DK73080A - METHOD FOR MANUFACTURING MONACOLIN K. - Google Patents
METHOD FOR MANUFACTURING MONACOLIN K.Info
- Publication number
- DK73080A DK73080A DK73080A DK73080A DK73080A DK 73080 A DK73080 A DK 73080A DK 73080 A DK73080 A DK 73080A DK 73080 A DK73080 A DK 73080A DK 73080 A DK73080 A DK 73080A
- Authority
- DK
- Denmark
- Prior art keywords
- monacolin
- manufacturing
- manufacturing monacolin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/145—Fungi isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Obesity (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compounds Of Unknown Constitution (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK47085A DK165990C (en) | 1979-02-20 | 1985-02-01 | PROCEDURE FOR PREPARING THE CARBOXYLIC ACID OF A CHOLESTEROL SYNTHESIS INHIBITIVE COMPOUND CALLED MONACOLIN K OR SALTS THEREOF |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP54017856A JPS5925599B2 (en) | 1979-02-20 | 1979-02-20 | New physiologically active substance monacolin K and its production method |
| JP1785679 | 1979-02-20 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK73080A true DK73080A (en) | 1980-08-21 |
| DK149095B DK149095B (en) | 1986-01-20 |
| DK149095C DK149095C (en) | 1986-06-16 |
Family
ID=11955290
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK73080A DK149095C (en) | 1979-02-20 | 1980-02-20 | PROCEDURE FOR PREPARING A CHOLESTEROL SYNTHESIS INHIBITIVE COMPOUND called MONACOLIN K |
| DK021889A DK21889A (en) | 1979-02-20 | 1989-01-18 | APPLICATION OF MONACOLIN K, THE SIMILAR CARBOXYLIC ACID COMPOUND OR SALTS OF THE CARBOXYLIC ACID FOR THE PREPARATION OF A MEDICINE TO TREAT HYPERCHOLESTEROLAEMIA |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK021889A DK21889A (en) | 1979-02-20 | 1989-01-18 | APPLICATION OF MONACOLIN K, THE SIMILAR CARBOXYLIC ACID COMPOUND OR SALTS OF THE CARBOXYLIC ACID FOR THE PREPARATION OF A MEDICINE TO TREAT HYPERCHOLESTEROLAEMIA |
Country Status (27)
| Country | Link |
|---|---|
| JP (1) | JPS5925599B2 (en) |
| KR (1) | KR830002801B1 (en) |
| AT (1) | AT373915B (en) |
| AU (1) | AU532626B2 (en) |
| BE (1) | BE881825A (en) |
| CA (1) | CA1129794A (en) |
| CH (1) | CH645890A5 (en) |
| DD (1) | DD154494A5 (en) |
| DE (2) | DE3006216C2 (en) |
| DK (2) | DK149095C (en) |
| ES (1) | ES488796A0 (en) |
| FI (1) | FI66427C (en) |
| FR (1) | FR2449685B1 (en) |
| GB (1) | GB2046737B (en) |
| HU (1) | HU182069B (en) |
| IE (1) | IE49743B1 (en) |
| IT (1) | IT1175260B (en) |
| MX (1) | MX6314E (en) |
| NL (1) | NL191540C (en) |
| NO (1) | NO153974C (en) |
| NZ (1) | NZ192919A (en) |
| PH (1) | PH15145A (en) |
| PL (1) | PL124304B1 (en) |
| SE (1) | SE453301B (en) |
| SG (1) | SG6784G (en) |
| SU (2) | SU1158048A3 (en) |
| ZA (1) | ZA80962B (en) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55150898A (en) * | 1979-05-11 | 1980-11-25 | Sankyo Co Ltd | Preparation of a new physiologically active substance mb-530b |
