DK91488A - 3-aminomethylderivater af indan, dihydrobenzofuran, dihydrobenzothiophen og indolin - Google Patents

3-aminomethylderivater af indan, dihydrobenzofuran, dihydrobenzothiophen og indolin

Info

Publication number: DK91488A
Authority: DK; Denmark
Prior art keywords: indane; indoline; dihydrobenzothiophen; dihydrobenzofuran; derivatives
Prior art date: 1987-02-26

Application number

DK091488A

Other languages

English (en)

Other versions

DK170636B1 (da

DK91488D0 (da

Inventor

Klaus Peter Boegesoe

Jens Kristian Perregaard

Original Assignee

Lundbeck & Co As H

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-02-26

Filing date

1988-02-23

Publication date

1988-08-27

1988-02-23 Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H

1988-02-23 Publication of DK91488D0 publication Critical patent/DK91488D0/da

1988-08-27 Publication of DK91488A publication Critical patent/DK91488A/da

1995-11-20 Application granted granted Critical

1995-11-20 Publication of DK170636B1 publication Critical patent/DK170636B1/da

Links

HBEDSQVIWPRPAY-UHFFFAOYSA-N 2,3-dihydrobenzofuran Chemical compound C1=CC=C2OCCC2=C1 HBEDSQVIWPRPAY-UHFFFAOYSA-N 0.000 title 2
SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 1
150000002468 indanes Chemical class 0.000 title 1
210000003169 central nervous system Anatomy 0.000 abstract 2
230000003518 presynaptic effect Effects 0.000 abstract 2
-1 1-aminomethyl Chemical class 0.000 abstract 1
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
208000018737 Parkinson disease Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
PQNFLJBBNBOBRQ-UHFFFAOYSA-N indane Chemical compound C1=CC=C2CCCC2=C1 PQNFLJBBNBOBRQ-UHFFFAOYSA-N 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
230000003287 optical effect Effects 0.000 abstract 1
230000001242 postsynaptic effect Effects 0.000 abstract 1
201000000980 schizophrenia Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/58—Radicals substituted by nitrogen atoms

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Furan Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

DK091488A 1987-02-26 1988-02-23 3-Aminomethylderivater af dihydrobenzofuran, dihydrobenzothiophen og indolin og farmaceutisk acceptable syreadditionssalte deraf, en fremgangsmåde til fremstilling deraf og en farmaceutisk komposition heraf DK170636B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB8704572		1987-02-26
GB878704572A GB8704572D0 (en)	1987-02-26	1987-02-26	Organic compounds

Publications (3)

Publication Number	Publication Date
DK91488D0 DK91488D0 (da)	1988-02-23
DK91488A true DK91488A (da)	1988-08-27
DK170636B1 DK170636B1 (da)	1995-11-20

Family

ID=10613009

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK091488A DK170636B1 (da)	1987-02-26	1988-02-23	3-Aminomethylderivater af dihydrobenzofuran, dihydrobenzothiophen og indolin og farmaceutisk acceptable syreadditionssalte deraf, en fremgangsmåde til fremstilling deraf og en farmaceutisk komposition heraf

Country Status (18)

