DK537589D0 - Renininhiberende peptidasesubstratanaloge, hydrater, isostere eller farmaceutisk acceptable salte deraf - Google Patents

Renininhiberende peptidasesubstratanaloge, hydrater, isostere eller farmaceutisk acceptable salte deraf

Info

Publication number
DK537589D0
DK537589D0 DK537589A DK537589A DK537589D0 DK 537589 D0 DK537589 D0 DK 537589D0 DK 537589 A DK537589 A DK 537589A DK 537589 A DK537589 A DK 537589A DK 537589 D0 DK537589 D0 DK 537589D0
Authority
DK
Denmark
Prior art keywords
isosters
hydrates
inhibited
pure
acceptable salts
Prior art date
Application number
DK537589A
Other languages
English (en)
Other versions
DK537589A (da
Inventor
Daniel Schirlin
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of DK537589D0 publication Critical patent/DK537589D0/da
Publication of DK537589A publication Critical patent/DK537589A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/20—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/18—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Luminescent Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyridine Compounds (AREA)
  • Radio Relay Systems (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Pyrrole Compounds (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Inspection Of Paper Currency And Valuable Securities (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK537589A 1988-10-28 1989-10-27 Renininhiberende peptidasesubstratanaloge, hydrater, isostere eller farmaceutisk acceptable salte deraf DK537589A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP88402735A EP0371179A1 (en) 1988-10-28 1988-10-28 Novel analogs of peptidase substrates

Publications (2)

Publication Number Publication Date
DK537589D0 true DK537589D0 (da) 1989-10-27
DK537589A DK537589A (da) 1990-04-29

Family

ID=8200435

Family Applications (1)

Application Number Title Priority Date Filing Date
DK537589A DK537589A (da) 1988-10-28 1989-10-27 Renininhiberende peptidasesubstratanaloge, hydrater, isostere eller farmaceutisk acceptable salte deraf

Country Status (18)

Country Link
US (1) US5114927A (da)
EP (2) EP0371179A1 (da)
JP (1) JP2899327B2 (da)
CN (1) CN1031880C (da)
AT (1) ATE147405T1 (da)
AU (1) AU622723B2 (da)
CA (1) CA2001265C (da)
DE (1) DE68927630T2 (da)
DK (1) DK537589A (da)
ES (1) ES2099072T3 (da)
FI (1) FI95272C (da)
GR (1) GR3023027T3 (da)
HU (1) HU209311B (da)
IL (1) IL92102A (da)
NO (1) NO301074B1 (da)
PH (1) PH27239A (da)
PT (1) PT92140B (da)
ZA (1) ZA898026B (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0356595A1 (en) * 1988-09-01 1990-03-07 Merrell Dow Pharmaceuticals Inc. Novel peptidase inhibitors
ZA905737B (en) * 1989-07-26 1991-05-29 Merrell Dow Pharma Novel peptidase inhibitors
IL95380A0 (en) * 1989-09-05 1991-06-30 Abbott Lab Peptidyl difluorodiol renin inhibitors
US5714470A (en) 1991-08-22 1998-02-03 Merrell Pharmaceuticals, Inc. Orally-active elastase inhibitors
US5478811A (en) * 1991-08-22 1995-12-26 Merrell Dow Pharmaceuticals Inc. Orally-active elastase inhibitors
DE69522940T2 (de) * 1994-06-02 2002-04-04 Merrell Pharmaceuticals Inc., Cincinnati Acylierte enolderivate als vorläufdrogen von elastaseinhibitoren
EP0763055B1 (en) * 1994-06-02 1999-11-03 Merrell Pharmaceuticals Inc. Perfluoroalkyl ketone inhibitors of elastase and processes for making the same
US6172044B1 (en) 1995-12-01 2001-01-09 Aventis Pharmaceuticals Inc. Acylated enol derivative of α-ketoesters and α-ketoamides
US5948886A (en) * 1996-11-20 1999-09-07 Hoechst Marion Roussel, Inc. Acylated enol derivatives of α-ketoesters and α-ketoamides
AP1019A (en) 1996-10-18 2001-10-16 Vertex Pharma Inhibitors of serinre proteases, particularly hepatitis C virus NS3 protease.
UY28500A1 (es) 2003-09-05 2005-04-29 Vertex Pharma Inhibidores de proteasas de serina, en particular proteasa ns3-ns4a del vhc.
FR2914920B1 (fr) * 2007-04-11 2011-09-09 Clariant Specialty Fine Chem F Procede de deacetalisation d'alpha-aminoacetals.

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4518528A (en) * 1983-05-19 1985-05-21 Rasnick David W α Amino fluoro ketones
ZA86746B (en) * 1985-02-04 1986-09-24 Merrell Dow Pharma Novel peptidase inhibitors
WO1986006379A1 (en) * 1985-04-19 1986-11-06 The Upjohn Company Dihalo-statine substituted renin inhibitors
DE3683541D1 (de) * 1985-06-07 1992-03-05 Ici America Inc Selektionierte difluorverbindungen.
EP0258289A4 (en) * 1986-01-16 1991-01-02 Joseph Dellaria Peptide analogs
GB8711748D0 (en) * 1986-06-05 1987-06-24 Ici America Inc Difluoro keto compounds
NZ223148A (en) * 1987-01-16 1989-10-27 Merrell Dow Pharma Peptide derivatives having peptidase inhibition activity

Also Published As

Publication number Publication date
DE68927630D1 (de) 1997-02-20
NO894300D0 (no) 1989-10-27
ES2099072T3 (es) 1997-05-16
JPH02172961A (ja) 1990-07-04
ATE147405T1 (de) 1997-01-15
EP0371179A1 (en) 1990-06-06
CA2001265C (en) 2001-05-01
ZA898026B (en) 1990-07-25
PT92140A (pt) 1990-04-30
GR3023027T3 (en) 1997-07-30
NO894300L (no) 1990-04-30
IL92102A0 (en) 1990-07-12
JP2899327B2 (ja) 1999-06-02
PH27239A (en) 1993-05-04
IL92102A (en) 1994-07-31
PT92140B (pt) 1996-03-29
AU622723B2 (en) 1992-04-16
FI95272B (fi) 1995-09-29
HU895473D0 (en) 1990-01-28
DK537589A (da) 1990-04-29
CN1031880C (zh) 1996-05-29
CA2001265A1 (en) 1990-04-28
FI95272C (fi) 1996-01-10
DE68927630T2 (de) 1997-06-12
US5114927A (en) 1992-05-19
HU209311B (en) 1994-04-28
AU4386789A (en) 1990-05-03
HUT51649A (en) 1990-05-28
CN1043504A (zh) 1990-07-04
EP0368719A3 (en) 1991-10-02
NO301074B1 (no) 1997-09-08
EP0368719B1 (en) 1997-01-08
FI895109A0 (fi) 1989-10-27
EP0368719A2 (en) 1990-05-16

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Legal Events

Date Code Title Description
AHS Application shelved for other reasons than non-payment