EA021584B1 - Ингибитор рецептора фактора роста фибробластов-3 (fgfr-3) и его применение - Google Patents

Ингибитор рецептора фактора роста фибробластов-3 (fgfr-3) и его применение Download PDF

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Publication number
EA021584B1
EA021584B1 EA201170590A EA201170590A EA021584B1 EA 021584 B1 EA021584 B1 EA 021584B1 EA 201170590 A EA201170590 A EA 201170590A EA 201170590 A EA201170590 A EA 201170590A EA 021584 B1 EA021584 B1 EA 021584B1
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antibody
popk
zeg
cells
rgo
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EA201170590A
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English (en)
Russian (ru)
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EA201170590A1 (ru
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Хайцзюнь Сунь
Лин Лю
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Имклоун Элэлси
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Publication of EA201170590A1 publication Critical patent/EA201170590A1/ru
Publication of EA021584B1 publication Critical patent/EA021584B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EA201170590A 2008-10-20 2009-10-15 Ингибитор рецептора фактора роста фибробластов-3 (fgfr-3) и его применение EA021584B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19685508P 2008-10-20 2008-10-20
PCT/US2009/060840 WO2010048026A2 (en) 2008-10-20 2009-10-15 Fibroblast growth factor receptor-3 (fgfr-3) inhibitors and methods of treatment

Publications (2)

Publication Number Publication Date
EA201170590A1 EA201170590A1 (ru) 2011-10-31
EA021584B1 true EA021584B1 (ru) 2015-07-30

Family

ID=42062445

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201170590A EA021584B1 (ru) 2008-10-20 2009-10-15 Ингибитор рецептора фактора роста фибробластов-3 (fgfr-3) и его применение

Country Status (17)

Country Link
US (3) US8043618B2 (2)
EP (1) EP2342232A2 (2)
JP (1) JP5577345B2 (2)
KR (1) KR101370798B1 (2)
CN (2) CN103524620A (2)
AR (1) AR073770A1 (2)
AU (1) AU2009307841B2 (2)
BR (1) BRPI0919832A8 (2)
CA (1) CA2741127C (2)
EA (1) EA021584B1 (2)
IL (1) IL211807A0 (2)
MX (1) MX2011004317A (2)
NZ (1) NZ592369A (2)
TW (1) TWI381848B (2)
UA (1) UA101681C2 (2)
WO (1) WO2010048026A2 (2)
ZA (1) ZA201101938B (2)

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AR073770A1 (es) * 2008-10-20 2010-12-01 Imclone Llc Anticuerpo aislado que se enlaza especificamente con, e induce la degradacion del receptor-3 del factor de crecimiento del fibroblasto humano (fgfr-3), fragmento de enlace fgfr-3 humano del mismo, composicion farmaceutica y producto que lo comprenden
MA33208B1 (fr) 2009-03-25 2012-04-02 Genentech Inc Anticorps anti-fgfr3 et procédés d'utilisation de ceux-ci
WO2013088191A1 (en) 2011-12-12 2013-06-20 Institut National De La Sante Et De La Recherche Medicale (Inserm) Antagonist of the fibroblast growth factor receptor 3 (fgfr3) for use in the treatment or the prevention of skeletal disorders linked with abnormal activation of fgfr3
EA201591324A1 (ru) 2013-01-16 2016-01-29 Инсерм (Энститю Насьональ Де Ля Сантэ Э Де Ля Решерш Медикаль) Полипептид растворимого рецептора 3 фактора роста фибробластов (fgr3) для применения с целью предотвращения или лечения нарушений, связанных с замедлением роста скелета
MX2015011428A (es) 2013-03-06 2016-02-03 Genentech Inc Metodos para tratar y prevenir la resistencia a los farmacos para el cancer.
TWI541022B (zh) * 2013-12-18 2016-07-11 應克隆公司 針對纖維母細胞生長因子受體－３（ｆｇｆｒ３）之化合物及治療方法
AU2015236073B2 (en) 2014-03-25 2020-04-30 Regeneron Pharmaceuticals, Inc. FGF21 receptor agonists and uses thereof
US20170101466A1 (en) * 2014-06-03 2017-04-13 Masahisa Handa Anti-blys antibodies
CN107073121A (zh) 2014-06-13 2017-08-18 基因泰克公司 治疗及预防癌症药物抗性的方法
KR20170048560A (ko) * 2014-09-05 2017-05-08 하이퍼파인 리서치, 인크. 낮은 필드 자기 공명 이미징 방법들 및 장치
KR102470456B1 (ko) 2014-09-26 2022-11-23 얀센 파마슈티카 엔.브이. Fgfr 억제제를 사용한 치료에 반응할 암 환자를 확인하는 데 있어서 fgfr 돌연변이 유전자 패널의 사용
BR112017017700A2 (pt) * 2015-02-19 2018-07-31 Bioclin Therapeutics Inc métodos, composições e kits para tratamento do câncer
EP3265462A1 (en) 2015-03-03 2018-01-10 INSERM - Institut National de la Santé et de la Recherche Médicale Fgfr3 antagonists
TW201711702A (zh) 2015-06-04 2017-04-01 應克隆公司 使用針對纖維母細胞生長因子受體３（ｆｇｆｒ３）之化合物的療法
MA43416A (fr) 2015-12-11 2018-10-17 Regeneron Pharma Méthodes pour ralentir ou empêcher la croissance de tumeurs résistantes au blocage de l'egfr et/ou d'erbb3
MX2018016257A (es) 2016-07-07 2019-11-21 Therachon Sas Polipéptidos del receptor 3 del factor de crecimiento de fibroblastos solubles (sfgfr3) y usos de los mismos.
TW201833140A (zh) * 2017-01-09 2018-09-16 美商莫瑞麥克製藥公司 抗fgfr抗體及使用方法
CA3189470A1 (en) 2020-08-21 2022-02-24 Yves SABBAGH Fgfr3 antibodies and methods of use
CN114015770B (zh) * 2021-12-30 2022-04-26 佛山市第三人民医院(佛山市精神卫生中心) 精神分裂全外周血rna标志物fgfr3及其应用
KR20250116795A (ko) * 2022-11-14 2025-08-01 리제너론 파마슈티칼스 인코포레이티드 별아교세포로의 섬유아세포 성장 인자 수용체 3-매개된 전달을 위한 조성물 및 방법
KR20250148746A (ko) 2023-01-13 2025-10-14 리제너론 파아마슈티컬스, 인크. Fgfr3 결합 분자 및 그의 사용 방법
WO2025240335A1 (en) 2024-05-13 2025-11-20 Regeneron Pharmaceuticals, Inc. Fgfr3 binding molecules and methods of use thereof

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WO2002102973A2 (en) * 2001-06-20 2002-12-27 Prochon Biotech Ltd. Antibodies that block receptor protein tyrosine kinase activation, methods of screening for and uses thereof
WO2005066211A2 (en) * 2003-12-19 2005-07-21 Five Prime Therapeutics, Inc. Fibroblast growth factor receptors 1, 2, 3, and 4 as targets for therapeutic intervention
US20100003258A1 (en) * 2008-07-01 2010-01-07 Zhigang Weng Fibroblast growth factor receptor 3 (fgfr3) binding proteins

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AR073770A1 (es) * 2008-10-20 2010-12-01 Imclone Llc Anticuerpo aislado que se enlaza especificamente con, e induce la degradacion del receptor-3 del factor de crecimiento del fibroblasto humano (fgfr-3), fragmento de enlace fgfr-3 humano del mismo, composicion farmaceutica y producto que lo comprenden

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WO2002102973A2 (en) * 2001-06-20 2002-12-27 Prochon Biotech Ltd. Antibodies that block receptor protein tyrosine kinase activation, methods of screening for and uses thereof
WO2005066211A2 (en) * 2003-12-19 2005-07-21 Five Prime Therapeutics, Inc. Fibroblast growth factor receptors 1, 2, 3, and 4 as targets for therapeutic intervention
US20100003258A1 (en) * 2008-07-01 2010-01-07 Zhigang Weng Fibroblast growth factor receptor 3 (fgfr3) binding proteins