| US4231938A (en) * | 1979-06-15 | 1980-11-04 | Merck & Co., Inc. | Hypocholesteremic fermentation products and process of preparation |
| JPS5621594A (en) * | 1979-07-27 | 1981-02-28 | Sankyo Co Ltd | Mb-530b carboxylic acid metal salt and its preparation |
| AU548996B2 (en) * | 1980-02-04 | 1986-01-09 | Merck & Co., Inc. | Tetrahydro-2h-pyran-2-one derivatives |
| PT72394B (en) * | 1980-02-04 | 1982-09-06 | Merck & Co Inc | Process for preparing dihydro and tetrahydromevinoline hypocholesterolimics |
| JPH0692381B2 (en) * | 1980-03-31 | 1994-11-16 | 三共株式会社 | MB-530A derivative |
| JPS56142236A (en) | 1980-04-08 | 1981-11-06 | Sankyo Co Ltd | Ml-236a and mb-530a derivative |
| MX7065E (en) * | 1980-06-06 | 1987-04-10 | Sankyo Co | A MICROBIOLOGICAL PROCEDURE FOR PREPARING DERIVATIVES OF ML-236B |
| JPS5835144A (en) * | 1981-08-27 | 1983-03-01 | Sankyo Co Ltd | Mb-530b derivative and its preparation |
| US4782084A (en) * | 1987-06-29 | 1988-11-01 | Merck & Co., Inc. | HMG-COA reductase inhibitors |
| US4997848A (en) * | 1987-10-27 | 1991-03-05 | Sankyo Company, Limited | Octahydronaphthalene oxime derivatives for cholesterol synthesis inhibition |
| CA2062023A1 (en) * | 1992-02-10 | 1993-08-11 | Jagroop S. Dahiya | Novel fungal strains and use thereof in antibiotic production |
| EP0629184A1 (en) * | 1992-03-04 | 1994-12-21 | Fujisawa Pharmaceutical Co., Ltd. | TETRALIN DERIVATIVES AS HMG-CoA REDUCTASE INHIBITORS |
| FI932188L (en) | 1992-05-15 | 1993-11-16 | Sankyo Co | OCTAHYDRONAPTHALENOXIME DERIVATIVES FOER INHIBERING AV CHOLESTEROLBIOSYNTESEN, DERAS FRAMSTAELLNING OCH ANVAENDNING |
| US6812007B1 (en) * | 1992-11-04 | 2004-11-02 | Keri Vilmos | Process for the isolation and purification of mevinolin |
| HU210867B (en) * | 1992-11-04 | 1995-10-30 | Biogal Gyogyszergyar | Method for extraction and purification of mevinolin from culture medium |
| SI9300303A (en) * | 1993-06-08 | 1994-12-31 | Krka Tovarna Zdravil | Process for isolation of hypolipemic effective substance |
| US5409820A (en) * | 1993-08-06 | 1995-04-25 | Apotex, Inc. | Process for the production of lovastatin using Coniothyrium fuckelii |
| US7238348B2 (en) | 1996-09-30 | 2007-07-03 | Beijing Peking University Wbl Corporation Ltd. | Method of treatment of osteoporosis with compositions of red rice fermentation products |
| US6046022A (en) | 1996-09-30 | 2000-04-04 | Peking University | Methods and compositions employing red rice fermentation products |
| NZ500870A (en) | 1998-03-20 | 2002-03-01 | Biogal Gyogyszergyar | Metabolic controlled fermentation process for preparing mevinolin (lovastatin) |
| HRP20020683A2 (en) | 2000-02-24 | 2004-12-31 | Biogal Gyogyszergyar | Method of purifying a fermentation broth |
| TR200403001T3 (en) | 2000-03-03 | 2005-02-21 | Plus Chemical, S.A. | A process for the treatment of lovastatin and simvastatin with reduced dimeric impurity levels |