Country	Link
US (2)	US4847254A (da)
EP (1)	EP0281261B1 (da)
JP (1)	JP2677588B2 (da)
AT (1)	ATE75723T1 (da)
AU (1)	AU608293B2 (da)
CA (1)	CA1338934C (da)
DE (1)	DE3870666D1 (da)
DK (1)	DK170636B1 (da)
ES (1)	ES2037208T3 (da)
FI (1)	FI97380C (da)
GB (1)	GB8704572D0 (da)
GR (1)	GR3004984T3 (da)
IE (1)	IE61257B1 (da)
IL (1)	IL85342A (da)
NO (1)	NO169119C (da)
NZ (1)	NZ223440A (da)
PT (1)	PT86836B (da)
ZA (1)	ZA881217B (da)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2059570T3 (es) *	1988-01-15	1994-11-16	Abbott Lab	1-aminometil-1,2,3,4-tetrahidronaftalenos e -indanos.
JP2931986B2 (ja) *	1989-02-17	1999-08-09	武田薬品工業株式会社	アラルキルアミン誘導体
EP0389425B1 (de) *	1989-03-22	1995-04-26	Ciba-Geigy Ag	Neue Benzothiopyranylamine
JPH0318935A (ja) *	1989-06-15	1991-01-28	Hitachi Ltd	データリストに対するアクセスの直列化方式
US5500444A (en) *	1989-11-14	1996-03-19	Hoechst Marion Roussel, Inc.	Cardioprotective tocopherol analogs
TW199152B (da) *	1990-11-01	1993-02-01	Takeda Pharm Industry Co Ltd
US5643784A (en) *	1990-12-04	1997-07-01	H, Lundbeck A/S	Indan derivatives
DK36291D0 (da) *	1991-03-01	1991-03-01	Lundbeck & Co As H	Anvendelse af piperidylsubstituerede indolderivater til behandling af kognitive lidelser
NZ243065A (en)	1991-06-13	1995-07-26	Lundbeck & Co As H	Piperidine derivatives and pharmaceutical compositions
EP0550292A1 (en) *	1992-01-02	1993-07-07	Merrell Dow Pharmaceuticals Inc.	Tissue protective tocopherol analogs
US5721233A (en) *	1992-04-06	1998-02-24	Merrell Pharmaceuticals Inc.	Derivatives of 2,3-dihydro benzofuranols
US5510373A (en) *	1992-04-06	1996-04-23	Merrell Pharmaceuticals Inc.	Cardioprotective agents
AU670433B2 (en) *	1992-04-06	1996-07-18	Merrell Dow Pharmaceuticals Inc.	Novel derivatives of 2,3-dihydro-benzofuranols
US5545660A (en) *	1992-04-07	1996-08-13	Merrell Pharmaceuticals Inc.	Hydrazide derivatives of 3,4-dihydro-2H-1-benzopyrans
DK55192D0 (da) *	1992-04-28	1992-04-28	Lundbeck & Co As H	1-piperazino-1,2-dihydroindenderivater
DK78692D0 (da) *	1992-06-12	1992-06-12	Lundbeck & Co As H	Dimere piperidin- og piperazinderivater
DK148292D0 (da) *	1992-12-09	1992-12-09	Lundbeck & Co As H	Forbindelser
US5792791A (en) *	1993-01-12	1998-08-11	Asahi Kasei Kogyo Kabushiki Kaisha	2,3-dihydrobenzofuran derivatives
DE69328495T2 (de) *	1993-01-12	2001-01-25	Asahi Kasei Kogyo K.K., Osaka	2,3-Dihydrobenzofuran Derivate
JPH09507071A (ja) *	1993-12-21	1997-07-15	イーライ・リリー・アンド・カンパニー	アミロイド原性ペプチドに関連した状態を治療又は予防する方法
JPH09512542A (ja) *	1994-04-28	1997-12-16	メルクシヤープエンドドームリミテツド	Ｄ▲下４▼リセプタ拮抗剤としてのベンゾフラン誘導体
US5798382A (en) *	1994-07-07	1998-08-25	Asahi Kasei Kogyo Kabushiki Kaisha	2,3-dihydrobenzofuran derivatives, method for producing the same, and use thereof
JPH09124643A (ja) *	1995-08-14	1997-05-13	Bristol Myers Squibb Co	抗うつ作用を有する１−アリールアルキル−４−（アルコキシピリジニル）−又は４−（アルコキシピリミジニル）ピペラジン誘導体
GB9521347D0 (en) *	1995-10-18	1995-12-20	Merck Sharp & Dohme	Therapeutic agents
CA2268164A1 (en) *	1996-10-08	1998-04-16	Yao-Chang Xu	New serotonin 5-ht1f agonists
EP0988289A2 (en)	1997-06-05	2000-03-29	Takeda Pharmaceutical Company Limited	Heterocyclic compounds, their production and use
AU7887501A (en) *	2000-07-06	2002-01-21	Us Gov Health & Human Serv	Tetrahydrobenzothiazole analogues as neuroprotective agents
TWI320783B (en)	2005-04-14	2010-02-21	Otsuka Pharma Co Ltd	Heterocyclic compound

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE623403A (da) *	1962-08-08
US3553093A (en) *	1965-03-19	1971-01-05	Xerox Corp	Color photoelectrophoretic imaging process
US3513239A (en) *	1967-03-15	1970-05-19	Smithkline Corp	Pharmaceutical compositions containing 2-aminoalkyl coumaran derivatives and methods of treating depression therewith
BE786748A (fr) *	1971-07-26	1973-01-26	Basf Ag	1-aminomethyl-indanes-n-substitues
CH601166A5 (da) *	1974-02-14	1978-06-30	Ciba Geigy Ag
JPS535146A (en) *	1976-07-02	1978-01-18	Tanabe Seiyaku Co Ltd	Indane derivatives and their preparation
US4505932A (en) *	1983-05-13	1985-03-19	Abbott Laboratories	Method of producing α2 -adrenergic receptor agonist activity
US4777168A (en) *	1984-10-23	1988-10-11	Rorer Pharmaceutical Corporation	Bicyclic benzo-oxy heterocyclic ethers and thioethers, pharmaceutical compositions and use

