DK82893D0 - Peptid - Google Patents

Peptid

Info

Publication number
DK82893D0
DK82893D0 DK93828A DK82893A DK82893D0 DK 82893 D0 DK82893 D0 DK 82893D0 DK 93828 A DK93828 A DK 93828A DK 82893 A DK82893 A DK 82893A DK 82893 D0 DK82893 D0 DK 82893D0
Authority
DK
Denmark
Prior art keywords
pct
sequence encoding
dna sequence
date
peptide
Prior art date
Application number
DK93828A
Other languages
English (en)
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Priority to DK93828A priority Critical patent/DK82893D0/da
Publication of DK82893D0 publication Critical patent/DK82893D0/da
Priority to ZA944912A priority patent/ZA944912B/xx
Priority to IL11023894A priority patent/IL110238A/xx
Priority to SG1996004717A priority patent/SG52452A1/en
Priority to JP50376895A priority patent/JP3542604B2/ja
Priority to US08/446,646 priority patent/US5726038A/en
Priority to UA96010072A priority patent/UA40625C2/uk
Priority to PL94312436A priority patent/PL178924B1/pl
Priority to PCT/DK1994/000281 priority patent/WO1995002059A1/en
Priority to AT94920419T priority patent/ATE207124T1/de
Priority to PT94920419T priority patent/PT792367E/pt
Priority to DK94920419T priority patent/DK0792367T3/da
Priority to DE69428719T priority patent/DE69428719T2/de
Priority to EP94920419A priority patent/EP0792367B1/en
Priority to ES94920419T priority patent/ES2165881T3/es
Priority to HU9600053A priority patent/HU222406B1/hu
Priority to AU71221/94A priority patent/AU7122194A/en
Priority to CA002166684A priority patent/CA2166684A1/en
Priority to NZ268346A priority patent/NZ268346A/en
Priority to RU96103364/13A priority patent/RU2143495C1/ru
Priority to KR1019960700049A priority patent/KR100245173B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8103—Exopeptidase (E.C. 3.4.11-19) inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
    • C12N9/60—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi from yeast
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
DK93828A 1993-07-08 1993-07-08 Peptid DK82893D0 (da)

Priority Applications (21)

Application Number Priority Date Filing Date Title
DK93828A DK82893D0 (da) 1993-07-08 1993-07-08 Peptid
ZA944912A ZA944912B (en) 1993-07-08 1994-07-07 A DNA construct comprising the YAP3 signal peptide
IL11023894A IL110238A (en) 1993-07-08 1994-07-07 Dna construct comprising a dna sequence encoding the yeast aspartic protease 3 signal peptide
RU96103364/13A RU2143495C1 (ru) 1993-07-08 1994-07-08 Способ получения гетерологичного белка
PCT/DK1994/000281 WO1995002059A1 (en) 1993-07-08 1994-07-08 A dna construct encoding the yap3 signal peptide
DE69428719T DE69428719T2 (de) 1993-07-08 1994-07-08 Für das yap3 signalpeptid kodierendes dna-konstrukt
US08/446,646 US5726038A (en) 1993-07-08 1994-07-08 DNA construct encoding the YAP3 signal peptide
UA96010072A UA40625C2 (uk) 1993-07-08 1994-07-08 Конструкція днк, рекомбінантний експресуючий вектор, спосіб одержання гетерологічного поліпептиду
PL94312436A PL178924B1 (pl) 1993-07-08 1994-07-08 Konstrukt DNA, zrekombinowany wektor ekspresji, komórka transformowana i sposób wytwarzania heterologicznego polipeptydu
SG1996004717A SG52452A1 (en) 1993-07-08 1994-07-08 A dna construct encoding the yap3 singal peptide
AT94920419T ATE207124T1 (de) 1993-07-08 1994-07-08 Für das yap3 signalpeptid kodierendes dna- konstrukt
PT94920419T PT792367E (pt) 1993-07-08 1994-07-08 Constructo de adn que codifica o peptido sinal yap3
DK94920419T DK0792367T3 (da) 1993-07-08 1994-07-08 DNA-konstruktion, der koder YAP3-signalpeptidet
JP50376895A JP3542604B2 (ja) 1993-07-08 1994-07-08 Ｙａｐ３シグナルペプチドをコードするｄｎａ構築体
EP94920419A EP0792367B1 (en) 1993-07-08 1994-07-08 A dna construct encoding the yap3 signal peptide
ES94920419T ES2165881T3 (es) 1993-07-08 1994-07-08 Constructo de adn que codifica el peptido señal yap3.
HU9600053A HU222406B1 (hu) 1993-07-08 1994-07-08 YAP3 szignál peptidet kódoló DNS-szerkezet
AU71221/94A AU7122194A (en) 1993-07-08 1994-07-08 A dna construct encoding the yap3 signal peptide
CA002166684A CA2166684A1 (en) 1993-07-08 1994-07-08 A dna construct encoding the yap3 signal peptide
NZ268346A NZ268346A (en) 1993-07-08 1994-07-08 Improved secretion of proteins using the "signal protein" of yeast aspartic protease
KR1019960700049A KR100245173B1 (en) 1993-07-08 1996-01-08 A dna construct encoding the yap3 signal peptide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK93828A DK82893D0 (da) 1993-07-08 1993-07-08 Peptid