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CHELLAIAH A. ET AL.: "MAPPING LIGAND BINDING DOMAINS IN CHIMERIC FIBROBLAST GROWTH FACTOR RECEPTOR MOLECULES". JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, INC, US LNKD- DOI:10.1074/JBC.274.49.34785, vol. 274, no. 49, 3 December 1999 (1999-12-03), pages 34785-34794, XP002951247, ISSN: 0021-9258 the whole document *
DVORAK P. ET AL.: "Increased expression of fibroblast growth factor receptor 3 in CD34+ BCR-ABL+ cells from patients with chronic myeloid leukemia". LEUKEMIA (BASINGSTOKE), vol. 17, no. 12, December 2003 (2003-12), pages 2418-2425, XP007913082, ISSN: 0887-6924, The whole document, in particular the methods; line 1 - page 2420, column 2, line 2 *
KEEGAN K. ET AL.: "ISOLATION OF AN ADDITIONAL MEMBER OF THE FIBROBLAST GROWTH FACTOR RECEPTOR FAMILY, FGFR-3" PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES (PNAS), NATIONAL ACADEMY OF SCIENCE, US LNKD-DOI:10.1073/PNAS.88.4.1095, vol. 88, 1 February 1991 (1991-02-01), pages 1095-1099, XP002071229, ISSN: 0027-8424, the whole document *
MARTINEZ-TORRECUADRADA J. ET AL.: "Targeting the Extracellular Domain of Fibroblast Growth Factor Receptor 3 with Human Single-Chain Fv Antibodies Inhibits Bladder Carcinoma Cell Line Proliferation". CLINICAL CANCER RESEARCH, THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, US LNKD-DOI:10.1158/1078-0432.CCR-05-0282, vol. 11, no. 17, 1 September 2005 (2005-09-01), pages 6280-6290, XP003013913, ISSN: 1078-0432, cited in the application, the whole document *
RAUCHENBERGER R. ET AL.: "Human combinatorial Fab library yielding specific and functional antibodies against the human fibroblast growth factor receptor 3". JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, INC, US LNKD-DOI:10.1074/JBC.M303164200, vol. 278, no. 40, 3 July 2003 (2003-07-03), pages 38194-38205, XP002404703, ISSN: 0021-9258, the whole document *
SCOTET EMMANUEL ET AL.: "The choice between alternative IHb and IIIc exons of the FGFR-3 gene is not strictly tissue-specific". BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1264, no. 2, 1995, pages 238-242, XP009133572, ISSN: 0006-3002, the whole document *
SUZANNE TRUDEL ET AL.: "The inhibitory anti-FGFR3 antibody, PRO-OOl, is cytotoxic to t(4;14) multiple myeloma cells". BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US LNKD- DOI:10.1182/BL00D-2005-10-4179, vol. 107, no. 10, 15 May 2006 (2006-05-15), pages 4039-4046, XP007913063, ISSN: 0006-4971, cited in the application, the whole document *
WANG W. ET AL.: "200 POSTER Transcriptome analysis method for in vivo mechanism of action study: IMC-DI1 anti-FGFR3 +/- cisplatin in bladder cancer models". EUROPEAN JOURNAL OF CANCER. SUPPLEMENT, PERGAMON, OXFORD, GB LNKD-DOI:10.1016/S1359-6349 (08)72132-3, vol. 6, no. 12, 1 October 2008 (2008-10-01), page 63, XP025534262, ISSN: 1359-6349 [retrieved on 2008-10-01], cited in the application, Abstract 200 *

Also Published As

Publication number Publication date
CN102186884A (zh) 2011-09-14
MX2011004317A (es) 2011-06-24
KR20110056554A (ko) 2011-05-30
AR073770A1 (es) 2010-12-01
EA201170590A1 (ru) 2011-10-31
JP5577345B2 (ja) 2014-08-20
ZA201101938B (en) 2012-08-29
TWI381848B (zh) 2013-01-11
AU2009307841A1 (en) 2010-04-29
CN103524620A (zh) 2014-01-22
WO2010048026A3 (en) 2010-07-15
JP2012505912A (ja) 2012-03-08
US20120219563A1 (en) 2012-08-30
CA2741127C (en) 2015-06-02
US8182815B2 (en) 2012-05-22
AU2009307841B2 (en) 2013-09-12
BRPI0919832A8 (pt) 2019-01-08
KR101370798B1 (ko) 2014-03-14
NZ592369A (en) 2013-02-22
US8404240B2 (en) 2013-03-26
UA101681C2 (ru) 2013-04-25
US8043618B2 (en) 2011-10-25
WO2010048026A2 (en) 2010-04-29
IL211807A0 (en) 2011-06-30
TW201026325A (en) 2010-07-16
CA2741127A1 (en) 2010-04-29
US20100098696A1 (en) 2010-04-22
EP2342232A2 (en) 2011-07-13
CN102186884B (zh) 2014-08-13
US20120009200A1 (en) 2012-01-12
BRPI0919832A2 (pt) 2015-12-15

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