DZ1396A1 - Dérivés de glycine. - Google Patents

Dérivés de glycine.

Info

Publication number: DZ1396A1
Authority: DZ; Algeria
Prior art keywords: group; hydrogen; formula; amino; amidino
Prior art date: 1989-02-23

Application number

DZ900030A

Other languages

English (en)

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-02-23

Filing date

1990-02-21

Publication date

2004-09-13

1990-02-21 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2004-09-13 Application granted granted Critical

2004-09-13 Publication of DZ1396A1 publication Critical patent/DZ1396A1/fr

Links

150000002332 glycine derivatives Chemical class 0.000 title abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 5
239000001257 hydrogen Substances 0.000 abstract 5
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 abstract 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
239000000853 adhesive Substances 0.000 abstract 1
230000001070 adhesive effect Effects 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
-1 amino, amidino Chemical group 0.000 abstract 1
210000001772 blood platelet Anatomy 0.000 abstract 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
230000017455 cell-cell adhesion Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004185 ester group Chemical group 0.000 abstract 1
125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 abstract 1
150000004677 hydrates Chemical class 0.000 abstract 1
150000002431 hydrogen Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000006239 protecting group Chemical group 0.000 abstract 1
102000004169 proteins and genes Human genes 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1
208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/75—Fibrinogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0815—Tripeptides with the first amino acid being basic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1019—Tetrapeptides with the first amino acid being basic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Toxicology (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Hematology (AREA)
Crystallography & Structural Chemistry (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Diabetes (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Compounds Of Unknown Constitution (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pyrrole Compounds (AREA)

DZ900030A 1989-02-23 1990-02-21 Dérivés de glycine. DZ1396A1 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CH66989		1989-02-23
CH426589		1989-11-29

Publications (1)

Publication Number	Publication Date
DZ1396A1 true DZ1396A1 (fr)	2004-09-13

Family

ID=25685313

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DZ900030A DZ1396A1 (fr)	1989-02-23	1990-02-21	Dérivés de glycine.

Country Status (18)

Country	Link
US (1)	US5663297A (fr)
EP (1)	EP0384362B1 (fr)
JP (1)	JPH0662672B2 (fr)
AT (1)	ATE187737T1 (fr)
AU (1)	AU633872B2 (fr)
CA (1)	CA2008116C (fr)
CZ (1)	CZ282730B6 (fr)
DE (1)	DE59010889D1 (fr)
DZ (1)	DZ1396A1 (fr)
ES (1)	ES2141079T3 (fr)
FI (1)	FI900864A7 (fr)
HU (1)	HUT52784A (fr)
IL (1)	IL93422A (fr)
MC (1)	MC2097A1 (fr)
NO (1)	NO900839L (fr)
NZ (1)	NZ232591A (fr)
PT (1)	PT93245B (fr)
RU (1)	RU2024549C1 (fr)