| KR20010095780A (en) * | 2000-04-12 | 2001-11-07 | 나가오카 마사시 | Embryo monascus |
| IN192861B (en) | 2000-06-30 | 2004-05-22 | Ranbaxy Lab Ltd | |
| EP1358343A2 (en) * | 2001-02-09 | 2003-11-05 | Unilever N.V. | Process for the preparation of one or more statins by fermentation |
| KR100379075B1 (en) | 2002-03-07 | 2003-04-08 | Jinis Biopharmaceuticals Co | Method for producing low cholesterol animal food product and food product therefrom |
| KR20020093147A (en) * | 2002-05-30 | 2002-12-13 | 지니스생명공학 주식회사 | Preventive and Dietary Supplement for adult chronic disease |
| KR100710500B1 (en) | 2005-05-18 | 2007-04-24 | 고려대학교 산학협력단 | Method for producing Monacholine K using red yeast bacteria |
| WO2010069593A1 (en) | 2008-12-19 | 2010-06-24 | Krka, D. D., Novo Mesto | Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates |
| EP2327682A1 (en) | 2009-10-29 | 2011-06-01 | KRKA, D.D., Novo Mesto | Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates |
| RO128803A0 (en) | 2012-10-12 | 2013-09-30 | Ion Gigel Fulga | COMPOSITION FOR TREATMENT OR PREVENTION OF DISLIPIDEMS |
| CN110331151A (en) * | 2019-04-11 | 2019-10-15 | 北京工商大学 | The construction method of purple Monascus mokH gene overexpression bacterial strain |
| CN111297938A (en) * | 2020-03-11 | 2020-06-19 | 北京康立生医药技术开发有限公司 | Method for detecting lovastatin in composition for assisting in reducing blood fat |
| JP2022135089A (en) * | 2021-03-04 | 2022-09-15 | 小林製薬株式会社 | cholesterol lowering agent |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5612114B2 (en) * | 1974-06-07 | 1981-03-18 | ||
| JPS55150898A (en) * | 1979-05-11 | 1980-11-25 | Sankyo Co Ltd | Preparation of a new physiologically active substance mb-530b |
| IL60219A (en) * | 1979-06-15 | 1985-05-31 | Merck & Co Inc | Hypocholesteremic fermentation products of the hmg-coa reductase inhibitor type,their preparation and pharmaceutical compositions containing them |
-
1979
- 1979-02-20 JP JP54017856A patent/JPS5925599B2/en not_active Expired
-
1980
- 1980-02-19 CA CA345,983A patent/CA1129794A/en not_active Expired
- 1980-02-19 KR KR1019800000654A patent/KR830002801B1/en not_active Expired
- 1980-02-19 AU AU55673/80A patent/AU532626B2/en not_active Expired
- 1980-02-19 IE IE321/80A patent/IE49743B1/en not_active IP Right Cessation
- 1980-02-20 MX MX808652U patent/MX6314E/en unknown
- 1980-02-20 DE DE3006216A patent/DE3006216C2/en not_active Expired
- 1980-02-20 SU SU802887300A patent/SU1158048A3/en active
- 1980-02-20 BE BE0/199476A patent/BE881825A/en not_active IP Right Cessation
- 1980-02-20 PL PL1980222120A patent/PL124304B1/en unknown
- 1980-02-20 NL NL8001041A patent/NL191540C/en not_active IP Right Cessation
- 1980-02-20 FI FI800506A patent/FI66427C/en not_active IP Right Cessation
- 1980-02-20 DD DD80219159A patent/DD154494A5/en unknown
- 1980-02-20 NZ NZ192919A patent/NZ192919A/en unknown
- 1980-02-20 ES ES488796A patent/ES488796A0/en active Granted
