DK71486A - 4-substituerede androstendion-derivater og fremgangsmaade til fremstilling deraf - Google Patents

4-substituerede androstendion-derivater og fremgangsmaade til fremstilling deraf Download PDF

Info

Publication number: DK71486A
Authority: DK; Denmark
Prior art keywords: androstendion; procedures; derivatives; substituted; producing
Prior art date: 1985-02-15

Application number

DK71486A

Other languages

English (en)

Other versions

DK167221B1 (da

DK71486D0 (da

Inventor

Franco Faustini

Alessio Roberto D

Vittoria Villa

Salle Enrico Di

Paolo Lombardi

Original Assignee

Erba Farmitalia

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-02-15

Filing date

1986-02-14

Publication date

1986-08-16

1986-02-14 Application filed by Erba Farmitalia filed Critical Erba Farmitalia

1986-02-14 Publication of DK71486D0 publication Critical patent/DK71486D0/da

1986-08-16 Publication of DK71486A publication Critical patent/DK71486A/da

1993-09-20 Application granted granted Critical

1993-09-20 Publication of DK167221B1 publication Critical patent/DK167221B1/da

Links

UURSGYCYDHBXDS-CIMZGTONSA-N (8R,9S,10R,13R,14S)-10,13-dimethyl-2,3,6,7,8,9,11,12,14,17-decahydro-1H-cyclopenta[a]phenanthrene-15,16-dione Chemical class [C@@H]12C(C(C[C@@]1(C)CC[C@H]1[C@H]2CCC2=CCCC[C@]12C)=O)=O UURSGYCYDHBXDS-CIMZGTONSA-N 0.000 title 1
238000000034 method Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C07J41/0027—Azides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK071486A 1985-02-15 1986-02-14 4-aminoandrostendion-derivater, fremgangsmaade til fremstilling deraf, samt farmaceutiske praeparater indeholdende disse forbindelser DK167221B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB8503940		1985-02-15
GB858503940A GB8503940D0 (en)	1985-02-15	1985-02-15	4-substituted androstendione derivatives

Publications (3)

Publication Number	Publication Date
DK71486D0 DK71486D0 (da)	1986-02-14
DK71486A true DK71486A (da)	1986-08-16
DK167221B1 DK167221B1 (da)	1993-09-20

Family

ID=10574550

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK071486A DK167221B1 (da)	1985-02-15	1986-02-14	4-aminoandrostendion-derivater, fremgangsmaade til fremstilling deraf, samt farmaceutiske praeparater indeholdende disse forbindelser

Country Status (28)

