ATE97893T1 - 1,2,3,4-tetrahydroisoquinoline, verfharen zu ihrer herstellung und ihre verwendung als kappa- rezeptor agonisten. - Google Patents

1,2,3,4-tetrahydroisoquinoline, verfharen zu ihrer herstellung und ihre verwendung als kappa- rezeptor agonisten.

Info

Publication number: ATE97893T1
Authority: AT; Austria
Prior art keywords: alkyl; group; hydrogen; same; different
Prior art date: 1988-02-19

Application number

AT89301374T

Other languages

English (en)

Inventor

Vittorio Vecchietti

Giuseppe Giardina

Original Assignee

Smithkline Beecham Farma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-02-19

Filing date

1989-02-14

Publication date

1993-12-15

1988-02-19 Priority claimed from GB888803919A external-priority patent/GB8803919D0/en

1988-06-24 Priority claimed from GB888815089A external-priority patent/GB8815089D0/en

1989-02-14 Application filed by Smithkline Beecham Farma filed Critical Smithkline Beecham Farma

1993-12-15 Application granted granted Critical

1993-12-15 Publication of ATE97893T1 publication Critical patent/ATE97893T1/de

Links

239000000018 receptor agonist Substances 0.000 title 1
229940044601 receptor agonist Drugs 0.000 title 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 6
229910052739 hydrogen Inorganic materials 0.000 abstract 6
239000001257 hydrogen Substances 0.000 abstract 6
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 6
125000003118 aryl group Chemical group 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
-1 polymethylene Polymers 0.000 abstract 2
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 abstract 1
125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 1
125000006590 (C2-C6) alkenylene group Chemical group 0.000 abstract 1
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
125000002183 isoquinolinyl group Chemical class C1(=NC=CC2=CC=CC=C12)* 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1
150000003573 thiols Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pain & Pain Management (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Mechanical Treatment Of Semiconductor (AREA)
Photoreceptors In Electrophotography (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Hydrogenated Pyridines (AREA)

AT89301374T 1988-02-19 1989-02-14 1,2,3,4-tetrahydroisoquinoline, verfharen zu ihrer herstellung und ihre verwendung als kappa- rezeptor agonisten. ATE97893T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB888803919A GB8803919D0 (en)	1988-02-19	1988-02-19	Novel compounds
GB888815089A GB8815089D0 (en)	1988-06-24	1988-06-24	Novel compounds
EP89301374A EP0330360B1 (de)	1988-02-19	1989-02-14	1,2,3,4-Tetrahydroisoquinoline, Verfharen zu ihrer Herstellung und ihre Verwendung als Kappa-Rezeptor Agonisten

Publications (1)

Publication Number	Publication Date
ATE97893T1 true ATE97893T1 (de)	1993-12-15

Family

ID=26293513

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT89301374T ATE97893T1 (de)	1988-02-19	1989-02-14	1,2,3,4-tetrahydroisoquinoline, verfharen zu ihrer herstellung und ihre verwendung als kappa- rezeptor agonisten.

Country Status (12)

