MA35932B1 - Pyrazolopyrimidinyle inhibiteurs de l'enzyme d'activation de l'ubiquitine - Google Patents
Pyrazolopyrimidinyle inhibiteurs de l'enzyme d'activation de l'ubiquitineInfo
- Publication number
- MA35932B1 MA35932B1 MA37338A MA37338A MA35932B1 MA 35932 B1 MA35932 B1 MA 35932B1 MA 37338 A MA37338 A MA 37338A MA 37338 A MA37338 A MA 37338A MA 35932 B1 MA35932 B1 MA 35932B1
- Authority
- MA
- Morocco
- Prior art keywords
- activating enzyme
- chemical entities
- ubiquitin activating
- pyrazolopyrimidinyl
- inhibitors
- Prior art date
Links
- 102000018478 Ubiquitin-Activating Enzymes Human genes 0.000 title abstract 2
- 108010091546 Ubiquitin-Activating Enzymes Proteins 0.000 title abstract 2
- -1 Pyrazolopyrimidinyl Chemical group 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000005829 chemical entities Chemical class 0.000 abstract 4
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000035269 cancer or benign tumor Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La présente invention concerne des entités chimiques inhibiteurs de l'enzyme d'activation de l'ubiquitine (uae), dont chacune est un composé de formule (i), ou un sel pharmaceutiquement acceptable de celles-ci, dans laquelle y est formule (2) et w, z, xy, ry1, ry2 et ry3 sont tels que définis dans la description; des compositions pharmaceutiques comportant les entités chimiques; et des procédés d'utilisation des entités chimiques. Ces entités chimiques sont utiles pour le traitement de troubles, en particulier des troubles de prolifération cellulaire, y compris des cancers.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261600070P | 2012-02-17 | 2012-02-17 | |
| PCT/US2013/026113 WO2013123169A1 (fr) | 2012-02-17 | 2013-02-14 | Pyrazolopyrimidinyle inhibiteurs de l'enzyme d'activation de l'ubiquitine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA35932B1 true MA35932B1 (fr) | 2014-12-01 |
Family
ID=48982730
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA37338A MA35932B1 (fr) | 2012-02-17 | 2014-09-10 | Pyrazolopyrimidinyle inhibiteurs de l'enzyme d'activation de l'ubiquitine |
Country Status (30)
| Country | Link |
|---|---|
| US (4) | US9290500B2 (fr) |
| EP (3) | EP3536692B1 (fr) |
| JP (1) | JP6122877B2 (fr) |
| KR (1) | KR20140123104A (fr) |
| CN (1) | CN104136399B (fr) |
| AR (1) | AR092797A1 (fr) |
| BR (1) | BR112014020365B1 (fr) |
| CA (1) | CA2864672C (fr) |
| CL (1) | CL2014002181A1 (fr) |
| CO (1) | CO7071135A2 (fr) |
| CR (1) | CR20140380A (fr) |
| DO (1) | DOP2014000187A (fr) |
| EA (1) | EA035020B1 (fr) |
| EC (1) | ECSP14019113A (fr) |
| ES (1) | ES2739150T3 (fr) |
| GE (1) | GEP201706687B (fr) |
| HK (1) | HK1201817A1 (fr) |
| IL (1) | IL234016A0 (fr) |
| MA (1) | MA35932B1 (fr) |
| MX (1) | MX352963B (fr) |
| NZ (1) | NZ628969A (fr) |
| PE (1) | PE20142244A1 (fr) |
| PH (1) | PH12014501832A1 (fr) |
| SG (2) | SG11201404757WA (fr) |
| TN (1) | TN2014000351A1 (fr) |
| TW (1) | TWI593688B (fr) |
| UA (1) | UA116534C2 (fr) |
| UY (1) | UY34629A (fr) |
| WO (1) | WO2013123169A1 (fr) |
| ZA (1) | ZA201406103B (fr) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8008307B2 (en) | 2006-08-08 | 2011-08-30 | Millennium Pharmaceuticals, Inc. | Heteroaryl compounds useful as inhibitors of E1 activating enzymes |
| US9290500B2 (en) | 2012-02-17 | 2016-03-22 | Millennium Pharmaceuticals, Inc. | Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme |
| WO2014022744A1 (fr) | 2012-08-03 | 2014-02-06 | Millennium Pharmaceuticals, Inc. | Inhibiteurs de pyrrolopyrimidinyle substitué par indole d'uba6 |
