ECSP14019113A - Inhibidores de pirazolopirimidinilo de enzima activadora de ubiquitina - Google Patents

Inhibidores de pirazolopirimidinilo de enzima activadora de ubiquitina

Info

Publication number
ECSP14019113A
ECSP14019113A ECIEPI201419113A ECPI201419113A ECSP14019113A EC SP14019113 A ECSP14019113 A EC SP14019113A EC IEPI201419113 A ECIEPI201419113 A EC IEPI201419113A EC PI201419113 A ECPI201419113 A EC PI201419113A EC SP14019113 A ECSP14019113 A EC SP14019113A
Authority
EC
Ecuador
Prior art keywords
chemical entities
activating enzyme
ubiquitin activating
pyrazolopyrimidinyl
inhibitors
Prior art date
Application number
ECIEPI201419113A
Other languages
English (en)
Inventor
Roushan Afroze
Francois Soucy
Indu Bharathan
Jeffrey Ciavarri
Tzu-Tshin Wong
Paul Fleming
Mario Girard
Yingchun Ye
Jeffrey Gaulin
Steven Langston
Original Assignee
Millennium Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millennium Pharm Inc filed Critical Millennium Pharm Inc
Publication of ECSP14019113A publication Critical patent/ECSP14019113A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Se describen entidades químicas que inhiben la enzima activadora de ubiquitina (UAE), cada una de las cuales es un compuesto de Fórmula (I) o una sal farmacéuticamente aceptable de este, donde Y es Fórmula (II) y W, Z, XY, RY1, RY2 y RY3 se definen en la presente; composiciones farmacéuticas que comprenden las entidades químicas; y métodos para usar las entidades químicas. Estas entidades químicas son útiles para tratar trastornos, particularmente trastornos de proliferación celular, incluyendo cánceres. (ver fórmulas en el archivo adjunto)
ECIEPI201419113A 2012-02-17 2014-09-17 Inhibidores de pirazolopirimidinilo de enzima activadora de ubiquitina ECSP14019113A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261600070P 2012-02-17 2012-02-17

Publications (1)

Publication Number Publication Date
ECSP14019113A true ECSP14019113A (es) 2015-09-30

Family

ID=48982730

Family Applications (1)

Application Number Title Priority Date Filing Date
ECIEPI201419113A ECSP14019113A (es) 2012-02-17 2014-09-17 Inhibidores de pirazolopirimidinilo de enzima activadora de ubiquitina

Country Status (30)

Country Link
US (4) US9290500B2 (es)
EP (3) EP3536692B1 (es)
JP (1) JP6122877B2 (es)
KR (1) KR20140123104A (es)
CN (1) CN104136399B (es)
AR (1) AR092797A1 (es)
BR (1) BR112014020365B1 (es)
CA (1) CA2864672C (es)
CL (1) CL2014002181A1 (es)
CO (1) CO7071135A2 (es)
CR (1) CR20140380A (es)
DO (1) DOP2014000187A (es)
EA (1) EA035020B1 (es)
EC (1) ECSP14019113A (es)
ES (1) ES2739150T3 (es)
GE (1) GEP201706687B (es)
HK (1) HK1201817A1 (es)
IL (1) IL234016A0 (es)
MA (1) MA35932B1 (es)
MX (1) MX352963B (es)
NZ (1) NZ628969A (es)
PE (1) PE20142244A1 (es)
PH (1) PH12014501832A1 (es)
SG (2) SG10201606581RA (es)
TN (1) TN2014000351A1 (es)
TW (1) TWI593688B (es)
UA (1) UA116534C2 (es)
UY (1) UY34629A (es)
WO (1) WO2013123169A1 (es)
ZA (1) ZA201406103B (es)

