DK607187A - 17beta-acyl-4-aza-5alfa-androst-1-en-3-oner og praeparater indeholdende disse forbindelser - Google Patents

17beta-acyl-4-aza-5alfa-androst-1-en-3-oner og praeparater indeholdende disse forbindelser

Info

Publication number: DK607187A
Authority: DK; Denmark
Prior art keywords: androst; aza; acyl; ones; compounds
Prior art date: 1986-11-20

Application number

DK607187A

Other languages

English (en)

Other versions

DK164915B (da

DK164915C (da

DK607187D0 (da

Inventor

Gary H Rasmusson

Glenn F Reynolds

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-11-20

Filing date

1987-11-19

Publication date

1988-05-21

1987-11-19 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

1987-11-19 Publication of DK607187D0 publication Critical patent/DK607187D0/da

1988-05-21 Publication of DK607187A publication Critical patent/DK607187A/da

1992-09-07 Publication of DK164915B publication Critical patent/DK164915B/da

1993-11-08 Application granted granted Critical

1993-11-08 Publication of DK164915C publication Critical patent/DK164915C/da

Links

150000001875 compounds Chemical class 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 abstract 1
125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
125000000389 2-pyrrolyl group Chemical group [H]N1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
239000002677 5-alpha reductase inhibitor Substances 0.000 abstract 1
208000002874 Acne Vulgaris Diseases 0.000 abstract 1
206010004446 Benign prostatic hyperplasia Diseases 0.000 abstract 1
206010020112 Hirsutism Diseases 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
208000004403 Prostatic Hyperplasia Diseases 0.000 abstract 1
206010039792 Seborrhoea Diseases 0.000 abstract 1
206010000496 acne Diseases 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
208000008742 seborrheic dermatitis Diseases 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
229940095585 testosterone-5-alpha reductase inhibitors for benign prostatic hypertrophy Drugs 0.000 abstract 1
125000001544 thienyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
- C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
- C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
- C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
- C07C2603/16—Benz[e]indenes; Hydrogenated benz[e]indenes

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Reproductive Health (AREA)
Dermatology (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)

DK607187A 1986-11-20 1987-11-19 Anvendelse af 17beta-methoxycarbonyl-4-aza-4-methyl-5alfa-androst-1-en-3-on til fremstilling af et topisk praeparat DK164915C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US93254986A	1986-11-20	1986-11-20
US93254986		1986-11-20

Publications (4)

Publication Number	Publication Date
DK607187D0 DK607187D0 (da)	1987-11-19
DK607187A true DK607187A (da)	1988-05-21
DK164915B DK164915B (da)	1992-09-07
DK164915C DK164915C (da)	1993-11-08

Family

ID=25462482

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK607187A DK164915C (da)	1986-11-20	1987-11-19	Anvendelse af 17beta-methoxycarbonyl-4-aza-4-methyl-5alfa-androst-1-en-3-on til fremstilling af et topisk praeparat

Country Status (5)

Country	Link
EP (1)	EP0271219B1 (da)
JP (1)	JPS63139196A (da)
AT (1)	ATE78827T1 (da)
DE (1)	DE3780778T2 (da)
DK (1)	DK164915C (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5237061A (en) *	1988-10-31	1993-08-17	Merck & Co., Inc.	Methods of synthesizing benign prostatic hypertropic agents and their intermediates
EP0462665A3 (en) *	1990-06-20	1993-06-30	Merck & Co. Inc.	Selected 17beta-polyaroyl-4-aza-5alpha-androst-1-en-3-ones as steroidal reductase inhibitors
US5098908A (en) *	1990-06-20	1992-03-24	Merck & Co., Inc.	17β-hydroxybenzoyl-4-aza-5α-androst-1-en-3-ones as testosterone reductase inhibitors
EP0462664A3 (en) *	1990-06-20	1992-11-25	Merck & Co. Inc.	Specific 17beta-thiobenzoyl-4-aza-5alpha-androst-1-en-3-ones as antiandrogenic agents
US5061802A (en) *	1990-06-20	1991-10-29	Merck & Co. Inc.	17β-aminobenzoyl-4-aza-5α-androst-1-en-3-ones as benign prostatic hypertrophy agents
US5151430A (en) *	1990-06-20	1992-09-29	Merck & Co., Inc.	Specific 17β-thiobenzoyl-4-aza-5α-androst-1-en-3-ones as antiandrogen agents
US5061803A (en) *	1990-09-24	1991-10-29	Merck & Co., Inc.	Process for making 17-beta alkanoyl 3-oxo-4-aza-5-α-androst-1-enes
US5304562A (en) *	1991-10-09	1994-04-19	Ciba-Geigy Corporation	17β-substituted Aza-androstane derivatives
JPH07502511A (ja) *	1991-12-20	1995-03-16	グラクソ、インコーポレーテッド	５‐α‐テストステロンレダクターゼ阻害剤
KR950701527A (ko) *	1992-05-21	1995-04-28	라브리 페르낭	테스토스테론 5α 환원효소 활성 저해제(INHIBITORS OF TESTOSTERONE 5α-REDUCTASE ACTIVITY)
US5302589A (en) *	1992-08-07	1994-04-12	Glaxo, Inc.	Heterocyclic inhibitors of 5-α-testosterone reductase
TW369521B (en) *	1993-09-17	1999-09-11	Smithkline Beecham Corp	Androstenone derivative
TW408127B (en) *	1993-09-17	2000-10-11	Glaxo Inc	Androstenones
US5817818A (en) *	1994-09-16	1998-10-06	Glaxo Wellcome Inc.	Androstenones
US5541322A (en) *	1994-10-14	1996-07-30	Glaxo Wellcome Inc.	Synthesis of 6-azaandrostenones
US5656613A (en) *	1995-01-04	1997-08-12	Merck & Co., Inc.	Treatment of hyperandrogenic conditions
US5998427A (en) *	1998-05-14	1999-12-07	Glaxo Wellcome Inc.	Androstenones

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU527030B2 (en) *	1978-04-13	1983-02-10	Merck & Co., Inc.	4-aza-17-substituted-5a-androstan-3-ones
NZ211145A (en) *	1984-02-27	1988-10-28	Merck & Co Inc	4-aza-5-alpha-androst-1-en-3-ones and pharmaceutical compositions

1987
- 1987-11-11 DE DE8787309949T patent/DE3780778T2/de not_active Expired - Fee Related
- 1987-11-11 AT AT87309949T patent/ATE78827T1/de not_active IP Right Cessation
- 1987-11-11 EP EP87309949A patent/EP0271219B1/en not_active Expired - Lifetime
- 1987-11-19 DK DK607187A patent/DK164915C/da not_active IP Right Cessation
- 1987-11-20 JP JP62292214A patent/JPS63139196A/ja active Pending

Also Published As

Publication number	Publication date
DK164915B (da)	1992-09-07
DK164915C (da)	1993-11-08
EP0271219B1 (en)	1992-07-29
JPS63139196A (ja)	1988-06-10
DK607187D0 (da)	1987-11-19
ATE78827T1 (de)	1992-08-15
DE3780778T2 (de)	1993-01-14
EP0271219A1 (en)	1988-06-15
DE3780778D1 (de)	1992-09-03

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Legal Events

Date	Code	Title	Description
1994-07-25	PBP	Patent lapsed