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US5389631A (en) *	1991-10-29	1995-02-14	Merck & Co., Inc.	Fibrinogen receptor antagonists
US5272158A (en) *	1991-10-29	1993-12-21	Merck & Co., Inc.	Fibrinogen receptor antagonists
US5227490A (en) *	1992-02-21	1993-07-13	Merck & Co., Inc.	Fibrinogen receptor antagonists
US5206373A (en) *	1992-02-28	1993-04-27	Merck & Co., Inc.	Process for preparing fibrinogen receptor antagonists
JP3322878B2 (ja) *	1992-10-14	2002-09-09	メルクエンドカンパニーインコーポレーテッド	フィブリノーゲンレセプターアンタゴニスト
US5340798A (en) *	1992-10-14	1994-08-23	Merck & Co., Inc.	Fibrinogen receptor antagonists
US5358956A (en) *	1992-10-14	1994-10-25	Merck & Co., Inc.	Fibrinogen receptor antagonists
WO1994008962A1 (fr) *	1992-10-14	1994-04-28	Merck & Co., Inc.	Antagonistes des recepteurs du fibrinogene
WO1994012181A1 (fr) *	1992-12-01	1994-06-09	Merck & Co., Inc.	Antagonistes des recepteurs du fibrinogene
US5753659A (en) *	1993-03-29	1998-05-19	Zeneca Limited	Heterocyclic compouds
WO1994022834A1 (fr) *	1993-03-29	1994-10-13	Zeneca Limited	Derives heterocycliques utilises comme inhibiteurs d'agregation plaquettaire
GB9406144D0 (en) *	1993-03-29	1994-05-18	Zeneca Ltd	Heterocyclic compounds
US5652242A (en) *	1993-03-29	1997-07-29	Zeneca Limited	Heterocyclic derivatives
US5750754A (en) *	1993-03-29	1998-05-12	Zeneca Limited	Heterocyclic compounds
US5441952A (en) *	1993-04-05	1995-08-15	Merck & Co., Inc.	Fibrinogen receptor antagonists
US5334596A (en) *	1993-05-11	1994-08-02	Merck & Co., Inc.	Fibrinogen receptor antagonists
GB9313268D0 (en) *	1993-06-28	1993-08-11	Zeneca Ltd	Chemical compounds
GB9313285D0 (en) *	1993-06-28	1993-08-11	Zeneca Ltd	Acid derivatives
US5463011A (en) *	1993-06-28	1995-10-31	Zeneca Limited	Acid derivatives
ES2169080T3 (es) *	1993-07-01	2002-07-01	Merck Patent Gmbh	Inhibidor de la agregacion de plaquetas estimulada por colageno.
US5397791A (en) *	1993-08-09	1995-03-14	Merck & Co., Inc.	Fibrinogen receptor antagonists
SK47796A3 (en) *	1993-10-15	1997-03-05	Rhone Poulenc Rorer Pharma	Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides
DE4427979A1 (de) *	1993-11-15	1996-02-15	Cassella Ag	Substituierte 5-Ring-Heterocyclen, ihre Herstellung und ihre Verwendung
US5821241A (en) *	1994-02-22	1998-10-13	Merck & Co., Inc.	Fibrinogen receptor antagonists
HUT76346A (en) *	1994-04-26	1997-08-28	Selectide Corp	Factor xa inhibitors
USRE39263E1 (en) *	1994-05-04	2006-09-05	Bayer Aktiengesellschaft	Substituted aromatic thiocarboxylic acid amides and their use as herbicides
WO1995030661A1 (fr)	1994-05-04	1995-11-16	Bayer Aktiengesellschaft	Amides aromatiques substitues d'acides thiocarboxyliques et leur utilisation comme herbicides
DE4421052A1 (de) *	1994-06-17	1995-12-21	Basf Ag	Neue Thrombininhibitoren, ihre Herstellung und Verwendung
US6387880B1 (en)	1994-10-24	2002-05-14	G.D. Searle & Co.	Transdermal N-[N-[5-[4-(aminoiminomethly)phenyl]-1-oxopentyl]-L-α-aspartyl]-L-phenylalainine or its esters and their pharmaceutically acceptable salts
US5719144A (en) *	1995-02-22	1998-02-17	Merck & Co., Inc.	Fibrinogen receptor antagonists
US5811398A (en) *	1995-04-11	1998-09-22	G. D. Searle & Co.	Platelet aggregation inhibitors containing C-terminal aminergic side chain amino acid residues
US5789421A (en) *	1995-10-26	1998-08-04	Merck & Co., Inc.	Fibrinogen receptor antagonist
US5952306A (en) *	1996-01-16	1999-09-14	Merck & Co., Inc.	Integrin receptor antagonists
WO1997026250A1 (fr) *	1996-01-16	1997-07-24	Merck & Co., Inc.	Antagonistes du recepteur integrine
AU719216B2 (en) *	1996-02-13	2000-05-04	Akzo Nobel N.V.	Serine protease inhibitors
US5780480A (en) *	1996-02-28	1998-07-14	Merck & Co., Inc.	Fibrinogen receptor antagonists
IL120310A (en) *	1996-03-01	2002-02-10	Akzo Nobel Nv	Serine protease inhibitors and pharmaceuticals containing them
US5889023A (en) *	1996-05-10	1999-03-30	Merck & Co., Inc.	Fibrinogen receptor antagonist
WO1999019294A1 (fr) *	1997-05-14	1999-04-22	Aventis Pharmaceuticals Products Inc. Legal/Patents	Preparation des pseudotetrapeptides azacycloalkylalcanoyles
AU728435B2 (en) *	1997-05-29	2001-01-11	Merck & Co., Inc.	Sulfonamides as cell adhesion inhibitors
US6221888B1 (en) *	1997-05-29	2001-04-24	Merck & Co., Inc.	Sulfonamides as cell adhesion inhibitors
US6294549B1 (en)	1997-07-23	2001-09-25	Merck & Co., Inc.	Method for eliciting an αvβ5 or dual αvβ3/αvβ5 antagonizing effect
EP1030831A4 (fr) *	1997-10-10	2003-01-02	Aventis Pharm Prod Inc	Preparation des pseudotetrapeptides azacycloalkylalcanoyles
TWI236476B (en) *	1997-11-25	2005-07-21	Schering Corp	Thrombin receptor antagonists
EP1063973B1 (fr)	1998-03-19	2016-11-16	Bristol-Myers Squibb Company	Systeme d'apport a liberation lente biphasique destine a des medicaments a solubilite elevee et procede associe
EP0987274A1 (fr) *	1998-09-15	2000-03-22	Hoechst Marion Roussel Deutschland GmbH	Inhibiteurs du facteur VIIa
CN1398189A (zh)	1998-12-23	2003-02-19	G.D.西尔公司	用于治疗肿瘤形成的放疗与cox－2抑制剂的联合治疗
KR20000047461A (ko) *	1998-12-29	2000-07-25	성재갑	트롬빈 억제제
US6548694B2 (en) *	2000-05-23	2003-04-15	Hoffman-La Roche Inc.	N-(4-carbamimidoyl-phenyl)-glycine derivatives
CN107080846A (zh)	2010-07-09	2017-08-22	詹姆斯.特林卡.格林	用于包括瑞格列净的短半衰期药物的组合立即/延迟释放递送系统

