DK567084A - Gnrh-antagonister - Google Patents

Gnrh-antagonister Download PDF

Info

Publication number: DK567084A
Authority: DK; Denmark
Prior art keywords: phe; arg; 2nal; gonads; steroids
Prior art date: 1983-11-29

Application number

DK567084A

Other languages

English (en)

Other versions

DK164409B (da

DK164409C (da

DK567084D0 (da

Inventor

Roger William Roeske

Jean Edouard Frederic Rivier

Jr Wylie Walker Vale

Original Assignee

Salk Inst For Biological Studi

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-11-29

Filing date

1984-11-29

Publication date

1985-05-30

1984-11-29 Application filed by Salk Inst For Biological Studi filed Critical Salk Inst For Biological Studi

1984-11-29 Publication of DK567084D0 publication Critical patent/DK567084D0/da

1985-05-30 Publication of DK567084A publication Critical patent/DK567084A/da

1992-06-22 Publication of DK164409B publication Critical patent/DK164409B/da

1992-11-09 Application granted granted Critical

1992-11-09 Publication of DK164409C publication Critical patent/DK164409C/da

Links

229940121381 gonadotrophin releasing hormone (gnrh) antagonists Drugs 0.000 title 1
210000002149 gonad Anatomy 0.000 abstract 2
102000004196 processed proteins & peptides Human genes 0.000 abstract 2
108090000765 processed proteins & peptides Proteins 0.000 abstract 2
150000003431 steroids Chemical class 0.000 abstract 2
HQMLIDZJXVVKCW-UWTATZPHSA-N (2r)-2-aminopropanamide Chemical compound C[C@@H](N)C(N)=O HQMLIDZJXVVKCW-UWTATZPHSA-N 0.000 abstract 1
ODKSFYDXXFIFQN-SCSAIBSYSA-N D-arginine Chemical compound OC(=O)[C@H](N)CCCNC(N)=N ODKSFYDXXFIFQN-SCSAIBSYSA-N 0.000 abstract 1
125000002849 D-tyrosine group Chemical group [H]N([H])[C@@]([H])(C(=O)[*])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H] 0.000 abstract 1
102000006771 Gonadotropins Human genes 0.000 abstract 1
108010086677 Gonadotropins Proteins 0.000 abstract 1
206010062767 Hypophysitis Diseases 0.000 abstract 1
235000013601 eggs Nutrition 0.000 abstract 1
BEBCJVAWIBVWNZ-UHFFFAOYSA-N glycinamide Chemical group NCC(N)=O BEBCJVAWIBVWNZ-UHFFFAOYSA-N 0.000 abstract 1
239000002622 gonadotropin Substances 0.000 abstract 1
229940094892 gonadotropins Drugs 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
230000016087 ovulation Effects 0.000 abstract 1
210000003635 pituitary gland Anatomy 0.000 abstract 1
230000028327 secretion Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/13—Luteinizing hormone-releasing hormone; related peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Endocrinology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Diabetes (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK567084A 1983-11-29 1984-11-29 Lhrh-antagonister og ikke-toksiske salte deraf samt farmaceutisk middel indeholdende disse DK164409C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US06/556,148 US4547370A (en)	1983-11-29	1983-11-29	GnRH Antagonists
US55614883		1983-11-29

Publications (4)

Publication Number	Publication Date
DK567084D0 DK567084D0 (da)	1984-11-29
DK567084A true DK567084A (da)	1985-05-30
DK164409B DK164409B (da)	1992-06-22
DK164409C DK164409C (da)	1992-11-09

Family

ID=24220086

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK567084A DK164409C (da)	1983-11-29	1984-11-29	Lhrh-antagonister og ikke-toksiske salte deraf samt farmaceutisk middel indeholdende disse

Country Status (18)

