DK557189A - 1,2,3,4-tetrahydro-1,9-acridindiaminer, deres fremstilling og anvendelse som laegemidler - Google Patents

1,2,3,4-tetrahydro-1,9-acridindiaminer, deres fremstilling og anvendelse som laegemidler

Info

Publication number
DK557189A
DK557189A DK557189A DK557189A DK557189A DK 557189 A DK557189 A DK 557189A DK 557189 A DK557189 A DK 557189A DK 557189 A DK557189 A DK 557189A DK 557189 A DK557189 A DK 557189A
Authority
DK
Denmark
Prior art keywords
arylloweralkyl
loweralkyl
preparation
tetrahydro
chem
Prior art date
Application number
DK557189A
Other languages
English (en)
Other versions
DK166620B1 (da
DK557189D0 (da
Inventor
Gregory Michael Shutske
Kevin James Kapples
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Publication of DK557189D0 publication Critical patent/DK557189D0/da
Publication of DK557189A publication Critical patent/DK557189A/da
Application granted granted Critical
Publication of DK166620B1 publication Critical patent/DK166620B1/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D219/00Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D219/00Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/08Nitrogen atoms
    • C07D219/10Nitrogen atoms attached in position 9
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D221/00Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04Ortho- or peri-condensed ring systems
    • C07D221/06Ring systems of three rings
    • C07D221/16Ring systems of three rings containing carbocyclic rings other than six-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK557189A 1988-11-09 1989-11-08 4-amino-2,3-alkylen-quinolinderivater, en fremgangsmaade til deres fremstilling og anvendelse til fremstilling af et laegemiddel samt farmaceutisk praeparat indeholdende disse derivater DK166620B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26903888 1988-11-09
US07/269,038 US4868177A (en) 1988-11-09 1988-11-09 1,2,3,4-tetrahydro-1,9-acridinediamines, pharmaceutical compositions and use

Publications (3)

Publication Number Publication Date
DK557189D0 DK557189D0 (da) 1989-11-08
DK557189A true DK557189A (da) 1990-05-30
DK166620B1 DK166620B1 (da) 1993-06-21

Family

ID=23025549

Family Applications (1)

Application Number Title Priority Date Filing Date
DK557189A DK166620B1 (da) 1988-11-09 1989-11-08 4-amino-2,3-alkylen-quinolinderivater, en fremgangsmaade til deres fremstilling og anvendelse til fremstilling af et laegemiddel samt farmaceutisk praeparat indeholdende disse derivater

Country Status (18)

Country Link
US (1) US4868177A (da)
EP (1) EP0368188B1 (da)
JP (1) JPH03153667A (da)
KR (1) KR900007808A (da)
AT (1) ATE111899T1 (da)
AU (1) AU623701B2 (da)
CA (1) CA2002531A1 (da)
DE (1) DE68918402T2 (da)
DK (1) DK166620B1 (da)
ES (1) ES2059677T3 (da)
FI (1) FI895288A7 (da)
HU (1) HU208530B (da)
IE (1) IE64499B1 (da)
IL (1) IL92233A0 (da)
NO (1) NO894445L (da)
NZ (1) NZ231293A (da)
PT (1) PT92234B (da)
ZA (1) ZA898498B (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL85741A (en) * 1987-03-17 1996-05-14 Hoechst Roussel Pharma Substituted tetrahydroacridines a process for their preparation and pharmaceutical compositions containing substituted alpha-amino-tetrahydroacridines
US6075144A (en) 1987-04-20 2000-06-13 Hoechst Marion Roussel, Inc. 9-hydroxyamino tetrahydroacridine and related compounds
US4970316A (en) * 1987-05-07 1990-11-13 American Home Products Corporation Pyrano-, thiopyrano- and cyclohexylquinolines as inhibitors of interleukin 1
US5053513A (en) * 1990-03-29 1991-10-01 Hoechst-Roussel Pharmaceuticals Incorporated Method of reducing a carbonyl containing acridine
US5783584A (en) * 1995-12-11 1998-07-21 Mayo Foundation For Medical Education And Research THA analogs useful as cholinesterase inhibitors
US5929093A (en) * 1996-06-13 1999-07-27 Mayo Foundation For Medical Education And Research Bifunctional acetylcholinesterase reactivators
EP1891954A3 (en) 1998-09-30 2009-01-14 Takeda Pharmaceutical Company Limited Acetylcholinesterase inhibitors for improving excretory potency of urinary bladder
AR047759A1 (es) * 2003-09-26 2006-02-22 Vertex Pharma Derivados de fenil - piperazina como moduladores de receptores muscarnicos
WO2005072713A2 (en) 2004-01-27 2005-08-11 The Feinstein Institute For Medical Research Cholinesterase inhibitors for treating inflammation
DE102021119724A1 (de) * 2021-07-29 2023-02-02 Brückner Maschinenbau GmbH & Co. KG Folienaufwickelsystem, Verbund aus einer Folienreckanlage und einem solchen Folienaufwickelsystem und Verwendung eines solchen Verbunds zur Herstellung von Dünnstfilmen und Membranen

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4695573A (en) * 1984-10-25 1987-09-22 Hoechst-Roussel Pharmaceuticals Inc. 9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds
EP0268871A1 (en) * 1986-10-31 1988-06-01 Sumitomo Pharmaceuticals Company, Limited Quinoline derivatives
IL85741A (en) * 1987-03-17 1996-05-14 Hoechst Roussel Pharma Substituted tetrahydroacridines a process for their preparation and pharmaceutical compositions containing substituted alpha-amino-tetrahydroacridines
US5013741A (en) * 1987-09-08 1991-05-07 Hoechst-Roussel Pharmaceuticals Incorporated N-[substituted alkylidene]-1,2,3,4-tetrahydro-9-acridinamines useful for enhancing the cholinergic function in a mammal
IL87861A0 (en) * 1987-10-05 1989-03-31 Pfizer 4-aminopyridine derivatives

Also Published As

Publication number Publication date
FI895288A7 (fi) 1990-05-10
DK166620B1 (da) 1993-06-21
IE893592L (en) 1990-05-09
AU4442389A (en) 1990-05-17
KR900007808A (ko) 1990-06-02
NO894445D0 (no) 1989-11-08
EP0368188B1 (en) 1994-09-21
IL92233A0 (en) 1990-07-26
AU623701B2 (en) 1992-05-21
NO894445L (no) 1990-05-10
ES2059677T3 (es) 1994-11-16
DE68918402D1 (de) 1994-10-27
PT92234A (pt) 1990-05-31
DK557189D0 (da) 1989-11-08
NZ231293A (en) 1991-09-25
CA2002531A1 (en) 1990-05-09
ATE111899T1 (de) 1994-10-15
IE64499B1 (en) 1995-08-09
HU895830D0 (en) 1990-01-28
EP0368188A1 (en) 1990-05-16
PT92234B (pt) 1995-07-06
ZA898498B (en) 1990-08-29
FI895288A0 (fi) 1989-11-07
US4868177A (en) 1989-09-19
HU208530B (en) 1993-11-29
JPH03153667A (ja) 1991-07-01
DE68918402T2 (de) 1995-03-09

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed