ZA882562B - Sulfonyldecahydro-8h-isoquino-(2,1-g)(1,6)-naphthyridines,optical isomers thereof and related compounds - Google Patents

Sulfonyldecahydro-8h-isoquino-(2,1-g)(1,6)-naphthyridines,optical isomers thereof and related compounds

Info

Publication number: ZA882562B
Authority: ZA; South Africa
Prior art keywords: lower alkyl; sulfonyldecahydro; isoquino; naphthyridines; optical isomers
Prior art date: 1987-04-13

Application number

ZA882562A

Other languages

English (en)

Inventor

Robin D Clark

D Clark Robin

Original Assignee

Syntex Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-04-13

Filing date

1988-04-12

Publication date

1989-12-27

1988-04-12 Application filed by Syntex Inc filed Critical Syntex Inc

1989-12-27 Publication of ZA882562B publication Critical patent/ZA882562B/xx

Links

150000001875 compounds Chemical class 0.000 title abstract 2
230000003287 optical effect Effects 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
-1 methylenedioxy Chemical group 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Hematology (AREA)
Endocrinology (AREA)
Cardiology (AREA)
Obesity (AREA)
Psychiatry (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Child & Adolescent Psychology (AREA)
Ophthalmology & Optometry (AREA)
Anesthesiology (AREA)
Emergency Medicine (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Compounds Of Unknown Constitution (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

ZA882562A 1987-04-13 1988-04-12 Sulfonyldecahydro-8h-isoquino-(2,1-g)(1,6)-naphthyridines,optical isomers thereof and related compounds ZA882562B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/037,320 US4791108A (en)	1987-04-13	1987-04-13	Sulfonyl-decahydro-8H-isoquino[2,1-G][1,6]-naphthyridines and related compounds useful as α2 -blockers

Publications (1)

Publication Number	Publication Date
ZA882562B true ZA882562B (en)	1989-12-27

Family

ID=21893706

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA882562A ZA882562B (en)	1987-04-13	1988-04-12	Sulfonyldecahydro-8h-isoquino-(2,1-g)(1,6)-naphthyridines,optical isomers thereof and related compounds

Country Status (20)

