DOP2016000127A - Inhibidores de quinasa relacionada con la tropomiosina (trk). - Google Patents

Inhibidores de quinasa relacionada con la tropomiosina (trk).

Info

Publication number
DOP2016000127A
DOP2016000127A DO2016000127A DO2016000127A DOP2016000127A DO P2016000127 A DOP2016000127 A DO P2016000127A DO 2016000127 A DO2016000127 A DO 2016000127A DO 2016000127 A DO2016000127 A DO 2016000127A DO P2016000127 A DOP2016000127 A DO P2016000127A
Authority
DO
Dominican Republic
Prior art keywords
tropomyosin
trk
related kinase
useful
treatment
Prior art date
Application number
DO2016000127A
Other languages
English (en)
Inventor
Gloria Matthews
Markus Metz
Michael Kothe
Jinyu Liu
Andrew Scholte
John L Kane Jr
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp filed Critical Genzyme Corp
Publication of DOP2016000127A publication Critical patent/DOP2016000127A/es

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Los inhibidores de quinasa relacionada con la tropomiosina (inhibidores de Trk) son compuestos de molécula pequeña útiles en el tratamiento de enfermedades. Los inhibidores de Trk se pueden usar como agentes farmacéuticos y en composiciones farmacéuticas. Los inhibidores de Trk son útiles en el tratamiento de enfermedades inflamatorias, enfermedad autoinmune, defectos de metabolismo óseo y/o cáncer, y son particularmente útiles en el tratamiento de osteoartritis (OA), dolor, y dolor asociado con con OA. Los inhibidores de Trk también son útiles para inhibir quinasa A relacionada con la tropomiosina (TrkA), quinasa B relacionada con la tropomiosina (TrkB), quinasa C relacionada con la tropomiosina (TrkC), y/o c-FMS (el receptor celular para el factor 1 estimulante de colonias (CSF-1)).
DO2016000127A 2013-12-10 2016-06-07 Inhibidores de quinasa relacionada con la tropomiosina (trk). DOP2016000127A (es)

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