Country	Link
US (1)	US4757061A (da)
JP (1)	JPS61189295A (da)
KR (1)	KR930005994B1 (da)
AT (1)	AT396239B (da)
AU (1)	AU577667B2 (da)
BE (1)	BE904226A (da)
CA (1)	CA1319362C (da)
CH (1)	CH669199A5 (da)
CZ (1)	CZ413691A3 (da)
DE (1)	DE3604179A1 (da)
DK (1)	DK167221B1 (da)
ES (2)	ES8706165A1 (da)
FI (1)	FI84272C (da)
FR (1)	FR2577556B1 (da)
GB (2)	GB8503940D0 (da)
GR (1)	GR860430B (da)
HK (1)	HK94090A (da)
HU (1)	HU194909B (da)
IE (1)	IE58864B1 (da)
IT (1)	IT1190335B (da)
MY (1)	MY102038A (da)
NL (1)	NL8600383A (da)
NZ (1)	NZ215163A (da)
PT (1)	PT82030B (da)
SE (2)	SE468515B (da)
SG (1)	SG80890G (da)
SU (1)	SU1574178A3 (da)
ZA (1)	ZA861118B (da)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8622330D0 (en) *	1986-09-17	1986-10-22	Erba Farmitalia	4-substituted 6-alkylidenandrostene-3,17-dione derivatives
GB8624251D0 (en) *	1986-10-09	1986-11-12	Erba Farmitalia	"1,2-beta-methylene-4-substituted androstene-3,17 dione derivatives
DE3711772A1 (de) *	1987-04-08	1988-10-27	Schering Ag	4- und 15-disubstituierte 4-androsten-3,17-dione und verfahren zu deren herstellung
GB8711579D0 (en) *	1987-05-15	1987-06-17	Erba Farmitalia	4-amino-androstenedione derivatives
US5595985A (en)	1989-03-10	1997-01-21	Endorecherche Inc.	Combination therapy for prophylaxis and/or treatment of benign prostatic hyperplasia
CA2062973C (en) *	1989-07-07	2003-09-23	Fernand Labrie	Combination therapy for prophylaxsis and/or treatment of benign prostatic hyperplasia
US5143909A (en) *	1991-03-19	1992-09-01	Merrell Dow Pharmaceuticals Inc.	Aminosteroids in a method for inhibiting c17-20 lyase
US5120840A (en) *	1990-08-01	1992-06-09	Merrell Dow Pharmaceuticals Inc.	4-amino-4-ene-steroids and their use as 5α-reductase inhibitors
AU642757B2 (en) *	1990-08-01	1993-10-28	Merrell Dow Pharmaceuticals Inc.	4-amino-delta4, 6-steroids and their use as 5alpha-reductase inhibitors
NZ239142A (en) *	1990-08-01	1994-05-26	Merrell Dow Pharma	4-amino-delta-4-steroids; preparatory processes and pharmaceutical compositions
US5130424A (en) *	1990-08-01	1992-07-14	Merrell Dow Pharmaceuticals Inc.	4-amino-delta-4,6-steroids and their use as 5 alpha-reductase inhibitors
US5218110A (en) *	1990-08-01	1993-06-08	Merrell Dow Pharmaceuticals	4-amino-Δ4 -steroids and their use as 5α-reductase inhibitors
US5318961A (en) *	1990-08-01	1994-06-07	Merrell Dow Pharmaceuticals Inc.	4-amino-Δ4-steroids and their use as 5α-reductase inhibitors
US5162337A (en) *	1990-10-05	1992-11-10	Merck & Co., Inc.	Animal growth promotion
US5189032A (en) *	1991-03-19	1993-02-23	Merrell Dow Pharmaceuticals Inc.	4-amino-Δ4,6 -steroids and their use as 5α-reductase inhibitors
CA2107102A1 (en) *	1991-03-28	1992-09-29	Naoyuki Koizumi	Novel oxa- or azasteroid derivatives
CH683151A5 (de) *	1991-04-24	1994-01-31	Ciba Geigy Ag	Antikonzeption bei weiblichen Primaten ohne Beeinflussung des menstruellen Zyklus.
GB9111260D0 (en) *	1991-05-24	1991-07-17	Erba Carlo Spa	Process for the preparation of 4-amino-unsaturated androstanedione derivatives
GB9217035D0 (en) *	1992-08-11	1992-09-23	Erba Carlo Spa	Androst-4-eno(4,5-b)pyrrole derivatives and process for their preparation
HU221191B1 (en) *	1992-09-30	2002-08-28	Teikoku Hormone Mfg Co Ltd	7-substituted oxasteroid compounds, process for their preparation and pharmaceutical compositions containing the same
JPH07506120A (ja) *	1993-02-18	1995-07-06	フアルマシア・エ・アツプジヨン・エツセ・ピー・アー	フッ素化４−アミノアンドロスタジエノン誘導体及びその製造方法
US5486511A (en) *	1993-05-25	1996-01-23	Merrell Dow Pharmaceuticals Inc.	4-amino-17β-(cyclopropyloxy)androst-4-en-3-one, 4-amino-17β-(cyclopropylamino)androst-4-en-3-one and related compounds as C17-20 lyase and 5α-reductase
US6407082B1 (en) *	1996-09-13	2002-06-18	New Life Pharmaceuticals Inc.	Prevention of ovarian cancer by administration of a vitamin D compound
GB2284605A (en) *	1993-12-09	1995-06-14	Erba Carlo Spa	6-or 7-substituted 4-aminoandrostadienone derivatives
CN1042540C (zh) *	1994-05-02	1999-03-17	默里尔药物公司	通过4－硝基－△4－3－酮甾类化合物制备4－氨基－△4－3－酮甾类化合物的方法
US6365597B1 (en)	1996-02-14	2002-04-02	Aventis Pharmaceuticals Inc.	4-aza steroids
US6034074A (en)	1996-09-13	2000-03-07	New Life Pharmaceuticals Inc.	Prevention of ovarian cancer by administration of a Vitamin D compound
US6028064A (en)	1996-09-13	2000-02-22	New Life Pharmaceuticals Inc.	Prevention of ovarian cancer by administration of progestin products
US6511970B1 (en)	1996-09-13	2003-01-28	New Life Pharmaceuticals Inc.	Prevention of ovarian cancer by administration of products that induce transforming growth factor-beta and/or apoptosis in the ovarian epithelium
US6765002B2 (en)	2000-03-21	2004-07-20	Gustavo Rodriguez	Prevention of ovarian cancer by administration of products that induce transforming growth factor-β and/or apoptosis in the ovarian epithelium
US20010044431A1 (en) *	2000-03-21	2001-11-22	Rodriguez Gustavo C.	Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium
US7435757B2 (en) *	2004-07-02	2008-10-14	Schering Ag	2-substituted D-homo-estra-1,3,5(10)-trienes as inhibitors of 17β-hydroxy steroid dehydrogenase type 1