Publications (1)

Publication Number Publication Date
DK82893D0 true DK82893D0 (da) 1993-07-08

Family

ID=8098010

Family Applications (2)

Application Number Title Priority Date Filing Date
DK93828A DK82893D0 (da) 1993-07-08 1993-07-08 Peptid
DK94920419T DK0792367T3 (da) 1993-07-08 1994-07-08 DNA-konstruktion, der koder YAP3-signalpeptidet

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK94920419T DK0792367T3 (da) 1993-07-08 1994-07-08 DNA-konstruktion, der koder YAP3-signalpeptidet

Country Status (20)

Country Link
US (1) US5726038A (da)
EP (1) EP0792367B1 (da)
JP (1) JP3542604B2 (da)
KR (1) KR100245173B1 (da)
AT (1) ATE207124T1 (da)
AU (1) AU7122194A (da)
CA (1) CA2166684A1 (da)
DE (1) DE69428719T2 (da)
DK (2) DK82893D0 (da)
ES (1) ES2165881T3 (da)
HU (1) HU222406B1 (da)
IL (1) IL110238A (da)
NZ (1) NZ268346A (da)
PL (1) PL178924B1 (da)
PT (1) PT792367E (da)
RU (1) RU2143495C1 (da)
SG (1) SG52452A1 (da)
UA (1) UA40625C2 (da)
WO (1) WO1995002059A1 (da)
ZA (1) ZA944912B (da)

Families Citing this family (44)

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FR2686899B1 (fr) * 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
US6500645B1 (en) 1994-06-17 2002-12-31 Novo Nordisk A/S N-terminally extended proteins expressed in yeast
US5861267A (en) * 1995-05-01 1999-01-19 Vertex Pharmaceuticals Incorporated Methods, nucleotide sequences and host cells for assaying exogenous and endogenous protease activity
US5772629A (en) * 1995-10-23 1998-06-30 Localmed, Inc. Localized intravascular delivery of TFPI for inhibition of restenosis in recanalized blood vessels
ZA9610456B (en) * 1995-12-20 1997-06-20 Novo Nordisk As N-terminally extended proteins expressed in yeast
PT948538E (pt) * 1996-12-13 2008-08-05 Novartis Vaccines & Diagnostic Análise e separação de proteínas do factor de crescimento derivado de plaquetas
WO1998032867A1 (en) * 1997-01-24 1998-07-30 Novo Nordisk A/S Synthetic leader peptide sequences
US6451572B1 (en) 1998-06-25 2002-09-17 Cornell Research Foundation, Inc. Overexpression of phytase genes in yeast systems
US6420157B1 (en) * 1999-04-30 2002-07-16 Ortho-Mcneil Pharmaceutical, Inc. Zymogen activation system
AU4239600A (en) * 1999-04-30 2000-11-17 Ortho-Mcneil Pharmaceutical Research Inc. Zymogen activation system
JP4795599B2 (ja) 1999-12-29 2011-10-19 ノボ ノルディスク アクティーゼルスカブ 酵母において改良された発酵収率を有するインスリン前駆体及びインスリン前駆体類似体の製造方法
US20050100991A1 (en) * 2001-04-12 2005-05-12 Human Genome Sciences, Inc. Albumin fusion proteins
US6926898B2 (en) * 2000-04-12 2005-08-09 Human Genome Sciences, Inc. Albumin fusion proteins
WO2002097038A2 (en) * 2001-05-25 2002-12-05 Human Genome Sciences, Inc. Chemokine beta-1 fusion proteins
WO2003059934A2 (en) * 2001-12-21 2003-07-24 Human Genome Sciences, Inc. Albumin fusion proteins
WO2005003296A2 (en) 2003-01-22 2005-01-13 Human Genome Sciences, Inc. Albumin fusion proteins
CA2841097A1 (en) 2001-12-21 2003-07-24 Human Genome Sciences, Inc. Albumin and g-csf fusion proteins
EP1534835B1 (en) * 2002-06-29 2010-09-08 Korea Research Institute of Bioscience and Biotechnology Hansenula polymorpha yapsin deficient mutant strain and process for the preparation of recombinant proteins using the same
CA2925807C (en) 2002-09-13 2020-09-15 Cornell Research Foundation, Inc. Using mutations to improve aspergillus phytases
KR100470978B1 (ko) * 2003-01-02 2005-03-10 한국생명공학연구원 앱신 다중 결손 효모 변이 균주 및 이를 이용한 재조합 단백질의 생산 방법
EP1687428A1 (en) 2003-11-14 2006-08-09 Novo Nordisk A/S Processes for making acylated insulin
ES2369895T3 (es) 2003-12-03 2011-12-07 Novo Nordisk A/S Insulina monocatenaria.
CN102816241B (zh) * 2004-02-09 2015-07-22 人类基因科学公司 清蛋白融合蛋白
ATE513921T1 (de) 2005-08-16 2011-07-15 Novo Nordisk As Verfahren zur herstellung reifer insulinpolypeptide
JP5202338B2 (ja) 2006-02-27 2013-06-05 ノボ・ノルデイスク・エー／エス 新規インシュリン誘導体
WO2008037735A1 (en) 2006-09-27 2008-04-03 Novo Nordisk A/S Method for making maturated insulin polypeptides
WO2008062010A2 (en) 2006-11-22 2008-05-29 Novo Nordisk A/S Method for making activated carboxypeptidases
EP2170945A1 (en) 2007-07-16 2010-04-07 Novo Nordisk A/S Protease stabilized, pegylated insulin analogues
HUE032284T2 (en) 2008-03-18 2017-09-28 Novo Nordisk As Protease-stabilized, acylated insulin analogues
EP2258855A1 (en) 2009-05-28 2010-12-08 Universität für Bodenkultur Wien Expression sequences
CN103476928B (zh) 2010-12-09 2017-03-29 巴斯德研究所 用于获得高产量重组蛋白表达的基于mgmt的方法
DE102011007313A1 (de) * 2011-04-13 2012-10-18 Henkel Ag & Co. Kgaa Expressionsverfahren
DE102011118032A1 (de) * 2011-05-31 2012-12-06 Henkel Ag & Co. Kgaa Expressionsvektoren zur verbesserten Proteinsekretion
EP2788478B1 (en) 2011-12-09 2017-08-23 Institut Pasteur Multiplex immuno screening assay
EP3130598B1 (en) 2012-10-29 2020-02-12 Lonza Ltd Expression sequences
EP2925345B1 (en) 2012-12-03 2018-09-05 Merck Sharp & Dohme Corp. Method for making o-glycosylated carboxy terminal portion (ctp) peptide-based insulin and insulin analogues
US20160115216A1 (en) 2013-06-07 2016-04-28 Novo Nordisk A/S Method for Making Mature Insulin Polypeptides
PL233560B1 (pl) 2014-12-05 2019-10-31 Mabion Spolka Akcyjna Sposób otrzymywania insuliny lub analogu insuliny z prekursora rekombinowanego białka
EP3268384B1 (en) 2015-03-10 2021-11-03 Merck Sharp & Dohme Corp. Process for preparing recombinant insulin using microfiltration
EA037848B1 (ru) 2016-07-14 2021-05-27 Общество С Ограниченной Ответственностью "Биохимический Агент" Гибридный белок, полинуклеотид, генетическая конструкция, продуцент, препарат для регенерации хряща (варианты)
WO2019099615A1 (en) 2017-11-17 2019-05-23 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Use of copeptin to modulate the immune response and hematopoiesis, and stimulate bone growth
WO2022049409A1 (en) 2020-09-02 2022-03-10 Sia Terragen Express diagnosticum for sars-cov-2
CN112920280B (zh) * 2021-04-22 2022-07-05 江南大学 一种酸性蛋白酶高效表达的方法及其应用
WO2026009000A1 (en) 2024-07-04 2026-01-08 Solasta Bio Limited Methods for production of insecticidal neuropeptides

