DK570282A - Fremgangsmaade til fremstilling af et indolderivat - Google Patents

Fremgangsmaade til fremstilling af et indolderivat Download PDF

Info

Publication number: DK570282A
Authority: DK; Denmark
Prior art keywords: incident; derivative; procedure; preparation; chlorobenzoyl
Prior art date: 1981-12-28

Application number

DK570282A

Other languages

English (en)

Other versions

DK154760C (da

DK154760B (da

Inventor

Rene Gnehm

Rolf Weber

Original Assignee

Siegfried Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-12-28

Filing date

1982-12-23

Publication date

1983-06-29

1982-12-23 Application filed by Siegfried Ag filed Critical Siegfried Ag

1983-06-29 Publication of DK570282A publication Critical patent/DK570282A/da

1988-12-19 Publication of DK154760B publication Critical patent/DK154760B/da

1989-06-05 Application granted granted Critical

1989-06-05 Publication of DK154760C publication Critical patent/DK154760C/da

Links

238000000034 method Methods 0.000 title abstract 2
FSQKKOOTNAMONP-UHFFFAOYSA-N acemetacin Chemical compound CC1=C(CC(=O)OCC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 FSQKKOOTNAMONP-UHFFFAOYSA-N 0.000 abstract 1
238000005903 acid hydrolysis reaction Methods 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
239000012467 final product Substances 0.000 abstract 1
125000004187 tetrahydropyran-2-yl group Chemical group [H]C1([H])OC([H])(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
- C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Indole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrane Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Cephalosporin Compounds (AREA)

DK570282A 1981-12-28 1982-12-23 Fremgangsmaade til fremstilling af acemetacin DK154760C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CH8306/81A CH653326A5 (de)	1981-12-28	1981-12-28	Verfahren zur herstellung eines indolderivates.
CH830681		1981-12-28

Publications (3)

Publication Number	Publication Date
DK570282A true DK570282A (da)	1983-06-29
DK154760B DK154760B (da)	1988-12-19
DK154760C DK154760C (da)	1989-06-05

Family

ID=4338290

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK570282A DK154760C (da)	1981-12-28	1982-12-23	Fremgangsmaade til fremstilling af acemetacin

Country Status (9)

Country	Link
US (2)	US4503237A (da)
EP (1)	EP0084127B1 (da)
JP (1)	JPS58118568A (da)
AT (1)	ATE18905T1 (da)
CH (1)	CH653326A5 (da)
DE (1)	DE3270313D1 (da)
DK (1)	DK154760C (da)
ES (1)	ES518419A0 (da)
FI (1)	FI77445C (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH653326A5 (de) *	1981-12-28	1985-12-31	Siegfried Ag	Verfahren zur herstellung eines indolderivates.
DE3206885A1 (de) *	1982-02-26	1983-09-15	Troponwerke GmbH & Co KG, 5000 Köln	Indolderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
JPS59204172A (ja) *	1983-04-28	1984-11-19	Kowa Co	アセメタシンの製造法
DE3416895A1 (de) *	1984-05-08	1985-11-14	Bayer Ag, 5090 Leverkusen	Verfahren zur herstellung von acemetacin
DE3443993A1 (de) *	1984-12-01	1986-06-05	Bayer Ag, 5090 Leverkusen	Verfahren zur herstellung von neuen indolderivaten und deren verwendung

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA837084A (en) *		1970-03-17	Sletzinger Meyer	Method for preparing indolylacetic acid esters
DE2234651C3 (de) *	1972-07-14	1978-11-09	Troponwerke Gmbh & Co Kg, 5000 Koeln	Eckige Klammer auf l-(p-Chlorbenzoyl)-5-methoxy-2-methyl-3-indol] -acetoxj essigsaure, ihre Salze mit Basen, Verfahren zu ihrer Herstellung sowie pharmakologische Zubereitungen
DE2943125A1 (de) *	1979-10-25	1981-05-14	Troponwerke GmbH & Co KG, 5000 Köln	Verfahren zur herstellung von 1-(4-chlorbenzoyl)-5-methoxy-2-methyl-3-indol acetoxyessigsaeure
CH653326A5 (de) *	1981-12-28	1985-12-31	Siegfried Ag	Verfahren zur herstellung eines indolderivates.
JPS59204172A (ja) *	1983-04-28	1984-11-19	Kowa Co	アセメタシンの製造法

1981
- 1981-12-28 CH CH8306/81A patent/CH653326A5/de not_active IP Right Cessation
1982
- 1982-12-14 AT AT82111622T patent/ATE18905T1/de not_active IP Right Cessation
- 1982-12-14 DE DE8282111622T patent/DE3270313D1/de not_active Expired
- 1982-12-14 EP EP82111622A patent/EP0084127B1/de not_active Expired
- 1982-12-16 US US06/450,507 patent/US4503237A/en not_active Expired - Lifetime
- 1982-12-21 ES ES518419A patent/ES518419A0/es active Granted
- 1982-12-22 FI FI824420A patent/FI77445C/fi not_active IP Right Cessation
- 1982-12-23 DK DK570282A patent/DK154760C/da not_active IP Right Cessation
- 1982-12-27 JP JP57227184A patent/JPS58118568A/ja active Granted
1984
- 1984-10-16 US US06/661,537 patent/US4652659A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US4652659A (en)	1987-03-24
DK154760C (da)	1989-06-05
ATE18905T1 (de)	1986-04-15
CH653326A5 (de)	1985-12-31
DE3270313D1 (en)	1986-05-07
FI824420L (fi)	1983-06-29
FI824420A0 (fi)	1982-12-22
FI77445B (fi)	1988-11-30
JPS58118568A (ja)	1983-07-14
ES8401939A1 (es)	1984-01-16
US4503237A (en)	1985-03-05
EP0084127A1 (de)	1983-07-27
FI77445C (fi)	1989-03-10
EP0084127B1 (de)	1986-04-02
DK154760B (da)	1988-12-19
ES518419A0 (es)	1984-01-16
JPH0222747B2 (da)	1990-05-21

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Legal Events

Date	Code	Title	Description
1999-08-23	PBP	Patent lapsed