Roussel, Inc. | Acylated enol derivatives of α-ketoesters and α-ketoamides |
| KR100509388B1 (ko) | 1996-10-18 | 2005-08-23 | 버텍스 파마슈티칼스 인코포레이티드 | 세린 프로테아제, 특히 간염 ｃ 바이러스 ｎｓ３ 프로테아제의 저해제 |
| TWI359147B (en) | 2003-09-05 | 2012-03-01 | Vertex Pharma | Inhibitors of serine proteases, particularly hcv n |
| FR2914920B1 (fr) * | 2007-04-11 | 2011-09-09 | Clariant Specialty Fine Chem F | Procede de deacetalisation d'alpha-aminoacetals. |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4518528A (en) * | 1983-05-19 | 1985-05-21 | Rasnick David W | α Amino fluoro ketones |
| CA1341029C (en) * | 1985-02-04 | 2000-06-20 | Michael Kolb | Peptidase inhibitors |
| FI865196A7 (fi) * | 1985-04-19 | 1986-12-18 | Upjohn Co | Halostatiinisubstituoituja reniini-inhibiittoreita. |
| ATE71934T1 (de) * | 1985-06-07 | 1992-02-15 | Ici America Inc | Selektionierte difluorverbindungen. |
| EP0258289A4 (en) * | 1986-01-16 | 1991-01-02 | Joseph Dellaria | Peptide analogs |
| ES2052560T3 (es) * | 1986-06-05 | 1994-07-16 | Ici America Inc | Compuestos difluorcetonicos. |
| NZ223148A (en) * | 1987-01-16 | 1989-10-27 | Merrell Dow Pharma | Peptide derivatives having peptidase inhibition activity |
-
1988
- 1988-10-28 EP EP88402735A patent/EP0371179A1/en not_active Withdrawn
-
1989
- 1989-10-23 ZA ZA898026A patent/ZA898026B/xx unknown
- 1989-10-23 CA CA002001265A patent/CA2001265C/en not_active Expired - Fee Related
- 1989-10-24 IL IL9210289A patent/IL92102A/en not_active IP Right Cessation
- 1989-10-27 DK DK537589A patent/DK537589A/da not_active Application Discontinuation
- 1989-10-27 AT AT89402976T patent/ATE147405T1/de not_active IP Right Cessation
- 1989-10-27 ES ES89402976T patent/ES2099072T3/es not_active Expired - Lifetime
- 1989-10-27 AU AU43867/89A patent/AU622723B2/en not_active Ceased
- 1989-10-27 HU HU895473A patent/HU209311B/hu not_active IP Right Cessation
- 1989-10-27 PT PT92140A patent/PT92140B/pt not_active IP Right Cessation
- 1989-10-27 NO NO894300A patent/NO301074B1/no not_active IP Right Cessation
- 1989-10-27 EP EP89402976A patent/EP0368719B1/en not_active Expired - Lifetime
- 1989-10-27 FI FI895109A patent/FI95272C/fi not_active IP Right Cessation
- 1989-10-27 JP JP1278753A patent/JP2899327B2/ja not_active Expired - Fee Related
- 1989-10-27 PH PH39423A patent/PH27239A/en unknown
- 1989-10-27 DE DE68927630T patent/DE68927630T2/de not_active Expired - Fee Related
- 1989-10-28 CN CN89108935A patent/CN1031880C/zh not_active Expired - Fee Related
-
1991
- 1991-09-05 US US07/759,057 patent/US5114927A/en not_active Expired - Fee Related
-
1997
- 1997-04-03 GR GR970400694T patent/GR3023027T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE147405T1 (de) | 1997-01-15 |
| IL92102A (en) | 1994-07-31 |
| CA2001265C (en) | 2001-05-01 |
| EP0368719A2 (en) | 1990-05-16 |
| FI95272C (fi) | 1996-01-10 |
| HU209311B (en) | 1994-04-28 |
| AU622723B2 (en) | 1992-04-16 |
| NO894300L (no) | 1990-04-30 |
| HUT51649A (en) | 1990-05-28 |
| GR3023027T3 (en) | 1997-07-30 |
| FI895109A0 (fi) | 1989-10-27 |
| EP0368719A3 (en) | 1991-10-02 |
| PT92140A (pt) | 1990-04-30 |
| PT92140B (pt) | 1996-03-29 |
| CN1043504A (zh) | 1990-07-04 |
| AU4386789A (en) | 1990-05-03 |
| JPH02172961A (ja) | 1990-07-04 |
| FI95272B (fi) | 1995-09-29 |
| CN1031880C (zh) | 1996-05-29 |
| US5114927A (en) | 1992-05-19 |
| EP0368719B1 (en) | 1997-01-08 |
| IL92102A0 (en) | 1990-07-12 |
| CA2001265A1 (en) | 1990-04-28 |
| PH27239A (en) | 1993-05-04 |
| DE68927630D1 (de) | 1997-02-20 |
| DK537589D0 (da) | 1989-10-27 |
| DE68927630T2 (de) | 1997-06-12 |
| EP0371179A1 (en) | 1990-06-06 |
| NO894300D0 (no) | 1989-10-27 |
| JP2899327B2 (ja) | 1999-06-02 |
| HU895473D0 (en) | 1990-01-28 |
| NO301074B1 (no) | 1997-09-08 |
| ZA898026B (en) | 1990-07-25 |
| ES2099072T3 (es) | 1997-05-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AHS | Application shelved for other reasons than non-payment |