Country	Link
US (1)	US4791108A (da)
EP (1)	EP0288196B1 (da)
JP (1)	JP2527784B2 (da)
KR (1)	KR960007864B1 (da)
AT (1)	ATE92066T1 (da)
AU (1)	AU613610B2 (da)
CA (1)	CA1331459C (da)
DE (1)	DE3882571T2 (da)
DK (2)	DK171106B1 (da)
ES (1)	ES2058264T3 (da)
FI (1)	FI88162C (da)
HU (2)	HU199469B (da)
IE (1)	IE60624B1 (da)
IL (1)	IL86039A (da)
MX (1)	MX11083A (da)
NO (1)	NO170805C (da)
NZ (1)	NZ224221A (da)
PH (1)	PH25961A (da)
PT (1)	PT87219B (da)
ZA (1)	ZA882562B (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4956365A (en) *	1987-04-13	1990-09-11	Syntex (U.S.A.) Inc.	Decahydro-8H-isoquino(2,1-g)(1,6)naphthyridine derivatives and related compounds
US4886798A (en) *	1987-04-13	1989-12-12	Syntex (U.S.A.) Inc.	Optical isomers of sulfonyldecahydro-8H-isoquino-(2,1-G)(1,6) naphthyridines and related compounds useful as α2 -blockers
US4960891A (en) *	1987-04-13	1990-10-02	Syntex (U.S.A.) Inc.	Process for the preparation of decahydro-8H-isoquino[2,1-g][1,6]naphthyridine derivatives
GB9012469D0 (en) *	1990-06-05	1990-07-25	Glaxo Group Ltd	Medicaments
US5231181A (en) *	1991-03-21	1993-07-27	Syntex (U.S.A.) Inc.	Process for the preparation of (8as,12as,13as)-decahydroisoquino ((2,1-g) (1,6)-naphthyridin-8-one derivatives
FI923267L (fi) *	1991-07-17	1993-01-18	Syntex Inc	Dekahydro-8h-isokino(2,1-g) (1,6)naftyridin- och dekahydrobenso(a)pyrrolo(2,3-e)-kinolizinderivat
US5229387A (en) *	1991-09-20	1993-07-20	Syntex (U.S.A.) Inc.	Decahydro-8H-isoquino[2,1-g][1,6]naphthyridine and decahydrobenzo[a]pyrrolo [2,3-e]quinolizine derivatives
JP2005519110A (ja) *	2002-03-04	2005-06-30	ベーリンガーインゲルハイムファルマゲゼルシャフトミットベシュレンクテルハフツングウントコンパニーコマンディトゲゼルシャフト	新規なケイ皮酸塩、その調製方法及び医薬品としての使用
CN103387583B (zh) *	2012-05-09	2018-04-13	中国科学院上海药物研究所	二芳基并[a,g]喹嗪类化合物、其制备方法、药物组合物及其应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3953598A (en) *	1972-09-08	1976-04-27	The Upjohn Company	Compounds, compositions and methods of use
GB1513824A (en) *	1975-05-22	1978-06-14	Wyeth John & Brother Ltd	1,3,4,6,7,11b-hexahydro-2h-benzo(a)quinolizine derivative
US4353911A (en) *	1979-07-20	1982-10-12	Andre Buzas	Indolo(2,3-a)quinolizidines, useful in increasing femoral and vertebral blood flow
CH645653A5 (de) *	1980-08-01	1984-10-15	Ciba Geigy Ag	Quaternaere, copolymere, hochmolekulare ammoniumsalze auf acrylbasis, deren herstellung und verwendung als aktive komponente in kosmetischen mitteln.
US4454139A (en) *	1980-08-28	1984-06-12	John Wyeth & Brother, Limited	α2 -Adrenoceptor antagonistic benzoquinolizines
GB8302499D0 (en) *	1983-01-29	1983-03-02	Wyeth John & Brother Ltd	Benzoquinolizines
US4690928A (en) *	1984-02-02	1987-09-01	Merck & Co., Inc.	Substituted hexahydro arylquinolizines as α2 blockers
US4673680A (en) *	1985-09-18	1987-06-16	Pendleton Robert G	α2 -adrenergic receptor antagonists as modifiers of gastrointestinal motility

1987
- 1987-04-13 US US07/037,320 patent/US4791108A/en not_active Expired - Fee Related
1988
- 1988-04-12 DE DE88303271T patent/DE3882571T2/de not_active Expired - Fee Related
- 1988-04-12 JP JP63090154A patent/JP2527784B2/ja not_active Expired - Lifetime
- 1988-04-12 AU AU14502/88A patent/AU613610B2/en not_active Ceased
- 1988-04-12 MX MX1108388A patent/MX11083A/es unknown
- 1988-04-12 AT AT88303271T patent/ATE92066T1/de not_active IP Right Cessation
- 1988-04-12 IL IL86039A patent/IL86039A/xx not_active IP Right Cessation
- 1988-04-12 NO NO881574A patent/NO170805C/no unknown
- 1988-04-12 ZA ZA882562A patent/ZA882562B/xx unknown
- 1988-04-12 PT PT87219A patent/PT87219B/pt not_active IP Right Cessation
- 1988-04-12 FI FI881687A patent/FI88162C/fi not_active IP Right Cessation
- 1988-04-12 PH PH36784A patent/PH25961A/en unknown
- 1988-04-12 KR KR1019880004144A patent/KR960007864B1/ko not_active Expired - Fee Related
- 1988-04-12 DK DK199388A patent/DK171106B1/da not_active IP Right Cessation
- 1988-04-12 HU HU881816A patent/HU199469B/hu not_active IP Right Cessation
- 1988-04-12 EP EP88303271A patent/EP0288196B1/en not_active Expired - Lifetime
- 1988-04-12 CA CA000563919A patent/CA1331459C/en not_active Expired - Fee Related
- 1988-04-12 ES ES88303271T patent/ES2058264T3/es not_active Expired - Lifetime
- 1988-04-12 IE IE109788A patent/IE60624B1/en not_active IP Right Cessation
- 1988-04-12 NZ NZ224221A patent/NZ224221A/xx unknown
1993
- 1993-07-15 DK DK93846A patent/DK84693D0/da not_active Application Discontinuation
1994
- 1994-07-01 HU HU94P/P00005P patent/HU210349A9/hu unknown

