DOP2011000057A - Compuestos de pirrolo-pirimidina como inhibidores de cdk - Google Patents

Compuestos de pirrolo-pirimidina como inhibidores de cdk

Info

Publication number
DOP2011000057A
DOP2011000057A DO2011000057A DO2011000057A DOP2011000057A DO P2011000057 A DOP2011000057 A DO P2011000057A DO 2011000057 A DO2011000057 A DO 2011000057A DO 2011000057 A DO2011000057 A DO 2011000057A DO P2011000057 A DOP2011000057 A DO P2011000057A
Authority
DO
Dominican Republic
Prior art keywords
cancer
tumor
lymphoma
cell lymphoma
lymphocytic leukemia
Prior art date
Application number
DO2011000057A
Other languages
English (en)
Inventor
Wojciech Wrona
Christopher Thomas Brain
Clinton A Brooks
Miles Stuart Congreve
Claudio Dagostin
Ying Huo
Howard Steven
Yue Li
Yipin Lu
Paul Mortenson
Troy Smith
Steven Woodhead
Moo Sung
Gilbert Besong
Guo He
Original Assignee
Novartis Ag
Astex Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41171100&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DOP2011000057(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag, Astex Therapeutics Ltd filed Critical Novartis Ag
Publication of DOP2011000057A publication Critical patent/DOP2011000057A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Los compuestos que se reclaman presentan la fórmula: que tiene el nombre dimetilamida del ácido 7-ciclopentil-2-(5-piperazín-1-il-piridín-2-ilamino)-7H-pirrolo[2,3-d]pirimidín-6-carboxílico y sus sales farmacéuticamente aceptables, cuyos usos particulares son en la fabricación de un medicamento en el tratamiento del cáncer de mama, cáncer pancreático, cáncer colorrectal, cáncer de pulmón, melanoma, sarcoma, glioma, melanoma familiar, carcinoma de vejiga, colon, riñón, epidermis, hígado, esófago, de vesícula biliar, ovario, estómago, cérvix, tiroides, nariz, cabeza y cuello, próstata, o piel; un tumor hematopoiético de linaje linfoide que puede ser leucemia, leucemia linfocítica aguda, leucemia linfocítica crónica, linfoma de células-B, linfoma de células-T, mieloma múltiple, linfoma de Hodgkin, linfoma no de Hodgkin, linfoma de células pilosas, o linfoma de Burkett; un tumor hematopoiético de linaje mieloide; cáncer folicular de tiroides; un tumor de origen mesenquimal, un tumor del sistema nervioso central o periférico que puede ser es astrocitoma, neuroblastoma, o schwanoma, seminoma; teratocarcinoma; osteosarcoma; xerodermia pigmentosa; queratoctantoma; cáncer folicular de tiroides; sarcoma de Kaposi, cáncer pulmonar microcelular, cáncer pulmonar no microcelular, glioblastoma multiforme, leucemia linfocítica aguda de células-T, y linfoma de células de manto.
DO2011000057A 2008-08-22 2011-02-21 Compuestos de pirrolo-pirimidina como inhibidores de cdk DOP2011000057A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US9103708P 2008-08-22 2008-08-22

Publications (1)

Publication Number Publication Date
DOP2011000057A true DOP2011000057A (es) 2015-11-15

Family

ID=41171100

Family Applications (1)

Application Number Title Priority Date Filing Date
DO2011000057A DOP2011000057A (es) 2008-08-22 2011-02-21 Compuestos de pirrolo-pirimidina como inhibidores de cdk

Country Status (48)

Country Link
US (8) US8685980B2 (es)
EP (2) EP2331547B1 (es)
JP (2) JP5560496B2 (es)
KR (2) KR101353857B1 (es)
CN (2) CN103788100A (es)
AR (2) AR073116A1 (es)
AU (1) AU2009284098B2 (es)
BR (1) BRPI0917791B1 (es)
CA (1) CA2734802C (es)
CL (1) CL2011000306A1 (es)
CO (1) CO6341561A2 (es)
CR (1) CR20110101A (es)
CU (1) CU24062B1 (es)
CY (2) CY1115703T1 (es)
DK (1) DK2331547T3 (es)
DO (1) DOP2011000057A (es)
EA (1) EA019094B1 (es)
EC (1) ECSP11010843A (es)
ES (1) ES2522346T3 (es)
FR (1) FR17C1059I2 (es)
GE (1) GEP20135785B (es)
HN (1) HN2011000542A (es)
HR (1) HRP20141018T1 (es)
HU (1) HUS1700051I1 (es)
IL (1) IL211164A (es)
JO (1) JO2924B1 (es)
LT (1) LTC2331547I2 (es)
LU (1) LUC00048I2 (es)
MA (1) MA32555B1 (es)
ME (1) ME01282B (es)
MX (1) MX2011001879A (es)
MY (1) MY150560A (es)
NI (1) NI201100042A (es)
NL (1) NL300909I2 (es)
NO (1) NO2017059I1 (es)
NZ (1) NZ591176A (es)
PE (1) PE20110419A1 (es)
PL (1) PL2331547T3 (es)
PT (1) PT2331547E (es)
RS (1) RS53574B1 (es)
SI (1) SI2331547T1 (es)
SM (1) SMT201500017B (es)
TN (1) TN2011000062A1 (es)
TW (1) TWI468409B (es)
UA (1) UA103628C2 (es)
UY (2) UY32067A (es)
WO (1) WO2010020675A1 (es)
ZA (1) ZA201100994B (es)

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