Country	Link
US (1)	US4954509A (de)
EP (1)	EP0330360B1 (de)
JP (1)	JPH0219379A (de)
AT (1)	ATE97893T1 (de)
AU (1)	AU620845B2 (de)
CA (1)	CA1333067C (de)
DE (1)	DE68910999T2 (de)
DK (1)	DK75589A (de)
ES (1)	ES2061972T3 (de)
IE (1)	IE62031B1 (de)
NZ (1)	NZ228032A (de)
PT (1)	PT89746B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT89780A (pt) *	1988-02-23	1989-10-04	Glaxo Group Ltd	Processo para a preparacao de derivados da tetrahidroisoquinolina
GB8824400D0 (en) *	1988-10-18	1988-11-23	Glaxo Group Ltd	Chemical compounds
GB8827479D0 (en) *	1988-11-24	1988-12-29	Zambeletti Spa L	Novel compounds
DE3935371A1 (de) *	1988-12-23	1990-07-05	Merck Patent Gmbh	Stickstoffhaltige ringverbindungen
GB8830219D0 (en) *	1988-12-23	1989-02-22	Zambeletti Spa L	Novel compounds
GB8916395D0 (en) *	1989-07-18	1989-09-06	Zambeletti Spa L	Pharmaceuticals
GB8926560D0 (en) *	1989-11-24	1990-01-17	Zambeletti Spa L	Pharmaceuticals
EP0501997B1 (de) *	1989-11-24	1997-01-29	Smithkline Beecham S.p.A.	N-acyl-substituierte azazyklische verbindungen, verfahren zu deren herstellung und deren verwendung als arzneimittel
US5532243A (en) *	1992-02-14	1996-07-02	The Dupont Merck Pharmaceutical Company	Antipsychotic nitrogen-containing bicyclic compounds
US5389638A (en) *	1993-09-10	1995-02-14	Abbott Laboratories	Tetrahydroisoquinolines as alpha-2 antagonists and biogenic amine uptake inhibitors
TW427978B (en) *	1996-02-03	2001-04-01	Hoffmann La Roche	Tetrahydroisoquinoline derivatives
TW436484B (en) *	1996-04-24	2001-05-28	Dev Center Biotechnology	1,2,3,4-tetrahydroisoquinoline derivatives having a nitrogen-containing heterocyclic methyl substituent, the preparation process and pharmaceutical composition thereof
MXPA05005586A (es) *	2002-12-02	2005-07-27	Pharmacia & Up John Company Ll	El uso de tetrahidroisoquinolinas 4-fenilsustituidas en el tratamiento del dolor, migrana e incontinencia urinaria.
EP1572658A1 (de) *	2002-12-02	2005-09-14	Pharmacia & Upjohn Company LLC	Verwendung von 4-phenyl substituierten tetrahydroisochinolinen zur behandlung von schmerz, migränen und harninkontinenz
AU2003283646A1 (en) *	2002-12-02	2004-06-23	Pharmacia & Upjohn Company Llc	The use of aryl- and heteroaryl-substituted tetrahydroisoquinolines in the treatment of chronic and neuropathic pain, migraine headaches, and urge, stress and mixed urinary incontinence
JO3316B1 (ar)	2013-05-30	2019-03-13	Lilly Co Eli	مركبات 3، 4-داي هيدرو أيزو كوينولين -2(1h)-يل
TWI725408B (zh)	2018-04-20	2021-04-21	美商美國禮來大藥廠	多巴胺d1受體正向異位調節劑
MY207469A (en) *	2018-10-22	2025-02-27	C4X Discovery Ltd	Therapeutic compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2361390A1 (de) *	1973-12-10	1975-06-19	Merck Patent Gmbh	Isochinolinderivate und verfahren zu ihrer herstellung
DE2504250A1 (de) *	1975-02-01	1976-08-05	Merck Patent Gmbh	Tetrahydroisochinolin-derivate und verfahren zu ihrer herstellung
US4232160A (en) *	1978-10-18	1980-11-04	Miles Laboratories, Inc.	Isoquinoline propionamides exhibiting analgesic properties
US4518779A (en) *	1982-09-27	1985-05-21	Pennwalt Corporation	1,2,3,4-Tetrahydro-1-aminomethyl-4-phenyl isoquinolines
GB8531615D0 (en) *	1985-12-23	1986-02-05	Zambeletti Spa L	Compounds
GB8601796D0 (en) *	1986-01-24	1986-02-26	Zambeletti Spa L	Compounds
PT89780A (pt) *	1988-02-23	1989-10-04	Glaxo Group Ltd	Processo para a preparacao de derivados da tetrahidroisoquinolina
DE3935371A1 (de) *	1988-12-23	1990-07-05	Merck Patent Gmbh	Stickstoffhaltige ringverbindungen

1989
- 1989-02-14 AT AT89301374T patent/ATE97893T1/de not_active IP Right Cessation
- 1989-02-14 DE DE89301374T patent/DE68910999T2/de not_active Expired - Fee Related
- 1989-02-14 ES ES89301374T patent/ES2061972T3/es not_active Expired - Lifetime
- 1989-02-14 EP EP89301374A patent/EP0330360B1/de not_active Expired - Lifetime
- 1989-02-17 PT PT89746A patent/PT89746B/pt not_active IP Right Cessation
- 1989-02-17 DK DK075589A patent/DK75589A/da not_active Application Discontinuation
- 1989-02-17 IE IE51989A patent/IE62031B1/en not_active IP Right Cessation
- 1989-02-17 US US07/312,648 patent/US4954509A/en not_active Expired - Fee Related
- 1989-02-17 NZ NZ228032A patent/NZ228032A/en unknown
- 1989-02-17 AU AU30070/89A patent/AU620845B2/en not_active Ceased
- 1989-02-17 CA CA000591455A patent/CA1333067C/en not_active Expired - Fee Related
- 1989-02-20 JP JP8938504A patent/JPH0219379A/ja active Pending