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US8008307B2 (en) 2006-08-08 2011-08-30 Millennium Pharmaceuticals, Inc. Heteroaryl compounds useful as inhibitors of E1 activating enzymes
CN104136399B (zh) 2012-02-17 2018-08-07 米伦纽姆医药公司 泛素活化酶的吡唑并嘧啶基抑制剂
JP2015524442A (ja) 2012-08-03 2015-08-24 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． Ｕｂａ６のインドール置換ピロロピリミジニル阻害剤
CN105492429A (zh) 2013-07-02 2016-04-13 米伦纽姆医药公司 Sumo活化酶的杂芳基抑制剂
BR112016030787B1 (pt) 2014-07-01 2022-12-20 Takeda Pharmaceutical Company Limited Entidade química, composição farmacêutica e seu uso
TW201628621A (zh) 2014-10-29 2016-08-16 千禧製藥公司 泛素活化酶抑制劑及輻射之施用
US20180133221A1 (en) * 2014-10-29 2018-05-17 Millennium Pharmaceuticals, Inc. Administration of ubiquitin-activating enzyme inhibitor and chemotherapeutic agents
US11155560B2 (en) 2018-10-30 2021-10-26 Kronos Bio, Inc. Substituted pyrazolo[1,5-a]pyrimidines for modulating CDK9 activity
CN117412973A (zh) * 2021-05-31 2024-01-16 上海瑛派药业有限公司 含氮稠合杂芳双环化合物作为usp1抑制剂及其应用
WO2023021498A1 (en) * 2021-08-16 2023-02-23 Moya Bio Ltd. Fused azole and furan based nucleoside analogs and uses thereof

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JP2005524662A (ja) 2002-02-28 2005-08-18 ビオタ インコーポレーティッド ヌクレオシド５’−一リン酸模倣物およびこれらのプロドラッグ
DE60313872T2 (de) 2002-09-04 2008-01-17 Schering Corp. Pyrazoloä1,5-aüpyrimidine als hemmstoffe cyclin-abhängiger kinasen
ES2285164T3 (es) 2002-09-04 2007-11-16 Schering Corporation Pirazolopirimidinas como inhibidores de quinasas dependientes de ciclina.
US7563798B2 (en) 2002-09-04 2009-07-21 Schering Corporation Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors
US7196092B2 (en) 2002-09-04 2007-03-27 Schering Corporation N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors
US20070179161A1 (en) 2003-03-31 2007-08-02 Vernalis (Cambridge) Limited. Pyrazolopyrimidine compounds and their use in medicine
JP2005008581A (ja) * 2003-06-20 2005-01-13 Kissei Pharmaceut Co Ltd 新規なピラゾロ［１，５−ａ］ピリミジン誘導体、それを含有する医薬組成物およびそれらの用途
EP1680431A1 (en) 2003-10-17 2006-07-19 Rigel Pharmaceuticals, Inc. Benzothiazole and thiazole'5,5-b!pyridine compositions and their use as ubiquitin ligase inhibitors
US20050282818A1 (en) 2004-06-22 2005-12-22 Rigel Pharmaceuticals, Inc. Ubiquitin ligase inhibitors
PT1848718E (pt) 2005-02-04 2012-10-11 Millennium Pharm Inc Inibidores de enzimas de activação e1
CN101321759A (zh) 2005-10-06 2008-12-10 先灵公司 作为蛋白激酶抑制剂的吡唑并嘧啶化合物
KR101450535B1 (ko) 2006-02-02 2014-10-14 밀레니엄 파머슈티컬스 인코퍼레이티드 Ｅ１ 활성화 효소의 억제제
WO2007099021A1 (en) * 2006-02-28 2007-09-07 Sez Ag Device and method for liquid treating disc-like articles
US8008307B2 (en) 2006-08-08 2011-08-30 Millennium Pharmaceuticals, Inc. Heteroaryl compounds useful as inhibitors of E1 activating enzymes
EA201501088A1 (ru) * 2006-08-08 2017-01-30 Миллениум Фармасьютикалз, Инк. Гетероарильные соединения, применяемые в качестве ингибиторов e1 активирующих ферментов
TWI519508B (zh) 2007-06-12 2016-02-01 Achaogen Inc 抗菌劑
WO2009042013A1 (en) 2007-08-02 2009-04-02 Millennium Pharmaceuticals, Inc. Process for the synthesis of e1 activating enzyme inhibitors
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WO2010086040A1 (en) 2009-01-29 2010-08-05 Biomarin Iga, Ltd. Pyrazolo-pyrimidines for treatment of duchenne muscular dystrophy
WO2010088518A2 (en) 2009-01-31 2010-08-05 Kalypsys, Inc. Heterocyclic modulators of gpr119 for treatment of disease
SG175929A1 (en) 2009-05-14 2011-12-29 Millennium Pharm Inc Hydrochloride salt of ((1s,2s,4r)-4-{4-[(1s)-2,3-dihydro-1h-inden-1-ylamino]-7h-pyrrolo [2,3-d]pyrimidin-7-yl}-2-hydroxycyclopentyl)methyl sulfamate
JP5879273B2 (ja) 2010-03-01 2016-03-08 ジーティーエックス・インコーポレイテッド 癌を処置するための化合物
US20120077814A1 (en) 2010-09-10 2012-03-29 Zhong Wang Sulfonamide, sulfamate, and sulfamothioate derivatives
SG11201400102WA (en) 2011-08-24 2014-03-28 Millennium Pharm Inc Inhibitors of nedd8-activating enzyme
CN104136399B (zh) 2012-02-17 2018-08-07 米伦纽姆医药公司 泛素活化酶的吡唑并嘧啶基抑制剂
JP2015524442A (ja) 2012-08-03 2015-08-24 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． Ｕｂａ６のインドール置換ピロロピリミジニル阻害剤
CN105492429A (zh) 2013-07-02 2016-04-13 米伦纽姆医药公司 Sumo活化酶的杂芳基抑制剂
BR112016030787B1 (pt) 2014-07-01 2022-12-20 Takeda Pharmaceutical Company Limited Entidade química, composição farmacêutica e seu uso