| WO2015002994A2 (fr) | 2013-07-02 | 2015-01-08 | Millennium Pharmaceuticals, Inc. | Composés hétéroaryliques pouvant être utilisés en tant qu'inhibiteurs de l'enzyme sae |
| HUE045748T2 (hu) | 2014-07-01 | 2020-01-28 | Millennium Pharm Inc | Heteroaril vegyületek mint SUMO aktiváló enzimek inhibitorai |
| JP6698648B2 (ja) * | 2014-10-29 | 2020-05-27 | ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | ユビキチン活性化酵素阻害物質及び化学療法剤の投与 |
| US10335411B2 (en) * | 2014-10-29 | 2019-07-02 | Millennium Pharmaceuticals, Inc. | Administration of ubiquitin-activating enzyme inhibitor and radiation |
| IL282254B2 (en) | 2018-10-30 | 2025-08-01 | Kronos Bio Inc | Compounds, compositions, and methods for modulating cdk9 activity |
| CN117412973A (zh) * | 2021-05-31 | 2024-01-16 | 上海瑛派药业有限公司 | 含氮稠合杂芳双环化合物作为usp1抑制剂及其应用 |
| WO2023021498A1 (fr) * | 2021-08-16 | 2023-02-23 | Moya Bio Ltd. | Analogues de nucléosides à base d'azole et de furane fusionnés et leurs utilisations |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003073989A2 (fr) | 2002-02-28 | 2003-09-12 | Biota, Inc. | Analogues de nucleoside 5'-monophosphate et leurs promedicaments |
| US7196092B2 (en) | 2002-09-04 | 2007-03-27 | Schering Corporation | N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors |
| US7563798B2 (en) | 2002-09-04 | 2009-07-21 | Schering Corporation | Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors |
| CN1310918C (zh) | 2002-09-04 | 2007-04-18 | 先灵公司 | 作为细胞周期蛋白依赖激酶抑制剂的吡唑并嘧啶 |
| CA2497544C (fr) | 2002-09-04 | 2010-11-02 | Schering Corporation | Nouveaux pyrazolopyrimidines en tant qu'inhibiteurs de la kinase dependantes des cyclines |
| US20070179161A1 (en) | 2003-03-31 | 2007-08-02 | Vernalis (Cambridge) Limited. | Pyrazolopyrimidine compounds and their use in medicine |
| JP2005008581A (ja) | 2003-06-20 | 2005-01-13 | Kissei Pharmaceut Co Ltd | 新規なピラゾロ［１，５−ａ］ピリミジン誘導体、それを含有する医薬組成物およびそれらの用途 |
| WO2005037845A1 (fr) | 2003-10-17 | 2005-04-28 | Rigel Pharmaceuticals, Inc. | Compositions de benzothiazole et de thiazole'5,5-b!pyridine et leur utilisation comme inhibiteurs de l'ubiquitine ligase |
| WO2006002284A1 (fr) | 2004-06-22 | 2006-01-05 | Rigel Pharmaceuticals, Inc. | Inhibiteurs de l'ubiquitine ligase |
| JP5048520B2 (ja) | 2005-02-04 | 2012-10-17 | ミレニアム ファーマシューティカルズ， インコーポレイテッド | Ｅ１活性化酵素の阻害剤 |
| US7642266B2 (en) | 2005-10-06 | 2010-01-05 | Schering Corporation | Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors |
| SG169369A1 (en) | 2006-02-02 | 2011-03-30 | Millennium Pharm Inc | Inhibitors of e1 activating enzymes |
| CN101395698B (zh) * | 2006-02-28 | 2010-06-09 | 兰姆研究股份公司 | 用于液体处理盘形物体的装置及方法 |
| US8008307B2 (en) | 2006-08-08 | 2011-08-30 | Millennium Pharmaceuticals, Inc. | Heteroaryl compounds useful as inhibitors of E1 activating enzymes |
| ATE485276T1 (de) * | 2006-08-08 | 2010-11-15 | Millennium Pharm Inc | Heteroarylverbindungen als hemmer der e1- aktivierenden enzyme |
| CA2934114A1 (fr) | 2007-06-12 | 2008-12-18 | Achaogen, Inc. | Agents antibacteriens |
| EP2540727B1 (fr) | 2007-08-02 | 2018-07-25 | Millennium Pharmaceuticals, Inc. | Reactif de sulfamoylation |
| WO2009082691A1 (fr) | 2007-12-21 | 2009-07-02 | Board Of Regents, University Of Texas System | Inhibiteurs de dihydroorotate déshydrogénase présentant une activité antipaludéenne sélective |
| WO2010086040A1 (fr) | 2009-01-29 | 2010-08-05 | Biomarin Iga, Ltd. | Pyrazolo-pyrimidines pour traitement de la myopathie de duchenne |
| WO2010088518A2 (fr) | 2009-01-31 | 2010-08-05 | Kalypsys, Inc. | Modulateurs hétérocycliques du gpr119 pour le traitement de maladies |