- 1980-02-20 FR FR8003662A patent/FR2449685B1/en not_active Expired
- 1980-02-20 AT AT0092980A patent/AT373915B/en not_active IP Right Cessation
- 1980-02-20 NO NO800451A patent/NO153974C/en unknown
- 1980-02-20 HU HU80397A patent/HU182069B/en unknown
- 1980-02-20 ZA ZA00800962A patent/ZA80962B/en unknown
- 1980-02-20 PH PH23668A patent/PH15145A/en unknown
- 1980-02-20 DK DK73080A patent/DK149095C/en not_active IP Right Cessation
- 1980-02-20 DE DE3051175A patent/DE3051175C2/de not_active Expired
- 1980-02-20 GB GB8005748A patent/GB2046737B/en not_active Expired
- 1980-02-20 CH CH136680A patent/CH645890A5/en not_active IP Right Cessation
- 1980-02-20 SE SE8001339A patent/SE453301B/en not_active IP Right Cessation
- 1980-02-20 IT IT67262/80A patent/IT1175260B/en active
- 1980-09-12 SU SU802977031A patent/SU969702A1/en active
-
1984
- 1984-01-24 SG SG67/84A patent/SG6784G/en unknown
-
1989
- 1989-01-18 DK DK021889A patent/DK21889A/en not_active Application Discontinuation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK73080A (en) | METHOD FOR MANUFACTURING MONACOLIN K. | |
| DK73180A (en) | METHOD FOR MANUFACTURING MONACOLIN K. | |
| DK317180A (en) | PROCEDURE FOR MANUFACTURING FORMDDLE | |
| DK42480A (en) | METHOD FOR PREPARING 1-ARYL-2-ACYLAMIDO-3-FLUOR-1-PROPANOLS | |
| NO152964C (en) | PROCEDURE FOR MICROCAPPLES MANUFACTURING. | |
| DK156759C (en) | DRAIN CONSTRUCTION, ISSUED FOR AN UROSTOMIPOSE | |
| FI802267A7 (en) | Method for the preparation of oxoalkylxanthines. | |
| DK148498C (en) | CONTINUOUS PROCEDURE FOR MAKING MICROCAPPLES. | |
| DK78280A (en) | METHOD FOR LATEX MANUFACTURING | |
| DK153379A (en) | PROCEDURE FOR MAKING N, N, N!, N! -TETRAACETYLETHYLENDIAMINE | |
| DK271780A (en) | PROCEDURE FOR MANUFACTURING CEPHALOSPOR COMPOUNDS | |
| DK224681A (en) | METHOD FOR MANUFACTURING DIET-OEL | |
| FI810778A7 (en) | Method for the preparation of pyrimidinylquinazolines. | |
| DK174380A (en) | METHOD FOR PREPARING 2, 6, ADIAL COOL-N-ALCOXYMETHYL-2-CHLOR ACETANILLIDES | |
| FI800618A7 (en) | Method for manufacturing ammunition. | |
| DK123480A (en) | METHOD FOR MAKING CEPHALOSPOR COMPOUNDS | |
| DK158837C (en) | METHOD FOR PREPARING P-HYDROXYPHENYLGYLINE. | |
| DK454579A (en) | METHOD FOR PREPARING 6-PIPERIDINO-2,4-DIAMINOPYRIMIDIN-3-OXIDE | |
| DK139029B (en) | Analogous process for the preparation of 5-m-tolyloxyuracil. | |
| DK150684C (en) | METHOD FOR PREPARING ANTHOCYANES BY REDUCING THE SIMILAR FLAVONOID GYCOSIDES | |
| FI810935A7 (en) | Method for preparing substituted triarylthiazole compounds. | |
| DK477280A (en) | METHOD FOR MANUFACTURING MACROLIDE ANTIOTICS | |
| DK26881A (en) | METHOD FOR PREPARING ALPHACETOCARBOXYLIC ACID-N-TERT. BUTYLAMIDER | |
| DK375480A (en) | METHOD FOR PREPARING 1,2,4-TRIAZOL-3-THIOLES | |
| FI803776A7 (en) | Method for the preparation of 3-hydrazino-6-PY-pyridazines. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUP | Patent expired |