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JP2523562B2 (ja) * 1985-10-25 1996-08-14 ザイモジェネティックス インコーポレーテッド 外来タンパク質を分泌することを目的としたｂａｒ１の使用法
US5217891A (en) * 1987-07-28 1993-06-08 Chiron Corporation DNA constructs containing a kluyveromyces α factor leader sequence for directing secretion of heterologous polypeptides
US5037743A (en) * 1988-08-05 1991-08-06 Zymogenetics, Inc. BAR1 secretion signal
US5538863A (en) * 1993-07-01 1996-07-23 Immunex Corporation Expression system comprising mutant yeast strain and expression vector encoding synthetic signal peptide

Also Published As

Publication number Publication date
ZA944912B (en) 1995-03-27
US5726038A (en) 1998-03-10
DE69428719D1 (de) 2001-11-22
AU7122194A (en) 1995-02-06
HU222406B1 (hu) 2003-06-28
PL312436A1 (en) 1996-04-29
EP0792367A1 (en) 1997-09-03
RU2143495C1 (ru) 1999-12-27
IL110238A0 (en) 1994-10-21
JP3542604B2 (ja) 2004-07-14
IL110238A (en) 2003-04-10
ATE207124T1 (de) 2001-11-15
HU9600053D0 (en) 1996-03-28
UA40625C2 (uk) 2001-08-15
WO1995002059A1 (en) 1995-01-19
JPH08512202A (ja) 1996-12-24
DK0792367T3 (da) 2001-12-31
KR100245173B1 (en) 2000-02-15
EP0792367B1 (en) 2001-10-17
NZ268346A (en) 1997-05-26
CA2166684A1 (en) 1995-01-19
PT792367E (pt) 2002-04-29
SG52452A1 (en) 1998-09-28
PL178924B1 (pl) 2000-06-30
ES2165881T3 (es) 2002-04-01
HUT74253A (en) 1996-11-28
DE69428719T2 (de) 2002-08-08

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