Country	Link
US (2)	US4547370A (da)
EP (1)	EP0143573B1 (da)
JP (1)	JPH0689037B2 (da)
KR (1)	KR900007083B1 (da)
AT (1)	ATE39701T1 (da)
AU (1)	AU571595B2 (da)
CA (1)	CA1262399A (da)
DD (1)	DD235874A5 (da)
DE (1)	DE3475910D1 (da)
DK (1)	DK164409C (da)
ES (1)	ES8604265A1 (da)
GR (1)	GR81042B (da)
HU (1)	HU200785B (da)
IE (1)	IE57910B1 (da)
IL (1)	IL73364A0 (da)
PH (1)	PH19971A (da)
PT (1)	PT79473A (da)
ZA (1)	ZA848305B (da)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL70888A0 (en) *	1983-03-10	1984-05-31	Salk Inst For Biological Studi	Gn rh antagonist peptides and pharmaceutical compositions containing them
US4547370A (en) *	1983-11-29	1985-10-15	The Salk Institute For Biological Studies	GnRH Antagonists
US4740500A (en) *	1985-01-31	1988-04-26	The Salk Institute For Biological Studies	GnRH antagonists VIII
US4677193A (en) *	1985-02-22	1987-06-30	The Salk Institute For Biological Studies	Peptides containing an aliphatic-aromatic ketone side chain
WO1988007056A1 (en) *	1987-03-10	1988-09-22	Eastern Virginia Medical Authority	METHOD AND KIT FOR CONTRACEPTION WITH GnRH-ANTAGONIST AND PROGESTIN
US4851385A (en) *	1987-07-15	1989-07-25	Indiana University Foundation	LHRH antagonist analogs having low histamine-release activity
US4935491A (en) *	1987-08-24	1990-06-19	Board Of Regents, The University Of Texas System	Effective antagonists of the luteinizing hormone releasing hormone which release negligible histamine
GB2209937B (en) *	1987-09-21	1991-07-03	Depiopharm S A	Water insoluble polypeptides
US5110904A (en) *	1989-08-07	1992-05-05	Abbott Laboratories	Lhrh analogs
DE68928278T2 (de) *	1988-02-10	1998-03-12	Tap Pharmaceuticals Inc	Lhrh-analog
US5656727A (en) *	1992-09-15	1997-08-12	The Administrators Of The Tulane Educational Fund	Antagonists of LHRH
US5480969A (en) *	1992-09-15	1996-01-02	The Administrators Of The Tulane Educational Fund	Antagonists of LHRH
US5843901A (en) *	1995-06-07	1998-12-01	Advanced Research & Technology Institute	LHRH antagonist peptides
US5932547A (en) *	1996-07-03	1999-08-03	Alza Corporation	Non-aqueous polar aprotic peptide formulations
US5916582A (en) *	1996-07-03	1999-06-29	Alza Corporation	Aqueous formulations of peptides
US5981489A (en) *	1996-07-18	1999-11-09	Alza Corporation	Non-aqueous protic peptide formulations
US5968895A (en)	1996-12-11	1999-10-19	Praecis Pharmaceuticals, Inc.	Pharmaceutical formulations for sustained drug delivery
US5925730A (en) *	1997-04-11	1999-07-20	Ferring Bv	GnRH antagonists
US6217844B1 (en)	1998-04-27	2001-04-17	Praecis Pharmaceuticals, Inc.	Methods for detecting lesions in dense breast tissue using LHRH antagonists
US6455499B1 (en)	1999-02-23	2002-09-24	Indiana University Foundation	Methods for treating disorders associated with LHRH activity
US6598784B2 (en) *	2000-12-20	2003-07-29	Meadwestvaco Packaging Syatens, Llc	Beverage carton with strap type carrying handle
WO2002056903A2 (en) *	2001-01-17	2002-07-25	Praecis Pharmaceuticals Inc.	Methods for treating hormone associated conditions using a combination of lhrh antagonists and specific estrogen receptor modulators
GB0320806D0 (en)	2003-09-05	2003-10-08	Astrazeneca Ab	Therapeutic treatment
CA2552241C (en)	2003-12-30	2013-10-01	Durect Corporation	Co-polymeric devices for controlled release of active agents
MY150763A (en)	2006-10-24	2014-02-28	Repros Therapeutics Inc	Compositions and methods for suppressing endometrial proliferation
EP3600373A1 (en)	2017-03-31	2020-02-05	Institut National de la Santé et de la Recherche Medicale	A gnrh antagonist for use in the treatment of a women affected with polycystic ovary syndrome

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ188987A (en) *	1977-11-30	1982-02-23	Salk Inst For Biological Studi	Peptide analogues of luteinizing hormone releasing factor
US4234571A (en) *	1979-06-11	1980-11-18	Syntex (U.S.A.) Inc.	Nonapeptide and decapeptide derivatives of luteinizing hormone releasing hormone
US4317815A (en) *	1979-06-13	1982-03-02	Coy David Howard	LH-RH Antagonists
US4253997A (en) *	1979-12-17	1981-03-03	American Home Products Corporation	Anti-ovulatory decapeptides
NZ196558A (en) *	1980-04-15	1984-10-19	Salk Inst For Biological Studi	Lrf antagonists and pharmaceutical compositions
US4409208A (en) *	1980-04-15	1983-10-11	The Salk Institute For Biological Studies	GnRH antagonists
ATE8988T1 (de) *	1980-06-02	1984-09-15	Andrew Victor Schally	Lh-rh antagonisten.
US4341767A (en) *	1980-10-06	1982-07-27	Syntex Inc.	Nonapeptide and decapeptide analogs of LHRH, useful as LHRH antagonists
AU9102582A (en) *	1981-12-10	1983-06-16	David Howard Coy	Lh-rh antagonists
FI832053A7 (fi) *	1982-06-10	1983-12-11	Syntex Inc	LHRH-antagonistina käyttökelpoinen LHRH:n nonapeptidi- ja dekapeptidianalogit sekä niiden valmistusmenetevalmistusmenetelmä.
US4444759A (en) *	1982-07-26	1984-04-24	The Salk Institute For Biological Studies	GnRH Antagonists II
IL70888A0 (en) *	1983-03-10	1984-05-31	Salk Inst For Biological Studi	Gn rh antagonist peptides and pharmaceutical compositions containing them
US4547370A (en) *	1983-11-29	1985-10-15	The Salk Institute For Biological Studies	GnRH Antagonists