Also Published As

Publication number Publication date
US9290500B2 (en) 2016-03-22
US20170217968A1 (en) 2017-08-03
SG10201606581RA (en) 2016-09-29
US20130217682A1 (en) 2013-08-22
KR20140123104A (ko) 2014-10-21
IL234016A0 (en) 2014-09-30
SG11201404757WA (en) 2014-09-26
GEP201706687B (en) 2017-06-26
HK1201817A1 (en) 2015-09-11
WO2013123169A1 (en) 2013-08-22
US9796725B2 (en) 2017-10-24
PE20142244A1 (es) 2015-01-07
EP2814791A4 (en) 2015-08-19
US20160244455A1 (en) 2016-08-25
TW201345909A (zh) 2013-11-16
BR112014020365B1 (pt) 2023-02-23
EA201400831A1 (ru) 2014-12-30
AR092797A1 (es) 2015-05-06
ZA201406103B (en) 2017-11-29
CA2864672C (en) 2018-01-09
MX2014009944A (es) 2014-11-10
PH12014501832A1 (en) 2014-11-17
US20170369499A1 (en) 2017-12-28
US10202389B2 (en) 2019-02-12
CR20140380A (es) 2014-10-28
TWI593688B (zh) 2017-08-01
ES2739150T3 (es) 2020-01-29
EP2814791A1 (en) 2014-12-24
EP3173413A1 (en) 2017-05-31
MX352963B (es) 2017-12-15
UY34629A (es) 2013-09-02
EP3536692A1 (en) 2019-09-11
EP3173413B1 (en) 2019-05-01
JP6122877B2 (ja) 2017-04-26
CN104136399B (zh) 2018-08-07
DOP2014000187A (es) 2014-10-15
NZ628969A (en) 2017-03-31
CL2014002181A1 (es) 2014-12-12
TN2014000351A1 (en) 2015-12-21
CO7071135A2 (es) 2014-09-30
BR112014020365A2 (pt) 2020-12-22
CA2864672A1 (en) 2013-08-22
CN104136399A (zh) 2014-11-05
US20140088096A9 (en) 2014-03-27
EP3536692B1 (en) 2021-04-07
EA035020B1 (ru) 2020-04-17
MA35932B1 (fr) 2014-12-01
UA116534C2 (uk) 2018-04-10
JP2015508775A (ja) 2015-03-23
US9663525B2 (en) 2017-05-30

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