DOP2014000187A - Inhibidores de pirazolopirimidinilo de enzima activadora de ubiquitina. - Google Patents

Inhibidores de pirazolopirimidinilo de enzima activadora de ubiquitina.

Info

Publication number
DOP2014000187A
DOP2014000187A DO2014000187A DO2014000187A DOP2014000187A DO P2014000187 A DOP2014000187 A DO P2014000187A DO 2014000187 A DO2014000187 A DO 2014000187A DO 2014000187 A DO2014000187 A DO 2014000187A DO P2014000187 A DOP2014000187 A DO P2014000187A
Authority
DO
Dominican Republic
Prior art keywords
activating enzyme
pyrazolopirimidinyl
ubiquitine
inhibitors
chemical entities
Prior art date
Application number
DO2014000187A
Other languages
English (en)
Inventor
Mario Girard
Paul E Fleming
Roushan Afroze
Indu T Bharathan
Jeffrey P Ciavarri
Jeffrey L Gaulin
Steven P Langston
Tzu-Tshin Wong
Yingchun Ye
Francois R Soucy
Original Assignee
Millennium Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millennium Pharm Inc filed Critical Millennium Pharm Inc
Publication of DOP2014000187A publication Critical patent/DOP2014000187A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Se describen entidades químicas que inhiben la enzima activadora de ubiquitina (UAE), cada una de las cuales es un compuesto de Fórmula (I) o una sal farmacéuticamente aceptable de este, donde Y es Fórmula (II) y W, Z, XY, RY1, RY2 y RY3 se definen en la presente; composiciones farmacéuticas que comprenden las entidades químicas; y métodos para usar las entidades químicas. Estas entidades químicas son útiles para tratar trastornos, particularmente trastornos de proliferación celular, incluyendo cánceres.
DO2014000187A 2012-02-17 2014-08-15 Inhibidores de pirazolopirimidinilo de enzima activadora de ubiquitina. DOP2014000187A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261600070P 2012-02-17 2012-02-17

Publications (1)

Publication Number Publication Date
DOP2014000187A true DOP2014000187A (es) 2014-10-15

Family

ID=48982730

Family Applications (1)

Application Number Title Priority Date Filing Date
DO2014000187A DOP2014000187A (es) 2012-02-17 2014-08-15 Inhibidores de pirazolopirimidinilo de enzima activadora de ubiquitina.

Country Status (30)

Country Link
US (4) US9290500B2 (es)
EP (3) EP3536692B1 (es)
JP (1) JP6122877B2 (es)
KR (1) KR20140123104A (es)
CN (1) CN104136399B (es)
AR (1) AR092797A1 (es)
BR (1) BR112014020365B1 (es)
CA (1) CA2864672C (es)
CL (1) CL2014002181A1 (es)
CO (1) CO7071135A2 (es)
CR (1) CR20140380A (es)
DO (1) DOP2014000187A (es)
EA (1) EA035020B1 (es)
EC (1) ECSP14019113A (es)
ES (1) ES2739150T3 (es)
GE (1) GEP201706687B (es)
HK (1) HK1201817A1 (es)
IL (1) IL234016A0 (es)
MA (1) MA35932B1 (es)
MX (1) MX352963B (es)
NZ (1) NZ628969A (es)
PE (1) PE20142244A1 (es)
PH (1) PH12014501832A1 (es)
SG (2) SG11201404757WA (es)
TN (1) TN2014000351A1 (es)
TW (1) TWI593688B (es)
UA (1) UA116534C2 (es)
UY (1) UY34629A (es)
WO (1) WO2013123169A1 (es)
ZA (1) ZA201406103B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8008307B2 (en) 2006-08-08 2011-08-30 Millennium Pharmaceuticals, Inc. Heteroaryl compounds useful as inhibitors of E1 activating enzymes
US9290500B2 (en) 2012-02-17 2016-03-22 Millennium Pharmaceuticals, Inc. Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme
WO2014022744A1 (en) 2012-08-03 2014-02-06 Millennium Pharmaceuticals, Inc. INDOLE-SUBSTITUTED PYRROLOPYRIMIDINYL INHIBITORS OF Uba6
WO2015002994A2 (en) 2013-07-02 2015-01-08 Millennium Pharmaceuticals, Inc. Heteroaryl compounds useful as inhibitors of sumo activating enzyme
HUE045748T2 (hu) 2014-07-01 2020-01-28 Millennium Pharm Inc Heteroaril vegyületek mint SUMO aktiváló enzimek inhibitorai
JP6698648B2 (ja) * 2014-10-29 2020-05-27 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． ユビキチン活性化酵素阻害物質及び化学療法剤の投与
US10335411B2 (en) * 2014-10-29 2019-07-02 Millennium Pharmaceuticals, Inc. Administration of ubiquitin-activating enzyme inhibitor and radiation
IL282254B2 (en) 2018-10-30 2025-08-01 Kronos Bio Inc Compounds, compositions, and methods for modulating cdk9 activity
CN117412973A (zh) * 2021-05-31 2024-01-16 上海瑛派药业有限公司 含氮稠合杂芳双环化合物作为usp1抑制剂及其应用
WO2023021498A1 (en) * 2021-08-16 2023-02-23 Moya Bio Ltd. Fused azole and furan based nucleoside analogs and uses thereof

