NO800451L - ANTI-HYPERCOLESTEROL AGENT, MONACOLIN K, AND PROCEDURE FOR THE PREPARATION OF THE SAME - Google Patents

ANTI-HYPERCOLESTEROL AGENT, MONACOLIN K, AND PROCEDURE FOR THE PREPARATION OF THE SAME

Info

Publication number
NO800451L
NO800451L NO800451A NO800451A NO800451L NO 800451 L NO800451 L NO 800451L NO 800451 A NO800451 A NO 800451A NO 800451 A NO800451 A NO 800451A NO 800451 L NO800451 L NO 800451L
Authority
NO
Norway
Prior art keywords
hypercolesterol
monacolin
procedure
agent
preparation
Prior art date
Application number
NO800451A
Other languages
Norwegian (no)
Other versions
NO153974C (en
NO153974B (en
Inventor
Akira Endo
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of NO800451L publication Critical patent/NO800451L/en
Publication of NO153974B publication Critical patent/NO153974B/en
Publication of NO153974C publication Critical patent/NO153974C/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D309/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30Oxygen atoms, e.g. delta-lactones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14Fungi; Culture media therefor
    • C12N1/145Fungi isolates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02Oxygen as only ring hetero atoms
    • C12P17/06Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00Microorganisms ; Processes using microorganisms
    • C12R2001/645Fungi ; Processes using fungi

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
NO800451A 1979-02-20 1980-02-20 PROCEDURE FOR THE PREPARATION OF THE MONACOLIN K COMPOUND NO153974C (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP54017856A JPS5925599B2 (en) 1979-02-20 1979-02-20 New physiologically active substance monacolin K and its production method

Publications (3)

Publication Number Publication Date
NO800451L true NO800451L (en) 1980-08-21
NO153974B NO153974B (en) 1986-03-17
NO153974C NO153974C (en) 1986-06-25

Family

ID=11955290

Family Applications (1)

Application Number Title Priority Date Filing Date
NO800451A NO153974C (en) 1979-02-20 1980-02-20 PROCEDURE FOR THE PREPARATION OF THE MONACOLIN K COMPOUND

Country Status (27)

Country Link
JP (1) JPS5925599B2 (en)
KR (1) KR830002801B1 (en)
AT (1) AT373915B (en)
AU (1) AU532626B2 (en)
BE (1) BE881825A (en)
CA (1) CA1129794A (en)
CH (1) CH645890A5 (en)
DD (1) DD154494A5 (en)
DE (2) DE3006216C2 (en)
DK (2) DK149095C (en)
ES (1) ES488796A0 (en)
FI (1) FI66427C (en)
FR (1) FR2449685B1 (en)
GB (1) GB2046737B (en)
HU (1) HU182069B (en)
IE (1) IE49743B1 (en)
IT (1) IT1175260B (en)
MX (1) MX6314E (en)
NL (1) NL191540C (en)
NO (1) NO153974C (en)
NZ (1) NZ192919A (en)
PH (1) PH15145A (en)
PL (1) PL124304B1 (en)
SE (1) SE453301B (en)
SG (1) SG6784G (en)
SU (2) SU1158048A3 (en)
ZA (1) ZA80962B (en)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55150898A (en) * 1979-05-11 1980-11-25 Sankyo Co Ltd Preparation of a new physiologically active substance mb-530b
US4231938A (en) * 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
JPS5621594A (en) * 1979-07-27 1981-02-28 Sankyo Co Ltd Mb-530b carboxylic acid metal salt and its preparation
AU548996B2 (en) * 1980-02-04 1986-01-09 Merck & Co., Inc. Tetrahydro-2h-pyran-2-one derivatives
PT72394B (en) * 1980-02-04 1982-09-06 Merck & Co Inc Process for preparing dihydro and tetrahydromevinoline hypocholesterolimics
JPH0692381B2 (en) * 1980-03-31 1994-11-16 三共株式会社 MB-530A derivative
JPS56142236A (en) 1980-04-08 1981-11-06 Sankyo Co Ltd Ml-236a and mb-530a derivative
MX7065E (en) * 1980-06-06 1987-04-10 Sankyo Co A MICROBIOLOGICAL PROCEDURE FOR PREPARING DERIVATIVES OF ML-236B
JPS5835144A (en) * 1981-08-27 1983-03-01 Sankyo Co Ltd Mb-530b derivative and its preparation
US4782084A (en) * 1987-06-29 1988-11-01 Merck & Co., Inc. HMG-COA reductase inhibitors
US4997848A (en) * 1987-10-27 1991-03-05 Sankyo Company, Limited Octahydronaphthalene oxime derivatives for cholesterol synthesis inhibition
CA2062023A1 (en) * 1992-02-10 1993-08-11 Jagroop S. Dahiya Novel fungal strains and use thereof in antibiotic production
EP0629184A1 (en) * 1992-03-04 1994-12-21 Fujisawa Pharmaceutical Co., Ltd. TETRALIN DERIVATIVES AS HMG-CoA REDUCTASE INHIBITORS
FI932188L (en) 1992-05-15 1993-11-16 Sankyo Co OCTAHYDRONAPTHALENOXIME DERIVATIVES FOER INHIBERING AV CHOLESTEROLBIOSYNTESEN, DERAS FRAMSTAELLNING OCH ANVAENDNING
US6812007B1 (en) * 1992-11-04 2004-11-02 Keri Vilmos Process for the isolation and purification of mevinolin
HU210867B (en) * 1992-11-04 1995-10-30 Biogal Gyogyszergyar Method for extraction and purification of mevinolin from culture medium
SI9300303A (en) * 1993-06-08 1994-12-31 Krka Tovarna Zdravil Process for isolation of hypolipemic effective substance
US5409820A (en) * 1993-08-06 1995-04-25 Apotex, Inc. Process for the production of lovastatin using Coniothyrium fuckelii
US7238348B2 (en) 1996-09-30 2007-07-03 Beijing Peking University Wbl Corporation Ltd. Method of treatment of osteoporosis with compositions of red rice fermentation products
US6046022A (en) 1996-09-30 2000-04-04 Peking University Methods and compositions employing red rice fermentation products
IL132822A0 (en) 1998-03-20 2001-03-19 Biogal Gyogyszergyar Metabolic controlled fermentation procedure for the manufacture of lovastatin hydroxy acid
RU2265665C2 (en) 2000-02-24 2005-12-10 Тева Джиоджисзерджиар Ресзвенитаршашаг Method for purifying fermentation broth
TR200403001T3 (en) 2000-03-03 2005-02-21 Plus Chemical, S.A. A process for the treatment of lovastatin and simvastatin with reduced dimeric impurity levels
KR20010095780A (en) * 2000-04-12 2001-11-07 나가오카 마사시 Embryo monascus
IN192861B (en) 2000-06-30 2004-05-22 Ranbaxy Lab Ltd
WO2002064809A2 (en) * 2001-02-09 2002-08-22 Unilever N.V. Process for the preparation of one or more statins by fermentation
KR100379075B1 (en) 2002-03-07 2003-04-08 Jinis Biopharmaceuticals Co Method for producing low cholesterol animal food product and food product therefrom
KR20020093147A (en) * 2002-05-30 2002-12-13 지니스생명공학 주식회사 Preventive and Dietary Supplement for adult chronic disease
KR100710500B1 (en) 2005-05-18 2007-04-24 고려대학교 산학협력단 Method for producing Monacholine K using red yeast bacteria
SI2373609T1 (en) 2008-12-19 2013-12-31 Krka, D.D., Novo Mesto Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates
EP2327682A1 (en) 2009-10-29 2011-06-01 KRKA, D.D., Novo Mesto Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates
RO128803A0 (en) 2012-10-12 2013-09-30 Ion Gigel Fulga COMPOSITION FOR TREATMENT OR PREVENTION OF DISLIPIDEMS
CN110331151A (en) * 2019-04-11 2019-10-15 北京工商大学 The construction method of purple Monascus mokH gene overexpression bacterial strain
CN111297938A (en) * 2020-03-11 2020-06-19 北京康立生医药技术开发有限公司 Method for detecting lovastatin in composition for assisting in reducing blood fat
JP2022135089A (en) * 2021-03-04 2022-09-15 小林製薬株式会社 cholesterol lowering agent