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1042291A (en) *	1961-11-08	1966-09-14	Organon Labor Ltd	í¸-6ª‡-amino steroids and the preparation thereof
DE1203768B (de) *	1962-02-01	1965-10-28	Merck Ag E	Verfahren zur Herstellung von N-substituierten 4-Aminosteroiden der Testosteronreiheund Saeureadditionssalzen derselben
DK120154B (da) *	1968-02-29	1971-04-19	Schering Ag	Fremgangsmåde til fremstilling af N-substituerede 4-amino-3-oxosteroid-4,6-diener af androstan- eller pregnanrækken eller deres ammoniumsalte.
DE1668690C3 (de) *	1968-02-29	1978-09-14	Schering Ag, 1000 Berlin Und 4619 Bergkamen	Verfahren zur Herstellung von N-substituierten 4-Aminosteroiden der Androstan-Pregnan- und Cholestanreihe
US3780070A (en) *	1972-09-21	1973-12-18	Schering Corp	4-azido-17alpha-alkinyl-4-gonen-17beta-ol-3-ones and method for their preparation
CA1154008A (en) *	1979-05-02	1983-09-20	Thomas R. Blohm	STEROID 5.alpha.-REDUCTASE INHIBITORS

1985
- 1985-02-15 GB GB858503940A patent/GB8503940D0/en active Pending
1986
- 1986-02-10 US US06/828,637 patent/US4757061A/en not_active Expired - Fee Related
- 1986-02-10 HU HU86544A patent/HU194909B/hu not_active IP Right Cessation
- 1986-02-10 DE DE19863604179 patent/DE3604179A1/de not_active Ceased
- 1986-02-11 GB GB08603265A patent/GB2171100B/en not_active Expired
- 1986-02-11 IT IT19361/86A patent/IT1190335B/it active
- 1986-02-11 AU AU53433/86A patent/AU577667B2/en not_active Ceased
- 1986-02-11 CH CH549/86A patent/CH669199A5/de not_active IP Right Cessation
- 1986-02-13 FI FI860672A patent/FI84272C/fi not_active IP Right Cessation
- 1986-02-13 JP JP61028062A patent/JPS61189295A/ja active Granted
- 1986-02-13 GR GR860430A patent/GR860430B/el unknown
- 1986-02-14 DK DK071486A patent/DK167221B1/da not_active IP Right Cessation
- 1986-02-14 PT PT82030A patent/PT82030B/pt not_active IP Right Cessation
- 1986-02-14 ES ES552052A patent/ES8706165A1/es not_active Expired
- 1986-02-14 SU SU864021024A patent/SU1574178A3/ru active
- 1986-02-14 SE SE8600668A patent/SE468515B/sv unknown
- 1986-02-14 NZ NZ215163A patent/NZ215163A/en unknown
- 1986-02-14 IE IE41386A patent/IE58864B1/en not_active IP Right Cessation
- 1986-02-14 FR FR8602051A patent/FR2577556B1/fr not_active Expired
- 1986-02-14 CA CA000501861A patent/CA1319362C/en not_active Expired - Fee Related
- 1986-02-14 AT AT0038886A patent/AT396239B/de not_active IP Right Cessation
- 1986-02-14 ZA ZA861118A patent/ZA861118B/xx unknown
- 1986-02-14 SE SE8600668D patent/SE8600668L/xx not_active Application Discontinuation
- 1986-02-14 BE BE0/216266A patent/BE904226A/fr not_active IP Right Cessation
- 1986-02-14 NL NL8600383A patent/NL8600383A/nl not_active Application Discontinuation
- 1986-02-15 KR KR1019860001070A patent/KR930005994B1/ko not_active Expired - Fee Related
- 1986-11-20 ES ES557215A patent/ES8708235A1/es not_active Expired
1988
- 1988-12-30 MY MYPI88001589A patent/MY102038A/en unknown
1990
- 1990-10-04 SG SG808/90A patent/SG80890G/en unknown
- 1990-11-15 HK HK940/90A patent/HK94090A/xx unknown
1991
- 1991-12-30 CZ CS914136A patent/CZ413691A3/cs unknown