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003073989A2 (en) 2002-02-28 2003-09-12 Biota, Inc. Nucleoside 5'-monophosphate mimics and their prodrugs
US7196092B2 (en) 2002-09-04 2007-03-27 Schering Corporation N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors
US7563798B2 (en) 2002-09-04 2009-07-21 Schering Corporation Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors
CN1310918C (zh) 2002-09-04 2007-04-18 先灵公司 作为细胞周期蛋白依赖激酶抑制剂的吡唑并嘧啶
CA2497544C (en) 2002-09-04 2010-11-02 Schering Corporation Pyrazolo[1,5-a]pyrimidines compounds as cyclin dependent kinase inhibitors
US20070179161A1 (en) 2003-03-31 2007-08-02 Vernalis (Cambridge) Limited. Pyrazolopyrimidine compounds and their use in medicine
JP2005008581A (ja) 2003-06-20 2005-01-13 Kissei Pharmaceut Co Ltd 新規なピラゾロ［１，５−ａ］ピリミジン誘導体、それを含有する医薬組成物およびそれらの用途
WO2005037845A1 (en) 2003-10-17 2005-04-28 Rigel Pharmaceuticals, Inc. Benzothiazole and thiazole[5,5-b] pyridine compositions and their use as ubiquitin ligase inhibitors
WO2006002284A1 (en) 2004-06-22 2006-01-05 Rigel Pharmaceuticals, Inc. Ubiquitin ligase inhibitors
JP5048520B2 (ja) 2005-02-04 2012-10-17 ミレニアム ファーマシューティカルズ， インコーポレイテッド Ｅ１活性化酵素の阻害剤
US7642266B2 (en) 2005-10-06 2010-01-05 Schering Corporation Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors
SG169369A1 (en) 2006-02-02 2011-03-30 Millennium Pharm Inc Inhibitors of e1 activating enzymes
CN101395698B (zh) * 2006-02-28 2010-06-09 兰姆研究股份公司 用于液体处理盘形物体的装置及方法
US8008307B2 (en) 2006-08-08 2011-08-30 Millennium Pharmaceuticals, Inc. Heteroaryl compounds useful as inhibitors of E1 activating enzymes
ATE485276T1 (de) * 2006-08-08 2010-11-15 Millennium Pharm Inc Heteroarylverbindungen als hemmer der e1- aktivierenden enzyme
CA2934114A1 (en) 2007-06-12 2008-12-18 Achaogen, Inc. Antibacterial agents
EP2540727B1 (en) 2007-08-02 2018-07-25 Millennium Pharmaceuticals, Inc. Sulfamoylating reagent
WO2009082691A1 (en) 2007-12-21 2009-07-02 Board Of Regents, University Of Texas System Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity
WO2010086040A1 (en) 2009-01-29 2010-08-05 Biomarin Iga, Ltd. Pyrazolo-pyrimidines for treatment of duchenne muscular dystrophy
WO2010088518A2 (en) 2009-01-31 2010-08-05 Kalypsys, Inc. Heterocyclic modulators of gpr119 for treatment of disease
UA108986C2 (uk) * 2009-05-14 2015-07-10 Мілленніум Фармасьютікалз, Інк. Кристалічна форма гідрохлориду ((1s,2s,4r)-4-{4-[(1s)-2,3-дигідро-1h-інден-1-іламіно]-7h-піроло[2,3-d]піримідин-7іл}-2-гідроксициклопентил)метилсульфамату (варіанти)
KR101939704B1 (ko) 2010-03-01 2019-01-17 지티엑스, 인코포레이티드 암 치료용 화합물
US20120077814A1 (en) 2010-09-10 2012-03-29 Zhong Wang Sulfonamide, sulfamate, and sulfamothioate derivatives
SG11201400102WA (en) 2011-08-24 2014-03-28 Millennium Pharm Inc Inhibitors of nedd8-activating enzyme
US9290500B2 (en) 2012-02-17 2016-03-22 Millennium Pharmaceuticals, Inc. Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme
WO2014022744A1 (en) 2012-08-03 2014-02-06 Millennium Pharmaceuticals, Inc. INDOLE-SUBSTITUTED PYRROLOPYRIMIDINYL INHIBITORS OF Uba6
WO2015002994A2 (en) 2013-07-02 2015-01-08 Millennium Pharmaceuticals, Inc. Heteroaryl compounds useful as inhibitors of sumo activating enzyme
HUE045748T2 (hu) 2014-07-01 2020-01-28 Millennium Pharm Inc Heteroaril vegyületek mint SUMO aktiváló enzimek inhibitorai

