DK92784D0 - Dna-struktur til anvendelse ved fremstilling af insulin - Google Patents

Dna-struktur til anvendelse ved fremstilling af insulin

Info

Publication number: DK92784D0
Authority: DK; Denmark
Prior art keywords: insulin; preparation; secretion; dna structure; pyins1
Prior art date: 1983-04-07

Application number

DK0927/84A

Other languages

English (en)

Other versions

DK172738B1 (da

DK92784A (da

Inventor

Anthony J Brake

Lawrence S Cousens

Mikey S Urdea

Pablo D T Valenzuela

Original Assignee

Chiron Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-04-07

Filing date

1984-02-23

Publication date

1984-02-23

1984-02-23 Application filed by Chiron Corp filed Critical Chiron Corp

1984-02-23 Publication of DK92784D0 publication Critical patent/DK92784D0/da

1984-10-08 Publication of DK92784A publication Critical patent/DK92784A/da

1999-06-21 Application granted granted Critical

1999-06-21 Publication of DK172738B1 publication Critical patent/DK172738B1/da

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 4
102000004877 Insulin Human genes 0.000 title abstract 2
108090001061 Insulin Proteins 0.000 title abstract 2
229940125396 insulin Drugs 0.000 title abstract 2
230000028327 secretion Effects 0.000 abstract 2
108010076181 Proinsulin Proteins 0.000 abstract 1
240000004808 Saccharomyces cerevisiae Species 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
235000015097 nutrients Nutrition 0.000 abstract 1
229920001184 polypeptide Polymers 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
General Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Wood Science & Technology (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
Mycology (AREA)
Medicinal Chemistry (AREA)
Endocrinology (AREA)
Toxicology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Diabetes (AREA)
Plant Pathology (AREA)
Physics & Mathematics (AREA)
Microbiology (AREA)
Gastroenterology & Hepatology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

DK198400927A 1983-04-07 1984-02-23 Fremgangsmåde til at udtrykke modent insulin og DNA-struktur til anvendelse ved fremgangsmåden DK172738B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US48302383A	1983-04-07	1983-04-07
US48302383		1983-04-07

Publications (3)

Publication Number	Publication Date
DK92784D0 true DK92784D0 (da)	1984-02-23
DK92784A DK92784A (da)	1984-10-08
DK172738B1 DK172738B1 (da)	1999-06-21

Family

ID=23918330

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK198400927A DK172738B1 (da)	1983-04-07	1984-02-23	Fremgangsmåde til at udtrykke modent insulin og DNA-struktur til anvendelse ved fremgangsmåden

Country Status (6)

Country	Link
EP (1)	EP0121884B1 (da)
JP (2)	JP2512416B2 (da)
AT (1)	ATE71661T1 (da)
CA (1)	CA1341372C (da)
DE (1)	DE3485444D1 (da)
DK (1)	DK172738B1 (da)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7198919B1 (en)	1983-04-25	2007-04-03	Genentech, Inc.	Use of alpha factor sequences in yeast expression systems
NZ207926A (en) *	1983-04-25	1988-04-29	Genentech Inc	Use of yeast #a#-factor to assist in expression of proteins heterologus to yeast
DK58285D0 (da) *	1984-05-30	1985-02-08	Novo Industri As	Peptider samt fremstilling og anvendelse deraf
EP0170266B1 (en) *	1984-07-30	1993-03-24	Wakunaga Seiyaku Kabushiki Kaisha	Process for producing protein, and vector, recombinant dna and transformant used therefor
JP2549504B2 (ja) *	1984-12-21	1996-10-30	ア−ス製薬株式会社	Ｄｎａ塩基配列、ポリペプチド分泌発現ベクター及び形質転換微生物
DK129385A (da) *	1985-03-22	1986-09-23	Novo Industri As	Peptider og fremstilling deraf
EP0201208B1 (en) *	1985-04-09	1992-07-15	Collaborative Research Inc.	Supersecreting mutants of saccharomyces cerevisiae
JPS61271988A (ja) *	1985-05-27	1986-12-02	Agency Of Ind Science & Technol	プラスミド
RU2091490C1 (ru) *	1985-10-25	1997-09-27	Зимодженетикс, Инк.	Способ получения гетерологичного полипептида в эукариотических микроорганизмов
US5024941A (en) *	1985-12-18	1991-06-18	Biotechnica International, Inc.	Expression and secretion vector for yeast containing a glucoamylase signal sequence
US5037743A (en) *	1988-08-05	1991-08-06	Zymogenetics, Inc.	BAR1 secretion signal
FR2686899B1 (fr)	1992-01-31	1995-09-01	Rhone Poulenc Rorer Sa	Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
DE4336810A1 (de) *	1993-10-28	1995-05-18	Basf Ag	Verfahren zur rekombinanten Herstellung von Proteinen in Hefe
US6142857A (en) *	1998-01-06	2000-11-07	Speedfam-Ipec Corporation	Wafer polishing with improved backing arrangement
JPH11300608A (ja) *	1998-04-20	1999-11-02	Nec Corp	化学機械研磨装置
EP2206720A1 (en)	2000-04-12	2010-07-14	Human Genome Sciences, Inc.	Albumin fusion proteins
EP2261250B1 (en)	2001-12-21	2015-07-01	Human Genome Sciences, Inc.	GCSF-Albumin fusion proteins
CA2513213C (en)	2003-01-22	2013-07-30	Human Genome Sciences, Inc.	Albumin fusion proteins
US20160376330A1 (en)	2014-02-28	2016-12-29	Novo Nordisk A/S	Mating factor alpha pro-peptide variants