Also Published As

Publication number	Publication date
EP0330360A1 (de)	1989-08-30
AU3007089A (en)	1989-08-24
US4954509A (en)	1990-09-04
PT89746B (pt)	1994-03-31
PT89746A (pt)	1989-10-04
EP0330360B1 (de)	1993-12-01
DE68910999T2 (de)	1994-03-24
CA1333067C (en)	1994-11-15
DK75589A (da)	1989-08-20
DE68910999D1 (de)	1994-01-13
JPH0219379A (ja)	1990-01-23
IE890519L (en)	1989-08-19
NZ228032A (en)	1991-12-23
DK75589D0 (da)	1989-02-17
AU620845B2 (en)	1992-02-27
IE62031B1 (en)	1994-12-14
ES2061972T3 (es)	1994-12-16

Legal Events

Date	Code	Title	Description
1994-08-15	UEP	Publication of translation of european patent specification
1997-11-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE68910999D1 (de)	1994-01-13	1,2,3,4-Tetrahydroisoquinoline, Verfharen zu ihrer Herstellung und ihre Verwendung als Kappa-Rezeptor Agonisten.
PT885210E (pt)	2002-09-30	Compostos triciclicos que possuem afinidade de ligacao para receptores de melatonina sua producao e utilizacao
FI982436A0 (fi)	1998-11-10	Kondensoituneet heterosykliset yhdisteet
ATE89559T1 (de)	1993-06-15	Camptothecin-derivate und verfahren zu ihrer herstellung.
ES2065895T3 (es)	1995-03-01	2-aminobenzotiazoles sustituidos y derivados de los mismos utiles como agentes cerebrovasculares.
NZ228331A (en)	1991-10-25	Amine- and amido-containing heterocyclic compounds and pharmaceutical compositions
DE69929669D1 (de)	2006-04-13	Zyklische Amidderivate die Cathepsin K hemmen
DE68918609D1 (de)	1994-11-10	Piperidinoalkyl-Derivate von Carbonsäure-Amiden.
AU5905790A (en)	1991-01-24	2-acyl-1-(substituted aminomethyl-tetrahydroisoquinoline) derivatives
PT89677A (pt)	1989-10-04	Processo para a preparacao de novos derivados azaciclicos, em particular derivados de piperidina
DK0983238T3 (da)	2004-11-29	Fremgangsmåde og mellemprodukter til opspaltning af piperidylacetamidstereoisomerer
ATE312150T1 (de)	2005-12-15	Electrochrome lösung, enthaltend eine hydrazonverbindung und mit dieser hergestellte vorrichtung
DK584488D0 (da)	1988-10-20	Isoquinolinderivater
ATE137747T1 (de)	1996-05-15	Aminobenzolverbindungen, herstellung und verwendung
PT70740B (pt)	1982-06-08	Derivate des 2-hydroxy-naphtalins und ihre verwendung als kupplingskomponente in diazotypiematerialen
ES540332A0 (es)	1986-12-16	Procedimiento para preparar nuevos pirimido (2,1-b) benzo- tiazoles
DK0410953T3 (da)	1996-01-22	Piperidinforbindelser
SE8100743L (sv)	1981-08-14	Rifamycinderivat
HUP0003024A2 (hu)	2001-01-29	Eljárás nitro-guanidin-származékok előállítására és az új kiindulási vegyületek
DE69819315D1 (de)	2003-12-04	Verfahren zur herstellung von piperidincarbonsäureamiden
DE3664467D1 (de)	1989-08-24	Pineapple ketone l'alkoxyalkyl derivatives
FI863118A0 (fi)	1986-07-30	Kemiska foereningar.
DE60008561D1 (de)	2004-04-01	Verfahren zur herstellung von oxazol-derivaten