Also Published As

Publication number Publication date
TN2014000351A1 (en) 2015-12-21
SG11201404757WA (en) 2014-09-26
JP2015508775A (ja) 2015-03-23
ECSP14019113A (es) 2015-09-30
BR112014020365B1 (pt) 2023-02-23
EA201400831A1 (ru) 2014-12-30
CN104136399B (zh) 2018-08-07
US20140088096A9 (en) 2014-03-27
ZA201406103B (en) 2017-11-29
MX352963B (es) 2017-12-15
TWI593688B (zh) 2017-08-01
US20170217968A1 (en) 2017-08-03
US20170369499A1 (en) 2017-12-28
EP3536692B1 (en) 2021-04-07
PE20142244A1 (es) 2015-01-07
US20160244455A1 (en) 2016-08-25
EP2814791A4 (en) 2015-08-19
NZ628969A (en) 2017-03-31
UY34629A (es) 2013-09-02
PH12014501832A1 (en) 2014-11-17
HK1201817A1 (en) 2015-09-11
EP3173413A1 (en) 2017-05-31
AR092797A1 (es) 2015-05-06
MX2014009944A (es) 2014-11-10
SG10201606581RA (en) 2016-09-29
US9290500B2 (en) 2016-03-22
GEP201706687B (en) 2017-06-26
EP3173413B1 (en) 2019-05-01
CR20140380A (es) 2014-10-28
IL234016A0 (en) 2014-09-30
ES2739150T3 (es) 2020-01-29
CO7071135A2 (es) 2014-09-30
TW201345909A (zh) 2013-11-16
WO2013123169A1 (en) 2013-08-22
KR20140123104A (ko) 2014-10-21
MA35932B1 (fr) 2014-12-01
CL2014002181A1 (es) 2014-12-12
CA2864672A1 (en) 2013-08-22
US20130217682A1 (en) 2013-08-22
UA116534C2 (uk) 2018-04-10
US10202389B2 (en) 2019-02-12
EA035020B1 (ru) 2020-04-17
US9796725B2 (en) 2017-10-24
EP2814791A1 (en) 2014-12-24
BR112014020365A2 (pt) 2020-12-22
EP3536692A1 (en) 2019-09-11
JP6122877B2 (ja) 2017-04-26
US9663525B2 (en) 2017-05-30
CA2864672C (en) 2018-01-09
CN104136399A (zh) 2014-11-05

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