Also Published As

Publication number	Publication date
MX11083A (es)	1993-04-01
FI88162B (fi)	1992-12-31
DK199388A (da)	1988-10-14
EP0288196B1 (en)	1993-07-28
NO881574L (no)	1988-10-14
DK84693A (da)	1993-07-15
PT87219A (pt)	1988-05-01
NO881574D0 (no)	1988-04-12
AU613610B2 (en)	1991-08-08
HU210349A9 (en)	1995-03-28
DK199388D0 (da)	1988-04-12
NZ224221A (en)	1990-07-26
NO170805C (no)	1992-12-09
DE3882571T2 (de)	1994-01-20
KR880012601A (ko)	1988-11-28
FI881687A0 (fi)	1988-04-12
DK84693D0 (da)	1993-07-15
IL86039A0 (en)	1988-09-30
ATE92066T1 (de)	1993-08-15
FI881687A7 (fi)	1988-10-14
DE3882571D1 (de)	1993-09-02
AU1450288A (en)	1988-10-13
US4791108A (en)	1988-12-13
PH25961A (en)	1992-01-13
DK171106B1 (da)	1996-06-10
ES2058264T3 (es)	1994-11-01
KR960007864B1 (ko)	1996-06-13
EP0288196A1 (en)	1988-10-26
NO170805B (no)	1992-08-31
JP2527784B2 (ja)	1996-08-28
PT87219B (pt)	1992-12-31
HU199469B (en)	1990-02-28
IE881097L (en)	1988-10-13
HUT47107A (en)	1989-01-30
JPS63277679A (ja)	1988-11-15
IE60624B1 (en)	1994-07-27
CA1331459C (en)	1994-08-16
FI88162C (fi)	1993-04-13
IL86039A (en)	1993-05-13

Publication	Publication Date	Title
IL69912A (en)	1987-03-31	Substituted 1-hydroxyethyltriazolyl derivatives,their preparation and their use as plant protection agents
AU1450288A (en)	1988-10-13	Sulfonyldecahydro-8h-isoquino-(2,1-g) (1,6)-naphthyridines, optical isomers thereof and related compounds
ZA862278B (en)	1987-11-25	Novel(4.2.0)bicyclooctane derivatives with valuable therapeutic properties
PH19797A (en)	1986-07-02	Thiazol-4-yl pyrimidone derivatives useful as antiulcer agents
HUT53365A (en)	1990-10-28	Process for producing 1,8-benzonaphthyridine derivatives
EP0574271A3 (da)	1994-04-06
CA2007760A1 (fr)	1990-07-16	Nouveaux derives de benzonaphtyridine-1,8, leur preparation et les compositions qui les contiennent
GR3020488T3 (en)	1996-10-31	Benzo(b)thiophene-2-carboxamides for the treatment of disorders of the central nervous system
FI883507A0 (fi)	1988-07-26	Naftotiazepinderivat och deras framstaellning.
HU905000D0 (en)	1991-01-28	Process for producing compounds suitable for treatment of gastric ulcer
EP0364254A3 (en)	1991-08-14	Decahydro-8H-isoquino[2,1-g][1,6]naphthyridine derivatives and related compounds
EP0289935A3 (en)	1990-11-07	Stabilizing mixture of organic compounds of sulphur and organic compounds of nitrogen, use of the mixture in stabilizing oxyalkylene glycol alkyl ethers
ES2023760A6 (es)	1992-02-01	Procedimiento para la preparacion de derivados benzotiazinicos.
DE3362036D1 (en)	1986-03-13	Ketene-o,o-acetates and process for their preparation
IN161663B (da)	1988-01-09
GB2071093B (en)	1984-01-18	Benzothiopyrano(2,3-c)pyridines