| UA108986C2 (uk) * | 2009-05-14 | 2015-07-10 | Мілленніум Фармасьютікалз, Інк. | Кристалічна форма гідрохлориду ((1s,2s,4r)-4-{4-[(1s)-2,3-дигідро-1h-інден-1-іламіно]-7h-піроло[2,3-d]піримідин-7іл}-2-гідроксициклопентил)метилсульфамату (варіанти) |
| KR101939704B1 (ko) | 2010-03-01 | 2019-01-17 | 지티엑스, 인코포레이티드 | 암 치료용 화합물 |
| US20120077814A1 (en) | 2010-09-10 | 2012-03-29 | Zhong Wang | Sulfonamide, sulfamate, and sulfamothioate derivatives |
| SG11201400102WA (en) | 2011-08-24 | 2014-03-28 | Millennium Pharm Inc | Inhibitors of nedd8-activating enzyme |
| US9290500B2 (en) | 2012-02-17 | 2016-03-22 | Millennium Pharmaceuticals, Inc. | Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme |
| WO2014022744A1 (fr) | 2012-08-03 | 2014-02-06 | Millennium Pharmaceuticals, Inc. | Inhibiteurs de pyrrolopyrimidinyle substitué par indole d'uba6 |
| WO2015002994A2 (fr) | 2013-07-02 | 2015-01-08 | Millennium Pharmaceuticals, Inc. | Composés hétéroaryliques pouvant être utilisés en tant qu'inhibiteurs de l'enzyme sae |
| HUE045748T2 (hu) | 2014-07-01 | 2020-01-28 | Millennium Pharm Inc | Heteroaril vegyületek mint SUMO aktiváló enzimek inhibitorai |
-
2013
- 2013-02-14 US US13/767,314 patent/US9290500B2/en active Active
- 2013-02-14 MX MX2014009944A patent/MX352963B/es active IP Right Grant
- 2013-02-14 GE GEAP201313560A patent/GEP201706687B/en unknown
- 2013-02-14 EP EP19170607.6A patent/EP3536692B1/fr active Active
- 2013-02-14 PE PE2014001278A patent/PE20142244A1/es active IP Right Grant
- 2013-02-14 BR BR112014020365-2A patent/BR112014020365B1/pt not_active IP Right Cessation
- 2013-02-14 SG SG11201404757WA patent/SG11201404757WA/en unknown
- 2013-02-14 EP EP13748707.0A patent/EP2814791A4/fr not_active Withdrawn
- 2013-02-14 HK HK15102227.4A patent/HK1201817A1/xx unknown
- 2013-02-14 WO PCT/US2013/026113 patent/WO2013123169A1/fr not_active Ceased
- 2013-02-14 CN CN201380009784.8A patent/CN104136399B/zh active Active
- 2013-02-14 ES ES16205139T patent/ES2739150T3/es active Active
- 2013-02-14 JP JP2014557765A patent/JP6122877B2/ja not_active Expired - Fee Related
- 2013-02-14 KR KR1020147025556A patent/KR20140123104A/ko not_active Ceased
- 2013-02-14 EA EA201400831A patent/EA035020B1/ru not_active IP Right Cessation
- 2013-02-14 NZ NZ628969A patent/NZ628969A/en not_active IP Right Cessation
- 2013-02-14 UA UAA201409297A patent/UA116534C2/uk unknown
- 2013-02-14 EP EP16205139.5A patent/EP3173413B1/fr active Active
- 2013-02-14 CA CA2864672A patent/CA2864672C/fr active Active
- 2013-02-14 SG SG10201606581RA patent/SG10201606581RA/en unknown
- 2013-02-15 AR ARP130100480A patent/AR092797A1/es unknown
- 2013-02-15 UY UY0001034629A patent/UY34629A/es not_active Application Discontinuation
- 2013-02-18 TW TW102105676A patent/TWI593688B/zh not_active IP Right Cessation
-
2014
- 2014-08-07 IL IL234016A patent/IL234016A0/en unknown
- 2014-08-11 TN TNP2014000351A patent/TN2014000351A1/fr unknown
- 2014-08-12 CR CR20140380A patent/CR20140380A/es unknown
- 2014-08-13 PH PH12014501832A patent/PH12014501832A1/en unknown
- 2014-08-14 CL CL2014002181A patent/CL2014002181A1/es unknown
- 2014-08-15 DO DO2014000187A patent/DOP2014000187A/es unknown
- 2014-08-20 ZA ZA2014/06103A patent/ZA201406103B/en unknown
- 2014-09-10 MA MA37338A patent/MA35932B1/fr unknown
- 2014-09-16 CO CO14205517A patent/CO7071135A2/es unknown
- 2014-09-17 EC ECIEPI201419113A patent/ECSP14019113A/es unknown
-
2016
- 2016-02-19 US US15/048,007 patent/US9663525B2/en active Active
-
2017
- 2017-04-17 US US15/488,800 patent/US9796725B2/en active Active
- 2017-09-08 US US15/699,818 patent/US10202389B2/en active Active
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