DK84789D0 - Isoquinolinderivater - Google Patents

Isoquinolinderivater

Info

Publication number
DK84789D0
DK84789D0 DK084789A DK84789A DK84789D0 DK 84789 D0 DK84789 D0 DK 84789D0 DK 084789 A DK084789 A DK 084789A DK 84789 A DK84789 A DK 84789A DK 84789 D0 DK84789 D0 DK 84789D0
Authority
DK
Denmark
Prior art keywords
isoquinoline
Prior art date
Application number
DK084789A
Other languages
English (en)
Other versions
DK84789A (da
Inventor
Alan Naylor
Duncan Bruce Judd
John Bradshaw
David Edward Bays
Ann Gail Hayes
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB888804107A external-priority patent/GB8804107D0/en
Priority claimed from GB888816550A external-priority patent/GB8816550D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of DK84789D0 publication Critical patent/DK84789D0/da
Publication of DK84789A publication Critical patent/DK84789A/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10Antioedematous agents; Diuretics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK084789A 1988-02-23 1989-02-23 Isoquinolinderivater DK84789A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB888804107A GB8804107D0 (en) 1988-02-23 1988-02-23 Chemical compounds
GB888816550A GB8816550D0 (en) 1988-07-12 1988-07-12 Chemical compounds

Publications (2)

Publication Number Publication Date
DK84789D0 true DK84789D0 (da) 1989-02-23
DK84789A DK84789A (da) 1989-08-24

Family

ID=26293523

Family Applications (1)

Application Number Title Priority Date Filing Date
DK084789A DK84789A (da) 1988-02-23 1989-02-23 Isoquinolinderivater

Country Status (7)

Country Link
EP (1) EP0330469A3 (da)
JP (1) JPH01301662A (da)
KR (1) KR890012970A (da)
AU (1) AU3029389A (da)
DK (1) DK84789A (da)
FI (1) FI890867A7 (da)
PT (1) PT89780A (da)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE632371A (da) * 1962-05-15 1963-09-02
EP0330360B1 (en) * 1988-02-19 1993-12-01 SmithKline Beecham Farmaceutici S.p.A. 1,2,3,4-Tetrahydroisoquinolines, processes for their preparation, and their use as kappa-receptor agonists
GB8827479D0 (en) * 1988-11-24 1988-12-29 Zambeletti Spa L Novel compounds
FI895821A7 (fi) * 1988-12-07 1990-06-08 The Wellcome Foundation Ltd Farmaseuttisesti aktivisia CNS-yhdisteitä
DE3935371A1 (de) * 1988-12-23 1990-07-05 Merck Patent Gmbh Stickstoffhaltige ringverbindungen
GB8830219D0 (en) * 1988-12-23 1989-02-22 Zambeletti Spa L Novel compounds
GB8916395D0 (en) * 1989-07-18 1989-09-06 Zambeletti Spa L Pharmaceuticals
GB8926560D0 (en) * 1989-11-24 1990-01-17 Zambeletti Spa L Pharmaceuticals
AU641955B2 (en) * 1989-11-24 1993-10-07 Dr. Lo Zambeletti S.P.A. N-acyl-substituted azacyclic compounds, processes for their preparation, and their use as pharmaceuticals
US5428042A (en) * 1990-04-28 1995-06-27 Dr Lo Zambeletti S.P.A. 1-(2H-1-oxo-3,4-dihydronaphtyl-6-yl)-acetyl-piperidines as kappa agonists
WO1992017467A1 (en) * 1991-04-06 1992-10-15 Dr Lo. Zambeletti S.P.A. Substituted azacyclic compounds, process for their preparation and their use as analgesics
EP0585296A1 (en) * 1991-05-21 1994-03-09 Smithkline Beecham Farmaceutici S.p.A. 2-(pyrrolidinyl-1-methyl)-piperidine derivatives and their use as kappa-recept or agonists
IT1273751B (it) * 1994-02-11 1997-07-10 Smithkline Beecham Farma Derivati azaciclici
US6239154B1 (en) 1996-03-08 2001-05-29 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
US5763445A (en) 1996-03-08 1998-06-09 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
US5760023A (en) * 1997-07-14 1998-06-02 Adolor Corporation Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith
MXPA99011298A (es) * 1997-07-14 2004-10-28 Adolor Corp Formulaciones farmaceuticas antiprurito de agonista kappa y metodo para tratar prurito con las mismas.
DE60115227T2 (de) 2000-05-11 2006-08-24 Bristol-Myers Squibb Co. Tetrahydroisochinolin-analoga als wachstumshormon-sekretagoga
AU2002357692A1 (en) 2001-11-09 2003-05-26 Bristol-Myers Squibb Company Tetrahydroisoquinoline analogs as modulators of chemokine receptor activity
CN100503571C (zh) * 2006-07-12 2009-06-24 中国药科大学 四氢异喹啉类衍生物、其制备方法及其医药用途
US8445700B2 (en) 2008-11-24 2013-05-21 Council Of Scientific & Industrial Research Process for the preparation of optically active N-benzyl-3 hydroxypyrrolidines
CN103435545B (zh) * 2013-08-14 2015-10-07 中国药科大学 四氢异喹啉季铵盐类衍生物、其制备方法及其镇痛用途
CN103554021A (zh) * 2013-11-25 2014-02-05 中国药科大学 一类茚酮四氢异喹啉衍生物、其制备方法及医药用途
ES2963613T3 (es) 2018-10-22 2024-04-01 C4X Discovery Ltd Compuestos terapéuticos