1987
- 1987-02-26 GB GB878704572A patent/GB8704572D0/en active Pending
1988
- 1988-02-03 IE IE29788A patent/IE61257B1/en not_active IP Right Cessation
- 1988-02-07 IL IL85342A patent/IL85342A/xx not_active IP Right Cessation
- 1988-02-08 NZ NZ223440A patent/NZ223440A/xx unknown
- 1988-02-09 AT AT88301073T patent/ATE75723T1/de not_active IP Right Cessation
- 1988-02-09 ES ES198888301073T patent/ES2037208T3/es not_active Expired - Lifetime
- 1988-02-09 EP EP88301073A patent/EP0281261B1/en not_active Expired - Lifetime
- 1988-02-09 DE DE8888301073T patent/DE3870666D1/de not_active Expired - Lifetime
- 1988-02-12 US US07/155,354 patent/US4847254A/en not_active Expired - Fee Related
- 1988-02-22 ZA ZA881217A patent/ZA881217B/xx unknown
- 1988-02-23 DK DK091488A patent/DK170636B1/da not_active IP Right Cessation
- 1988-02-23 CA CA000559562A patent/CA1338934C/en not_active Expired - Fee Related
- 1988-02-25 PT PT86836A patent/PT86836B/pt not_active IP Right Cessation
- 1988-02-25 AU AU12167/88A patent/AU608293B2/en not_active Ceased
- 1988-02-25 NO NO880833A patent/NO169119C/no unknown
- 1988-02-26 FI FI880906A patent/FI97380C/fi not_active IP Right Cessation
- 1988-02-26 JP JP63042388A patent/JP2677588B2/ja not_active Expired - Lifetime
1989
- 1989-01-18 US US07/298,630 patent/US4946863A/en not_active Expired - Fee Related
1992
- 1992-06-18 GR GR920401319T patent/GR3004984T3/el unknown

Also Published As

Publication number	Publication date
IE880297L (en)	1988-08-26
FI97380B (fi)	1996-08-30
GR3004984T3 (da)	1993-04-28
EP0281261B1 (en)	1992-05-06
NO880833D0 (no)	1988-02-25
EP0281261A3 (en)	1989-11-23
NO880833L (no)	1988-08-29
NO169119C (no)	1992-05-13
PT86836B (pt)	1992-05-29
US4946863A (en)	1990-08-07
GB8704572D0 (en)	1987-04-01
US4847254A (en)	1989-07-11
IL85342A (en)	1993-01-14
IE61257B1 (en)	1994-10-19
DK170636B1 (da)	1995-11-20
EP0281261A2 (en)	1988-09-07
CA1338934C (en)	1997-02-25
DE3870666D1 (de)	1992-06-11
AU608293B2 (en)	1991-03-28
JPS63264557A (ja)	1988-11-01
ZA881217B (en)	1989-01-25
DK91488D0 (da)	1988-02-23
NO169119B (no)	1992-02-03
NZ223440A (en)	1991-02-26
FI97380C (fi)	1996-12-10
FI880906A7 (fi)	1988-08-27
AU1216788A (en)	1988-09-01
ATE75723T1 (de)	1992-05-15
FI880906A0 (fi)	1988-02-26
PT86836A (pt)	1988-03-01
JP2677588B2 (ja)	1997-11-17
ES2037208T3 (es)	1993-06-16

Legal Events

Date	Code	Title	Description
1995-11-20	B1	Patent granted (law 1993)
1999-05-17	PBP	Patent lapsed

Publication	Publication Date	Title
DK91488A (da)	1988-08-27	3-aminomethylderivater af indan, dihydrobenzofuran, dihydrobenzothiophen og indolin
PT88255A (pt)	1989-06-30	Processo para a preparacao de derivados do indole
PT92728A (pt)	1990-06-29	Processo para a preparacao de derivados de piperazinilo e de composicoes farmaceuticas que os contem
FR2430412A1 (fr)	1980-02-01	Derives substitues de propanolamine utiles comme medicaments et procede de leur preparation
PT91417A (pt)	1990-03-08	Processo para a preparacao de derivados indolicos
PT87770A (pt)	1989-05-31	Process for the preparation of indolinone replaced by products
KR920701121A (ko)	1992-08-11	신규한 8-치환-2-아미노테트랄린
NO176097C (no)	1995-02-01	Analogifremgangsmåte for fremstilling av terapeutisk aktive substituerte cykloheksener
DE69030665D1 (de)	1997-06-12	(1,2n) und (3,2n)-karbozyklische-2-amino-tetralinderivate
NO883605D0 (no)	1988-08-12	Optiske isomerer av et spiroquinuklidinderivat.
DE69028355D1 (de)	1996-10-10	4,5-Dihydro-6H-imidazo[4,5,1-ij]chinolin-6-on-6-oxim-O-sulfonsäurederivate
CA2112981A1 (fr)	1993-01-21	Procede de preparation des isomeres optiques d'un derive de l'amino-2 naphtyridine
FR2398073A1 (fr)	1979-02-16	Derives d'acides n-pyridylaminomethylene-diphosphoniques, herbicides les contenant et procede de preparation de ces derniers