1983
- 1983-11-29 US US06/556,148 patent/US4547370A/en not_active Expired - Fee Related
1984
- 1984-10-24 ZA ZA848305A patent/ZA848305B/xx unknown
- 1984-10-26 AU AU34724/84A patent/AU571595B2/en not_active Ceased
- 1984-10-30 IL IL73364A patent/IL73364A0/xx unknown
- 1984-11-05 AT AT84307625T patent/ATE39701T1/de not_active IP Right Cessation
- 1984-11-05 EP EP84307625A patent/EP0143573B1/en not_active Expired
- 1984-11-05 DE DE8484307625T patent/DE3475910D1/de not_active Expired
- 1984-11-08 PT PT79473A patent/PT79473A/pt unknown
- 1984-11-15 CA CA000467930A patent/CA1262399A/en not_active Expired
- 1984-11-26 GR GR81042A patent/GR81042B/el unknown
- 1984-11-27 PH PH31496A patent/PH19971A/en unknown
- 1984-11-27 DD DD84269937A patent/DD235874A5/de unknown
- 1984-11-28 IE IE3043/84A patent/IE57910B1/en not_active IP Right Cessation
- 1984-11-28 KR KR1019840007446A patent/KR900007083B1/ko not_active Expired
- 1984-11-28 HU HU844393A patent/HU200785B/hu not_active IP Right Cessation
- 1984-11-28 ES ES538035A patent/ES8604265A1/es not_active Expired
- 1984-11-29 JP JP59252800A patent/JPH0689037B2/ja not_active Expired - Lifetime
- 1984-11-29 DK DK567084A patent/DK164409C/da not_active IP Right Cessation
1985
- 1985-08-30 US US06/771,517 patent/US4689396A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
HUT36143A (en)	1985-08-28
DK164409B (da)	1992-06-22
KR850004113A (ko)	1985-07-01
US4689396A (en)	1987-08-25
EP0143573B1 (en)	1989-01-04
US4547370A (en)	1985-10-15
PT79473A (en)	1984-12-01
IE843043L (en)	1985-05-29
JPH0689037B2 (ja)	1994-11-09
AU3472484A (en)	1985-06-06
IL73364A0 (en)	1985-01-31
GR81042B (en)	1985-03-27
DD235874A5 (de)	1986-05-21
IE57910B1 (en)	1993-05-05
ATE39701T1 (de)	1989-01-15
ES8604265A1 (es)	1986-01-16
PH19971A (en)	1986-08-26
HU200785B (en)	1990-08-28
JPS60136598A (ja)	1985-07-20
ZA848305B (en)	1985-06-26
ES538035A0 (es)	1986-01-16
DK164409C (da)	1992-11-09
CA1262399A (en)	1989-10-17
AU571595B2 (en)	1988-04-21
DK567084D0 (da)	1984-11-29
KR900007083B1 (ko)	1990-09-28
DE3475910D1 (en)	1989-02-09
EP0143573A1 (en)	1985-06-05

Legal Events

Date	Code	Title	Description
1996-07-22	PBP	Patent lapsed

Publication	Publication Date	Title
AU571595B2 (en)	1988-04-21	Gnrh antagonists
AU558402B2 (en)	1987-01-29	Gnrh antagonists ii
ATE73461T1 (de)	1992-03-15	Gnrh-antagonisten.
AU551892B2 (en)	1986-05-15	Gnrh antagonists
ES8504677A1 (es)	1985-05-01	Un procedimiento para obtener un peptido o una sal no toxica del mismo.
ES8207510A1 (es)	1982-09-16	Un metodo de preparacion de un peptido inhibidor de la liberacion de gonadotropinas por la glandula pituitaria en mamiferos.
GB2089209A (en)	1982-06-23	Contraceptive treatment of male mammals