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CA1102316A (fr) *	1975-12-09	1981-06-02	Shosuke Okamoto	Traduction non-disponible
US4578079A (en) *	1982-08-04	1986-03-25	La Jolla Cancer Research Foundation	Tetrapeptide
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DE3781263T2 (de) *	1986-12-15	1993-04-08	Inst Nat Sante Rech Med	Peptid-derivate und deren verwendung in der therapie.
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1990
- 1990-01-19 CA CA002008116A patent/CA2008116C/fr not_active Expired - Fee Related
- 1990-02-09 HU HU90735A patent/HUT52784A/hu unknown
- 1990-02-15 CZ CS90745A patent/CZ282730B6/cs unknown
- 1990-02-16 MC MC902109A patent/MC2097A1/fr unknown
- 1990-02-16 IL IL9342290A patent/IL93422A/en not_active IP Right Cessation
- 1990-02-19 NZ NZ232591A patent/NZ232591A/xx unknown
- 1990-02-19 DE DE59010889T patent/DE59010889D1/de not_active Expired - Fee Related
- 1990-02-19 AU AU49940/90A patent/AU633872B2/en not_active Ceased
- 1990-02-19 AT AT90103167T patent/ATE187737T1/de not_active IP Right Cessation
- 1990-02-19 ES ES90103167T patent/ES2141079T3/es not_active Expired - Lifetime
- 1990-02-19 EP EP90103167A patent/EP0384362B1/fr not_active Expired - Lifetime
- 1990-02-21 FI FI900864A patent/FI900864A7/fi not_active Application Discontinuation
- 1990-02-21 DZ DZ900030A patent/DZ1396A1/fr active
- 1990-02-22 NO NO90900839A patent/NO900839L/no unknown
- 1990-02-22 PT PT93245A patent/PT93245B/pt not_active IP Right Cessation
- 1990-02-22 RU SU904743250A patent/RU2024549C1/ru active
- 1990-02-23 JP JP2044275A patent/JPH0662672B2/ja not_active Expired - Lifetime
1995
- 1995-05-30 US US08/454,453 patent/US5663297A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
FI900864A7 (fi)	1990-08-24
ATE187737T1 (de)	2000-01-15
JPH02264795A (ja)	1990-10-29
NO900839D0 (no)	1990-02-22
CS9000745A2 (en)	1991-08-13
PT93245A (pt)	1990-08-31
HUT52784A (en)	1990-08-28
CZ282730B6 (cs)	1997-09-17
IL93422A (en)	1994-11-28
EP0384362B1 (fr)	1999-12-15
IL93422A0 (en)	1990-11-29
NO900839L (no)	1990-08-24
CA2008116C (fr)	2001-11-20
AU4994090A (en)	1990-09-20
RU2024549C1 (ru)	1994-12-15
ES2141079T3 (es)	2000-03-16
AU633872B2 (en)	1993-02-11
DE59010889D1 (de)	2000-01-20
FI900864A0 (fi)	1990-02-21
HU900735D0 (en)	1990-04-28
EP0384362A2 (fr)	1990-08-29
PT93245B (pt)	1996-01-31
CA2008116A1 (fr)	1990-08-23
NZ232591A (en)	1992-11-25
US5663297A (en)	1997-09-02
JPH0662672B2 (ja)	1994-08-17
MC2097A1 (fr)	1991-02-15
EP0384362A3 (fr)	1992-03-18

Publication	Publication Date	Title
ATE187737T1 (de)	2000-01-15	Glycinderivate
MY105375A (en)	1994-09-30	Acetic acid derivatives.
ATE127800T1 (de)	1995-09-15	N-acyl-alpha-aminosäurederivate.
LV11318A (lv)	1996-06-20	Etikskabes atvasinajumi
IE873418L (en)	1988-06-17	5-oxaproline based peptides
AU3595289A (en)	1989-12-07	Oligopeptides with cyclic proline-analogous amino acids
DE68925806D1 (de)	1996-04-04	C63-Amidderivate von 34-de(acetylglucosaminyl)-34-deoxy-teicoplaninen
SE8303913D0 (sv)	1983-07-08	Heterocykliska foreningar
ES2054989T3 (es)	1994-08-16	Derivados de aminodiol inhibidores de renina.
DE59909101D1 (de)	2004-05-13	Polymere für kosmetische Formulierungen
IE44034L (en)	1977-07-07	Pyrrolidone carboxylic acids.
SE9201731D0 (sv)	1992-06-04	Saett att sammanlimma traebaserade produkter
PT78155B (de)	1986-07-17	N-(3-trifluormethylphenyl)-n'-propargylpiperazin seine herstellung und verwendung
FI970667A0 (fi)	1997-02-17	Koostumukset
YU41791A (sh)	1994-06-10	Derivati sirćetne kiseline