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5612114B2 (en) * 1974-06-07 1981-03-18
JPS55150898A (en) * 1979-05-11 1980-11-25 Sankyo Co Ltd Preparation of a new physiologically active substance mb-530b
GR69216B (en) * 1979-06-15 1982-05-07 Merck & Co Inc

Also Published As

Publication number Publication date
JPS5925599B2 (en) 1984-06-19
DE3051175C2 (en) 1989-12-21
DE3006216A1 (en) 1980-09-04
PH15145A (en) 1982-08-24
IE800321L (en) 1980-08-20
FI66427C (en) 1984-10-10
FR2449685A1 (en) 1980-09-19
AT373915B (en) 1984-03-12
FR2449685B1 (en) 1985-06-28
PL222120A1 (en) 1980-10-20
MX6314E (en) 1985-04-01
ES8103171A1 (en) 1981-02-16
ATA92980A (en) 1983-07-15
NO153974C (en) 1986-06-25
GB2046737B (en) 1983-01-12
SU1158048A3 (en) 1985-05-23
JPS55111790A (en) 1980-08-28
DK149095B (en) 1986-01-20
SE453301B (en) 1988-01-25
SG6784G (en) 1985-02-08
DK21889D0 (en) 1989-01-18
NO153974B (en) 1986-03-17
NL191540B (en) 1995-05-01
DD154494A5 (en) 1982-03-24
CH645890A5 (en) 1984-10-31
KR830002801B1 (en) 1983-12-16
AU532626B2 (en) 1983-10-06
IE49743B1 (en) 1985-12-11
FI66427B (en) 1984-06-29
KR830002030A (en) 1983-05-21
NL191540C (en) 1995-09-04
PL124304B1 (en) 1983-01-31
ZA80962B (en) 1981-03-25
GB2046737A (en) 1980-11-19
DK149095C (en) 1986-06-16
AU5567380A (en) 1980-08-28
ES488796A0 (en) 1981-02-16
FI800506A7 (en) 1980-08-21
NZ192919A (en) 1984-07-06
IT1175260B (en) 1987-07-01
NL8001041A (en) 1980-08-22
SE8001339L (en) 1980-08-21
SU969702A1 (en) 1982-10-30
DE3006216C2 (en) 1985-10-31
DK73080A (en) 1980-08-21
DK21889A (en) 1989-01-18
CA1129794A (en) 1982-08-17
IT8067262A0 (en) 1980-02-20
BE881825A (en) 1980-08-20
HU182069B (en) 1983-12-28

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