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ207926A (en) *	1983-04-25	1988-04-29	Genentech Inc	Use of yeast #a#-factor to assist in expression of proteins heterologus to yeast

1984
- 1984-02-23 DK DK198400927A patent/DK172738B1/da not_active IP Right Cessation
- 1984-02-29 CA CA000448492A patent/CA1341372C/en not_active Expired - Fee Related
- 1984-03-23 JP JP59054554A patent/JP2512416B2/ja not_active Expired - Lifetime
- 1984-04-02 DE DE8484103611T patent/DE3485444D1/de not_active Expired - Lifetime
- 1984-04-02 EP EP84103611A patent/EP0121884B1/en not_active Expired - Lifetime
- 1984-04-02 AT AT84103611T patent/ATE71661T1/de not_active IP Right Cessation
1994
- 1994-08-08 JP JP6185950A patent/JP2511251B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DK172738B1 (da)	1999-06-21
JP2511251B2 (ja)	1996-06-26
EP0121884B1 (en)	1992-01-15
CA1341372C (en)	2002-07-02
DE3485444D1 (de)	1992-02-27
DK92784A (da)	1984-10-08
JPS59196093A (ja)	1984-11-07
EP0121884A2 (en)	1984-10-17
EP0121884A3 (en)	1987-01-14
JP2512416B2 (ja)	1996-07-03
ATE71661T1 (de)	1992-02-15
JPH0767665A (ja)	1995-03-14

Legal Events

Date	Code	Title	Description
1999-06-21	B1	Patent granted (law 1993)
2004-03-15	PUP	Patent expired

Publication	Publication Date	Title
DK92784D0 (da)	1984-02-23	Dna-struktur til anvendelse ved fremstilling af insulin
DK163932C (da)	1996-12-23	Fremgangsmåde til fremstilling af et pattedyrprotein, som er heterologt for en gærorganisme, som produkt af gærudtrykkelse -forarbejdning og -sekretion samt gærorganisme-cellekultur, dyrkningsmedium af cellekulturen og gærudtrykkelsesmedium
EP0233915A4 (en)	1988-03-23	MOLECULAR CULTURE.
AU586855B2 (en)	1989-07-27	Insulin precursors, process for their preparation and process for the preparation of human insulin
EP0177957A3 (en)	1988-02-03	Expression of biologically active platelet derived growth factor analogs in eucaryotic cells
AU551726B2 (en)	1986-05-08	Cocultures production of butanol by fermentation
IL61982A (en)	1984-01-31	Genetically engineered microorganisms for massive production of amyloytic enzymes and process for preparing same using the corresponding recombinant dnas containing amylase coding genes
EP0283942A3 (en)	1989-11-15	Basal nutrient medium for cell culture
EP0248637A3 (en)	1988-11-17	Induction of galactose regulated gene expression in yeast
IE871504L (en)	1987-12-06	Producing plasminogen activator.
AU7685087A (en)	1988-06-16	Amylolytic enzymes producing microorganisms, constructed by recombinant DNA technology and their use for fermentation processes
DE3484212D1 (de)	1991-04-11	Hybride dns-synthese von reifem wachstumshormonausloesendem faktor.
IE893053L (en)	1990-03-26	Process for the production of human lysozyme
DE3264296D1 (en)	1985-07-25	Process for culturing human fibroblasts and fibroblast-like cells
BG44029A3 (en)	1988-09-15	Method for preparing of n- dimethyl morphinanic derivatives
AU6280686A (en)	1987-03-05	Process for the production of a protein-vitamin food supplement from autotrophic micro-organism, in particular for alga spirulina
ES8703932A1 (es)	1987-03-01	Un procedimiento para preparar una molecula de adn recombinante.
Lechat et al.	1985	Gambierdiscus toxicus: culture and toxin production
FI872031A7 (fi)	1987-11-09	Streptokinaasin tuottaminen DNA-tekniikalla saadulla hiivalla.
EP0390327A3 (en)	1990-11-14	Improved tissue culture method
GR3006212T3 (da)	1993-06-21
Domoroshchenkova et al.	1984	Use of anitrogenous extractive substances from soybean seeds in the production of baker's yeast.
JPS54107582A (en)	1979-08-23	Preparation of cells of actinomycetes
IL80901A0 (en)	1987-03-31	Growth-promoting cell culture medium and process for the cultivation of cells employing the same
Domoroschchenkova et al.	1984	Application of a nitrogenous extractive compounds from soybean seeds for the baker's yeast production.