Also Published As

Publication number	Publication date
NL8600383A (nl)	1986-09-01
FI860672A0 (fi)	1986-02-13
PT82030B (pt)	1988-07-01
HK94090A (en)	1990-11-23
GB8503940D0 (en)	1985-03-20
ATA38886A (de)	1992-11-15
JPH0469638B2 (da)	1992-11-06
PT82030A (en)	1986-03-01
ES552052A0 (es)	1987-06-01
DK167221B1 (da)	1993-09-20
FR2577556A1 (fr)	1986-08-22
BE904226A (fr)	1986-08-14
AU5343386A (en)	1986-08-21
IE58864B1 (en)	1993-11-17
HU194909B (en)	1988-03-28
IT8619361A0 (it)	1986-02-11
FI84272C (fi)	1991-11-11
FI860672A7 (fi)	1986-08-16
DK71486D0 (da)	1986-02-14
SG80890G (en)	1990-11-23
GB2171100B (en)	1988-11-30
AU577667B2 (en)	1988-09-29
CZ413691A3 (en)	1994-03-16
KR860006485A (ko)	1986-09-11
MY102038A (en)	1992-02-29
SE8600668L (sv)	1986-08-16
FI84272B (fi)	1991-07-31
JPS61189295A (ja)	1986-08-22
ES8708235A1 (es)	1987-10-01
ZA861118B (en)	1986-10-29
DE3604179A1 (de)	1986-08-21
CA1319362C (en)	1993-06-22
IT1190335B (it)	1988-02-16
SU1574178A3 (ru)	1990-06-23
CH669199A5 (de)	1989-02-28
US4757061A (en)	1988-07-12
GB8603265D0 (en)	1986-03-19
IE860413L (en)	1986-08-15
SE468515B (sv)	1993-02-01
SE8600668D0 (sv)	1986-02-14
IT8619361A1 (it)	1987-08-11
GR860430B (en)	1986-06-12
NZ215163A (en)	1988-02-29
KR930005994B1 (ko)	1993-07-01
ES8706165A1 (es)	1987-06-01
FR2577556B1 (fr)	1988-01-08
HUT40454A (en)	1986-12-28
AT396239B (de)	1993-07-26
ES557215A0 (es)	1987-10-01
GB2171100A (en)	1986-08-20

Legal Events

Date	Code	Title	Description
1993-09-20	B1	Patent granted (law 1993)
1996-10-14	PBP	Patent lapsed

Publication	Publication Date	Title
DK71486D0 (da)	1986-02-14	4-substituerede androstendion-derivater og fremgamgsmaade til fremstilling deraf
DK491186A (da)	1987-04-18	Pyridonderivater og fremgangsmaade til fremstilling deraf
DK356485D0 (da)	1985-08-06	Pyridinderivater og fremgangsmaade til fremstilling deraf
NO860190L (no)	1986-07-23	Peptid-derivater og fremgangsmaate for fremstilling derav.
DK301886D0 (da)	1986-06-26	Furanon-derivater og fremgangsmaade til fremstilling heraf
DK335886D0 (da)	1986-07-15	Distamycinderivat og fremgangsmaade til fremstilling deraf
DK291385D0 (da)	1985-06-27	Benzamidderivater og fremgangsmaade til fremstilling deraf
DK335986A (da)	1987-01-17	Poly-4-aminopropyl-2-carboxamidoderivat og fremgangsmaade til fremstilling deraf
DK103986D0 (da)	1986-03-07	Quinoloncarboxylsyre-derivat og fremgangsmaade til fremstilling heraf
DK165952C (da)	1993-07-05	1,3-oxazolidin-2-on-derivater og fremgangsmaade til fremstilling heraf
DK4187D0 (da)	1987-01-06	Triazolylquinolin-derivater og fremgangsmaade til fremstilling deraf
DK375085D0 (da)	1985-08-19	Quinolon-carboxylsyre-derivater og fremgangsmaade til fremstilling deraf
DK477287A (da)	1988-03-13	Pyrido-benzoxadiazin-derivater og fremgangsmaade til fremstilling deraf
DK260086D0 (da)	1986-06-03	Vitamin-d-derivater og fremgangsmaade til fremstilling heraf
DK357385A (da)	1986-03-11	Dihydropyridin-derivater og fremgangsmaade til fremstilling deraf
DK313785A (da)	1986-01-11	Dihydroorotsyrederivat og fremgangsmaade til fremstilling deraf
DK401385A (da)	1986-03-05	7-oxomitosan-derivater og fremgangsmaade til fremstilling deraf
DK443186A (da)	1986-09-16	Vitamin d derivater og fremgangsmaade til fremstilling deraf
DK487688D0 (da)	1988-09-02	Benzofuranderivater og fremgangsmaade til fremstilling deraf
DK446685A (da)	1986-04-03	Carbapenemderivater og fremgangsmaade til fremstilling deraf
DK182585D0 (da)	1985-04-24	Fosfomycinderivat og fremgangsmaade til fremstilling deraf
DK624588A (da)	1989-05-11	4-demethoxy-anthracyclin-derivater og fremgangsmaade til fremstilling deraf
DK165634C (da)	1993-06-01	Arylsulfonforbindelser og fremgangsmaader til fremstilling deraf
DK443787A (da)	1987-08-25	Hydrazonderivater og fremgangsmaade til fremstilling deraf
DK230286D0 (da)	1986-05-16	Phosphinguldforbindelser og fremgangsmaade til fremstilling deraf