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2361390A1 (de) * 1973-12-10 1975-06-19 Merck Patent Gmbh Isochinolinderivate und verfahren zu ihrer herstellung
GB8531615D0 (en) * 1985-12-23 1986-02-05 Zambeletti Spa L Compounds
GB8601796D0 (en) * 1986-01-24 1986-02-26 Zambeletti Spa L Compounds
EP0330360B1 (en) * 1988-02-19 1993-12-01 SmithKline Beecham Farmaceutici S.p.A. 1,2,3,4-Tetrahydroisoquinolines, processes for their preparation, and their use as kappa-receptor agonists

Also Published As

Publication number Publication date
FI890867A7 (fi) 1989-08-24
EP0330469A3 (en) 1990-05-09
PT89780A (pt) 1989-10-04
AU3029389A (en) 1989-08-24
KR890012970A (ko) 1989-09-20
JPH01301662A (ja) 1989-12-05
FI890867A0 (fi) 1989-02-23
DK84789A (da) 1989-08-24
EP0330469A2 (en) 1989-08-30

Similar Documents

Publication Publication Date Title
ATA901789A (de) Somatostatinpeptid
DK103389A (da) Forbedret braender
BR8806093A (pt) Trepano
DK5789D0 (da) Isoquinolinderivater
ATA900689A (de) Calcitoninpeptide
ATA172889A (de) Furanderivate
DK84789A (da) Isoquinolinderivater
DE68926597D1 (de) Mikrorechner
BR8902098A (pt) Eletrolisador
DK113291D0 (da) Homogent enzymimmunassay
PT8062U (pt) Oculos melhorados
BR8906898A (pt) Jamela
DE68926367D1 (de) Hydroxymethylcyclobutylpurine
DK632988A (da) Isoquinolinderivater
DK255687D0 (da) Isoquinolinderivater
ATA296888A (de) Labyrinthanordnung
DD277186A3 (de) Waelzlagerseparator
SE8802859D0 (sv) Hengbrygga - tak
BR8806526A (pt) Locate
BR6800600U (pt) Hidro-serra
BR6801036U (pt) Rechaud
BR6801307U (pt) Boneco-luva
BR6801330U (pt) Caixa-arquivo
BR6801430U (pt) Auto-sombreiro
BR6802550U (pt) Bicicleta-skate

Legal Events

Date Code Title Description
AHB Application shelved due to non-payment